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Abbreviation : NF-kappaB
Long Form : nuclear factor-kappaB
No. Year Title Co-occurring Abbreviation
2021 (-)-Loliolide Isolated from Sargassum horneri Suppressed Oxidative Stress and Inflammation by Activating Nrf2/HO-1 Signaling in IFN-γ/TNF-α-Stimulated HaCaT Keratinocytes. HO-1, IFN, IL, MAPK, MDC, Nrf2, RANTES, ROS, S. horneri, TARC, TNF, TSLP
2021 (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages. COX-2, IL-6, iNOS, LPS, MAPKs, NO, PGE2, ROS, TNF-alpha
2021 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. ERK, OA, PGRN
2021 17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway. ECM, ERbeta, IVDD, MMPs, NPC
2021 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. 18beta-GA, COX-2, DMM, ECM, HO-1, IL-1beta, IL-6, iNOS, MMP-13, NO, Nrf2, OA, PGE2, TNF-alpha
2021 2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression. 2-ME, ANXA1, FPRs, HPAECs, HR, IR
2021 2-NPPA Mitigates Osteoclastogenesis via Reducing TRAF6-Mediated c-fos Expression. 2-NPPA
2021 20-Hydroxy-3-Oxolupan-28-Oic Acid, a Minor Component From Mahonia bealei (Fort.) Carr. Leaves Alleviates Lipopolysaccharide-Induced Inflammatory in Murine Macrophages. DEGs, GO, HOA, JAK-STAT, KEGG, LPS, MAPK
2021 3,5-Dimethoxy-4-hydroxy myricanol attenuated oxidative stress-induced toxicity on cardiomyoblast cells. DHM, ELISA, HO-1, MAPKs
10  2021 4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts. 4-PBA, CIA, ER, IL, MAPK, MMPs, SFs
11  2021 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β). DSS, GSK-3beta, i.p, IBD, IL-6, iNOS, ITCs, PDTC, SS
12  2021 9-Methylfascaplysin exerts anti-ischemic stroke neuroprotective effects via the inhibition of neuroinflammation and oxidative stress in rats. MCAO
13  2021 A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase. beta-TrCP, EMT, HCC, IFN, IkappaB, ISRE, SH2, STAT3
14  2021 A chinese herbal formula ameliorates COPD by inhibiting the inflammatory response via downregulation of p65, JNK, and p38. BYF, COPD, FVC, IL-6, JNK, KAM, KAM-BYF, MMP-9, TCM, TNF-alpha
15  2021 A Combination of Polybacterial MV140 and Candida albicans V132 as a Potential Novel Trained Immunity-Based Vaccine for Genitourinary Tract Infections. DCs, GUTIs, MAPK, mTOR, rUTIs, RVVCs, TIbV
16  2021 A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thunb. COX-2, DPPH, EOs, GC-MS, IL-6, TNF-alpha
17  2021 A folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancer. CD, CRC, DTX, FA, siRNA
18  2021 A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. BCR, CLL, IKZF3
19  2021 A Kinase Assay for Measuring the Activity of the NIK-IKK1 Complex Induced via the Noncanonical NF-κB Pathway. ---
20  2021 A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells. EMT, HKC, IL, IL-1R, RIF, TIR8, UUO
21  2021 A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway. LPS, MyD88, NO, ROS, TLR4
22  2021 A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation. circRNAs, CRC
23  2021 A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species. BMMs, MAPK, NFATc1, Rob, ROS, TRACP
24  2021 A nuclear factor-kappa B inhibiting peptide suppresses innate immune receptors and gliosis in a transgenic mouse model of Alzheimer's disease. AD, GFAP, GILZ
25  2021 A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy. 10MWT, 5-LOX, COX, DMD, GPx, IL, MAPKs, TNF
26  2021 A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage. ICH, KLF2, mNSS, USP11
27  2021 A putative exosporium lipoprotein GBAA0190 of Bacillus anthracis as a potential anthrax vaccine candidate. BMDMs, ELISA, GP, IL-6, MAP, MCP-1, MIP-1alpha, PA, TNF-alpha
28  2021 A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression. BET, CBP, LPS, MAPK, MPO
29  2021 A Salmonella type III effector, PipA, works in a different manner than the PipA family effectors GogA and GtgA. S. Typhimurium
30  2021 A transposon screen identifies enhancement of NF-κB pathway as a mechanism of resistance to eribulin. ---
31  2021 A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB. IKK
32  2021 A20 deficiency in myeloid cells deteriorates the onset of vitiligo in mice. BMDMs, FACS, PMEL
33  2021 A20 functions as a negative regulator in macrophage for DSS-induced colitis. BMDMs, DSS, LPS
34  2021 A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation. EC, eNOS, ERK5, HCAEC, TNF
