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Abbreviation : PGC-1alpha
Long Form : proliferator-activated receptor gamma coactivator-1alpha
No. Year Title Co-occurring Abbreviation
2022 Activating PGC-1α-mediated signaling cascades in the aorta contributes to the amelioration of vascular senescence and atherosclerosis by 2,3,4',5-tetrahydroxystilbene-2-O-β-d-glycoside. HAECs, HFD, ox-LDL, TSG
2022 Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPKα-SIRT1-PGC-1α Pathway. AGEs, AMPK, OA, SIRT1
2022 Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway. AMPK, HDL-C, LDL-C, MI/RI, SIRT1, T2DM, TC, TG
2022 Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer's Disease-A Longitudinal Study. AD, CREB1, SYP1
2022 Aged green tea reduces high-fat diet-induced fat accumulation and inflammation via activating the AMP-activated protein kinase signaling pathway. AMPK, EC, FAS, GSK-3beta, HFD, IL-6, JXGT, p-AMPK, TNF-alpha
2022 Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats. Cpt-I, GLUT4, SCR, Sirt3, SM
2022 Aluminum oxide and zinc oxide induced nanotoxicity in rat brain, heart, and lung. ACh, AChE, mtTFA, PON1, TAC, ZnO NPs
2022 Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet. BW, CFED
2022 An original amino acid formula favours in vitro corneal epithelial wound healing by promoting Fn1, ITGB1, and PGC-1α expression. BCAA, FN1, ITGB1
10  2022 Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice. ACC, ART, ATGL, FASN, HFD, MCD, NAFLD, NASH, RNA-Seq, SREBP-1c
11  2022 Association of rare PPARGC1A variants with Parkinson's disease risk. PD, WES, WGS
12  2022 Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks. AMPK, APS, PPARalpha, PPARgamma, SIRT1
13  2022 Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts. alpha-SMA, BAC, CHOP, Col, ECM, FN, GRP, HConF, HIF1alpha, sXBP1, TEER, XBP1
14  2022 Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity. alpha-SMA, BPA, CD44, EDCs, EMT, ERalpha
15  2022 Bone morphogenic protein 9 is a novel thermogenic hepatokine secreted in response to cold exposure. BMP9, CBP, CREB, iWAT, MAPK, rBMP9, S-V, UCP1
16  2022 Branched-Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary. BCAA
17  2022 Cell-Based Assays to Identify ERR and ERR/PGC Modulators. ---
18  2022 Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism. CGA, ECM, HMGB1, HSCs, MCD
19  2022 Codonopsis lanceolata and its active component Tangshenoside I ameliorate skeletal muscle atrophy via regulating the PI3K/Akt and SIRT1/PGC-1α pathways. CL, CSA, DEX, IM, mTORC1, MuRF1, PI3K, SIRT1, TSI
20  2022 Covering the Role of PGC-1α in the Nervous System. CNS
21  2022 Demethyleneberberine blocked the maturation of IL-1β in inflammation by inhibiting TLR4-mitochondria signaling. DMB, DSS, EtBr, NLRP3, TLR4, UC
22  2022 Deoxynivalenol triggers porcine intestinal tight junction disorder through hijacking SLC5A1 and PGC1α-mediated mitochondrial function. DON
23  2022 Dietary dimethylglycine sodium salt supplementation alleviates redox status imbalance and intestinal dysfunction in weaned piglets with intrauterine growth restriction. DMG-Na, IUGR, NBW, SIRT1
24  2022 Dietary iron modulates hepatic glucose homeostasis via regulating gluconeogenesis. AMPK
25  2022 Differential Immunometabolic Effects of High-Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice. EVOOs, HFDs, IL-6, Nrf2, TNF-alpha, UCP1
26  2022 Dihydromyricetin alters myosin heavy chain expression via AMPK signaling pathway in porcine myotubes. AMPK, DHM, MyHC, NRF1, p-CaMKKbeta, Sirt1
27  2022 Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes. NAFLD, NASH, OA
28  2022 Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome. DNs, DS, Hsa21, ROS
29  2022 Dual Effects of Korean Red Ginseng on Astrocytes and Neural Stem Cells in Traumatic Brain Injury: The HO-1-Tom20 Axis as a Putative Target for Mitochondrial Function. ATP, HO-1, KRGE, NAD, NSCs, TBI
30  2022 Dysfunction of insulin-AKT-UCP1 signalling inhibits transdifferentiation of human and mouse white preadipocytes into brown-like adipocytes. AMP, p-Akt, PI3K, PPARgamma, PRDM16, SIRT1, UCP1
31  2022 Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke-induced model of chronic obstructive pulmonary disease. COPD, CSE, Mstn
32  2022 Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1α and SOD2. ECE, mtDNA, mtROS, NADPH, SHRs, SIRT3, SOD, VC, VSMCs, WKY
