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Abbreviation : Rb
Long Form : retinoblastoma protein
No. Year Title Co-occurring Abbreviation
2023 BET Inhibitors Induce p53-Independent Growth Arrest in HCT116 Cells via Epigenetic Control of the E2F1/c-MYC Axis. BET, ChIP
2022 "RB-reactivator screening" as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist). FDA
2022 Case of Glioblastoma Multiforme in the Left Temporoparietal Region of the Brain. MGMT, PET, PI3K, RAS, RTK
2022 CDK4/6 inhibitor resistance: A bibliometric analysis. CDKs, HER2
2022 CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition. CDKs
2022 Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk. AAA, Ang, Ccni, Cdk5, DHFR, E2f1, GEO, WT
2022 Functions and Interactions of Mammalian KDM5 Demethylases. 2OG, HDAC
2022 Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1alpha and HIF-2alpha. HIF, HIF-X, mTORC1, rS6
2022 Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition. ERK5, HER2
10  2022 Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis. aaRSs, LUAD, mROS, mtDNA, OS, TARS, TARS2
11  2022 Lidocaine enhances the efficacy of palbociclib in triple-negative breast cancer. CDK
12  2022 Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6. RNF6
13  2022 RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells. APC, CRC, MIZ1, rDNA
14  2022 Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. ---
15  2022 The HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis. pRb
16  2022 The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis. SREBP
17  2022 Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis. Bcl-2, CCK-8, CESC, TIMER, TMEM121
18  2021 Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development. NSC
19  2021 Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration. CDK, GTIN, MMP, NF-kappaB, PKB, ROS, VSMCs
20  2021 Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context. ---
21  2021 Biomarkers of Response to Etoposide-Platinum Chemotherapy in Patients with Grade 3 Neuroendocrine Neoplasms. EP, G3 NEN, NET, ORR
22  2021 Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer. BLCA, CAM, PARP
23  2021 Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment. CDKs
24  2021 Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma. HCC
25  2021 Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property. Cd, CSC, DMR, DNMTs, lncRNA
26  2021 In vitro to Clinical Translation of Combinatorial Effects of Doxorubicin and Abemaciclib in Rb-Positive Triple Negative Breast Cancer: A Systems-Based Pharmacokinetic/Pharmacodynamic Modeling Approach. CI, DOX, Imax, PD, PK, pRb, TNBC, TTP
27  2021 p21 produces a bioactive secretome that places stressed cells under immunosurveillance. PASP
28  2021 Potential Prospect of CDK4/6 Inhibitors in Triple-Negative Breast Cancer. CDK, ER, FDA, HER2, TNBC
29  2021 Prognostic factors of metastatic neuroendocrine carcinoma under first-line treatment with platinum etoposide with a focus on NEC score and Rb expression: Results from the multicentre RBNEC study of the Groupe d'Etude des Tumeurs Endocrines (GTE) and the ENDOCAN-RENATEN network. GTE, NECs, OS, PE
30  2021 Purification of Cyclin-Dependent Kinase Fusion Complexes for In Vitro Analysis. CDK
31  2021 Recent Understanding and Future Directions of Recurrent Corticotroph Tumors. ACTH, CABLES1, CD, CDKs, CTs, EGFR, HDAC2, Hsp90, SCT, TR4, USP
32  2021 Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. AILI, ERK, IL-11, Il11ra1, JNK, NOX4, PCNA, rhIL11
33  2021 Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion. CCA
34  2021 SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma. SUMO, UM
35  2021 The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time. ER
36  2021 The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype. LAP2alpha, NE, NHA9
37  2020 A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels. circRNAs, siRNAs
38  2020 A Cyclin D1-Specific Single-Chain Variable Fragment Antibody that Inhibits HepG2 Cell Growth and Proliferation. ER, HCC, scFv
39  2020 A genome-wide association study for highly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in the Japanese general population. CVD, GWAS, hs-cTnT, KRAB, ZNF890P
40  2020 A highly stable RNA aptamer probe for the retinoblastoma protein in live cells. ---
41  2020 A masked initiation region in retinoblastoma protein regulates its proteasomal degradation. HPV
42  2020 A pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cells. CDK4
43  2020 Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division. ---
44  2020 Cyclin D-CDK4/6 functions in cancer. CDKs
45  2020 Effect of Yanggan Jiedu Sanjie formula on human hepatocellular carcinoma Bel-7402 cells. CDKN1a, SA-beta-gal, YGJDSJ
46  2020 Hypothesis: Retinoblastoma protein inactivation mediates effects of histone deacetylase inhibitor-induced Wnt hyperactivation in colorectal cancer cells. ---