35  2021 Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. DEG, GO, KEGG, LADA
36  2021 Acer tataricum subsp. ginnala Inhibits Skin Photoaging via Regulating MAPK/AP-1, NF-κB, and TGFβ/Smad Signaling in UVB-Irradiated Human Dermal Fibroblasts. AG, AGE, HDF, IkappaB, MMP-1, UV
37  2021 Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB. CCK, CLIC1, Co-IP, GEPIA, PDTC
38  2021 Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway. ACh, CCK-8, DHE, p38 MAPK, PE, ROS
39  2021 Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-κB, inflammatory cytokines, iNOS, and oxidative stress. DAI, IFN, IL, iNOS, MCP, MDA, MMP, MPO, NO, SOD, TNF
40  2021 Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. AgPP, CBP, CTLs, ICIT, MHC-I
41  2021 Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway. AMPK, CaMKK, DMMB, IL, MMP, TRPV4
42  2021 Acylated Ghrelin Attenuates l-Thyroxin-induced Cardiac Damage in Rats by Antioxidant and Anti-inflammatory Effects and Downregulating Components of the Cardiac Renin-angiotensin System. ACE2, AG, Ang, DAG, GHS-R, IL-6, L-Thy, LV, MDA, mPTP, Nox1, ROS, TNF-alpha
43  2021 ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-κB Pathway in Human Gastric Cancer. GC, IHC, qRT-PCR, S100A16
44  2021 Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs. APN, COX, hPDLCs, IL, LPS, OPN, TNF-alpha
45  2021 Adoptive transfer of immunomodulatory M2 macrophages suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice via blockading NF-κB pathway. EAE, MS
46  2021 Advanced glycosylation end products inhibit the proliferation of bone-marrow stromal cells through activating MAPK pathway. AGEs, BMSCs, CCK-8, MAPK, PI3K
47  2021 Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-κB pathway. AOPPs, FLS, IkappaBalpha, IL-6, MMP-3, mRNA, RA, RAGE, TNF-alpha
48  2021 Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt/GSK3β/NF-κB pathway to mitigate myocardial ischemia/reperfusion injury. AES, AKT, GSK-3beta, MIRI, NLRP3, NRCMs, OGD/R
49  2021 Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice. CNS, LPS, MyD88, TLR4
50  2021 AGTR1 blocker attenuates activation of Tenon's capsule fibroblasts after glaucoma filtration surgery via the NF-κB signaling pathway. AGTR1, alpha-SMA, FN, GFS, HTFs, TGF-beta2
51  2021 Albendazole inhibits NF-κB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma. ABZ, ALDH, MM, MMSCs
52  2021 Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy. AR, KO, LPS
53  2021 Algae-derived polysaccharides supplementation ameliorates heat stress-induced impairment of bursa of Fabricius via modulating NF-κB signaling pathway in broilers. ADP, GST, HO-1, HS, IkappaBalpha, IL, INF-gamma, MDA, Nrf2, T-AOC, TNF-alpha
54  2021 Alginate oligosaccharide alleviates senile osteoporosis via the RANKL-RANK pathway in D-galactose-induced C57BL/6J mice. AOS, BMD, D-gal, OPG, RANKL
55  2021 Alginate oligosaccharide protects against enterotoxigenic Escherichia coli-induced porcine intestinal barrier injury. AOS, ETEC, LPS
56  2021 Alkaloid leonurine exerts anti-inflammatory effects via modulating MST1 expression in trophoblast cells. LNR, LPS, PE, WT
57  2021 Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates. AIM2, AST, ERK, IL, JNK, LPS, MAPK, TLR, TNF
58  2021 Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-κB/MAPK signaling pathways. I/R, MAPK
59  2021 Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats. GFAP, I/R, Iba1, JNK, MCAO, pASK1, T3JAM, TLR4, TRAF3, YZR, YZR-0.2g
60  2021 Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca2+ -activated K+ channel (BKCa ) upregulation. BKCa, JNKs, p-MLC, PKCzeta, S1P, S1PR2, siRNA, SLs, SMCs
61  2021 Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence-associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining. HIF-1alpha, hs-CRP, JNK, p-Akt, p38 MAPK, SASP
62  2021 Ameliorative Effect of Dietary Tryptophan on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut Microbiota. AMP
63  2021 Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro. Nrf2, SAA
64  2021 Amentoflavone Induces Cell-cycle Arrest, Apoptosis, and Invasion Inhibition in Non-small Cell Lung Cancer Cells. MMP, NSCLC, VEGF
65  2021 Amplification of DDR2 mediates sorafenib resistance through NF-κB/c-Rel signaling in hepatocellular carcinoma. DDR2, HCC, qPCR
66  2021 An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice. ASBMR, CUL, IPMK, MAPKs, ROS