33  2022 Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets. AMP, CnA, HO-1, LT, MDH, NQO1, Nrf2, Prox1, SDH
34  2022 Effect of different intensities aerobic exercise to cardiac angiogenesis regulation on Wistar rats. HIF, VEGF
35  2022 Effect of Qingyangshen glycosides on social defeat mice model. BDNF, CSDS, FNDC5, MAPK, QYS, SIRT1, TrkB
36  2022 Effects of bacteriophage supplement on the growth performance, microbial population, and PGC-1α and TLR4 gene expressions of broiler chickens. BP, FCR, Ig, IL-10, TLR4
37  2022 Effects of long-term resveratrol treatment in hypothalamic astrocyte cultures from aged rats. HO-1, Nrf2, PI3K, SIRT1
38  2022 Ellagic Acid Alters Muscle Fiber-Type Composition and Promotes Mitochondrial Biogenesis through the AMPK Signaling Pathway in Healthy Pigs. AMPKalpha1, CS, EA, LDH, LT, MDH, mtDNA, MyHC, P-LKB1, pAMPK, PSCs, SIRT1
39  2022 Elucidating the Beneficial Effects of Ginger (Zingiber officinale Roscoe) in Parkinson's Disease. AD, AKT, AMPK, ERK, MAPK, NF-kappaB, PD, PI3K
40  2022 Endoplasmic Reticulum Stress Contributes to Ventilator-Induced Diaphragm Atrophy and Weakness in Rats. 4-HNE, 4-PBA, ER, MV, NAC, ROS, TUN, VIDD
41  2022 Endurance Training Increases the Running Performance of Untrained Men without Changing the Mitochondrial Volume Density in the Gastrocnemius Muscle. COX, CS, Mff, MitoVD, OPA1, VDAC1
42  2022 Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α. AMPK, mTORC1, PRLR
43  2022 Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability. IBD, IECs, SMYD5
44  2022 Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways. AKI, COX-2, HSP70, I/R, IL-6, NF-kappaB, SIRT1, TNF-alpha
45  2022 Exercise Preconditioning Blunts Early Atrogenes Expression and Atrophy in Gastrocnemius Muscle of Hindlimb Unloaded Mice. AMPK, CSA, HU, SIRT1
46  2022 Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension. GLUT4, LDH, PAH, PPARgamma, RV
47  2022 Exogenous Nucleotides Improved the Oxidative Stress and Sirt-1 Protein Level of Brown Adipose Tissue on Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice. AMP, BAT, MDA, NMN, nts, PRDM16, SAMP8, SAMP8-NC, SAMP8-young-NC, SAMR1, SOD, UCP1
48  2022 FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. cAMP, Cas9, CRISPR, FACI, HNF4alpha, SREBP1
49  2022 Fenofibrate Improves Cognitive Impairment Induced by High-Fat High-Fructose Diet: A Possible Role of Irisin and Heat Shock Proteins. HFFD, HSP70
50  2022 Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity. I/R
51  2022 Gardeniae Fructus Extract Alleviates Dexamethasone-Induced Muscle Atrophy in Mice. AMPK, DEX, FOXO, GF, GF100, GF200, MA, SIRT1
52  2022 Genetic Variants of VDR and PGC-1α Are Not Associated with the Risk of Endometriosis in Indian Women. VDR
53  2022 Glioprotective Effects of Resveratrol Against BMAA-Induced Astroglial Dysfunctions. BMAA, CNS, HO-1, Nrf2, PI3K, SOD
54  2022 Gynostemma pentaphyllum extract and Gypenoside L enhance skeletal muscle differentiation and mitochondrial metabolism by activating the PGC-1α pathway in C2C12 myotubes. CPT1B, FNDC5, GL, GPE, Gys
55  2022 Gynostemma pentaphyllum extract and its active component gypenoside L improve the exercise performance of treadmill-trained mice. GL, GPE, SOL
56  2022 Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway. AMPK, ICS II, MI, OGD, SIRT3
57  2022 IGF-1 Signaling Regulates Mitochondrial Remodeling during Myogenic Differentiation. BNIP3, IGF-1, mTOR
58  2022 IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1α in Septic Mice. CLP, CSA, KO, ROS
59  2022 Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training. CNT, EAM, HIIT, PF, SAMs
60  2022 Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway. AMPK, NO, UUO
61  2022 Integrating network pharmacology and in vivo experimental validation to reveal the alleviation of mailuoning oral liquid on non-alcoholic fatty liver disease. MCD, MLN, NAFLD, NASH, NEFA, PPARalpha
62  2022 Intermittent hypoxia promotes the recovery of motor function in rats with cerebral ischemia by regulating mitochondrial function. AMPK, ATP, IH, SED, Sham, Sirt3, tMCAO
63  2022 IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction. HNF4alpha, IRF2BP2
64  2022 Jian Pi Tiao Gan Yin alleviates obesity phenotypes through mTORC1/SREBP1 signaling in vitro and in vivo. EDNRA, HFD, JPTGY, mTORC1, PPARgamma, PSTA, SREBP, UCP1
