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Abbreviation : PHY
Long Form : physostigmine
No. Year Title Co-occurring Abbreviation
2021 Effects of Increased Central Cholinergic Activity on the Metabolic Challenge Induced by Submaximal Exercise in Rats: Adrenomedullary Secretion Influences. FFAs, i.c.v, sham-SAL
2021 The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons. AChEIs, AXT, DFP, GWI, OPs
2019 Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats. CPFE, dHPC, IEGs, mPFC, PD, SAL, SI, vHPC
2018 Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats. HR, SAP, SHRs
2018 The Neuroinflammatory Phenotype in a Mouse Model of Gulf War Illness is Unrelated to Brain Regional Levels of Acetylcholine as Measured by Quantitative HILIC-UPLC-MS/MS. ACh, AChEIs, CORT, CPO, CTX, DFP, GW, GWI, HIP, MS/MS, STR
2018 Therapeutic effects of physostigmine during systemic inflammation. LPS
2017 Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition. AChE, CORT, CPO, DFP, GWI, PB, STAT3
2017 N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. AD, NAC, STZ
2016 [Anti-inflammatory effect of acetylcholine on lipopolysaccharide induced inflammatory response of alveolar macrophages]. ACh, AChE, ELISA, LPS, TNF-alpha
10  2015 The dynamics of physical exercise-induced increases in thalamic and abdominal temperatures are modified by central cholinergic stimulation. T thal, VEH
11  2013 PET imaging of acetylcholinesterase inhibitor-induced effects on alpha4beta2 nicotinic acetylcholine receptor binding. ACh, AChEIs, GAL, nAChR
12  2013 [Involvement of cross interaction between central cholinergic and histaminergic systems in the nucleus tractus solitarius in regulating carotid sinus baroreceptor reflex]. CHL, CIM, CSR, HA, HEX, i.c.v, ISP, MAP, NTS, PRZ
13  2012 Acetylcholinesterase inhibition interacts with training to reverse spatial learning deficits after cortical impact injury. AChE, BBB, TBI, TBI-PHY3.2, WM1
14  2012 The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: synergism with the benzodiazepine diazepam. AChE, CED, DZP, NMDA
15  2011 Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats. AMS, GAL, HA, HBH, MWM
16  2010 Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. ACh, AChE, AChEIs, GAL, HA, HBH, MWM
17  2010 Sinoaortic denervation prevents enhanced heat loss induced by central cholinergic stimulation during physical exercise. SAD, SHAM
18  2009 Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. ACh, AChE, AChEI, GAL, HBH, MWM
19  2009 Evaluation of two scopolamine and physostigmine pretreatment regimens against nerve agent poisoning in the dog. SCO
20  2009 Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin. anti-ChE, AVP, ChE
21  2007 Activation of the central cholinergic pathway increases post-exercise tail heat loss in rats. Tc
22  2007 Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease. AD, APP, ChEI, PHE
23  2007 Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice. ---
24  2006 Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. ACh, AChEI's, AD, GAL
25  2006 Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor. ACh
26  2005 A T-cell-dependent humoral immune response is preserved during the administration of the nerve agent pre-treatment pyridostigmine bromide in a murine model. AChE, Con A, PB, SRBC
27  2005 Skin permeation of physostigmine from fatty acids-based formulations: evaluating the choice of solvent. MO, PG, SC
28  2004 An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. ACh, AChE, PB, PBMC
29  2004 Behavioral changes after acetylcholinesterase inhibition with physostigmine in mice. AChE, ASR, ChEI, i.p, PB, PPI
30  2004 Intracerebroventricular physostigmine facilitates heat loss mechanisms in running rats. ---
31  2003 Determination of physostigmine and pyridostigmine in pharmaceutical formulations by capillary electrophoresis. CZE, PYR
32  2003 Potentiation effects of (+/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes. GAL
33  2000 Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats. ACh, AChE, AD, BDF, DRH, DRL, HEP, OP
34  2000 Nitrone spin trapping compound N-tert-butyl-alpha-phenylnitrone prevents seizures induced by anticholinesterases. AChE, DFP, IEG, KA, PBN, PIL, ROS
35  2000 Scopolamine augments the efficacy of physostigmine against soman poisoning in guinea pigs. SCO
36  2000 Subchronic physostigmine pretreatment in marmosets: absence of side effects and effectiveness against soman poisoning with negligible postintoxication incapacitation. ---
37  1999 Effects of cholinergic drugs on neocortical EEG and flash-visual evoked potentials in the mouse. EEG, FVEP, HEP
38  1999 Physostigmine blocked nicotinic acetylcholine receptors in rat sympathetic ganglion neurons. nAChR, SCG
39  1998 Development and in vivo assessment of a transdermal system for physostigmine. TD
40  1998 Effects of physostigmine on the startle in guinea pigs: two mechanisms involved. SCO
41  1998 Physiological, biochemical and histological changes due to physostigmine in monkeys. OP
42  1998 Physostigmine and acetylcholine differentially activate nicotinic receptor subpopulations in Locusta migratoria neurons. ACh, nAChR
43  1998 Subchronic physostigmine pretreatment in guinea pigs: effective against soman and without side effects. SCO
44  1997 Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis. ACh
45  1996 Acetylcholinesterase inhibitors block acetylcholine-evoked release of dopamine in rat striatum, in vivo. ACh, AChE-I, DA
46  1996 Side effects of physostigmine as a pretreatment in guinea pigs. ChE
47  1996 The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex. AD, APP, BETHA, ChE, ChEI, DDVP, HEP, TTX
48  1995 Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. AD, APP, BETHA, ChE, ChEI, DDVP, HEP, TTX
