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Abbreviation : SHP2
Long Form : Src homology-2 domain containing protein tyrosine phosphatase-2
No. Year Title Co-occurring Abbreviation
2021 Druggable cancer phosphatases. PP2A
2021 Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2). p-ERK, PTP
2021 SHP2 Nuclear/Cytoplasmic Trafficking in Granulosa Cells Is Essential for Oocyte Meiotic Resumption and Maturation. FSH
2021 SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer. cGAS, dsDNA, STING
2021 Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin. DMM, IL-1beta, MAPK, NF-kappaB, OA
2021 Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies. ---
2021 Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway. AMP, AST, CK, Cx43, ECG, JNK, LDH, RTCA
2020 A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2. 3-AG
2020 Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. EGFRi, NSCLC, RTK, RTK
10  2020 Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2-phenylthiazole-5-carboxylate as Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors. JMML, LS, NS, PTP
11  2020 Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. ERK, PROTAC
12  2020 Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels. cSHP2-KO, HFD, IL-18
13  2020 Elevated expressions of SHP2 and GAB2 correlated with VEGF in eutopic and ectopic endometrium of women with ovarian endometriosis. GAB2
14  2020 Elevated hippocampal CD24 in astrocytes participates in neural regeneration possibly via activating SHP2/ERK pathway after experimental traumatic brain injury in mice. AAV-CD24, ERK, GAP43, TBI
15  2020 Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells. DARTS, EA, PTP1B, STAT3
16  2020 Exploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations. ITIM, ITSM, MD, PD-1, SH2
17  2020 Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development. ---
18  2020 Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells. ---
19  2020 Medicinal chemistry strategies for the development of protein tyrosine phosphatase SHP2 inhibitors and PROTAC degraders. MAPK, SAR
20  2020 Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling. EGFR, ERK, IAV, IFNs, ISGs, siRNA
21  2020 SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations. METex14, NSCLC, RTKs
22  2020 SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model. AKI, BUN, CLP, CRE, HEM, HMGB1, NGAL, PHPS1, PTPs, STAT3
23  2020 SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer. ECM, MBC
24  2020 SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro. NS
25  2020 SHP2-Independent Tyrosine Dephosphorylation of Cortactin and Vinculin during Infection with Helicobacter pylori. CagA
26  2020 Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase. MD, PTP, pY
27  2020 Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors. ---
28  2020 The Noonan syndrome-associated D61G variant of the protein tyrosine phosphatase SHP2 prevents synaptic down-scaling. ---
29  2020 Therapeutic effect of the injectable thermosensitive hydrogel loaded with SHP099 on intervertebral disc degeneration. IVD, NP, SOX9
30  2019 Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099. HS
31  2019 Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions. NS, NSML
32  2019 Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery. Bcr-Abl, IDH, MEK, PKB
33  2019 Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway. ERK/CREB, GBM, GOF
34  2019 Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation. LOF, LS, NSML, PTPN11, SHP2WT
35  2019 Overriding Adaptive Resistance to Sorafenib Through Combination Therapy With Src Homology 2 Domain-Containing Phosphatase 2 Blockade in Hepatocellular Carcinoma. ERK, HCC, MEK, RTKs
36  2019 Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla. ATP
37  2019 Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner. ---
38  2019 Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics. MAPK, MD, N-SH2
39  2019 Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway. RhoA, ROCK
40  2019 PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development. GVBD, ICM, LIF, MAPK
41  2019 SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody. Abs, MG, MuSK
42  2019 Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2. SH2
43  2019 Targeting SHP2 as a promising strategy for cancer immunotherapy. ---
44  2019 Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles. NPs
45  2018 Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma. Hook1, TCs
46  2018 Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types. HeLa
47  2018 Integrin-linked kinase (ILK) and src homology 2 domain-containing phosphatase 2 (SHP2): Novel targets in EGFR-mutation positive non-small cell lung cancer (NSCLC). AECC, gp130, HGF, IL-6, ILK, MAPK, NSCLC, TKIs
48  2018 Off-target inhibition by active site-targeting SHP2 inhibitors. MAPK
