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Abbreviation : Nrf2
Long Form : NF-E2-related factor 2
No. Year Title Co-occurring Abbreviation
2023 Activation of NRF2 blocks HIV replication and apoptosis in macrophages. HIV
2023 Apigenin ameliorates hypercholesterolemic-induced kidney injury via modulating renal KIM-1, Fn1, and Nrf2 signaling pathways. APG, FN1, HC, KIM-1, NPD
2023 Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis. AST-IV, CIRI, Keap1, MCAO/R, OGD/R
2023 Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2. CN, WHFDCn, WHFDS, WHFDSCn, WSCn
2023 Contribution of NRF2 to sulfur metabolism and mitochondrial activity. MMP, OCR, SQOR
2023 Curcumin intake during lactation suppresses oxidative stress through upregulation of nuclear factor erythroid 2-related factor 2 in the kidneys of fructose-loaded female rat offspring exposed to maternal protein restriction. Fr, Glc, GPx, HO-1, MDA, SOD1, TG
2023 Depleted uranium causes renal mitochondrial dysfunction through the ETHE1/Nrf2 pathway. DU, ETHE1, HO-1, NQO1
2023 Divulging the Intricacies of Crosstalk Between NF-kB and Nrf-2/Keap1 Pathway in the Treatment of Arthritis by Dimethyl Fumarate. CAT, CIA, DMF, SOD
2023 FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway. ccRCC, FXR1, KEAP1, qRT-PCR
10  2023 The KEAP1-NRF2 system and neurodegenerative diseases. AD, CNC, CNS, CUL3, DMF, Keap1, MS, PD
11  2023 The role of ferroptosis in chronic intermittent hypoxia-induced cognitive impairment. ACSL4, CIH, GPX4, MDA, MWM, OSA, SD, SOD, TEM
12  2022 11,12-Diacetyl-carnosol Protects SH-SY5Y Cells from Hydrogen Peroxide Damage through the Nrf2/HO-1 Pathway. AD, HO-1, siRNA
13  2022 7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling. 7-d-GDN, DMF, HO-1, Keap1, MS, NF-E2, NQO1, RA, RASFs, ROS
14  2022 A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases. AD, Ass, PD
15  2022 Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice. CAT, Cr, IL-1beta, MDA, SOD
16  2022 An update of Nrf2 activators and inhibitors in cancer prevention/promotion. ---
17  2022 Antioxidant activity and protective effect of wheat germ peptides in an in vitro celiac disease model via Keap1/Nrf2 signaling pathway. CAT, CD, GCLC, GCLM, GPx, GR, Keap1, ROS
18  2022 Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients: a randomized double-blind controlled clinical trial. AST, SOD, T2DM, TAC
19  2022 BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma. BAP1, CUL3, KEAP1, LUAD
20  2022 Cellular antioxidant mechanism of mannan-oligosaccharides involving in enhancing flesh quality in grass carp (Ctenopharyngodon idella). IMP, MOS, n-3 PUFAs, TOR, UFA
21  2022 Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice. BDNF, bFGF, GFAP, KO, RBPMS, RGCs, WT
22  2022 Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid. AhR, ERK, HDAC, JNK, MAPKs, UGT, VPA
23  2022 Chlorogenic Acid, the Main Antioxidant in Coffee, Reduces Radiation-Induced Apoptosis and DNA Damage via NF-E2-Related Factor 2 (Nrf2) Activation in Hepatocellular Carcinoma. CGA, HCC, ROS
24  2022 Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway. HCC
25  2022 Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway. DN, SIRT1
26  2022 Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway. HFD, Keap1, NAFLD, PA, ROS, Se, SEPP1
27  2022 Dietary Soy Saponin Improves Antioxidant and Immune Function of Layer Hens. LYZ, MDA, PHA, SOD, SS
28  2022 Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation. BBB, DFZ
29  2022 Effect of autophagy on ferroptosis in foam cells via Nrf2. CQ
30  2022 Effect of Coffee on Lipopolysaccharide-Induced Immortalized Human Oral Keratinocytes. AC, CA, CGA, IHOKs, LPS, ROS
31  2022 Effects of M. oleifera leaf extract on the growth, physiological response and related immune gene expression of crucian carp fingerlings under Aeromonas hydrophila infection. ALB, Bach1, GSH-Px, Keap1, MDA, NOX, PRX, RBC, SOD
32  2022 Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation. PKM2
