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Abbreviation : ST
Long Form : staurosporine
No. Year Title Co-occurring Abbreviation
2021 Differential ROS-Mediated Phosphorylation of Drp1 in Mitochondrial Fragmentation Induced by Distinct Cell Death Conditions in Cerebellar Granule Neurons. CGN, Drp1, mtROS, ROS
2020 Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells. BDNF, PMA, RA, TH
2019 Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-alpha-mediated G2/M phase arrest in chronic myeloid leukaemia. CML, IM, PKCs
2018 New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. DOX, Glu, mGluR7
2017 The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a gammaH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. ATM, DOX, RA
2016 The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage. CGC, DIV, DOX, Glu, HIP, mGluRs, PAM
2015 Peroxynitrite is Involved in the Apoptotic Death of Cultured Cerebellar Granule Neurons Induced by Staurosporine, but not by Potassium Deprivation. CGN, NO, RNS, sGC
2014 Effect of staurosporine in the morphology and viability of cerebellar astrocytes: role of reactive oxygen species and NADPH oxidase. NOX
2013 Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner. ---
10  2013 Staurosporine maintains the activation of store-operated Ca⁺ entry even after the refilling of Ca⁺ stores. CPA, SOCE
11  2013 The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways. ADs, DOX, RA-SH-SY5Y, Tian
12  2011 A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. CM-CQ, CQ, MOMP, PCD, zFA, zLLL
13  2011 The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. AS, BUT, COX, DI, GOS, IN, PG, PK, SUL, TPA
14  2011 [Effects of staurosporine on the proliferation and apoptosis of prostate cancer PC-3 cells]. ---
15  2010 Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies. CEA, CEA, CK
16  2009 Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect. AIF, CGC, DIV, LP, NMDA
17  2009 Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents. ---
18  2009 NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons. CGN, ROS, WT
19  2009 Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation. EMT, MT-PCR
20  2008 Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons. CGN, ROS
21  2007 PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat. AMPARs, PAs, UDU
22  2007 Voltage-dependent potassium channels are involved in staurosporine-induced apoptosis of rat mesenchymal stem cells. MSCs, TEA
23  2006 Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells. ---
24  2005 Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits. 8-SPT, IS, PC, PIA, TYR
25  2005 Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells. 5-FU, BIS, CEA, GEN, HERB, PKI
26  2005 Staurosporine inhibits voltage-dependent K+ current through a PKC-independent mechanism in isolated coronary arterial smooth muscle cells. Kv, PKA-IP, PKC
27  2005 The protein kinase inhibitor, staurosporine, inhibits L-type Ca2+ current in rabbit atrial myocytes. PKC
28  2004 Overexpression of human KCNA5 increases IK V and enhances apoptosis. 4-AP, AVD, IPAH, Kv, PASMC
29  2004 Role of ionic fluxes in the apoptotic cell death of cultured cerebellar granule neurons. ---
30  2003 A potential role for cx43-hemichannels in staurosporin-induced apoptosis. FACS
31  2003 Human papillomaviruses type 16+ and 18+ cervical carcinoma cells are sensitive to staurosporine-mediated apoptosis. PARP
32  2003 Mussel blood cells, resistant to the cytotoxic effects of okadaic acid, do not express cell membrane p-glycoprotein activity (multixenobiotic resistance). DSP, OA, p-gp
33  2003 Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells. ---
34  2003 Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists. ---
35  2003 Teratogen-induced activation of caspase-6 and caspase-7 in early postimplantation mouse embryos. ---
36  2003 Teratogen-induced activation of the mitochondrial apoptotic pathway in the yolk sac of day 9 mouse embryos. ---
37  2003 [Effect of staurosporine on cell cycle of human gastric cancer cells]. PKC
38  2003 [Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II]. Ang II, HSMCs, NO, PKC, PMA, Pra-C, PTX, SMC
39  2002 A novel method for monitoring response to chemotherapy based on the detection of circulating cancer cells: a case report. CEA
40  2002 Cytochrome c activates K+ channels before inducing apoptosis. cyt c
41  2002 Mechanism of superoxide anion production by hepatic sinusoidal endothelial cells and Kupffer cells during short-term ethanol perfusion in the rat. 4-MP, DPI, IB, KCs, PKC, SECs
42  2002 Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. PI3K, PS
43  2002 Protein kinase C-dependent inhibition of the lysosomal degradation of endocytosed proteins in rat hepatocytes. CHE, MARCKS, PKC, PMA
