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Abbreviation : THIP
Long Form : 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
No. Year Title Co-occurring Abbreviation
2021 Diurnal properties of tonic and synaptic GABAA receptor-mediated currents in suprachiasmatic nucleus neurons. Eq, GABAAR, GABAARs, SCN, sGPSCs, ZT
2021 Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. GAR, IBD, VMR
2021 Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells. CCI, CCI, DGGCs, sIPSCs, TBI
2018 Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia. CIs, GABA, MD, RRs, TD
2018 Sleep regulates visual selective attention in Drosophila. ---
2017 Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease. APP, APS, dlg, LTM, STM
2017 Fast Ca2+ responses in astrocyte end-feet and neurovascular coupling in mice. a,d, CBF, GABAAR
2017 Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells. BRB, IAA, TauT
2017 Temporal Regulation of GABAA Receptor Subunit Expression: Role in Synaptic and Extrasynaptic Communication in the Suprachiasmatic Nucleus. GABAAR, IR, SCN
10  2015 Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons. ---
11  2015 Regulation of Extrasynaptic GABAA alpha4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons. GABAAR, PDBu, PKA, PKC
12  2015 Sleep restores behavioral plasticity to Drosophila mutants. dnc, LTM, rut, STM
13  2014 Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons. CTZ, PSs
14  2014 Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster. AMPAR, CeA, CNQX, EPM, GluR
15  2014 Thalamic delta-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo. deltaGABAARs, NREM
16  2013 Acutely increasing deltaGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus. DG, LTP, WT
17  2013 gamma-aminobutyric acid type A receptors that contain the delta subunit promote memory and neurogenesis in the dentate gyrus. DG, WT
18  2013 Increased voluntary ethanol consumption and changes in hippocampal synaptic plasticity in isolated C57BL/6J mice. DG, DGGCs, EtOH, GABAARs, GH, LTP, SI
19  2013 Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor delta subunit in cerebellar granule neurons and delays motor development in rats. CGNs, EtOH, PAE, SECs
20  2013 Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. FS-BCs, GABA, GABA, SE, sIPSC
21  2012 Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs? ---
22  2012 Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. GABA
23  2012 GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons. VTA
24  2012 Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro. TETRAC
25  2012 Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. KCC, KCC2, ZAPA
26  2012 Phasic GABAA -receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus. ---
27  2012 Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons. DRG, sqRT-PCR
28  2011 Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. BDNF, GABA, SSRI
29  2011 Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. CI, GABA, MD, NNT, RR, TD
30  2011 Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons. MNCs, SON
31  2010 Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. ---
32  2010 Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptors. ---
33  2009 Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits. GABA, GIS, KO
34  2009 Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. VB, WT
35  2009 Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood. ---
36  2009 Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor. Per1, SCN
37  2009 The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors. DHEA, DHEAS
38  2008 Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors. ---
39  2008 Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors. PFH, REM
40  2008 The role of GABA(A) receptors in the control of transient lower oesophageal sphincter relaxations in the dog. GERD, TLESRs
41  2007 The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. DGGCs, mIPSCs, WT
42  2006 Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone. 1,4-BD, GABA, GBL, GHB
43  2005 An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. VB
44  2005 Effects of gabaergic drugs on reserpine-induced oral dyskinesia. ---
45  2005 Excitability of cortical neurons depends upon a powerful tonic conductance in inhibitory networks. ---
46  2005 GABAA receptor-mediated tonic inhibition in thalamic neurons. dLGN, GBZ, NRT, TC
47  2005 Ischemic tolerance induction in organotypic hippocampal slices: role for the GABA(A) receptor? IPC, OGD
48  2005 Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. GABAR
49  2005 Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder. BDZ, GABAR, PMDD
50  2004 Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. 4-PIOL, IAA, P4S
51  2004 Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists. ---
52  2004 Effects of a low dose of ethanol in an animal model of premenstrual anxiety. ASR