33  2022 Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. AMPK, DKD, FTH1, GPX4, HG, MDA, NDRD, SLC7A11
34  2022 Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions. Fer-1, HG, MMP, STZ
35  2022 Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal. Bach1, FSP1
36  2022 Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1alpha/Nrf2 Signaling. HO-1, PGC-1alpha, SIRT1
37  2022 Heme Oxygenase-1 Protects Hair Cells From Gentamicin-Induced Death. HCs, HO-1, PCR, ROS
38  2022 Hydroxytyrosol attenuates diquat-induced oxidative stress by activating Nrf2 pathway and modulating colonic microbiota in mice. CAT, DQ, GSH-Px, HT, MDA, NQO1, SOD, T-AOC
39  2022 Keap1 as Target of Genistein on Nrf2 Signaling Pathway Antagonizing Abeta induced Oxidative Damage of Cerebrovascular Endothelial Cells. GEN, Keap1, MDA, SOD
40  2022 Lack of Type I Interferon Signaling Ameliorates Respiratory Syncytial Virus-Induced Lung Inflammation and Restores Antioxidant Defenses. AOEs, IFN, RSV
41  2022 Limonene protects human skin keratinocytes against UVB-induced photodamage and photoaging by activating the Nrf2-dependent antioxidant defense system. alpha-MSH, HaCaT, HO-1, NQO-1, POMC, ROS, UVB
42  2022 Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway. AS, HF, LXA4
43  2022 Machine learning for the micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in glioblastoma. GBM, SLC2A10
44  2022 Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota. CMG, DSS, IBD, IL-1beta, IL-6, MDA, TNF-alpha, ZO-1
45  2022 Mokko Lactone Alleviates Doxorubicin-Induced Cardiotoxicity in Rats via Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities. DOX, HO-1, ML
46  2022 Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice. HO-1, PD
47  2022 Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation. 7-KC, M IL-10, NPY
48  2022 New Insight on the Immune Modulation and Physical Barrier Protection Caused by Vitamin A in Fish Gills Infected With Flavobacterium columnare. ACP, GPx, GR, GSTs, IFN-gamma2, IkappaBalpha, IKKbeta, IL-10, LEAP-2A and LEAP-2B, MDA, MLCK, NF-kappaB p65, p38 MAPK, PC, ROS, S6K1, TGF-beta1, TJ, TNF-alpha, TOR, ZO-1
49  2022 Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2. ATF3, Bach1, beta-TrCP, ER, Keap1, NASH, NF-kappaB, TGF-beta
50  2022 NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR. Keap1
51  2022 NRF2 and the Moirai: Life and Death Decisions on Cell Fates. ---
52  2022 Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice. DKD
53  2022 Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of beta-thalassemia. AHSP, ROS, tBHQ
54  2022 Nrf2 Signaling in the Oxidative Stress Response After Spinal Cord Injury. SCI
55  2022 Nrf2-Dependent Protective Effect of Paeoniflorin on alpha-Naphthalene Isothiocyanate-Induced Hepatic Injury. ALP, ALT, ANIT, AST, DBIL, GB, MDA, NOX4, PEA, PEN-induced ST, siRNA, TBA, TBIL, UDPGT
56  2022 Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer. ABC, ROS, VR
57  2022 Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells. ---
58  2022 Pilot Study: Nutritional and Preclinical Safety Investigation of Fermented Hispidin-Enriched Sanghuangporus sanghuang Mycelia: A Promising Functional Food Material to Improve Sleep. NREM, REM
59  2022 Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats. AhR, BDL, Drp1, FXR, HIF-1alpha, HMGB1, Hsp90, IL-1beta, TFEB, TGF-beta1, TLR4
60  2022 Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway. DFO, Fer-1, MI, Sal B, TCM
61  2022 Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity. BDNF, DLB, HDO, MeCP2, MPTP, PD
62  2022 S-Allylcysteine Potently Protects against PhIP-Induced DNA Damage via Nrf2/AhR Signaling Pathway Modulation in Normal Human Colonic Mucosal Epithelial Cells. HO-1, Keap1, PhIP, SAC
63  2022 Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function. Bax, Sal, SOD1
64  2022 Salt-Induced Hepatic Inflammatory Memory Contributes to Cardiovascular Damage Through Epigenetic Modulation of SIRT3. AMPK, SIRT3
65  2022 Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium. ESCC, Keap1, Keap1-cKO
