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Abbreviation : SHRSP
Long Form : spontaneously hypertensive rats
No. Year Title Co-occurring Abbreviation
2021 Ajuga iva water extract antihypertensive effect on stroke-prone spontaneously hypertensive rats, vasorelaxant effects ex vivo and in vitro activity of fractions. L-NNA, SBP
2021 Altered Properties of Neurons and Astrocytes and the Effects of Food Components in Stroke-Prone Spontaneously Hypertensive Rats. ---
2021 Maternal protein restriction induces renal AT2R promoter hypomethylation in salt-sensitive, hypertensive rats. AT2R
2021 Placental Glycoredox Dysregulation Associated with Disease Progression in an Animal Model of Superimposed Preeclampsia. TBARS
2021 Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats. ANP, PK ASO, PKa
2021 Thromboxane A2 receptor antagonist (ONO-8809) attenuates renal disorders caused by salt overload in stroke-prone spontaneously hypertensive rats. CKD, HIF-1alpha, MCP-1, TXA2
2020 Alterations of lymphocyte count and platelet volume precede cerebrovascular lesions in stroke-prone spontaneously hypertensive rats. CSVD
2020 Association between low doses of ionizing radiation, administered acutely or chronically, and time to onset of stroke in a rat model. ---
2020 Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats. GDNF, Izm, MCT
10  2020 Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats. BP, JD, LV-UCP2, UCP2
11  2020 Defective Function of the Blood-Brain Barrier in a Stroke-Prone Spontaneously Hypertensive Rat: Evaluation in an In Vitro Cell Culture Model. BBB, BECs, WKYs
12  2020 LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) Deletion Has Protective Effects on Stroke in the Genetic Background of Stroke-Prone Spontaneously Hypertensive Rat. LOX-1
13  2020 Potential Therapeutic Value of Urotensin II Receptor Antagonist in Chronic Kidney Disease and Associated Comorbidities. CKD, UII, UT
14  2020 Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474. FAAH
15  2019 A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. AD, MXD, SVD
16  2019 Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation. PVMs, WKY
17  2019 Dual inhibition of NADPH oxidases and xanthine oxidase potently prevents salt-induced stroke in stroke-prone spontaneously hypertensive rats. NOXs
18  2019 Ectopic TWEAKR expression in type I fiber of stroke-prone spontaneously hypertensive rats is related to slow muscle-specific hypotrophy. MuRF1, TWEAKR, WKY
19  2019 Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats. BP
20  2019 Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat. QTL
21  2019 Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp. PVAT
22  2019 Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-β dehydrogenase 7 levels for low cholesterol biosynthesis. HSD17B7, MPD, SQE, WKY
23  2019 Use of mTRAQ derivatization reagents on tissues for imaging neurotransmitters by MALDI imaging mass spectrometry: the triple spray method. GABA, MALDI, WKY
24  2018 A preventive injection of endothelial progenitor cells prolongs lifespan in stroke-prone spontaneously hypertensive rats. EPCs
25  2018 Association of mRNA expression of iron metabolism-associated genes and progression of non-alcoholic steatohepatitis in rats. NASH, ND
26  2018 Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function. ACh, DHE, NO, ROS, UCP2
27  2018 Diverse associations between oxidative stress and thromboxane A2 in hypertensive glomerular injury. TXA2, TXAS, WKY
28  2018 Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. SVD
29  2018 Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat. BP
30  2018 Further dissection of QTLs for salt-induced stroke and identification of candidate genes in the stroke-prone spontaneously hypertensive rat. Chr, SHR
31  2018 Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats. ---
32  2018 Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring. ptger1
33  2018 Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation. ACh, eNOS, iNOS, NO, WKY
34  2018 Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. PRES
35  2018 The effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and Wistar rats. DETC, HR, SOD
36  2017 A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat. ---
37  2017 A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines. SHRSR, UCP2
38  2017 Defective trophoblast invasion underlies fetal growth restriction and preeclampsia-like symptoms in the stroke-prone spontaneously hypertensive rat. FGR, GD, NK, PE, SBPs
39  2017 Involvement of arterial baroreflex and nicotinic acetylcholine receptor alpha7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. alpha7nAChR, KO, MCAO, MET, VAChT
40  2017 Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat. ---
41  2017 Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP). ---
42  2017 Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage. COX, IP, NO
43  2016 A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes. STIM1
44  2016 Analysis of Vascular Cell Response to Hypertension Induced by Pressure Loading and Its Application as a Tool for Exploring Pharmacological Modes of Action. COX-2, DHA, IL-1beta, iNOS, VSMCs, WKY
45  2016 Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension. EDH, TRPV4, WKY
46  2016 Effect of Angelica acutiloba Extract on Blood flow Regulation in Stroke-prone Spontaneously Hypertensive Rats. ---
47  2016 Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain. BP, Glu, NOX, RVLM, WKY
48  2016 Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats. ROS, SHSP, SOD
49  2016 Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. FRB
