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Abbreviation : PPT
Long Form : polypurine tract
No. Year Title Co-occurring Abbreviation
2021 INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay. DTG, env, IN, INSTIs, NNRTIs, NRTIs
2021 Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization. IDLVs, SIV
2018 Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase. INSTIs, NNRTIs, RH, RT
2017 A transposition-active Phyllostachys edulis long terminal repeat (LTR) retrotransposon. LTR, PBS, PHRE2
2017 Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase. RT
2017 Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors. HIV-1, INSTIs
2017 Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3. HIV, LTR, RT
2016 Abolishing HIV-1 infectivity using a polypurine tract-specific G-quadruplex-forming oligonucleotide. ODN, SEVI
2015 Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis. NNRTIs, RT
10  2015 Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors. cSIN, IDLV, IU
11  2013 [Oligo(2'-O-Methylribonucleotides) and their derivatives: IV. Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders and intercalators: synthesis, properties and application]. BIQ, MGB
12  2012 Structure of an RNA/DNA dodecamer corresponding to the HIV-1 polypurine tract at 1.6 A resolution. ---
13  2012 The removal of RNA primers from DNA synthesized by the reverse transcriptase of the retrotransposon Tf1 is stimulated by Tf1 integrase. RT
14  2012 Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract. HIV-1, NNRTI, NtRTI, PBS, RT, TFV
15  2012 Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract. AMV, MuLV, RT
16  2011 A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID mice. ODN
17  2010 Highly conserved motifs in non-coding regions of Sirevirus retrotransposons: the key for their pattern of distribution within and across plants? 3'LTR, RM
18  2010 Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector. LTR, RT, ZFNs
19  2010 Using triplex-forming oligonucleotide probes for the reagentless, electrochemical detection of double-stranded DNA. TFOs
20  2009 Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein. NC, RT
21  2009 Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B. NB, RTs
22  2009 Reduction of gene expression by a hairpin-loop structured oligodeoxynucleotide: alternative to siRNA and antisense. ODN
23  2009 Retroviral self-inactivation in the mouse vagina induced by short DNA. cDNA, HIV
24  2009 Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions. RNase H, RT
25  2009 SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids. NMIA, SHAMS, SHAPE
26  2008 High-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers. dF, LTR, RT, WT
27  2008 Involvement of glycosaminoglycans in vesicular stomatitis virus G glycoprotein pseudotyped lentiviral vector-mediated gene transfer into airway epithelial cells. GAGs, GFP, LV, VSV-G, ZO
28  2008 Mutations in the human immunodeficiency virus type 1 polypurine tract (PPT) reduce the rate of PPT cleavage and plus-strand DNA synthesis. HIV-1
29  2008 Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands. RNase H, RT
30  2008 Structural studies of RNA/DNA polypurine tracts. RT
31  2008 The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase. PPTs, RSV, RT
32  2007 Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA. PNA
33  2007 Complex effects of foamy virus central purine-rich regions on viral replication. FVs, PFV
34  2007 Short partially double-stranded oligodeoxynucleotide induces reverse transcriptase/RNase H-mediated cleavage of HIV RNA and contributes to abrogation of infectivity of virions. ODN A
35  2007 [Expression of green fluorescent protein gene in mouse T lymphocytes mediated by lentiviral vector]. FACS, GFP, MOI, PUB
36  2006 Alternate polypurine tracts affect rous sarcoma virus integration in vivo. LTR, RSV
37  2006 Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. RT
38  2006 In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity. HIV-1
39  2006 PpRT1: the first complete gypsy-like retrotransposon isolated in Pinus pinaster. LTRs, PBS
40  2006 Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis. 2,6-DAP, 2AP, iG, PR, RTs
41  2005 A ribose sugar conformational switch in the LTR-retrotransposon Ty3 polypurine tract-containing RNA/DNA hybrid. ---
42  2005 Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivity. WT
43  2005 Examining Ty3 polypurine tract structure and function by nucleoside analog interference. ---
44  2005 Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target. dauno-TFO, TFOs, TGGE
45  2005 Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer. HIV-1
46  2005 Ribonuclease H evolution in retrotransposable elements. RNH
47  2005 Specific recognition and cleavage of the plus-strand primer by reverse transcriptase. LTR, RTs
48  2004 Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage. ---
49  2004 Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase. ---
50  2004 Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cells. LTR, PBS
