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Abbreviation : ST
Long Form : strand transfer
No. Year Title Co-occurring Abbreviation
2016 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. HIV, HPD, IN, pol, RNase H, RT, SAR
2016 Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site. DTG, INSTIs, RAL
2015 Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors. HIV-1 IN
2015 Insight into the binding mode between N-methyl pyrimidones and prototype foamy virus integrase-DNA complex by QM-polarized ligand docking and molecular dynamics simulations. HIV-1, IN, MD, NMPs, PFV, QPLD
2015 Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of beta-Diketo Acids. ---
2015 N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase. CCD, DKA, IN, RNase H
2015 Novel HIV-1 Integrase Inhibitor Development by Virtual Screening Based on QSAR Models. IN, QSAR
2015 Synthesis of dihydropyrimidine alpha,gamma-diketobutanoic acid derivatives targeting HIV integrase. IN
2015 Synthesis, biological evaluation and molecular docking of calix[4]arene-based beta-diketo derivatives as HIV-1 integrase inhibitors. IN
10  2014 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. HIV-1 IN
11  2014 In vitro analysis of the susceptibility of HIV-1 subtype A and CRF01_AE integrases to raltegravir. HIV-1, INs, RAL
12  2013 Identification of potential HIV-1 integrase strand transfer inhibitors: in silico virtual screening and QM/MM docking studies. IN
13  2013 Prediction of bioactivity of HIV-1 integrase ST inhibitors by multilinear regression analysis and support vector machine. MLR, SOM, SVM
14  2013 Substrate recognition and motion mode analyses of PFV integrase in complex with viral DNA via coarse-grained models. ANM, DKA, GNM, IN, PFV
15  2013 Synthesis, docking, and biological studies of phenanthrene beta-diketo acids as novel HIV-1 integrase inhibitors. ---
16  2012 Classification of active and weakly active ST inhibitors of HIV-1 integrase using a support vector machine. MCC, SVM
17  2012 Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti-HIV Activity. UGTs
18  2012 Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir. IN, LTR, RAL
19  2011 Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells. IN
20  2010 Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir. IN, RAL
21  2008 A novel high-throughput format assay for HIV-1 integrase strand transfer reaction using magnetic beads. bio, DIG, IN
22  2008 Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. IN
23  2008 Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities. DKA, IN
24  2007 HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein. DKA, IN, MDR, P-gp
25  2006 Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site. BaP DE
26  2005 Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity. ADK, AIDS, HAART, HIV-1, IN, PR, RT
27  2002 Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. ADK, IN