65  2022 Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells. FOXO1, OA, SLN, SLN-KD
66  2022 Krill Oil Inhibits NLRP3 Inflammasome Activation in the Prevention of the Pathological Injuries of Diabetic Cardiomyopathy. DCM, DM, KO, NLRP3, SIRT3
67  2022 Kynurenine Metabolism as a Mechanism to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors Following Resistance Training. BCSs, KYN, KYNA, RT
68  2022 Lactate modulates cardiac gene expression in mice during acute physical exercise. COX IV, CS, HK, LDH, Nrf2
69  2022 Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation. CSCs, HIF-1alpha, OXPHOS, TME
70  2022 Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway. DEX, LXA4, Nrf2
71  2022 Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis. SCs, VEGF
72  2022 Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. AMPK, ME, MO, NST, OB, UCP3
73  2022 Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation. Cd, Drp1, Fis1, SIRT1
74  2022 Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. ---
75  2022 Metformin mitigates gas explosion-induced blast lung injuries through AMPK-mediated energy metabolism and NOX2-related oxidation pathway in rats. AMPK, BLI, CAT, MET
76  2022 Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle. MG, TLR4
77  2022 Methylmalonic acid induces inflammatory response and redox homeostasis disruption in C6 astroglial cells: potential glioprotective roles of melatonin and resveratrol. CNS, COX-2, iNOS, MMA, NF-kappaB, Nrf2
78  2022 miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo. iWAT, UCP1
79  2022 Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency. DNs, EMPF2, ER, Mff, ROS
80  2022 Mitochondrial Exhaustion of Memory CD4 T-Cells in Treated HIV-1 Infection. INR, PLWH
81  2022 MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. HIIT
82  2022 Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol. CS, FFAR2, MMP, ROS, TMAO, UC
83  2022 Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α. BMAL1
84  2022 Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1. BDNF, cTrkB KO, YY1
85  2022 Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis. AMPK, CIBP, GPX4, NF-kappaB
86  2022 Neuronal GPER Participates in Genistein-Mediated Neuroprotection in Ischemic Stroke by Inhibiting NLRP3 Inflammasome Activation in Ovariectomized Female Mice. ERT, GPER, I/R, NLRP3
87  2022 NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia. NF-kappaB, TNF-alpha
88  2022 NRF2/PGC-1α-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells. CNS, Nrf2
89  2022 Nuclease-Treated Stabilized Fermentation Product of Cetobacterium somerae Improves Growth, Non-specific Immunity, and Liver Health of Zebrafish (Danio rerio). FCR, HFD, IL-10, IL-1beta, IL-6, TAG, UCP2
90  2022 Oleuropein suppresses mitochondrial reactive oxygen species generation possibly via an activation of transient receptor potential V1 and sirtuin-1 in cultured chicken muscle cells. AMPK, avUCP, ER, mitROS, OLE, SIRT1, TRPV1
91  2022 Oolong tea extract alleviates weight gain in high-fat diet-induced obese rats by regulating lipid metabolism and modulating gut microbiota. FASN, HFD, OTE, SREBP1, UCP1
92  2022 Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells. Bcl-2, HO-1, LDH, MMP, Nrf2, PINK1, ROS, SMI
93  2022 Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction. AMPK, CKD, MuRF1, MyoG, ROS, SIRT1
94  2022 PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis. mtDNA, NRF1
95  2022 Pentamethylquercetin Regulates Lipid Metabolism by Modulating Skeletal Muscle-Adipose Tissue Crosstalk in Obese Mice. AMPK, FNDC5, PMQ, UCP1
96  2022 Perilipin Isoforms and PGC-1α Are Regulated Differentially in Rat Heart during Pregnancy-Induced Physiological Cardiac Hypertrophy. PLIN, TAG
97  2022 Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) overexpression alleviates endoplasmic reticulum stress after acute kidney injury. AKI, ER, Hes1, I/R, Mfn2, UPR
98  2022 Persistent diastolic dysfunction in chronically ischemic hearts following coronary artery bypass graft. CABG, HM, MRI, NF-kappaB
99  2022 PGC-1 alpha regulates mitochondrial biogenesis to ameliorate hypoxia-inhibited cementoblast mineralization. ---
100  2022 PGC-1α activity and mitochondrial dysfunction in preterm infants. BPD, ELGANs, RNS, ROS, WMI