| 1 |
2022 |
Cytochrome P450 isoforms contribution, plasma protein binding, toxicokinetics of enniatin A in rats and in vivo clearance prediction in humans. |
ENNA |
| 2 |
2022 |
Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation. |
BPA, BPZ |
| 3 |
2022 |
The construction and application of physiologically based toxicokinetic models for acrylamide, glycidamide and their biomarkers in rats and humans. |
AA, AAMA, AAVal, GA |
| 4 |
2022 |
The toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model. |
BPA, BPA sulf, BPA-gluc, TK |
| 5 |
2021 |
A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment. |
BCFs |
| 6 |
2021 |
Bayesian toxicokinetic modeling of cadmium exposure in Chinese population. |
ABC-MCMC, Cd, MCMC, RMSE, TK |
| 7 |
2021 |
Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks. |
IOCs |
| 8 |
2021 |
High-throughput PBTK models for in vitro to in vivo extrapolation. |
HTS, HTTK, IVIVE, TK |
| 9 |
2021 |
Liver-Based Probabilistic Risk Assessment of Exposure to Organophosphate Esters via Dust Ingestion Using a Physiologically Based Toxicokinetic (PBTK) Model. |
EDIs, IVIVE, MOE, OPEs, RfDs |
| 10 |
2021 |
Mapping blood lead levels in French children due to environmental contamination using a modeling approach. |
BLLs |
| 11 |
2021 |
Modeling acetylcholine esterase inhibition resulting from exposure to a mixture of atrazine and chlorpyrifos using a physiologically-based kinetic model in fish. |
AChE, ATR, CPF, CPF-oxon, TD |
| 12 |
2021 |
Tissue-Specific Accumulation, Biotransformation, and Physiologically Based Toxicokinetic Modeling of Benzotriazole Ultraviolet Stabilizers in Zebrafish (Danio rerio). |
BCFs, BUVSs |
| 13 |
2021 |
Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat. |
DM, ndl-PCBs |
| 14 |
2020 |
A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals. |
--- |
| 15 |
2020 |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
MRL, PM |
| 16 |
2020 |
Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S. |
BPA, BPS, p-PBTK |
| 17 |
2020 |
Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model. |
ADME, PFAAs |
| 18 |
2019 |
A Petri Net Approach to Physiologically Based Toxicokinetic Modeling. |
ODEs |
| 19 |
2019 |
Can the inhalation exposure of a specific worker in a cross-ventilated factory be evaluated by time- and spatial-averaged contaminant concentration? |
CFD, CSP |
| 20 |
2019 |
Elucidating the fate of perfluorooctanoate sulfonate using a rainbow trout (Oncorhynchus mykiss) physiologically-based toxicokinetic model. |
PFAS, PFOS |
| 21 |
2019 |
Evaluation of toxicokinetics of nonylphenol in the adult female Sprague-Dawley rats using a physiologically based toxicokinetic model. |
NP, RMSE |
| 22 |
2019 |
Physiologically based toxicokinetic models and in silico predicted partition coefficients to estimate tetrachlorodibenzo-p-dioxin transfer from feed into growing pigs. |
DDA, SIM, TCDD |
| 23 |
2019 |
Physiologically based toxicokinetics (PBTK) models for pharmaceuticals and personal care products in wild common carp (Cyprinus carpio). |
PPCPs |
| 24 |
2019 |
Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions. |
fup, IVIVE |
| 25 |
2018 |
Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments. |
TK |
| 26 |
2018 |
Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. |
AOP, IVIVE, POD, TD, TK |
| 27 |
2018 |
Computational Analysis of Deposition and Translocation of Inhaled Nicotine and Acrolein in the Human Body with E-cigarette Puffing Topographies. |
CFPD, EC |
| 28 |
2018 |
Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability. |
--- |
| 29 |
2018 |
In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds. |
IVIVE, YAS, YES |
| 30 |
2018 |
PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data. |
ADME, AOEL |
| 31 |
2018 |
QSAR modeling of adipose/blood partition coefficients of Alcohols, PCBs, PBDEs, PCDDs and PAHs: A data gap filling approach. |
AD, ADMET, PAHs, PBDEs, PCBs, PCDDs, QSAR |