51  2004 Two modes of HIV-1 polypurine tract cleavage are affected by introducing locked nucleic acid analogs into the (-) DNA template. HIV-1, LNA, RNase H, RT
52  2004 Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract. dC, pdC, RT
53  2003 An unusual sugar conformation in the structure of an RNA/DNA decamer of the polypurine tract may affect recognition by RNase H. RT
54  2003 Extension and cleavage of the polypurine tract plus-strand primer by Ty1 reverse transcriptase. RT
55  2003 Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection. HIV-1
56  2003 Mutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer. HIV-1, RTs
57  2003 Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase. RNase H, RTs
58  2003 Staying straight with A-tracts: a DNA analog of the HIV-1 polypurine tract. ---
59  2002 Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity. HIV-1 RT, RNase H
60  2002 Formation of DNA triple helices by an oligonucleotide conjugated to a fluorescent ruthenium complex. TFO
61  2002 Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes. HBV, HIV
62  2002 Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase. HIV-1
63  2001 A new class of anti-HIV-1 oligonucleotide targeted to the polypurine tract of viral RNA. ---
64  2001 Anti-HIV-1 activity by a triple-helix forming oligonucleotides targeted to polypurine tract on viral RNA. RT
65  2001 Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. RNase H
66  2001 Direct photocleavage of HIV-DNA by quinacridine derivatives triggered by triplex formation. ds, PQs, TFO
67  2001 Direct-methods determination of an RNA/DNA hybrid decamer at 1.15 A resolution. RT, SnB
68  2001 Identification of a central DNA flap in feline immunodeficiency virus. FIV, HIV-1
69  2001 New TFO conjugates containing a carminomycinone-derived chromophore. MDR, TFOs
70  2001 Polypurine tract formation by Ty1 RNase H. RT
71  2001 Transcription inhibition induced by modified triple helix-forming oligonucleotides: a quantitative assay for evaluation in cells. luc, Pso-TFOs
72  2000 Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases. ---
73  2000 Anti-human immunodeficiency virus type 1 of a two-strand-system targeted to the polypurine tract. HIV
74  2000 Deletion of a short, untranslated region adjacent to the polypurine tract in Moloney murine leukemia virus leads to formation of aberrant 5' plus-strand DNA ends in vivo. Mo-MuLV, WT
75  2000 RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation. RT
76  2000 Selection of optimal polypurine tract region sequences during Moloney murine leukemia virus replication. ---
77  2000 Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. np, TFOs
78  1999 Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication. ---
79  1999 Inhibition of HIV-1 replication by a two-strand system (FTFOs) targeted to the polypurine tract. FTFOs, RT
80  1999 Mutations designed to alter the stability of a putative RNA duplex in the HIV-1 pol gene. IR
81  1999 Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase. ---
82  1999 Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. RT
83  1999 RIRE2, a novel gypsy-type retrotransposon from rice. PBS
84  1998 Crystal structure and conformation of a DNA-RNA hybrid duplex with a polypurine RNA strand: d(TTCTTBr5CTTC)-r(GAAGAAGAA). HIV-1
85  1998 Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus. ---
86  1998 Inhibition of replication of drug-resistant HIV type 1 isolates by polypurine tract-specific oligodeoxynucleotide TFO A. HIV-1, ODN, RT, TFO A
87  1998 Polymorphism of insertion sites of Ty1-copia class retrotransposons and its use for linkage and diversity analysis in pea. SSAP
88  1998 Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis. att, RTs
89  1998 Structure and evolution of Cyclops: a novel giant retrotransposon of the Ty3/Gypsy family highly amplified in pea and other legume species. LTRs, PBS
90  1997 Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target. ---
91  1997 Inhibition of HIV-1 replication by foldback triple-helix forming oligonucleotides. FTFOs, RT
92  1997 Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract. ---
93  1997 Maintenance of an unusual polypurine tract in HIV-2: stability to passage in culture. HIV-2
94  1997 Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization. HIV-1 RT, RNase H
95  1997 Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase. RNase H
96  1996 Efficient initiation and strand transfer of polypurine tract-primed plus-strand DNA prevent strand transfer of internally initiated plus-strand DNA. att
97  1996 Role of RNA primers in initiation of minus-strand and plus-strand DNA synthesis of the yeast retrotransposon Ty1. ---
98  1996 Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract. HIV-1
99  1995 Defects in primer-template binding, processive DNA synthesis, and RNase H activity associated with chimeric reverse transcriptases having the murine leukemia virus polymerase domain joined to Escherichia coli RNase H. MuLV, RT
100  1995 DNA recombination is sufficient for retroviral transduction. LTR