49  1995 Coadministration of cholinesterase inhibitors and idazoxan: effects of neurotransmitters in rat cortex in vivo. ACh, ChEI, DA, HEP, IDA, NE
50  1995 Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo. ACh, CLO, HEP, NE
51  1995 Metabolic response to tacrine (THA) and physostigmine in the aged rat brain. LCGU
52  1995 Prophylactic transdermal treatment with physostigmine and scopolamine against soman intoxication in guinea-pigs. ChE
53  1994 Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. ACh, HEP
54  1994 Effect of AIT-082, a purine analog, on working memory in normal and aged mice. ---
55  1994 Effect of concurrent exercise and physostigmine on lactate and pyruvate in plasma, muscle, and brain tissue of rats. AE, Phy-D
56  1994 Oral administration of heptylphysostigmine in healthy volunteers: a preliminary study. ChE, HP, RBC
57  1993 A novel agonist binding site on nicotinic acetylcholine receptors. alpha-BGT, BZQ, MLA, nAChRs
58  1993 Cholinergic-opioid interactions at brainstem respiratory chemosensitive areas in cats. ACh, ATR, cVMS, mCSF
59  1993 Concurrent acute exercise alters central and peripheral responses to physostigmine. ChE, RBC
60  1993 Effect of physostigmine and exercise on choline acetyltransferase and acetylcholinesterase activities in fast and slow muscles of rat. AChE, ChAT, EDL
61  1993 Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. nAChRs
62  1993 Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. AChE
63  1993 Physostigmine and neuromuscular transmission. ACh, nAChR
64  1993 Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors. AChE, MIA, PCA, RIT, SCOP, THA
65  1992 Acetylcholinesterase inhibition and anti-soman efficacy of homologs of physostigmine. AChE, N-SAC
66  1992 Age-dependent changes in serotonergic modulation of yawning in the rat. ---
67  1992 Effect of physostigmine on plasma lactate and pyruvate in untrained/trained rats. AE, ET
68  1992 Endurance training changes central and peripheral responses to physostigmine. AE, ChE, ET, RBC
69  1992 Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). AChE, HPTL
70  1992 The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze. AChE, BChE, heptyl-Phy
71  1991 Effect of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta-(b)-quinoline monohydrate hydrochloride (NIK-247) on cholinergic enzyme activity in rats. ACh, ChAT, ChE, THA
72  1991 Effect of cholinesterase inhibitor and exercise on choline acetyltransferase and acetylcholinesterase activities in rat brain regions. AChE, ChAT
73  1991 Efficacy evaluation of physostigmine and anticholinergic adjuncts as a pretreatment for nerve agent intoxication. ---
74  1990 Assessing the efficacy of azaprophen and physostigmine as a pretreatment for soman-induced incapacitation in guinea pigs by response-surface modeling. ---
75  1990 Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain. 5-HIAA, ChE, DA, DOPAC, HVA, MTF, NA, THA
76  1990 Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure. PYR
77  1990 Extraction of physostigmine from biologic fluids and analysis by liquid chromatography with electrochemical detection. CSF, HPLC
78  1989 Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. AP, CAT, HR, RVL, SNA
79  1989 Comparing the response surfaces of two cholinolytics when used in combination with physostigmine as a pretreatment against organophosphate challenge. PRG, SCP
80  1989 Determination of physostigmine in plasma and cerebrospinal fluid by liquid chromatography with electrochemical detection. CSF
81  1989 Determination of physostigmine in plasma by high-performance liquid chromatography and fluorescence detection. CV
82  1989 In vivo dose response relationship between physostigmine and cholinesterase activity in RBC and tissues of rats. ---
83  1989 Interaction of reversible and irreversible cholinesterase inhibitors on the monosynaptic reflex in neonatal rats. ChE, PYR
84  1989 Modulation of acetylcholine release by nicotinic receptors in the rat brain. ACh, AChE, AD, i.c.v
85  1989 Pharmacokinetics and pharmacodynamics of physostigmine in the rat after oral administration. BuChE, ChE
86  1989 Physostigmine--an overview as pretreatment drug for organophosphate intoxication. ACh, BuChE, ChE
87  1989 The effect of heptyl-physostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat. ACh, AChE, AD, BuChE, ChE, ChEI
88  1989 The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication. 2-PAM, AChE, CA, PR
89  1988 A comparative study of the effects of four choline esters on the secretion of fluid and glycoprotein from rat submandibular glands. ACh, BET, CAR, GP, MET, SMG
90  1988 Modulation of memory by post-training epinephrine: involvement of cholinergic mechanisms. EPI, IA, OTM, YMD
91  1988 Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice. CXM, SDL
92  1987 Action and localization of acetylcholine in the cat retina. ACh, ChAT, DBE, LY, SCO
93  1987 Drug interaction for plasma protein binding: physostigmine and other drugs. ---
94  1987 Pharmacokinetics and pharmacodynamics of physostigmine after intravenous administration in beagle dogs. ChE
95  1987 Pharmacokinetics and pharmacodynamics of physostigmine in the rat after intravenous administration. BuChE, ChE
96  1986 Distribution and pharmacokinetics of physostigmine in rat after intramuscular administration. BuChE
97  1986 Hepatic and muscle clearance of physostigmine in the rat. Es
98  1986 Relation of brain regional physostigmine concentration to cholinesterase activity and acetylcholine and choline levels in rat. ACh, Ch, ChE, MO, ST
99  1986 Supersensitive endocrine response to physostigmine in dopamine-depleted rats: a model of depression? ACTH, CNS, DA, NE, PRL
100  1986 The effects of physostigmine on acetylcholinesterase activity of CSF plasma and brain. A comparison of intravenous and intraventricular administration in beagle dogs. AChE, ChE, CSF, i.c.v, i.v