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Abbreviation : ROCK2
Long Form : Rho-associated protein kinase 2
No. Year Title Co-occurring Abbreviation
2021 Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes. Azo-RGD, CD
2021 Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation. ceRNA, lncRNAs, MCAO/R, miR-30c-5p, OGD/R, PVT1
2021 Serum-derived exosomes containing NEAT1 promote the occurrence of rheumatoid arthritis through regulation of miR-144-3p/ROCK2 axis. CIA, ncRNAs, NEAT1, RA
2021 The adenosine A2A receptor alleviates postoperative delirium-like behaviors by restoring blood cerebrospinal barrier permeability in rats. A2AR, BBB, BCB, CSF, POD
2020 Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application. ---
2020 Down-regulation of ROCK2 alleviates ethanol-induced cerebral nerve injury partly by the suppression of the NF-κB signaling pathway. ---
2020 Hydrochloride fasudil attenuates brain injury in ICH rats. ELISA, HF, ICH
2020 Ligand-induced conformational rearrangements regulate the switch between membrane-proximal and distal functions of Rho kinase 2. SAXS
2020 lncRNA HAND2‑AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion. HB, HCC, lnc
10  2020 Long non-coding RNA AWPPH interacts with ROCK2 and regulates the proliferation and apoptosis of cancer cells in pediatric T-cell acute lymphoblastic leukemia. AWPPH, lnc
11  2020 Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis. I/R, lncRNA H19, MDA, miR-148a-3p, NO, OGD/R, SOD
12  2020 mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2. ---
13  2020 miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function. CFL2, ITGAV, Rac1, WASL
14  2020 Serum ROCK2, miR-300 and miR-450b-5p levels in two different clinical phenotypes of multiple sclerosis: Relation to patient disability and disease progression. RRMS, SPMS
15  2020 Stearic acid methyl ester​promotes migration of mesenchymal stem cells and accelerates cartilage defect repair. MSCs, SAME, SD, siRNA
16  2020 The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. Bcl-2, BDNF, COX-2, GLP-1R, HO-1, IGF-1R, iNOS, LPS, MG, Nrf2, p-IkappaBalpha, p-LIMK1, PPARgamma, ROS
17  2019 Epigenetic Control of Rho-Associated Protein Kinase 2 in Neurodegeneration. miR-291, MPTP
18  2019 MicroRNA‑122 downregulates Rho‑associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells. ---
19  2019 miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke. MCAO, SGs
20  2019 Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord. IL-1beta, IL-2, SCI, TNF-alpha
21  2019 Sema3A inhibits axonal regeneration of retinal ganglion cells via ROCK2. CNS, F-VEPs, GAP43, MLC2, PBS, Sema3A, Sprr1A
22  2018 Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). ALS, CacyBP, FTD, PHB, Pin1, TDP-43, TTR
23  2018 The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation. alpha-SMA, FDM, MRTF-A, RhoA, SRF
24  2017 Design and evaluation of EphrinA1 mutants with cerebral protective effect. I/R
25  2017 miR-135b Plays a Neuroprotective Role by Targeting GSK3beta in MPP+-Intoxicated SH-SY5Y Cells. GSK-3beta, PD, SNP
26  2017 Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis. IFA
27  2017 Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2‑mediated CyPA secretion and CD147‑ERK1/2‑cyclin pathway. CyPA, VSMCs
28  2017 The Effect of Microporous Polysaccharide Hemospheres on Wound Healing and Scarring in Wild-Type and db/db Mice. alpha-SMA, MPH
29  2016 Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance. ESCC
30  2016 Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease. MPTP, TH
31  2015 Quantitative proteomics analysis to identify diffuse axonal injury biomarkers in rats using iTRAQ coupled LC-MS/MS. CS, DAI, iTRAQ, MAP1B, Snap25, TBI
32  2014 Improving erectile function of spontaneously hypertensive rats by silencing ROCK2. eNOS, mRNA, SHRs, siRNA, WKYs
33  2014 Infantile hypertrophic pyloric stenosis (IHPS): a study of its pathophysiology utilizing the newborn hph-1 mouse model of the disease. hph-1, IHPS, nNOS, ROS
34  2011 [Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma]. ESCC
35  2009 Proteomic identification of proteins translocated to membrane microdomains upon treatment of fibroblasts with the glycosphingolipid, C8-beta-D-lactosylceramide. PM