49  2018 Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K. nIN-IN, PI3K, siRNA
50  2017 A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages. BMMs, Ptpn11
51  2017 Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. NOXs, PTPs, ROS
52  2017 Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors. ---
53  2017 Mechanotransduction properties of the cytoplasmic tail of PECAM-1. ECs, PECAM-1, CD31
54  2017 Reciprocal regulation of TLR2-mediated IFN-beta production by SHP2 and Gsk3beta. GSK-3beta, IFN, TLR2
55  2017 Role of SHP2 in hematopoiesis and leukemogenesis. ---
56  2017 Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein. CM, PAR1b
57  2017 SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells. HLA, JAK2, MEK, p-ERK, PBMC, PCa, PD-L1, pSTAT1
58  2017 Therapeutic Targeting of Oncogenic Tyrosine Phosphatases. PRL, PTK, PTP
59  2017 Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. ANT1
60  2016 Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. CML, GAB2, Ph, PI3K, TKIs
61  2016 Early signaling dynamics of the epidermal growth factor receptor. EGFR, Gab1, PI3K, RTK
62  2016 SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. IPF
63  2016 SIRPalpha1-SHP2 Interaction Regulates Complete Freund Adjuvant-Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats. CFA, p-Src, pSHP2, SIRPalpha1, t-Src, tSHP2
64  2016 T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. DSS
65  2016 The SHP2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of CCAAT/enhancer binding protein alpha to the IGnTC promoter region during erythroid differentiation. ERK, RBCs
66  2016 The use of SHP-2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat. BMSC
67  2015 CD99 inhibits CD98-mediated beta1 integrin signaling through SHP2-mediated FAK dephosphorylation. FAs, PKCalpha
68  2015 Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling. ---
69  2015 SHP2 sails from physiology to pathology. MAPK, NS, NSML, PI3K
70  2015 Structure and function of Gab2 and its role in cancer (Review). Gab, PI3K, PLCgamma, PTKs, SH2
71  2014 BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. HFS, SNL
72  2014 Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. AOM/DSS, CAC, IL-6, XIAP
73  2014 LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity. NSML
74  2014 Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway. BMI, JAK2, LEPR, qRT-PCR, SFK, siRNA, SK1, STAT3
75  2014 Leptin signaling. ACC, AMPK, IRS, JAK2, MAPK, PI3K, STAT3
76  2014 SH2 domain-containing protein tyrosine phosphatase 2 and focal adhesion kinase protein interactions regulate pulmonary endothelium barrier function. ALI, FAK
77  2014 Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis. EMT
78  2014 Therapeutic potential of targeting the oncogenic SHP2 phosphatase. ---
79  2014 Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases. TNBC
80  2013 Autophagy facilitates cytokine-induced ICAM-1 expression. ---
81  2013 Gab docking proteins in cardiovascular disease, cancer, and inflammation. Gab, SH2
82  2013 Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. AMPK, IL-6, JAK1, SAA, SOCS3, STAT3
83  2013 Signal regulatory protein alpha is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression. HCC, IKKbeta, KD, NF-kappaB, PI3Kp85, SIRPalpha
84  2012 Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome. PTP, SH2
85  2012 Protein tyrosine phosphatase SHP2 mediates chronic insulin-induced endothelial inflammation. eNOS
86  2012 Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts. ROCK
87  2012 Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. pNR2B, PSD-95, pSHP2, SIRPalpha1
88  2012 The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of beta-catenin phosphorylation. VE
89  2012 Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. HER2, ZEB1
90  2012 Vinculin functions as regulator of chondrogenesis. IGF-I
91  2011 Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-beta1/ERK/caspase-9 phosphorylation cascade. EF, ERK, FS, LV-ESD, LVEDd, PTPmu, VE
92  2011 Gab2, via PI-3K, regulates ARF1 in FcepsilonRI-mediated granule translocation and mast cell degranulation. ARF
93  2011 Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling. CM, EPIYA, PAR1
94  2011 Involvement of SHP2 in focal adhesion, migration and differentiation of neural stem cells. FAK
95  2011 LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3beta/beta-catenin signaling. GSK, HCM, LS
96  2011 Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. LD, SD
97  2010 PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. alpha-MSH, POMC, PTP1B
98  2010 Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). ---
99  2010 SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene. ET-1, GPCR, IL-6, LIF
100  2010 The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation. VSMCs