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Abbreviation : PHD2
Long Form : prolyl hydroxylase 2
No. Year Title Co-occurring Abbreviation
2022 Endothelial PHD2 deficiency induces nitrative stress via suppression of caveolin-1 in pulmonary hypertension. Cav-1
2022 Genetic and immune changes in Tibetan high-altitude populations contribute to biological adaptation to hypoxia. EGLN1, EPAS1, ERBB3, GROa, Hct, HGB, HIF-1alpha, HIF-2alpha, IL-8, MCH, MCHC, MCV, MIP-1b, SNPs, TNFRII
2022 GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells. GPER, HIF-1alpha, UCH-L1
2022 HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1alpha/HEY1 Signaling Pathway. HDFs, HOCl
2022 Hypoxia-induced HIF1alpha activation regulates small extracellular vesicle release in human embryonic kidney cells. EVs, HIFs
2022 In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. ISISS
2022 Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1alpha-PPARgamma pathway. HIF1alpha
2022 Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types. ET-1, MET, SVA
2022 PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis. ASMCs, BM, ECs, HIF, RV
10  2022 Production of functional recombinant prolyl hydroxylase-2 enzyme in insect cells for small molecule inhibitor screening studies. HIF, VBC
11  2022 Response to roxadustat in a patient undergoing long-term dialysis and allergic to erythropoiesis-stimulating agents: A case report. ESAs
12  2022 Screening of prolyl hydroxylase 2 inhibitors based on quantitative strategy of peptides. MEKC, TCMs
13  2022 Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1alpha: Therapeutic Implication in Alzheimer's Disease. AD, HIF-1alpha, iNOS
14  2022 Tetrahydropyridin-4-ylpicolinoylglycines as novel and orally active prolyl hydroxylase 2 (PHD2) inhibitors for the treatment of renal anemia. EPO, HIF-alpha
15  2022 The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. HIF
16  2021 alpha-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt. alpha-KG, DBT, pAkt1
17  2021 BNIP3 in melanoma: isn't it IRONic? Bcl-2, HIF-1alpha, Ncoa4
18  2021 Costunolide ameliorates colitis via specific inhibition of HIF1alpha/glycolysis-mediated Th17 differentiation. DAI, DSS, MPO, UC
19  2021 In silico identification of prolyl hydroxylase inhibitor by per-residue energy decomposition-based pharmacophore approach. HIF, MD, MM-GBSA, PRED
20  2021 Influence of hypoxia on biochemical aspects and on expression of genes related to oxygen-homeostasis of the Amazonian cichlid Astronotus ocellatus (Agassiz, 1831). HIF-1alpha
21  2021 kappa-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling. ALP, beta-GP, LDH, VSMCs
22  2021 LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in Ischemic Myocardium. HIF-1alpha, LRP5
23  2021 Overexpression of MicroRNA-429 Transgene Into the Renal Medulla Attenuated Salt-Sensitive Hypertension in Dahl S Rats. HIF
24  2021 PHD2 attenuates high-glucose-induced blood retinal barrier breakdown in human retinal microvascular endothelial cells by regulating the Hif-1alpha/VEGF pathway. BRB, DME, DMOG, HIF-1, HRMECs, RT-qPCR, TEER, VEGF, ZO-1
25  2021 Resveratrol suppresses malignant progression of oral squamous cell carcinoma cells by inducing the ZNF750/RAC1 signaling pathway. ITGA5, ITGB1, RGS5, VEGF
26  2021 Selinexor decreases HIF-1alpha via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity. CRM1, HIFs, NPCs
27  2021 The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1alpha pathway. DpdtbA, EMT, ROS
28  2020 Cystathione beta-synthase regulates HIF-1alpha stability through persulfidation of PHD2. CBS, HIF-1alpha
29  2020 Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury. Ang II, AT1R, ECs, HIF, PHD2ECKO, ROS, WT
30  2020 Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress. AMPK, CsA, ER, HIF, hPTEC, PHD, PHDi
31  2020 Macrophage HIF-1alpha mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M. AT, HFD, HIF-1alpha, Irak-M, PHDs
32  2020 Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1alpha Stabilization and Expression of Its Downstream Targets. CAIX, HIF-1alpha, HIF-2alpha, mtDNA, OXPHOS, ROS, VEGF
33  2020 Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats. ELISA, EPO, HIF-2alpha, IL-6, rhEPO, SFE
34  2020 Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-kappaB-dependent mechanism. BM-MSCs, MSC-CM, NEC, PHDMSC-CM
35  2020 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. ---
36  2019 A systematic review on the genetic analysis of paragangliomas: primarily focused on head and neck paragangliomas. MAX, NF1, RET, TMEM127, VHL
37  2019 Discovery of prolyl hydroxylase 2 inhibitors with new chemical scaffolds as in vivo active erythropoietin inducers through a combined virtual screening strategy. EPO, HIF
38  2019 Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1alpha are Associated with Endometrial Cancer Aggressiveness. HIF-1alpha, LVSI
39  2019 Early-Life Iron Deficiency Alters Glucose Transporter-1 Expression in the Adult Rodent Hippocampus. FID, GLUT, HIF, ID, WT
40  2019 Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans. HIF
41  2019 Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis. AILI, HIF-1
42  2019 Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1alpha. CAMs, ER, HIF, HUVECs, scFv
43  2019 PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-kappaB activity. EMT, MDSCs, TAMs
44  2019 Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light. ---
45  2019 Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens. DRS, Hb, HBM, Heph, NC, QB, WB
46  2019 Targeting ERbeta in Macrophage Reduces Crown-like Structures in Adipose Tissue by Inhibiting Osteopontin and HIF-1alpha. CLS, CNS, ERbeta, HIF-1alpha, OPN, SAT, VAT