50  2016 Importance of detoxifying enzymes in differentiating fibrotic development between SHRSP5/Dmcr and SHRSP rats. BA, HFC
51  2016 Increased myocardial vulnerability to ischemia-reperfusion injury in the presence of left ventricular hypertrophy. Exe-4, WKY
52  2016 Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease. TOD
53  2016 Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. JD, OR
54  2016 Pathological characterization and morphometric analysis of hepatic lesions in SHRSP5/Dmcr, an experimental non-alcoholic steatohepatitis model, induced by high-fat and high-cholesterol diet. NASH, SP
55  2016 Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP). GRH, P. gingivalis, WKY
56  2016 Role of Tumor Necrosis Factor-α and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat. ---
57  2015 A Cyclooxygenase-2 Inhibitor Reduces Vascular Wall Thickness and Ameliorates Cognitive Impairment in a Cerebral Small Vessel Diseases Rat Model. COX-2, CSVD, SD
58  2015 Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. WKY
59  2015 Blood-brain barrier damage in vascular dementia. BBB, MMP-13
60  2015 Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. AM, AT1R, BP, EM, HYD, i.c.v, MBP, NT, VEH
61  2015 Decreased proportion of Foxp3+ CD4+ regulatory T cells contributes to the development of hypertension in genetically hypertensive rats. IL, Treg, WKY
62  2015 Differential modulation of AMPK/PPARalpha/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains. UCP2
63  2015 Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Nrf2, WKY
64  2015 Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats. FBEP
65  2015 Fetal-adult cardiac transcriptome analysis in rats with contrasting left ventricular mass reveals new candidates for cardiac hypertrophy. LV
66  2015 Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases. MCA, MES, NOX
67  2015 Glomerular damage in experimental proliferative glomerulonephritis under glomerular capillary hypertension. WKY
68  2015 Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers. hnRNA, miR, MPD, WKY
69  2015 Porphyromonas gingivalis-induced alveolar bone loss is accelerated in the stroke-prone spontaneously hypertensive rat. P. gingivalis, ROS, WKY
70  2015 Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARalpha/UCP2 axis. AMPK, PGC1alpha, PPARalpha, SIRT1, UCP2
71  2015 Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. MR, PAs
72  2015 Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats. CVECs, DR, IL, MCP-1
73  2014 Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats. ADHD, CaMKII, D1R, D2R, ERK, GluR1, mPFC, MPH, PKC, WKY
74  2014 Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats. AF, AT1R, i.c.v
75  2014 Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats. ---
76  2014 Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model. AIC, BW, FCM, IDA
77  2014 Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat. Chr1, STIM1, WKY
78  2014 Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. MMP-9, NVU, VEGFR2
79  2014 Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage. EETs, HS, SBP, UPE
80  2014 Synergistic neuroprotective effects of combined treatment with olmesartan plus azelnidipine in stroke-prone spontaneously hypertensive rats. ---
81  2014 Temporary mineralocorticoid receptor antagonism during the development of hypertension improves cerebral artery dilation. MCA, MR
82  2014 Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. MSCs
83  2014 Tumor necrosis factor-α inhibition attenuates middle cerebral artery remodeling but increases cerebral ischemic damage in hypertensive rats. ETN, MCA, MCAO, TNF
84  2013 ALDH2 protects against stroke by clearing 4-HNE. 4-HNE, ALDH2, SHR
85  2013 Alpha-tocopherol in the brain tissue preservation of stroke-prone spontaneously hypertensive rats. ---
86  2013 Altered fatty acid profile in the liver and serum of stroke-prone spontaneously hypertensive rats: reduced proportion of cis-vaccenic acid. SHR, TAGs
87  2013 An MRI-histological study of white matter in stroke-free SHRSP. MRI, SVD, WMH
88  2013 Differential effects of antihypertensive treatments on apoptosis, oxidative stress, and expression of angiotensin receptors in the cerebral cortex from the onset of prehypertension and hypertension in stroke-prone spontaneous hypertensive rats. ---
89  2013 Differential modulation of uncoupling protein 2 in kidneys of stroke-prone spontaneously hypertensive rats under high-salt/low-potassium diet. miR, RNO, UCP2
90  2013 Effects of angiotensin II type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats. ---
91  2013 Effects of combination therapy with levamlodipine and bisoprolol on stroke in rats. BRS, HP, HR, MCAO, SAD, SBP, SBPV
92  2013 Effects of oxidative stress on vascular reactivity in the offspring of protein-restricted stroke-prone spontaneously hypertensive rats. ACh, dROM, eNOS, PMA, sGC
93  2013 Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion. ---
94  2013 Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ---
95  2013 Interleukin-1β accelerates the onset of stroke in stroke-prone spontaneously hypertensive rats. SHR, WKY
96  2013 Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats. BP, RAAS
97  2013 MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke. MCAO, OGD, SHR
98  2013 Possible involvement of oxidative stress as a causative factor in blood-brain barrier dysfunction in stroke-prone spontaneously hypertensive rats. BBB, d-ROM, WKY
99  2013 Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats. CBF, RD, WM
100  2013 Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/Izm. chr, QTL