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Abbreviation : PHD2
Long Form : prolyl hydroxylase domain-containing protein 2
No. Year Title Co-occurring Abbreviation
2022 A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury. BBB, CCI, HIF, TBI, TEER, ZO-1
2022 A computational evaluation of FDA medicines' ability to inhibit hypoxia-inducible factor prolyl hydroxylase-2 (PHD-2) for acute respiratory distress syndrome. ARDS, PHD-2
2022 Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. ATM, BMI, IL-1beta, LDHA
2022 HIF-1alpha Stabilization Boosts Pulp Regeneration by Modulating Cell Metabolism. HIF-1alpha, SHED
2022 Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1alpha. HIF
2021 Feedback of hypoxia-inducible factor-1alpha (HIF-1alpha) transcriptional activity via redox factor-1 (Ref-1) induction by reactive oxygen species (ROS). CSR, FIH-1, HIF-1alpha, Ref-1, ROS
2021 Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair. ALP, Col I, hPDLCs
2020 Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2alpha. eNAMPT's, PAH, SNAI1, VEGF
2020 HIF-1alpha Stabilization Enhances Angio-/Vasculogenic Properties of SHED. HIF-1alpha, HUVECs, SHED
10  2019 ERK Regulates HIF1alpha-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer. PROC, qHTCS
11  2019 Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers. ---
12  2019 The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer. alpha-KG, HIF1, mtDNA
13  2019 Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2. 5hmC, TETs
14  2018 Acceleration of Diabetic Wound Healing with PHD2- and miR-210-Targeting Oligonucleotides. HIF-1alpha, LbL, sshRNA, VEGF
15  2017 A positive feedback loop promotes HIF-1alpha stability through miR-210-mediated suppression of RUNX3 in paraquat-induced EMT. EMT, HIF-1alpha, PQ
16  2017 Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice. HIF-1alpha, VHL
17  2017 Inhibiting PHD2 in bone marrow mesenchymal stem cells via lentiviral vector-mediated RNA interference facilitates the repair of periodontal tissue defects in SD rats. BMMSCs, HIFs
18  2017 Inhibition of microRNA-429 in the renal medulla increased salt sensitivity of blood pressure in Sprague Dawley rats. HIF
19  2017 Protective Effect of Atazanavir Sulphate Against Pulmonary Fibrosis In Vivo and In Vitro. BLM, EMT, EndMT, HIF-1alpha, HPMECs, TLR4
20  2016 A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase. DMD, DSC
21  2016 Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans. ---
22  2016 HIF-1alpha Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. HIF-1alpha
23  2016 Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice. HIF, POCs, SOCs
24  2015 Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. cKO, HIF, Osx
25  2015 Impairment of hypoxia-induced HIF-1alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. HIF-1alpha, NHDF, NHEK, SM
26  2014 Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development. BV, Osx, TV
27  2014 Gingerol prevents prion protein-mediated neuronal toxicity by regulating HIF prolyl hydroxylase 2 and prion protein. DFO, DMOG, HIF, PrP, siRNA
28  2014 PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. EB, HIF-2alpha, PTEN
29  2013 Hypoxia promotes the production and inhibits the destruction of human articular cartilage. HIFs
30  2013 Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. HIF-2alpha, Xe
31  2013 Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors. ---
32  2012 Thermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approaches. ---
33  2010 Hypoxia-inducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. HIF
34  2010 Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes. HIF-2alpha
35  2009 Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. ---
36  2007 Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia-inducible factor-1 alpha signaling. AhR, HIF-1 alpha, TCDD
37  2006 Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. 2OG, FIH, HIF