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Abbreviation : SHRSP
Long Form : spontaneously hypertensive stroke-prone rats
No. Year Title Co-occurring Abbreviation
2021 Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat. IPA, RAAS, ROS, WKY
2021 Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation-gene expression profiling. LV, P-V
2021 Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. BA, BP, GF, IF
2021 The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats. BDNF, BP
2021 The gut microbiome contributes to blood-brain barrier disruption in spontaneously hypertensive stroke prone rats. BBB, CSVD, SBPs
2020 Retinal Vascular Pathology in a Rat Model of Cerebral Small Vessel Disease. AA, CAA, CAA, CSVD, HA, SVD
2019 Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease. EV, miRNA, SVD, tMCAO
2019 Host genetics and diet composition interact to modulate gut microbiota and predisposition to metabolic syndrome in spontaneously hypertensive stroke-prone rats. HFD, MONW, WKY
2019 Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. LSCI, pMCAO
10  2019 Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia. BCCAL, CCCoh, CCoh, HRV, WKY
11  2019 Whey Protein and Its Components Lactalbumin and Lactoferrin Affect Energy Balance and Protect against Stroke Onset and Renal Damage in Salt-Loaded, High-Fat Fed Male Spontaneously Hypertensive Stroke-Prone Rats. CO, LF
12  2018 Differential Stiffening between the Abdominal and Thoracic Aorta: Effect of Salt Loading in Stroke-Prone Hypertensive Rats. BP, WKY
13  2018 Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats. Ang II, JpD, STD, TF, WKY
14  2018 The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke-prone rats. CAA, CBF, HA
15  2017 Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection. PPARalpha, SDH
16  2017 Vascular basement membrane alterations and beta-amyloid accumulations in an animal model of cerebral small vessel disease. BMs, CAA, CSVD, TEM
17  2016 Alterations in the gut microbiota can elicit hypertension in rats. SBP
18  2016 Common Impact of Chronic Kidney Disease and Brain Microhemorrhages on Cerebral Aβ Pathology in SHRSP. AD
19  2016 Effect of hypertension and peroxynitrite decomposition with FeTMPyP on CBF and stroke outcome. PAs, SVR
20  2015 Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BBB, HRW, MMPs
21  2015 Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats. HDL, LDL, PCR, SQE, SRB1, WKY
22  2015 Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease. WKY
23  2015 Prehypertensive treatment with losartan, however not amlodipine, leads to long-term effects on blood pressure and reduces the risk of stroke in spontaneously hypertensive stroke-prone rats. SBP
24  2015 Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. TGs
25  2014 Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. SVD
26  2014 Effects of Losartan and Amlodipine on Left Ventricular Remodeling and Function in Young Stroke-Prone Spontaneously Hypertensive Rats. BNP, LV
27  2014 Hypertension drives parenchymal beta-amyloid accumulation in the brain parenchyma. AD, CSVD
28  2014 Impact of N-Acetylcysteine on cerebral amyloid-beta plaques and kidney damage in spontaneously hypertensive stroke-prone rats. BBB, CSVD, NAC
29  2014 Interplay between age, cerebral small vessel disease, parenchymal amyloid-beta, and tau pathology: longitudinal studies in hypertensive stroke-prone rats. AbetaPP, BBB, CSVD
30  2014 Intravital imaging in spontaneously hypertensive stroke-prone rats-a pilot study. BBB, CSVD, HE
31  2014 Origin of the Y chromosome influences intrarenal vascular responsiveness to angiotensin I and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. SHR, WKY
32  2013 Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ---
33  2013 Blood brain barrier breakdown as the starting point of cerebral small vessel disease? - New insights from a rat model. BBB, WML
34  2013 Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats. CSVD, MRI
35  2013 Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats. LV, LVH, QTL, RLVW
36  2013 NAC changes the course of cerebral small vessel disease in SHRSP and reveals new insights for the meaning of stases - a randomized controlled study. BBB, NAC, vWF
37  2012 Albuminuria indicates the pressure-associated injury of juxtamedullary nephrons and cerebral strain vessels in spontaneously hypertensive stroke-prone rats. CVD, MCP-1, TGF-beta
38  2012 Choice of diet impacts the incidence of stroke-related symptoms in the spontaneously hypertensive stroke-prone rat model. SRS
39  2012 Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. HSFD, I/R, MAP, NO, sGC
40  2012 Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. ADC, DWI, DWI, MCAO, PWI, PWI, WKY
41  2012 Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats. ONFH
42  2012 Renal outcome in equipotent antihypertensive treatment with telmisartan, ramipril and in combination in SHR-SP rats. ---
43  2012 Stases are associated with blood-brain barrier damage and a restricted activation of coagulation in SHRSP. CSVD
44  2011 Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. WKY
45  2011 Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats. CSVD
46  2011 Normal values of quantitative T2' in a spontaneously hypertensive stroke prone rat stem at 3T. ---
47  2011 The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. SD, VSMCs
48  2011 The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? BBB, CBF, CSVD
49  2010 Effectiveness of B vitamins on the control of hypertension and stroke events of SHRSP rats. MDA
50  2010 Feeding blueberry diets inhibits angiotensin II-converting enzyme (ACE) activity in spontaneously hypertensive stroke-prone rats. ACE
