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[Related PubMed/MEDLINE]
Total Number of Papers: 1413
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| Abbreviation |
: PDE5 |
| Long Form |
: phosphodiesterase type 5 |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2022 |
A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs. |
ACE inhibitors, DOAJ, NSAIDs |
| 2 |
2022 |
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats. |
ED |
| 3 |
2022 |
Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study. |
ICD-10, IHD, OR |
| 4 |
2022 |
Ameliorative Sexual Behavior and Phosphodiesterase-5 Inhibitory Effects of Spondias mangifera Fruit Extract in Rodents: In Silico, In Vitro, and In Vivo Study. |
SMFE |
| 5 |
2022 |
An update on the management algorithms of priapism during the last decade. |
IP, NIP, SP |
| 6 |
2022 |
Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach. |
ED, MD |
| 7 |
2022 |
Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy. |
ATVs, CTLs, iNOS, PD-L1, TCM |
| 8 |
2022 |
Combination therapy of doxorubicin and Sildenafil inhibits the growth of pediatric rhabdomyosarcoma. |
ROS |
| 9 |
2022 |
Diet, herbs and erectile function: A good friendship! |
ACE, AChE, ADA |
| 10 |
2022 |
Effect of Antioxidants Supplementation on Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. |
CIs, ED, IIEF, SMDs |
| 11 |
2022 |
Effects of phosphodiesterase 5 inhibition on cardiovascular function in resistant hypertension: A systematic review. |
BP, RH |
| 12 |
2022 |
Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial. |
HFrEF, IQR, PASP, PHT, SilHF |
| 13 |
2022 |
Effects of Tadalafil on skeletal muscle tissue: exploring interactions and novel mechanisms of action. |
--- |
| 14 |
2022 |
Evaluating the efficacy of intraplaque injection of dexamethasone with oral tadalafil in the chordee patients with Peyronie disease. |
PD |
| 15 |
2022 |
Gosha-Jinki-Gan Improved Erectile Dysfunction Caused by Anti-Cancer Agent Oxaliplatin by Decreasing Transcriptional Expression of Phosphodiesterase-5 in Rats. |
ED, eNOS, GJG, ICP, MAP, NADPH, nNOS |
| 16 |
2022 |
How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme. |
cGMP, CNS, GBM, TME |
| 17 |
2022 |
In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters. |
cAMP, CC, cGMP, EFS, NO |
| 18 |
2022 |
Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis. |
BLM, SSc, TGF |
| 19 |
2022 |
Modulation of SIRT1 expression improves erectile function in aged rats. |
cGMP, dUTP, FOXO3a, ICP, MAP, MDA, NAM, NO, SIRT1, SOD, TdT |
| 20 |
2022 |
Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation. |
AKI, DVR, sGC |
| 21 |
2022 |
Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension. |
CYP3A4, ED, FDA, PAH, UGT1A9 |
| 22 |
2022 |
Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. |
AD, cGMP, CREB, DKK1, GR, GSK-3beta |
| 23 |
2022 |
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. |
cyt c, GLUT1, HIF-1alpha, HKII, LDHA, OXPHOS, PDK1, PKM2, ROS |
| 24 |
2022 |
Phosphodiesterase-5 Inhibitory Activity of Canthin-6-One Alkaloids and the Roots of Eurycoma longifolia and Eurycoma harmandiana. |
EH, EL |
| 25 |
2022 |
Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats. |
ACE, AChE, ADA, ED, FSH, LH, PAR, TBARS |
| 26 |
2022 |
ROCK and PDE-5 Inhibitors for the Treatment of Dementia: Literature Review and Meta-Analysis. |
ROCK |
| 27 |
2022 |
Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial. |
T2DM |
| 28 |
2022 |
Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. |
AAA, SMC |
| 29 |
2022 |
Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives. |
AR, BPH, Cyp19a1, ED, ERbeta |
| 30 |
2021 |
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects. |
PAH |
| 31 |
2021 |
Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain. |
cGMP, L-NAME, NO |
| 32 |
2021 |
Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis. |
AEs, ED, IIEF, PRISMA, WMD |
| 33 |
2021 |
Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats. |
5ARI, CC, EFS, eNOS, HIF, HUCB, MNCs, nNOS |
| 34 |
2021 |
Beyond Antimuscarinics: A Review of Pharmacological and Interventional Options for Overactive Bladder Management in Men. |
BTX-A, CI, MIRA, OAB, PRISMA, RCTs |
| 35 |
2021 |
Bilateral Sequential Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). |
HVF, NAION |
| 36 |
2021 |
Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety. |
--- |
| 37 |
2021 |
Cerebrovascular Reactivity Measures Are Associated With Post-traumatic Headache Severity in Chronic TBI; A Retrospective Analysis. |
CVR, fMRI, HIT-6, PPTH, TBI, TCVI |
| 38 |
2021 |
Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and Ostrea gigas Thunberg on Sexual Function in Male Mice. |
cGMP, NO |
| 39 |
2021 |
Compliance with Testosterone Replacement Therapy in Patients with Testosterone Deficiency Syndrome: A 10-Year Observational Study in Korea. |
TDS, TRT |
| 40 |
2021 |
Cyclic GMP in Liver Cirrhosis-Role in Pathophysiology of Portal Hypertension and Therapeutic Implications. |
cGMP, eNOS, PH, sGC |
| 41 |
2021 |
Dapagliflozin reduces systolic blood pressure and modulates vasoactive factors. |
ANP, BP, cGMP, MNC, T2D |
| 42 |
2021 |
Diets supplemented with raw and roasted pumpkin (Cucurbita pepo L) seeds improved some biochemical parameters associated with erectile function in rats. |
AChE, ADA, MDA |
| 43 |
2021 |
Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile. |
--- |
| 44 |
2021 |
Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product. |
EP, ICH, PEI, RP-HPTLC, SDL N-oxide, SLD |
| 45 |
2021 |
Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study. |
--- |
| 46 |
2021 |
Efficacy Evaluation of Plant Products in the Treatment of Erectile Dysfunction Related to Diabetes. |
STZ |
| 47 |
2021 |
Endothelin receptor antagonists for pulmonary arterial hypertension. |
CENTRAL, CI, ERAs, NYHA, OR, WHO |
| 48 |
2021 |
Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl4 Treated Rats. |
miRNAs |
| 49 |
2021 |
First molecular modelling report on tri-substituted pyrazolines as phosphodiesterase 5 (PDE5) inhibitors through classical and machine learning based multi-QSAR analysis. |
cGMP |
| 50 |
2021 |
Functional nitrergic innervation of smooth muscle structures in the mucosa of pig lower urinary tract. |
CGRP, EFS, MM, nNOS, NO, SMC-LP, TH |
| 51 |
2021 |
Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review. |
ACE, KIM-1, MO |
| 52 |
2021 |
Impacts of caffeine on resistant chicken's performance and cardiovascular gene expression. |
ADORA1, BW, PH, SERT |
| 53 |
2021 |
Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway. |
cGMP, PKG |
| 54 |
2021 |
Is Tadalafil an Effective Treatment Option for Interstitial Cystitis/Painful Bladder Syndrome? A Report of a Challenging Case. |
cGMP, CPP, IC/PBS, NO |
| 55 |
2021 |
Lead and mercury 28day exposure at small concentrations reduces smooth muscle relaxation by decreasing cGMP. |
--- |
| 56 |
2021 |
New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil. |
cGMP |
| 57 |
2021 |
Novel synthesized attapulgite nanoparticles-based hydrophobic monolithic column for in-tube solid-phase microextraction of thiosildenafil, pseudovardenafil, and norneosildenafil in functional foods. |
ATP, EDMA, SPME, VBIMBr |
| 58 |
2021 |
On the Viability of Tadalafil-Based 18F-Radiotracers for In Vivo Phosphodiesterase 5 (PDE5) PET Imaging. |
cGMP, NO, PET |
| 59 |
2021 |
Osthole alleviates pulmonary vascular remodeling by modulating microRNA-22-3p mediated lipid metabolic reprogramming. |
cGMP, CPT1A, FAS, HDL-C, HK2, IDH3alpha, IR, ND1, PAH, PLA2, TC, TG |
| 60 |
2021 |
Over-expression of PDE5 in Oral Squamous Cell Carcinoma - Effect of Sildenafil Citrate. |
OSCC, SC |
| 61 |
2021 |
Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie's Disease. |
ED, PD |
| 62 |
2021 |
PDE-5 inhibitors in selected herbal supplements from the Ghanaian market for better erectile function as tested by a bioassay. |
ED, HTS |
| 63 |
2021 |
Recent applications of phosphodiesterase (PDE5) inhibition assays for detecting adulterated sexual enhancement products. |
ED |
| 64 |
2021 |
Relaxation effects of Eriobotrya japonica toward tracheal smooth muscle via action mechanism on histamine-1 receptor and phosphodiesterase-5 enzyme. |
--- |
| 65 |
2021 |
Retrospective Observational Real-World Outcome Study to Evaluate Safety Among Patients With Erectile Dysfunction (ED) With Co-Possession of Tadalafil and Anti-Hypertensive Medications (anti-HTN). |
anti-HTN, CI, ED, IRRs |
| 66 |
2021 |
Significant Increase of Erectile Dysfunction in Men With Post-stroke: A Comprehensive Review. |
CI, ED, IIEF-5, RR, SMD |
| 67 |
2021 |
Sildenafil 4.0-Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. |
--- |
| 68 |
2021 |
Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications. |
HDAC, NK |
| 69 |
2021 |
Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation. |
--- |
| 70 |
2021 |
Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement. |
--- |
| 71 |
2021 |
Tadalafil Reversed H-89 - and Scopolamine - Induced Spatial Learning Impairments in Male Rats. |
AD, MWM |
| 72 |
2021 |
Tadalafil Reverses the Effect of Three-Dimensional Cell Culture System on Stem Cell Features in A549 and SK-MES-1. |
CCK, CSC, EMT, qPCR |
| 73 |
2021 |
Tadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failure. |
DM, EFS, HF, LUTS, LV |
| 74 |
2021 |
The effect of pharmacotherapy on prostate volume, prostate perfusion and prostate-specific antigen (prostate morphometric parameters) in patients with lower urinary tract symptoms and benign prostatic obstruction. A systematic review and meta-analysis. |
5ARI, PRISMA, PSA, RCTs, SMD, TPV, TZV |
| 75 |
2021 |
The effect of phosphodiesterase-5 inhibitors on uteroplacental and fetal cerebral perfusion in pregnancies with fetal growth restriction: A systematic review and meta-analysis. |
CIs, FGR, WMDs |
| 76 |
2021 |
The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews. |
CI, ED, WMD |
| 77 |
2021 |
The PDE5 inhibitor udenafil ameliorates nonalcoholic fatty liver disease by improving mitochondrial function. |
NAFLD, TG |
| 78 |
2021 |
The Potential Role of Sildenafil in Cancer Management through EPR Augmentation. |
ABC, ED, EPR, ROS |
| 79 |
2021 |
Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia. |
--- |
| 80 |
2021 |
Visual Side Effects Linked to Sildenafil Consumption: An Update. |
cGMP, CTs, ED, ERG, IOP, NAION |
| 81 |
2020 |
A meta-analysis of efficacy and safety of PDE5 inhibitors in the treatment of ureteral stent-related symptoms. |
CI, MD, OR, RCTs |
| 82 |
2020 |
A new approach at diabetic foot treatment: Phosphodiesterase 5 inhibitors. |
DF, DM |
| 83 |
2020 |
A synthetic mimic of phosphodiesterase type 5 based on corona phase molecular recognition of single-walled carbon nanotubes. |
--- |
| 84 |
2020 |
Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. |
DIC, ED, ICUs |
| 85 |
2020 |
Aging-Related Increase of cGMP Disrupts Mitochondrial Homeostasis in Leydig Cells. |
--- |
| 86 |
2020 |
Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats. |
alpha1-AR, CCSM, ED, ES, NOS, SHR, WKY |
| 87 |
2020 |
An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy. |
Ang II, MRTF-A, Sp1 |
| 88 |
2020 |
Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study. |
--- |
| 89 |
2020 |
Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder. |
BPH/LUTS, NOS, OAB, PBOO, SNP |
| 90 |
2020 |
Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide. |
I/R, LV, MetS, NO |
| 91 |
2020 |
Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection? |
COVID-19 |
| 92 |
2020 |
Design and synthesis of pyrazolo[3,4-d]pyrimidinone derivatives: Discovery of selective phosphodiesterase-5 inhibitors. |
--- |
| 93 |
2020 |
Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors. |
--- |
| 94 |
2020 |
Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease. |
AD, CREB, NO |
| 95 |
2020 |
Direct-To-Consumer Internet Prescription Platforms Overlook Crucial Pathology Found During Traditional Office Evaluation of Young Men With Erectile Dysfunction. |
DTC, ED |
| 96 |
2020 |
Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket. |
EVO |
| 97 |
2020 |
Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers. |
Bcl-2, BUBR1, NSCLC |
| 98 |
2020 |
Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors. |
COX-2 |
| 99 |
2020 |
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis. |
cGMP, CLD, HDACs, HSC, PKG, TGF-beta |
| 100 |
2020 |
Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms: STROBE, a case-control study. |
ED, IIEF, LUTS, SDS |
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