66  2022 Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. GPX4, PT
67  2022 Silencing MR-1 Protects against Myocardial Injury Induced by Chronic Intermittent Hypoxia by Targeting Nrf2 through Antioxidant Stress and Anti-Inflammation Pathways. AAV, CIH, ELISA, HO-1, IL, Keap1, MDA, MR-1, OSAHS, ROS, SOD, TNF
68  2022 Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis. BE, EAC
69  2022 Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals. BBB, GPx, KO, NQO1, TBI
70  2022 Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy. AML, FLT3, HO-1, ITD, PDX, ROS, TKI, WT
71  2022 The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio). DEHP, MPs, PVC-MPs, ROS
72  2022 The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress. hTERT, SIRT1
73  2022 The effects of magnolol supplementation on growth performance, meat quality, oxidative capacity, and intestinal microbiota in broilers. ADG, GCLC, GCLM, GST, HO-1, MAG, MDA, NQO1, SOD, T-AOC
74  2022 The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway. AST, DBIL, eNOS, GST, iNOS, NQO1, OJ, TBIL, TCM, YCHD
75  2022 The molecular biology and therapeutic potential of Nrf2 in leukemia. ---
76  2022 The multiple biotoxicity integrated study in grass carp (Ctenopharyngodon idella) caused by Ochratoxin A: Oxidative damage, apoptosis and immunosuppression. HK, JAK/STAT, OTA, p38 MAPK, SP
77  2022 The Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus. SLE
78  2022 The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability. BBB, BMECs, LPS, SAE, TEER, TJ, ZO-1
79  2022 The Role of NRF2/KEAP1 Pathway in Glioblastoma: Pharmacological Implications. ARE, GBM, Keap1
80  2022 [Effect of Linggui Zhugan Decoction-containing serum on mitochondrial oxidative stress in cardiomyocytes: an exploration based on Nrf2/BNIP3 signaling pathway]. cyt c, LGZGD, mPTP, ROS
81  2022 [Role of ferroptosis in cerebellar injury of mice following lead exposure]. GPX4, HO-1, TfR1
82  2021 7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions. ECN, PSNL
83  2021 A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro. DMF, DMI
84  2021 A Role for NRF2-Signaling in the Treatment and Prevention of Solar Lentigines. BSE, TLR, UV
85  2021 ALK7 Inhibition Protects Osteoblast Cells Against High Glucoseinduced ROS Production via Nrf2/HO-1 Signaling Pathway. ALK7, CCK-8, HG, HO-1, qRT-PCR, ROS
86  2021 Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. HO-1, I/RI, LDH, MDA, ROS, SI/R, SOD
87  2021 Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway. 5-FU, ALT, ASP, AST, TG
88  2021 Antioxidant defense response during hibernation and arousal in Chinese soft-shelled turtle Pelodiscus sinensis juveniles. CAT, GPX3, GR, GSS, GST, POS
89  2021 Antioxidant response to severe hypoxia in Brandt's vole Lasiopodomys brandtii. AA
90  2021 Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome. CCS, CTA, HO-1
91  2021 Blueberry Polyphenol Extracts Enhance the Intestinal Antioxidant Capacity in Weaned Rats by Modulating the Nrf2-Keap1 Signal Pathway. BPE, Keap1
92  2021 Brg1 mutation alters oxidative stress responses in glioblastoma. ROS
93  2021 Caloric restriction inhibits renal artery ageing by reducing endothelin-1 expression. CR, ET-1, IL, SIRT1, TGF-beta1, TNF-alpha
94  2021 Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status. Tak
95  2021 Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice. AAV9, Ang II, CNTF
96  2021 Clostridium butyricum Protects IPEC-J2 Cells from ETEC K88-Induced Oxidative Damage by Activating the Nrf2/ARE Signaling Pathway. ARE, CB, ETEC K88, GPx, MDA, MOI, SOD
97  2021 Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2. CCK-8, CUL3, ELISA, PDLSCs, Pg-LPS, SHH
98  2021 Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3beta/Nrf2. AsT, BafA1, Co-IP, LAMP1, TFEB
99  2021 Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation‑induced HT22cells by activating the Nrf2/HO‑1 pathway. CIRI, DHM, MDA, OGD/R, SOD
100  2021 Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway. DMF, HO-1, ONC, pSTR, RBPMS, RGCs, TUBB3