44  2002 [Cardiocyte hypertrophy induced by cultured neonatal rat ventricular fibroblast conditioned growth medium]. FCGM, PTX
45  2001 Augmented K(+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis. PASMCs
46  2001 Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Kv, PASMC
47  2001 Staurosporine-induced apoptosis of HPV positive and negative human cervical cancer cells from different points in the cell cycle. ---
48  2000 A novel rice (Oryza sativa L.) acidic PR1 gene highly responsive to cut, phytohormones, and protein phosphatase inhibitors. CN, EN, JA, PR, SA
49  2000 Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. PARP
50  2000 Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption. PKC, PTH, TNF-alpha
51  2000 PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules. BIM, BK, DOG, FL, OA, PE, PKC, PMA
52  2000 Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line. CEA
53  2000 Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. CP, ERKs, HS, JNKs
54  1999 Staurosporine directly blocks Kv1.3 channels expressed in Chinese hamster ovary cells. CHO, PKC
55  1999 Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells. alpha-TH, PKC, PTH
56  1998 alpha-Adrenergic effects on Na+-K+ pump current in guinea-pig ventricular myocytes. NA, PKC, Str
57  1998 Protein kinase C-independent selective induction of nitric oxide synthase activity in rat alveolar macrophages by staurosporine. LPS, PKC
58  1998 Rubella virus induces apoptosis in culture cells. RUB
59  1997 Alteration of proto-oncogenes during apoptosis in the oral squamous cell carcinoma cell line, SAS, induced by staurosporine. ---
60  1997 Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells. BI, CaN
61  1997 P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells. 4 alpha-PDD, Cal-AM, DNR, MDR, OA, P-gp, PKC, VP
62  1997 Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. Cx43, PKC, TPA
63  1996 Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils. TPA
64  1996 Differential effects of protein kinase C activation on 5-HT1A receptor coupling to Ca2+ and K+ currents in rat serotonergic neurones. IK,5-HT, PKC, PMA
65  1996 Effects of corticotropin-releasing hormone, lysine vasopressin, oxytocin, and angiotensin II on adrenocorticotropin secretion from porcine anterior pituitary cells. AII, AP, CRH, FOR, LVP, OT, PKA, PKC, PMA
66  1996 Effects of staurosporine on ACTH-mediated stimulation of aldosterone production. ACTH, ALDO, cAMP, MIX
67  1996 Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. PKC
68  1996 Staurosporine-induced G1 arrest is associated with the induction and accumulation of cyclin-dependent kinase inhibitors. CDKs
69  1995 Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. OA, OC, VDRE
70  1995 Effect of protein kinase C modulation on gonadotrophin-induced granulosa cell steroidogenesis. PKC, PMA, Sph
71  1995 Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein. PDBu
72  1995 Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines. AhR, alpha-NF, CYP1A1, PKC, TCDD
73  1995 Protein kinase-C mediates chicken vasoactive intestinal peptide stimulated prolactin secretion and gene expression in turkey primary pituitary cells. PKC, PMA, PRL, VIP
74  1995 STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway. vps
75  1994 Effect of adenylate cyclase inhibitor and protein kinase C inhibitor on GnRH-induced LH release and LH beta subunit biosynthesis in rat anterior pituitary cells. 2',3'-DDA, PKC
76  1994 Effect of the protein kinase C inhibitor staurosporine on chemosensitivity to daunorubicin of normal and leukemic fresh myeloid cells. AML-CFU, CFU-GM, DNR, MDR, P-gp, PKC, Rh123
77  1994 Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells. CT, IAP, TPA
78  1994 Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors. IP, PKA, PKC
79  1994 The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells. CDK2
80  1993 Induction of immediate early and stress genes in rat proximal tubule epithelium following injury: the significance of cytosolic ionized calcium. 2AP, PTE, X/XOD
81  1993 Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver. PKC, PMA
82  1992 Is staurosporine (ST) a specific inhibitor of protein kinase C (PKC) in intact porcine coronary arteries? PKC
83  1992 The role of protein kinase-C in control of aldosterone production by rat adrenal glomerulosa cells: activation of protein kinase-C by stimulation with potassium. AII, PKC, PMA
84  1990 Effect of protein kinase C inhibitors on the actions of phorbol esters on vascular tone and adrenergic transmission in the isolated rat kidney. PDBu, PKC, PMB, RNS, SNG, Sph, TPA
85  1990 Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells. 3-MC, PC, TPA