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Abbreviation : RKIP
Long Form : Raf kinase inhibitor protein
No. Year Title Co-occurring Abbreviation
2023 NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP. CCK-8, EMS, ERK, MEK, NYKF, siRNA
2022 Activation of RKIP Binding ASC Attenuates Neuronal Pyroptosis and Brain Injury via Caspase-1/GSDMD Signaling Pathway After Intracerebral Hemorrhage in Mice. CSF, ICH
2022 Computational Analyses of YY1 and Its Target RKIP Reveal Their Diagnostic and Prognostic Roles in Lung Cancer. LC, YY1
2022 Harnessing RKIP to Combat Heart Disease and Cancer. beta-AR, PKA
2022 Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. beta-AR, GRK2, PKA, PKC
2022 RKIP suppresses the influenza A virus‑induced airway inflammatory response via the ERK/MAPK pathway. IAV
2022 RKIP: A Pivotal Gene Product in the Pathogenesis of Cancer. PEBP
2022 The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart. GPCR, NGS
2022 The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment. ---
10  2022 Understanding Mechanisms of RKIP Regulation to Improve the Development of New Diagnostic Tools. ---
11  2021 Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation. MD, WT
12  2021 Insights of RKIP-Derived Suppression of Prostate Cancer. ADT, AR, CRPC, EMT, mPC, PC
13  2021 Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands. MNP
14  2021 Limited inhibition of multiple nodes in a driver network blocks metastasis. ---
15  2021 Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein. ChAT, CON, FINS, H-DAR, HCNP, Ins1, LETO, LIRA, M3R, OLETF, PBO, qRT-PCR, RPMI
16  2021 Mycobacterium tuberculosis RKIP (Rv2140c) dephosphorylates ERK/NF-kappaB upstream signaling molecules to subvert macrophage innate immune response. ERK, Mtb, NF-kappaB
17  2021 Protective Effect of Raf-1 Kinase Inhibitory Protein on Diabetic Retinal Neurodegeneration through P38-MAPK Pathway. caspase-3, GFAP, GLAST, GS, p38 MAPK
18  2021 Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling. HSP60, MAPK, ROS, RTK
19  2021 Retraction: Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer. STAT3
20  2021 RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions. MPNST, TbetaR2
21  2021 RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity. ---
22  2021 Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-kappaB p65 pathway. AKI, EZH2, PRC2
23  2021 Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression. MTDH, PEBP1
24  2020 Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer. BMI1, GC, miRNA, qRT-PCR
25  2020 Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis. OSCC, qRT-PCR
26  2020 cMET promotes metastasis and epithelial-mesenchymal transition in colorectal carcinoma by repressing RKIP. c-Met, CRC
27  2020 Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia-Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-kappaB, and Oxidative Stress. CSE, eNOS, iNOS, IR, NF-kappaB, nNOS, NO
28  2020 GRK2 Dictates a Functional Switch of the Peripheral Mu-Opioid Receptor. BK, DRG, GRK2, MOR, PKC
29  2020 HIF-1alpha and RKIP: a computational approach for pancreatic cancer therapy. HADDOCK, HIF-1alpha, PC, PPIs
30  2020 LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP. GATA6-AS1, lncRNAs, NSCLC
31  2020 MicroRNA-18a induces epithelial-mesenchymal transition like cancer stem cell phenotype via regulating RKIP pathway in pancreatic cancer. EMT, miR-181a
32  2020 Mycobacterium tuberculosis Raf kinase inhibitor protein (RKIP) Rv2140c is involved in cell wall arabinogalactan biosynthesis via phosphorylation. PEBP
33  2020 PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-kappaB signaling. ART, EGCG, PEBP1
34  2020 PKCdelta mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression. CCNE1, HCC, HSP60, MAPKs, mtROS, PKC, ROS, TPA
35  2020 Resveratrol binds and activates RKIP protein in colorectal cancer. CRC, MAPK
36  2020 RKIP Regulates Differentiation-Related Features in Melanocytic Cells. ---
37  2020 The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases. HFD, MSU, T2D
38  2020 [Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein]. beta1AR, N/OFQ, p-RKIP, SD, VEB, VF, VT
39  2019 Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling. EGFR, NSCLC
40  2019 Identifying Crosstalk between Raf Kinase Inhibitor Protein and Systemic Lupus Erythematosus. SLE
41  2019 Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis. ---
42  2019 Overexpression of Raf-1 kinase inhibitor protein inhibits cell invasion and migration in lung cancer cells through suppressing epithelial-mesenchymal transition. EMT, NSCLC
43  2019 RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis. AML, MNs
44  2019 Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice. HCNP, KO, PEBP1
45  2019 RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer. ---
46  2019 RKIP negatively regulates the glucose induced angiogenesis and endothelial-mesenchymal transition in retinal endothelial cells. DR, HRCECs, PDR, WT
47  2019 The MAPK Pathway-Based Drug Therapeutic Targets in Pituitary Adenomas. CIRP, Eps8, GA, MAPKs, PAs, UA
48  2019 The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on beta-adrenoceptors. beta-AR, GRK2
49  2019 [Effect of RKIP on proliferation and migration of malignant melanoma cells and potential mechanism]. CCK-8, MMP, NF-kappaB, p-P65, qPCR
50  2018 A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics. EMT, MAP1LC3, LC3, NF-kappaB, STAT3
51  2018 Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors. GISTs, NIH