| 32 |
2018 |
Read across for the derivation of Indoor Air Guidance Values supported by PBTK modelling. |
DNEL, IAGV, LCI, PUF, RW, VOC |
| 33 |
2017 |
A framework and case studies for evaluation of enzyme ontogeny in children's health risk evaluation. |
TK |
| 34 |
2017 |
A review of quantitative structure-property relationships for the fate of ionizable organic chemicals in water matrices and identification of knowledge gaps. |
QSPRs |
| 35 |
2017 |
Bioaccumulation mechanism of organophosphate esters in adult zebrafish (Danio rerio). |
OPEs |
| 36 |
2017 |
Can poly-parameter linear-free energy relationships (pp-LFERs) improve modelling bioaccumulation in fish? |
BCF, PP-LFERs, sp |
| 37 |
2017 |
Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches. |
IVIVE |
| 38 |
2016 |
Activities of xenobiotic metabolizing enzymes in rat placenta and liver in vitro. |
ADH, ALDH, FMO, GST, UGT |
| 39 |
2016 |
Cross-Species Extrapolation of Uptake and Disposition of Neutral Organic Chemicals in Fish Using a Multispecies Physiologically-Based Toxicokinetic Model Framework. |
--- |
| 40 |
2016 |
Fipronil and two of its transformation products in water and European eel from the river Elbe. |
--- |
| 41 |
2016 |
Physicologically Based Toxicokinetic Models of Tebuconazole and Application in Human Risk Assessment. |
ADME |
| 42 |
2016 |
Tissue-Specific Accumulation, Depuration, and Transformation of Triphenyl Phosphate (TPHP) in Adult Zebrafish (Danio rerio). |
d10-DPHP, TPHP |
| 43 |
2016 |
Toxicokinetic models and related tools in environmental risk assessment of chemicals. |
--- |
| 44 |
2015 |
A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla). |
--- |
| 45 |
2015 |
Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals. |
ERPG-3 |
| 46 |
2014 |
Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients. |
AUC, NOAEL, QSPRs, RtR |
| 47 |
2014 |
In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine. |
--- |
| 48 |
2014 |
Physiologically-based toxicokinetic model for cadmium using Markov-chain Monte Carlo analysis of concentrations in blood, urine, and kidney cortex from living kidney donors. |
--- |
| 49 |
2014 |
Physiologically-based toxicokinetic modeling of zearalenone and its metabolites: application to the Jersey girl study. |
JGS, ZAL, ZEA |
| 50 |
2014 |
Understanding receptor-mediated effects in rainbow trout: in vitro-in vivo extrapolation using physiologically based toxicokinetic models. |
--- |
| 51 |
2013 |
A physiologically based toxicokinetic model for the zebrafish Danio rerio. |
--- |
| 52 |
2013 |
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. |
--- |
| 53 |
2012 |
Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. |
PCBs |
| 54 |
2012 |
Evaluation of occupational exposure: comparison of biological and environmental variabilities using physiologically based toxicokinetic modeling. |
BM, EM |
| 55 |
2012 |
Hexavalent chromium reduction kinetics in rodent stomach contents. |
--- |
| 56 |
2012 |
Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies. |
BPA, TDI |
| 57 |
2012 |
Predicting concentrations of organic chemicals in fish by using toxicokinetic models. |
TK |
| 58 |
2012 |
Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches. |
ADME, TK |
| 59 |
2011 |
A generic, cross-chemical predictive PBTK model with multiple entry routes running as application in MS Excel; design of the model and comparison of predictions with experimental results. |
PBPK |
| 60 |
2011 |
Extrapolating the acute behavioral effects of toluene from 1- to 24-h exposures in rats: roles of dose metric and metabolic and behavioral tolerance. |
C t, Tol |
| 61 |
2011 |
Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior. |
AQP9s, DMA, MMA, MRPs, TK, TR |
| 62 |
2011 |
Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical predictive PBTK-model. |
PAH, QSPR |
| 63 |
2010 |
A physiologically based toxicokinetic model for methylmercury in female American kestrels. |