47  2020 In Vitro Effect and Mechanism of Action of Ergot Alkaloid Dihydroergocristine in Chemoresistant Prostate Cancer Cells. AMPK, DHECS, E2F1, Mcl-1, MDM2, NF-B, PARP, PCa
48  2020 Inhibition of the CDK4/6-Cyclin D-Rb Pathway by Ribociclib Augments Chemotherapy and Immunotherapy in Renal Cell Carcinoma. RCC
49  2020 p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis. HPV
50  2020 Programmed cell death protein 1/programmed death ligand 1 but not HER2 is a potential therapeutic target in gastric neuroendocrine carcinoma. CPS, NEC, PD-L1, TIL
51  2020 RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer. RAGE, TAM
52  2020 Retinoblastoma protein expression and its predictors in triple-negative breast cancer. AR, CDK, TNBC
53  2020 Rosiglitazone ameliorates senescence and promotes apoptosis in ovarian cancer induced by olaparib. CCK-8, SA-beta-gal, SASP
54  2020 Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer. CDKs
55  2020 SPH3643: A novel cyclin-dependent kinase 4/6 inhibitor with good anticancer efficacy and strong blood-brain barrier permeability. CDK
56  2020 Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment. FT, HGSOC
57  2020 The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. ---
58  2019 A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach. CDK4
59  2019 A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort. CNS, CSF, PFS
60  2019 Antiproliferative activity of vanadium compounds: effects on the major malignant melanoma molecular pathways. ERK, MAPK, MM, ROS, VN
61  2019 ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. CDKs, SCC
62  2019 Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. CDK4
63  2019 DeltaNp63alpha modulates phosphorylation of p38 MAP kinase in regulation of cell cycle progression and cell growth. MKP3, p38 MAPK
64  2019 E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation. HCC
65  2019 Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection. AAA, Ang II, CVD, DHFR
66  2019 MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis. MSK2, PAX8, SCC
67  2019 Predictors of ribociclib-mediated antitumour effects in native and sorafenib-resistant human hepatocellular carcinoma cells. CDKs, HCC
68  2019 PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer. ---
69  2019 RB, p130and p107 differentially repress G1/S and G2/M genes after p53 activation. ---
70  2019 RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. ---
71  2019 Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma. CSF, GBM
72  2019 ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer. AR, CRPC
73  2018 Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling. CDX, ES, PDX
74  2018 Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells. eIF4E, mTOR, S6K1
75  2018 Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes. HDACIs
76  2018 Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer. ASCL1, EGFR, NSCLC, SCLC, TKI
77  2018 Control of the Restriction Point by Rb and p21. CDK
78  2018 Cooperative p16 and p21 action protects female astrocytes from transformation. CDK
79  2018 Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells. CMT, IVD, NP
80  2018 Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo. CDK, PCNA, pRb, SAE1, SUMO
81  2018 Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. ---
82  2018 Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy. PDX-TNBC, TNBC
83  2018 Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker. NSCLC, SCC
84  2018 Involvement of the STAT5-cyclin D/CDK4-pRb pathway in beta-cell proliferation stimulated by prolactin during pregnancy. p-Rb, PRL, Rb-KO
85  2018 Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer. DNMT, ESCC, ZD
86  2018 MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. ---
87  2018 Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. ASCs, KGF, NRP-1
88  2018 PIN1 in Cell Cycle Control and Cancer. CDKs
89  2018 Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model. AMPK, EEAC, MMP, mTOR
90  2018 [Pharmacological profile and clinical findings of palbociclib (IBRANCE capsule 25 mg/125 mg)]. CDK, ER, PFS
91  2017 Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture. ER, HCC, HCV
92  2017 Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation. BVP, MCM-7
93  2017 Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. CMs, CTDs
94  2017 Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock. EV, mTOR
95  2017 Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well-differentiated thyroid cancer cells. AC, cAMP, CDK4, MAPK, RTKs, TSH
96  2017 Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling. ---
97  2017 Host cell transcriptome modification upon exogenous HPV16 L2 protein expression. ---
98  2017 HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. HNSCC, HPV
99  2017 Inhibition of estrogen related receptor alpha attenuates vascular smooth muscle cell proliferation and migration by regulating RhoA/p27Kip1 and beta-Catenin/Wnt4 signaling pathway. RASMCs, VSMCs
100  2017 LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation. LSD1