67  2021 An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells. CRISPR, Exo III, TFs
68  2021 An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis. CIA, IgD, IgDR, p-Lck, PI3K, RA
69  2021 An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. LPS
70  2021 Androgenic modulation of arterial baroreceptor dysfunction and neuroinflammation in endotoxic male rats. BRS, NTS, PE, RVLM, SNP
71  2021 Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model. FLSs, HCQ, MCLT, OA, TNFR2
72  2021 Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity. DSS, HPLC, MAPK, TJ, UC
73  2021 Anthocyanin-Rich Aronia Berry Extract Mitigates High-Fat and High-Sucrose Diet-Induced Adipose Tissue Inflammation by Inhibiting Nuclear Factor-κB Activation. ARN, AT, BMDMs, HF, HS, LPS, SVF
74  2021 Anthocyanins from Hibiscus syriacus L. Inhibit NLRP3 Inflammasome in BV2 Microglia Cells by Alleviating NF-κB- and ER Stress-Induced Ca2+ Accumulation and Mitochondrial ROS Production. ER, IL-1beta, LPS/ATP, mtROS, NLRP3
75  2021 Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition. Con A, Nrf2
76  2021 Anti-inflammatory activities of amber extract in lipopolysaccharide-induced RAW 264.7 macrophages. COX-2, IL-6, iNOS, LPS, ROS, TNF-alpha
77  2021 Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-κB signaling pathway. CHD, EETMYX, ESR1, IPA, TMYX
78  2021 Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways. COX-2, IL-6, iNOS, LPS, MAPK, NO, PGE2, ROS, TNF-alpha, WECR
79  2021 Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts. CE, COX-2, iNOS, NO, PGE2, VVE
80  2021 Anti-inflammatory effect of Ailanthus altissima (Mill.) Swingle leaves in lipopolysaccharide-stimulated astrocytes. AAE, CNS, COX-2, ERK, iNOS, JNK, LPS, MAPK, NO
81  2021 Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways. IFN-gamma, IkBalpha, IL, JNK, NO, RA, TNF
82  2021 Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-κB- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells. CB, COX, IL, iNOS, LPS, MAPKs, NO, PB, TNF
83  2021 Anti-Inflammatory Effect of Wasp Venom in BV-2 Microglial Cells in Comparison with Bee Venom. BV, LPS, WV
84  2021 Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells. ATG5, LC3, LPS, NLRP3, ROS
85  2021 Anti-inflammatory effects of rhaponticin on LPS-induced human endothelial cells through inhibition of MAPK/NF-κβ signaling pathways. COX-2, IL-1beta, iNOS, LPS, MAPK, NOX, PCR, TNF-alpha
86  2021 Anti-Inflammatory Effects of Weigela subsessilis Callus Extract via Suppression of MAPK and NF-κB Signaling. LPS
87  2021 Anti-Neuroinflammatory and Anti-Inflammatory Activities of Phenylheptatriyne Isolated from the Flowers of Coreopsis lanceolata L. via NF-κB Inhibition and HO-1 Expression in BV2 and RAW264.7 Cells. COX-2, IL, iNOS, NO, TNF-alpha
88  2021 Anti-Neuroinflammatory Effects and Mechanism of Action of Fructus ligustri lucidi Extract in BV2 Microglia. FLL, FLLE, HO, IL-6, LPS, MAPKs, NO, TNF-alpha
89  2021 Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal Pathway. 7-OBA, CLP, JAK2, LPS, STAT3
90  2021 Anticancer activities of parthenolide in primary effusion lymphoma preclinical models. HHV-8, PEL
91  2021 Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2. CORT, HPA, Nrf2
92  2021 Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. IL, LPS, MAPK, MBJ, NO, Nrf2
93  2021 Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms. AMPK, IKK, MedDiet, NADPH, ROS, TNF-alpha
94  2021 Antioxidant and In Vitro Preliminary Anti-Inflammatory Activity of Castanea sativa (Italian Cultivar "Marrone di Roccadaspide" PGI) Burs, Leaves, and Chestnuts Extracts and Their Metabolite Profiles by LC-ESI/LTQOrbitrap/MS/MS. FRAP, NO, PGI, TEAC
95  2021 Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice. Bcl-2, CA, EC mice, FT-IR, TEM, VCAM-1, XRD, ZnO NPs, ZnO-CA NPs
96  2021 Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells. ATLL, CQ, HCQ, HTLV-1, SLE
97  2021 Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway. ApoC3, DN, HMCs, HTG, KO, Tg, TLR2, TRLs, WT
98  2021 Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages. APE1, IL, LPS, NLRP1, NLRP3, TAM, TNF-alpha
99  2021 Arachidonic acid inhibits the production of angiotensin-converting enzyme in human primary adipocytes via a NF-κB-dependent pathway. AA, ACE
100  2021 Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways. AIH, LPS, MAPK, NLRP3, NO