--- |
| 64 |
2010 |
Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity. |
GST |
| 65 |
2010 |
Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models. |
BaP, PAHs |
| 66 |
2009 |
Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb. |
AChE, AH-TK, ALU, ALX |
| 67 |
2009 |
Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment. |
--- |
| 68 |
2009 |
Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model. |
BPA |
| 69 |
2008 |
Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities. |
NHANES, NHEXAS |
| 70 |
2007 |
A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats. |
VOC |
| 71 |
2007 |
Approaches to acrylamide physiologically based toxicokinetic modeling for exploring child-adult dosimetry differences. |
AUC, CYP |
| 72 |
2007 |
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. |
BD, DEB, EB, EBD, GSA |
| 73 |
2007 |
Experimental exposure to 1,1,1-trifluoroethane (HFC-143a): uptake, disposition and acute effects in male volunteers. |
--- |
| 74 |
2007 |
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation. |
--- |
| 75 |
2007 |
PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. |
JP-8 |
| 76 |
2007 |
Physiologically-based toxicokinetic modeling of durene (1,2,3,5-tetramethylbenzene) and isodurene (1,2,4,5-tetramethylbenzene) in humans. |
TETMB, VMAX |
| 77 |
2007 |
Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats. |
DLM, GF, GI, SD, TK |
| 78 |
2006 |
A General Physiological and Toxicokinetic (GPAT) Model for Simulating Complex Toluene Exposure Scenarios in Humans. |
GPAT |
| 79 |
2006 |
Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models. |
MCMC, MLE, TD |
| 80 |
2006 |
Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes. |
AUC, TCE, THM |
| 81 |
2006 |
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models. |
--- |
| 82 |
2006 |
Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. |
--- |
| 83 |
2005 |
A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise. |
--- |
| 84 |
2005 |
Behavioural effects and kinetics in brain in response to inhalation of constant or fluctuating toluene concentrations in the rat. |
--- |
| 85 |
2005 |
Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry. |
EDR, nAChRs, PERC, TCE, VOCs, VSCCs |
| 86 |
2005 |
Human exposure and internal dose assessments of acrylamide in food. |
--- |
| 87 |
2004 |
Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. |
--- |
| 88 |
2003 |
A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. |
GI |
| 89 |
2003 |
A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: II. simulation of chronic exposure scenarios. |
--- |
| 90 |
2003 |
An in vivo microdialysis method for the qualitative analysis of hepatic phase I metabolites of phenol in rainbow trout (Oncorhynchus mykiss). |
CAT, HQ, MD |
| 91 |
2003 |
Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats. |
--- |
| 92 |
2003 |
Contribution of toxicokinetic modeling to the adjustment of exposure limits to unusual work schedules. |
ELs |
| 93 |
2003 |
Physiologically-based kinetic modeling of vapours toxic to the respiratory tract. |
--- |
| 94 |
2003 |
Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment. |
ICH |
| 95 |
2002 |
Impact of human variability on the biological monitoring of exposure to toluene: I. Physiologically based toxicokinetic modelling. |
EIs, GM, MCS, o-CR, TOL |
| 96 |
2002 |
The role of physiologically based toxicokinetic models in biologically based risk assessment. |
--- |
| 97 |
2002 |
[Specific nature of the software used to construct simulations: physiologically-based toxicokinetic models]. |
2,3,-DMBA, ACSL, TMB |
| 98 |
2001 |
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. |
AUC, BD |
| 99 |
2001 |
[Use of the ACSL simulation language for physiologic toxicokinetic models]. |
ACSL |
| 100 |
2000 |
A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush). |
HCE, PCE, TCE |
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