51  2010 Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, increases survival in stroke-prone rats by preventing systemic inflammation and endothelial dysfunction: comparison with aspirin and rosuvastatin. ---
52  2009 Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. BB, CON, SBP
53  2009 Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. COX-2, IL-1beta, MAPK, PRA, SFD
54  2009 Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats. ---
55  2009 Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. AUDA, sEH, WKY
56  2008 Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. 20-HETE, CYP, MCAO, rCBF, SHR, WKY
57  2008 Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats. Hp, SELDI-TOF-MS
58  2008 Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. ACE2
59  2007 Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. WKY
60  2007 Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists. MCA, MR
61  2007 Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats. MCA, WKY
62  2006 Gender differences in endothelial function and inflammatory markers along the occurrence of pathological events in stroke-prone rats. NO
63  2005 ACE inhibition reduces activity of the plasminogen/plasmin and MMP systems in the brain of spontaneous hypertensive stroke-prone rats. MMP, TIMP, tPA
64  2005 Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. ---
65  2005 Congenic/consomic models of hypertension. QTL
66  2005 Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker. ---
67  2005 Multiexponential T2-relaxation analysis in cerebrally damaged rats in the absence and presence of a gadolinium contrast agent. ---
68  2005 Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects. ---
69  2005 [Upregulation of adrenomedullin system in left ventricular hypertrophy of severe hypertension rats]. AM, AM, AM-m, AM-T, ANP, LV, WKY
70  2004 Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic. AM, CRLR, RAMP, WKY
71  2004 Analysis of pathological events at the onset of brain damage in stroke-prone rats: a proteomics and magnetic resonance imaging approach. BBB, MRI
72  2004 Anti-inflammatory effects of AT1 receptor blockade provide end-organ protection in stroke-prone rats independently from blood pressure fall. AT1
73  2004 Increased levels of superoxide in brains from old female rats. SOD, WKY
74  2004 Pentoxifylline prevents spontaneous brain ischemia in stroke-prone rats. IL, LPS, PTX, TNF-alpha
75  2003 Effect of hypertension on hearing function, LDH and ChE of the cochlea in older rats. ABR
76  2003 Endogenous proteolytic activity in a rat model of spontaneous cerebral stroke. MRI, PA, tPA, uPA
77  2003 p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension. HUVECs, MAPK, SFD
78  2003 Upregulation of ligand, receptor system, and amidating activity of adrenomedullin in left ventricular hypertrophy of severely hypertensive rats: effects of angiotensin-converting enzyme inhibitors and diuretic. AM, AM, AM-m, AM-T, ANP, CRLR, LV, RAMP, WKY
79  2002 Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats. l-NAME
80  2002 New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study. ADC
81  2002 Postischemic angiogenic factor expression in stroke-prone rats. SHR
82  2002 Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: effect of the alpha1 -receptor blocker doxazosin. BW, cGMP, MAP, NO, sGC, WKY
83  2002 The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. WKY
84  2001 Aldosterone as a mediator of progressive renal dysfunction: evolving perspectives. ACE, ESRD, PAI-1, ROS, TGF-beta1
85  2001 Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats. ACh, NO, SFD, WKY
86  2000 Inhibition of NOS enhances pulmonary vascular changes in stroke-prone spontaneously hypertensive rats. ACh, L-NNA, NO, PAs, RV, RV/BW, RVH, WKY, WT
87  2000 Nitric oxide deficiency contributes to large cerebral infarct size. MCA, NO, SD
88  2000 Oxotremorine-induced cerebral hyperemia does not predict infarction volume in spontaneously hypertensive or stroke-prone rats. CBF, SHR, WKY
89  1999 Effect of long-term ACE inhibition on myocardial tissue in hypertensive stroke-prone rats. ---
90  1999 Effect of nitro-L-arginine on electrical and mechanical responses to acetylcholine in the superior mesenteric artery from stroke-prone hypertensive rat. L-NA, WKY
91  1999 Impairment of the blood-brain barrier: a potential surrogate delineating the determinants of cerebral bleeding caused by fibrinolytic drugs. IgG, tPA
92  1999 Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. NO, WKY
93  1998 Long-term food restriction, deprenyl, and nimodipine treatment on life expectancy and blood pressure of stroke-prone rats. ---
94  1997 Role of nitric oxide in the contractile response to 5-hydroxytryptamine of the basilar artery from Wistar Kyoto and stroke-prone rats. 5-HT, WKY
95  1997 Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. ---
96  1996 Inhibition by bosentan, an endothelin antagonist, of the hypersensitivity to Ca2+ channel activator evoked by salt-loading in basilar artery of stroke-prone spontaneously hypertensive rats. ---
97  1995 Ameliorating effect of clentiazem (TA-3090), a new Ca antagonist, on the impaired learning ability of poststroke SHRSP. ECS
98  1995 Cerebral blood flow and glucose metabolism of the ischemic rim in spontaneously hypertensive stroke-prone rats with occlusion of the middle cerebral artery. LCBF, MCA
99  1995 Cerebral blood flow during inhibition of brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats. CBF, L-NA, L-NMMA, MABP, NO, SHR, WKY
100  1995 The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ---