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Abbreviation : OX1R
Long Form : orexin 1 receptor
No. Year Title Co-occurring Abbreviation
2021 Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of Vasopressin. AVP, DOCA, HR, MAP, PVN, SSH
2021 Activation of Orexin System Stimulates CaMKII Expression. BP, CaMKII, PVN, RSNA, SD, SNA
2021 Activation of Orexinergic Neurons Inhibits the Anesthetic Effect of Desflurane on Consciousness State via Paraventricular Thalamic Nucleus in Rats. BSR, OX2R, PeFLH, PVT
2021 Arousing Effects of Electroacupuncture on the "Shuigou Point" in Rats with Disorder of Consciousness after Traumatic Brain Injury. CCI, EA, ECoG, OX1
2021 Blockade of orexin receptors in the hippocampal dentate gyrus reduced the extinction latency of morphine-induced place preference in male rats. CPP, DG, OX2R
2021 Blockade of the orexin 1 receptors in the nucleus accumbens' shell reversed the reduction effect of olanzapine on motivation for positive reinforcers. AcbS, HRA, NAc, OLZ
2021 Orexin (hypocretin) mediates light-dependent fluctuation of hippocampal function in a diurnal rodent. AAV, brLD, dim-LD, MWM
2021 Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis. NAc, OX2R, PTSD, PVT, VTA
2021 Orexin-A differentially modulates inhibitory and excitatory synaptic transmission in rat inner retina. GCs, mEPSCs, mIPSCs, OX2R
10  2021 Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice. 2-AG, CB1R, CLEM, D2R, DA, LH, NAc, Ox-A, PLC, VTA, WT
11  2021 Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain. PBC, PET
12  2021 The Ciji-Hua'ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma. 5-HT, AgRP, CART, CHB-II-F, EGF, GAS, HCC, MDA, MTL, NPY, OXA, PGE2, POMC, SOD, SP, YZXJC
13  2020 A novel phosphorylation site on orexin receptor 1 regulating orexinA-induced GRK2-biased signaling. GPCRs
14  2020 Bilobalide assuages morphine-induced addiction in hippocampal neuron cells through upregulation of microRNA-101. OXA
15  2020 Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510. AD, FTD, IHC, LC, LH, OX2R, TH
16  2020 Evaluation of the relationship between the gene expression level of orexin-1 receptor in the rat blood and prefrontal cortex, novelty-seeking, and proneness to methamphetamine dependence: A candidate biomarker. METH, PFC
17  2020 Evolution of Orexin Neuropeptide System: Structure and Function. GPCR, LHA, orexin neurons, OX2R
18  2020 Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice. BCAO, CPSP, i.c.v, i.t, LC, RVM
19  2020 Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors. GHS-R, GPCRs, HEK293, NPY1R, NYT
20  2020 Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: Possible involvement of local Orexin-1 and Trk receptors. CNS, FST, OFT, OXA, TrkB, vmPFC
21  2020 Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen-Glucose Deprivation-Induced Neuronal Injury. 2-AG, ACEA, CB1, OGD, OXA, ROS
22  2020 Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats. CPP, FSS, s.c, VTA
23  2020 Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793. DORA
24  2020 The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues. GTs, LHA, OX2r, PavCA, PVT, STs
25  2020 The rostral ventromedial medulla orexin 1 receptors and extracellular signal-regulated kinase in hippocampus are involved in modulation of anxiety behavior induced by dental pulp nociception in adult male rats. EPM, OF, p-ERK, RVM
26  2020 Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. ---
27  2019 Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats. A1R, AD, EIC, ENT1, LHA, LORR, XNJI
28  2019 Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring. ---
29  2019 Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. ---
30  2019 Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. ---
31  2019 Expression of Dopamine Receptors in the Lateral Hypothalamic Nucleus and Their Potential Regulation of Gastric Motility in Rats With Lesions of Bilateral Substantia Nigra. ChAT, DMV, DR, GI, IR, LH, OXA, PD, SN
32  2019 Involvement of orexin receptors within the hippocampal dentate gyrus in morphine-induced reinstatement in food-deprived rats. CPP, DG, FD, OX2R
33  2019 Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway. lncRNAs, MEG3, si-MEG3
34  2019 Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes. 4-HNE, ATP, HBx, HCC, IL-8, JNK, LDH, NF-kappaB, NOX4, ROS, TNF-alpha
35  2019 Orexin Receptor-1 in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Electroacupuncture. BP, EA, HR, MAP, OX2R, RVLM
36  2019 Orexins alleviate motor deficits via increasing firing activity of pallidal neurons in a mouse model of Parkinson's disease. MPTP, OX2R
37  2019 Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil. VP
38  2019 Role of orexin receptors within the dentate gyrus of the hippocampus in antinociception induced by chemical stimulation of the lateral hypothalamus in the tail-flick test as a model of acute pain in rats. DG, LH, OX2R, OXRs
39  2019 Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor. PET, THIQ
40  2019 TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice. KO, NT1, OX2R, s.c, TMN
41  2019 The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats. HBO, LORR, OX2R
42  2018 Activation of orexin-1 receptors in the amygdala enhances feeding in the diet-induced obesity rats: Blockade with mu-opioid antagonist. BMA, DIO, DR, GD
43  2018 Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex. VTA
44  2018 Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity. ---
45  2018 Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection. ERK, NYHA, OR-B, OX2R, OXR, RT-PCR, TnI
46  2018 Ghrelin Through GHSR1a and OX1R Heterodimers Reveals a Galphas-cAMP-cAMP Response Element Binding Protein Signaling Pathway in Vitro. Co-IP, GHS-R1a
47  2018 Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats. CB1, EPM, OF, vlPAG
48  2018 Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. 2-AG, CB1Rs, MNS, MNS-PC6-IA, vlPAG
49  2018 Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making. ACC, OFC, PFC
50  2018 Orexin A prevents degradation of the articular matrixes in human primary chondrocyte culture. IL-1beta, OA, OX2R
51  2018 Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit. LA, NALC, PTSD
52  2018 Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats. ARC, CB1R, DIO, DR, GR
53  2018 Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats. BDNF, COX-2
54  2018 Orexin-A signaling in the paraventricular nucleus modulates spontaneous firing of glucose-sensitive neurons and promotes food intake via the NPY pathway in rats. ARC, GS, NPY, NPY-1R, PVN
55  2018 Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina. OX2R, RBCs
56  2018 Orexins Facilitates Osteogenic Differentiation of MC3T3-E1 Cells. ALP, MAPK, OX2R, PKD
57  2018 Role of orexins in the central and peripheral regulation of glucose homeostasis: Evidences & mechanisms. OX2R
58  2018 The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain. BDNF, COX-2
59  2018 The in vitro effect of progesterone on the orexin system in porcine uterine tissues during early pregnancy. OX2R, OXA, OXB
60  2017 Cardiovascular pressor effects of orexins in the dorsomedial hypothalamus. DMH, OX2R
61  2017 Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. ---
62  2017 Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor. KOR
63  2017 Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. ---
64  2017 Implicating the potential role of orexin in hypertension. HR, MAP, OX2R, RSNA
65  2017 Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension. AVP, Dahl S, HS, MAP, NS, PVN, SD, SSHTN
66  2017 Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1alpha-dependent and -independent mechanism. GLUT1, HIF-1alpha, LDHA, mTOR, PDH, PDHB, PDK1, PI3K
67  2017 Orexin A increases sympathetic nerve activity through promoting expression of proinflammatory cytokines in Sprague Dawley rats. PC12, PICs, PVN, SD, SNA
68  2017 Orexin modulates behavioral fear expression through the locus coeruleus. LA
69  2017 Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice. TWAA
70  2017 Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling. MRAP2, PKR1
71  2017 Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats. CPP, OX2R, VTA
72  2017 Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats. CPP
73  2017 The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats. MWM
74  2017 The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-Like Ethanol Drinking Behavior. CeA, DID, EtOH, OX, OXR, PCR, VTA
75  2016 Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. 1-SORA, 1-SORAs, 2-SORA, DORA, OX2R
76  2016 Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice. EAE, MOG, OX2R
77  2016 Orexin receptor expression in the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes of free-living European beavers (Castor fiber L.) in different periods of the reproductive cycle. HPA/HPG, OX2R
78  2016 Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice. AUDs, SB
79  2016 Orexin-A promotes Glu uptake by OX1R/PKCalpha/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro. Glu
80  2016 Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response. LC, VE, VT
81  2016 Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain. ORAs, OX2R, SNL
82  2016 Role of the orexin (hypocretin) system in contextual fear conditioning in rats. OX2R, ppOX
83  2016 The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. CIE, ORX
84  2016 The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat. CAP, EPM, TNC
85  2016 The role of trigeminal nucleus caudalis orexin 1 receptors in orofacial pain transmission and in orofacial pain-induced learning and memory impairment in rats. MWM
86  2016 Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback. HFD, VTA
87  2015 A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats. CB1R, i.c, nNOS, RVLM
88  2015 A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects. OXs, PeF
89  2015 Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior. ---
90  2015 Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. ---
91  2015 Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats. CPP, NAc, OX2R
92  2015 Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. DORA, OX2R, PK, SORAs
93  2015 Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP mice. GFP
94  2015 Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway. ---
95  2015 Effects of orexin A on glucose metabolism in human hepatocellular carcinoma invitro via PI3K/Akt/mTOR-dependent and -independent mechanism. GLUT1, LDHA, mTOR, PDH, PDHB, PDK1, PI3K
96  2015 Expression of the orexin system in the porcine uterus, conceptus and trophoblast during early pregnancy. OX2R, PPO
97  2015 Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. PTZ
98  2015 Hypothalamic dopaminergic neurons in an animal model of seasonal affective disorder. BLD, DA, DLD, SAD, SP, SST, TH
99  2015 Involvement of the orexin system in sympathetic nerve regulation. OXTg, SCG