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Abbreviation : MECL-1
Long Form : multicatalytic endopeptidase complex-like 1
No. Year Title Co-occurring Abbreviation
2020 Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. ICI, LMP2, LMP7, TLR7, TLR8, TnI-AM
2018 Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. ENU, SCID
2018 Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). LMP2, LMP7
2017 Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-kappaB activation. IkappaB, LMP
2016 Plasma Immunoproteasome Predicts Early Hemorrhagic Transformation in Acute Ischemic Stroke Patients. CD, hs-CRP, HT, IL-1beta, LMP2
2015 The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition. ERAP1, PA28
2011 The antiviral immune response in mice devoid of immunoproteasome activity. LMP
2007 The proteasome immunosubunit multicatalytic endopeptidase complex-like 1 is a T-cell-intrinsic factor influencing homeostatic expansion. MHC-I, WT
2006 HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity. LMP2
10  2006 Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1. ICS-2, IRF-1, LMP7
11  2003 Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. HLA, IFN-gamma, LMP2, PA28
12  2000 Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes. CTL, HBcAg, HBV, HLA, IFN, LMP
13  2000 Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope. LMP2, NP
14  1999 Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1. IRF, ISREs
15  1998 Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. IFN-gamma, LMP