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Abbreviation : PHD2
Long Form : prolyl hydroxylase domain protein 2
No. Year Title Co-occurring Abbreviation
2023 CHD1 deletion stabilizes HIF1α to promote angiogenesis and glycolysis in prostate cancer. Cas9, CHD1, CRISPR, GSEA, HIF1alpha, PCa, VHL
2022 Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema. EGLN1, HAPE, HIF1AN, HLs, SNM
2022 Myeloid Angiotensin II Type 1 Receptor Mediates Macrophage Polarization and Promotes Vascular Injury in DOCA/Salt Hypertensive Mice. Ang, AT1R, DOCA, HIF, TLR
2022 Oxygen sensors mediated HIF-1alpha accumulation and translocation: A pivotal mechanism of fine particles-exacerbated myocardial hypoxia injury. FIH-1, HIF-1alpha, IHD
2022 Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations. EPO, HIFs, VHL
2022 Screening prolyl hydroxylase domain 2 inhibitory activity of traditional Chinese medicine by CZE-UV. alpha-OG, CZE, HIF, TCM
2022 The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells. Treg
2022 The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α. HIF, NACA, PXLE
2022 [Effect of Biantie pretreatment on serum level of PHD2/HIF-1alpha and brain tissue damage in rats during acute hypobaric hypoxia exposure]. DMOG, HIF-1alpha, Lac, VEGF
10  2021 Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2. CORM-2
11  2021 Congenital erythrocytosis. CE, EPAS1, EPO, HIF
12  2021 HIF2alpha is a direct regulator of neutrophil motility. ---
13  2021 HIF2alpha regulates the synthesis and release of epinephrine in the adrenal medulla. EPO, HIF, PNMT
14  2021 WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1alpha accumulation in Myc-dependent and independent pathways. CCA, EMT, HDAC2, HIF-1alpha, MBIIIb, WDR5
15  2020 A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation. ---
16  2020 Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene. HIF-1
17  2020 Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction. BMSCs, IGF, UTMD
18  2020 Roxadustat attenuates experimental pulmonary fibrosis in vitro and in vivo. alpha-SMA, BLM, CTGF, HIF, TGF-beta1
19  2019 An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23. HIF-2alpha
20  2019 Update on mutations in the HIF: EPO pathway and their role in erythrocytosis. EPO, EPOR, HIF, VHL
21  2018 Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease. DAergic SNpc, HIF1alpha, iPSC, PD
22  2018 Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. ---
23  2018 Regulation of Hypoxia-Inducible Factor 1alpha during Hypoxia by DAP5-Induced Translation of PHD2. DAP5, eIF4GI, HIF-1alpha, PKC
24  2018 Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture. ---
25  2018 Transcriptome analysis demonstrates that long noncoding RNA is involved in the hypoxic response in Larimichthys crocea. HIF, lncRNAs
26  2017 Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. FSP-1, RI
27  2017 Endothelial HIF-2alpha contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. EC, EndMT, HIF-2alpha, IPAH, KO, LVECs, PASMCs, PH, SMC
28  2017 Hypoxia-inducible factor-1alpha activation in HPV-positive head and neck squamous cell carcinoma cell lines. HIF, HNSCC, HPV, IF
29  2017 Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity. HFD, RD, VEGF
30  2017 Tet1 facilitates hypoxia tolerance by stabilizing the HIF-alpha proteins independent of its methylcytosine dioxygenase activity. HIF-alpha, TET
31  2017 Uremic Toxins Affect the Imbalance of Redox State and Overexpression of Prolyl Hydroxylase 2 in Human Adipose Tissue-Derived Mesenchymal Stem Cells Involved in Wound Healing. CKD, CKD-AT-MSCs, HIF-1alpha, MSCs, nAT-MSCs, ROS
32  2016 Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. C/F, cKO, HIF
33  2016 Expression and effect of proline hydroxylase domain 2 in retina of diabetic rats. GFAP, HE, IF, SD, SPF, VEGF
34  2016 Homology modeling and molecular dynamics simulation of the HIF2alpha degradation-related HIF2alpha-VHL complex. DSSP, HIF2alpha, RMSD, SIE
35  2016 miR-21 contributes to renal protection by targeting prolyl hydroxylase domain protein 2 in delayed ischaemic preconditioning. HIF, IPC, IRI, LNA
36  2016 Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1alpha Activation. HIF-1alpha
37  2016 PHD2: from hypoxia regulation to disease progression. HIF
38  2016 Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury. HIF-alpha
39  2016 The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor alpha. HIF-alpha
40  2016 Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1alpha for Th17 suppression. DAPK, HIF-1alpha, Th17
41  2015 Acellular dermal matrix-based gene therapy augments graft incorporation. ADM, siRNA
42  2015 Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors. 2OG, HIF1alpha
43  2015 Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles. NP, siRNA-PA
44  2015 HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. AJ, ARDS, ECs, VE-PTP
45  2015 Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis. CAFs, HIF
46  2015 Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. EPO, REP, REP
47  2014 HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. HIF-1alpha, HRE, HS, NP, SRY
48  2014 Nanovector-based prolyl hydroxylase domain 2 silencing system enhances the efficiency of stem cell transplantation for infarcted myocardium repair. Arg-G4, MSC
49  2014 Prolyl hydroxylase domain-2 (PHD2) inhibition may be a better therapeutic strategy in renal anemia. CKD, HIF2, rHuEPO
50  2014 Tumor PHD2 expression is correlated with clinical features and prognosis of patients with HCC receiving liver resection. AFP, DFS, HCC, OR, OS
51  2013 Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. Ang II, HIF-alpha, L-NAME
52  2013 Expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features. SCC, SK, VEGF
53  2013 PHD2 regulates arteriogenic macrophages through TIE2 signalling. Ang-1
54  2013 Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. HIF-alpha, Hsp90, MYND
55  2013 Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium. ADSCs, IGF-1, shPHD2
56  2013 Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. hi, TAM
57  2012 Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. CAIX, GLUT1
58  2012 Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. HIF
59  2012 IDH1 mutations inhibit multiple alpha-ketoglutarate-dependent dioxygenase activities in astroglioma. 5hmC, alpha-KG, IDH1, TET
60  2012 Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2). SIE
61  2012 Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer. ---
62  2012 Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). alpha-KG, EPR, FIH, HIF
63  2011 Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia. ---
64  2011 Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides. FIH, HIF, PHD
65  2011 Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. HIF, PHD
66  2011 Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. HIF
67  2011 Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure. HIF, siRNA
68  2009 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. ---
69  2009 Analysis of HIF-1a and its regulator, PHD2, in retroperitoneal sarcomas: clinico-pathologic implications. EPO, HIF-1a, VEGF
70  2009 Erythrocytosis associated with a novel missense mutation in the HIF2A gene. EPO, HIF-alpha, VHL
71  2009 Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck. HIF-1alpha, RT
72  2009 Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. ESI-MS
73  2008 A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene. EpoR
74  2008 Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. FGF-2, HIF-1, RNAi, VEGF
75  2008 HIF in vascular development and tumour angiogenesis. HIF
76  2008 PHD2 mutation and congenital erythrocytosis with paraganglioma. HIF, PHD
77  2007 Disturbance in the HIF-1alpha pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. ---
78  2007 Hypoxia-inducible factor 1 (HIF-1) pathway. CBP, FIH-1, HIF-1, Hsp90, RACK1, VHL
79  2006 Oxygen sensing: recent insights from idiopathic erythrocytosis. Epo, HIF, IE, VHL
80  2006 Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation. ECs, HIF