47  2019 The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment. HIF-1alpha, PHDs
48  2018 Hepatic PHD2/HIF-1alpha axis is involved in postexercise systemic energy homeostasis. HIF-1alpha, LKO
49  2018 Hypoxia Upregulates Estrogen Receptor beta in Pulmonary Artery Endothelial Cells in a HIF-1alpha-Dependent Manner. ER, HIF-1alpha, HPH, PAECs
50  2018 PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes. PAI-1, PASMCs, PDLIM5, PH, UTR
51  2018 Prolyl hydroxylase 2: a promising target to inhibit hypoxia-induced cellular metabolism in cancer cells. HIF-1alpha, PPP, SREBP-1c
52  2018 Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis. Ang-2, ANP, HFD, NAFLD
53  2018 Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway. alpha-KG, FH, TKT, TNBC
54  2018 Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article). AMS, ARD1, HDM2, HIF-1, OS-9, RACK1, SSAT1, TCM
55  2018 ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. ITGA5, ITGB1, VEGF, ZNF750
56  2017 Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling. alpha-KG, Shh
57  2017 Hypoxia inducible factor-1alpha mediates the profibrotic effect of albumin in renal tubular cells. CKD, EMT, HIF, TIMP
58  2017 Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction. HIF-1alpha, UTMD
59  2016 15-Deoxy-Delta12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1alpha through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. HIF-1, HO-1, ROS
60  2016 Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans. ---
61  2016 Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. EGFR, HIF-1alpha
62  2016 Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells. EPO, HIF
63  2016 Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. FSP-1, PAH
64  2016 LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2alpha/Notch3 pathways. SIRT3
65  2016 miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. HIF, HIF1, PASMC, PHDs, SMC
66  2016 Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion. EPO, HIF, VEGF
67  2016 Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury. HIF-alpha
68  2016 Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma. HIF
69  2016 Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2alpha. PAH
70  2015 A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes. EPO
71  2015 Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP. BBB, HIF-1alpha, JPD, MMP-9, MRI, MWM, SHR/SP, UCAO, VCI, WM
72  2015 Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. MEFs, Phd2-LKO
73  2015 Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. EPO, FLTIM, HIF-1alpha, I/R, MB, OGD
74  2015 Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4alpha Expression. EPO, HCC, HIF, HNF-4alpha
75  2015 Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development. HIF, PHD
76  2015 The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts. CAFs
77  2015 The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1alpha Stability and Angiogenesis. CAMs, FAK, HIF, HMT, HUVECs, MMP-2, VEGF, VEGFR2
78  2015 [Effects of Bushen Wenyang Huayu Recipe on Expressions of HIF-1alpha, PHD2, and VHL in Endometriosis Rats with Shen Yang Deficiency Blood Stasis Syndrome]. BWHR, cAMP, cGMP, CM, EM, HIF-1alpha, VHL, WM
79  2014 A genetic mechanism for Tibetan high-altitude adaptation. HIFs
80  2014 Lactoferrin from bovine colostrum regulates prolyl hydroxylase 2 activity and prevents prion protein-mediated neuronal cell damage via cellular prion protein. HIF-1alpha, PrP
81  2014 NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro. CMECs, I/R, NOX4, ROS
82  2014 Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-alpha. HIF
83  2013 Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. ET-1, HIF-1, PASMCs
84  2013 Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. EPO, PI3K, VEGF
85  2013 Estrogen receptor beta sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. EGLN1, ERbeta, HIF-1alpha
86  2013 HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. BM, HIF, HSC, PHDs
87  2013 Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice. HIF
88  2013 Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-beta signaling. PDL, POSTN, rhPOSTN
89  2013 Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. COX-2, HIF, HO-1, shRNA
90  2013 Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change. 2OG, CODD, HDX, HIF, NODD
91  2012 Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study. HIF-1alpha, iNOS, NO, SAHA, TNF-alpha
92  2012 Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. COPD, CS, HIF-1alpha, UBE2D1, VEGF, VHL
93  2012 Hypoxia inducible factor-1alpha-mediated gene activation in the regulation of renal medullary function and salt sensitivity of blood pressure. COX-2, HIF, HO-1, NOS
94  2012 Inhibition of transforming growth factor beta1/Smad3 signaling decreases hypoxia-inducible factor-1alpha protein stability by inducing prolyl hydroxylase 2 expression in human periodontal ligament cells. HIF-1alpha, SIS3, TGF-beta1
95  2012 Investigation of possible endogenous hypoxia markers in colorectal cancer. CAIX, DFS, GLUT1, MCT1, MVD, OS
96  2012 Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. HIF-1, ROS
97  2012 Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). alpha-KG, EPR, FIH, HIF
98  2011 LDH-A influences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo. CAIX, FIH, HIF1alpha, Hif1alpha, LDH, VEGF
99  2011 Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia. Fluc, HIF-1alpha, HRE, shRNA
100  2011 Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer. HIF, PHD, siRNAs