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Abbreviation : MMB4 DMS
Long Form : 1,1'-methylenebis(4-((hydroxyimino)methyl)-pyridinium) dimethanesulfonate
No. Year Title Co-occurring Abbreviation
2021 Brain-targeting delivery of MMB4 DMS using carrier-free nanomedicine CRT-MMB4@MDZ. CRT, MDZ, MMB4-NC, Tf, TfR
2015 Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. OP, PHO
2013 Absorption, distribution, metabolism, and excretion of 14C-MMB4 DMS administered intramuscularly to Sprague-Dawley rats and New Zealand White rabbits. ---
2013 Comparative toxicology studies in Sprague-Dawley rats, rhesus monkeys, and New Zealand White rabbits to determine a no observed adverse effect level for 1,1'-methylenebis[4-[(hydroxyimino)methyl]-pyridinium] dimethanesulfonate. NZW
2013 Efficacy and pharmacokinetic/pharmacodynamic study of 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate in guinea pigs and rhesus macaques exposed to cyclosarin. HED, IM, NHPs, QoL
2013 Good manufacturing practice: manufacturing of a nerve agent antidote nanoparticle suspension. CSO, EF, GMP
2013 In vivo acetylcholinesterase reactivation in male guinea pigs and rhesus macaques following cyclosarin exposure and treatment with 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate. AChE, GPs, NHPs
2013 MMB4 DMS nanoparticle suspension formulation with enhanced stability for the treatment of nerve agent intoxication. PK
2013 MMB4 DMS: cardiovascular and pulmonary effects on dogs and neurobehavioral effects on rats. ---