52  2018 Functional Linkage of RKIP to the Epithelial to Mesenchymal Transition and Autophagy during the Development of Prostate Cancer. EMT, WGCNA
53  2018 Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. ---
54  2018 Inhibition of the Raf-1 kinase inhibitory protein (RKIP) by locostatin induces cell death and reduces the CXCR4-mediated migration of chronic lymphocytic leukemia cells. CLL, GRK2
55  2018 Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors. HPV, HSILs, SCC, SCCs
56  2018 Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress. LV, NNT, Nrf2, QTL, TAC
57  2018 Raf kinase inhibitor protein negatively regulates FcepsilonRI-mediated mast cell activation and allergic response. Gab2, IgE
58  2018 Raf kinase inhibitor protein protects microglial cells against 1-methyl-4-phenylpyridinium-induced neuroinflammation in vitro. PD, PEBP
59  2018 RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. CD44
60  2018 RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling. EAE, IL-17
61  2018 RKIP-Mediated NF-kappaB Signaling is involved in ELF-MF-mediated improvement in AD rat. AD, ELF-MF
62  2018 RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact. EMT
63  2018 Role of RKIP in human hepatic stellate cell proliferation, invasion, and metastasis. alpha-SMA, ERK, MAPK, NF-kappaB, siRNA
64  2018 Targeting enhancer of zeste homolog 2 protects against acute kidney injury. 3-DZNeP, AKI, EZH2, FA, I/R, MMP, TIMP
65  2018 Targeting Raf Kinase Inhibitory Protein Regulation and Function. ---
66  2018 The increase of miR-27a affects the role of cisplatin on proliferation and migration capacities of liver cancer cells. EMT, TNM
67  2018 Tumor suppressor RKIP inhibits prostate cancer cell metastasis and sensitizes prostate cancer cells to docetaxel treatment. ---
68  2017 A Model of Induction of Cerebellar Long-Term Depression Including RKIP Inactivation of Raf and MEK. AMPA, GRIP, LTD, MEK, PKC
69  2017 Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. ---
70  2017 Expression of Raf kinase inhibitor protein in human hepatoma tissues by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight methods. HCC
71  2017 Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer. YY1
72  2017 Mechanical stress promotes matrix synthesis of mandibular condylar cartilage via the RKIP-ERK pathway. MCCs
73  2017 MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP. ---
74  2017 Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma. MGUS, MM
75  2017 Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma. ESCC, MSP
76  2017 Raf Kinase Inhibitor Protein (RKIP) Inhibits Tumor Necrosis Factor-alpha (TNF-alpha) Induced Adhesion Molecules Expression in Vascular Smooth Muscle Bells by Suppressing (Nuclear Transcription Factor-kappaB (NF-kappaB) Pathway. ICAM-1, MOVACs, NF, NF-kappaB, TNF, TNF-alpha, VCAM-1
77  2017 Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-kappaB Pathway. OGD
78  2017 Raf Kinase Inhibitor Protein Preferentially Promotes TLR3-Triggered Signaling and Inflammation. MKK3
79  2017 Raf kinase inhibitor protein: lessons of a better way for beta-adrenergic receptor activation in the heart. beta-ARs
80  2017 Reduced RKIP expression levels are associated with frequent non-small cell lung cancer metastasis and STAT3 phosphorylation and activation. JAK/STAT, NSCLC
81  2017 RKIP is decreased in laboring myometrium and modulates inflammation-induced pro-labor mediators. ERK, NF-kappaB, siRKIP
82  2017 RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer. CSC, GLI1, NSCLC, Smo
83  2017 Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein. DC, PEBP1
84  2017 TWIN SISTER OF FT (TSF) Interacts with FRUCTOKINASE6 and Inhibits Its Kinase Activity in Arabidopsis. FRK6, FT, SD, TSF
85  2017 Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma. ccRCC, CKD, HS, PCa
86  2017 Various UVB doses affect change of raf kinase inhibitor protein, nitric oxide and proliferation in keratinocytes. NO
87  2016 A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-kappaB-Snail circuit. CRC, lncRNAs, ROC curve
88  2016 A Raf kinase inhibitor demonstrates antiviral activities both invitro and invivo against different genotypes of virulent Newcastle disease virus. ND, NDV, RKIV
89  2016 Didymin Alleviates Hepatic Fibrosis Through Inhibiting ERK and PI3K/Akt Pathways via Regulation of Raf Kinase Inhibitor Protein. ---
90  2016 Didymin ameliorates hepatic injury through inhibition of MAPK and NF-kappaB pathways by up-regulating RKIP expression. ---
91  2016 Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. OVD
92  2016 Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study. ---
93  2016 Enrichment of Metabolite-Binding Proteins by Affinity Elution in Tandem Hydrophobic Interaction Chromatography (AETHIC) Reveals RKIP Regulating ERK Signaling in an ATP-Dependent Manner. AETHIC
94  2016 Epigenetic changes and nuclear factor-kappaB activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple-negative breast cancer SUM 159 cells. 5-Aza, DHMEQ, NF-kappaB, PCR, TNBCs, TSA
95  2016 GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity. GRK2, MOR, PKC
96  2016 Increased chemoresistance via Snail-Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative. CRC, CSC, EMT
97  2016 Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP. AML
98  2016 Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells. ECM, MAPK
99  2016 Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis. ---
100  2016 Molecular mechanism of hepatitis B virus (HBV) on suppression of raf kinase inhibitor protein (RKIP) expression. HBV, HBx