53  2004 Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. CI, GABA, NNT, RR, TD, WMD
54  2004 Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. I4AA
55  2004 Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice. ---
56  2003 Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. BZ, DHEAS, GABA, PTZ
57  2003 Aza-THIP and related analogues of THIP as GABA C antagonists. Aza-THIP
58  2002 Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity. 4-PIOL, P4S
59  2002 Characterization of GABA(A) receptor ligands in the rat cortical wedge preparation: evidence for action at extrasynaptic receptors? ---
60  2002 Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. ---
61  2002 Inhibition of THIP on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. ---
62  2002 Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. P4S
63  2002 Prenatal protein malnutrition enhances stimulus control by CDP, but not a CDP/THIP combination in rats. BZ, CDP
64  2002 trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. 2-MeTACA, 3-APA, CACA, I4AA, TACA, TPMPA
65  2001 alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. ---
66  2001 Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. BMB, P4S
67  2001 Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors. ---
68  2001 Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. CI, GABA, RR, TD
69  2000 Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. CI, GABA, OR, TD
70  2000 gamma-aminobutyric Acid(A) (GABA(A)) agonist 4,5,6, 7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol persistently increases sleep maintenance and intensity during chronic administration to rats. EEG, REM
71  1999 In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol. 3alpha,5beta-P, LORR
72  1999 Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation. GABA, P4S
73  1998 Expression of the GABA(A) receptor alpha6 subunit in cultured cerebellar granule cells is developmentally regulated by activation of GABA(A) receptors. DIV, SDS-PAGE
74  1998 GABAergic drugs and sexual behaviour in the rabbit: evidence for species-specific effects. GABA
75  1998 The GABA(A) agonist THIP increases non-REM sleep and enhances non-REM sleep-specific delta activity in the rat during the dark period. non-REMS
76  1997 GABA receptors of bipolar cells from the skate retina: actions of zinc on GABA-mediated membrane currents. GABA
77  1997 GABAergic drugs and socio-sexual behavior. GAG
78  1995 Differential distribution of GABAA receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist. ---
79  1995 Effect of manipulation of the GABA system on dopamine-related behaviors. 3-MPA
80  1995 Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies. ---
81  1994 Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activation. EEG, GABA, PET, TLE
82  1994 Induction of low-affinity GABAA receptors by the GABA-agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in cultured rat cerebellar granule cells is prevented by inhibition of polyamine biosynthesis. DFMO
83  1994 The effects of GABAergic drugs on grooming behaviour in the open field. ---
84  1993 Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells. DFMO
85  1993 GABA alters GABAA receptor mRNAs and increases ligand binding. GABA
86  1993 GABA, THIP and baclofen inhibition of Purkinje cells and cerebellar nuclei neurons. BIC, GABA, PCs
87  1993 Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells. CACA, GABA, I4AA, P4S, TACA
88  1992 First direct electron microscopic visualization of a tight spatial coupling between GABAA-receptors and voltage-sensitive calcium channels. ---
89  1992 Inhibition of tetrahydroisoxazolo-pyridin-3-ol and muscimol and its mechanism on gastrointestinal transit in mice. ---
90  1992 The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. GABA
91  1991 Chronic flurazepam differentially regulates a behavioral effect of GABA agonists. FZP, GABA, SNpr
92  1991 Dopamine modulates the inhibition induced by GABA in rat cerebral cortex: an iontophoretic study. alpha-MPT, CA, DA, GABA
93  1991 Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells. ---
94  1991 Glycinergic control of [Leu5]enkephalin levels in chicken retina. LE-LI
95  1991 Pharmacological manipulations of anoxia-induced free fatty acid accumulation in the mouse brain. FFA
96  1991 Role of calcium in the analgesic action of tetrahydroisoxazolepyridinol and muscimol. ---
97  1991 Tolerance pattern to GABAmimetic analgesics and their influence on morphine tolerance and dependence. ---
98  1990 Development of benzodiazepine and picrotoxin (t-butylbicyclophosphorothionate) binding sites in rat cerebellar granule cells in culture. GABAA
99  1990 GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat. GABA, RFs
100  1990 Modulation of tolerance to the GABAA agonist THIP by environmental cues. ---