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Abbreviation : TRAF
Long Form : tumor necrosis factor receptor-associated factor
No. Year Title Co-occurring Abbreviation
2021 Mechanistic dissection of spatial organization in NF-κB signaling pathways by hybrid simulations. NF-kappaB
2021 Structural feature of TRAFs, their related human diseases and therapeutic intervention. ---
2021 TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways. cIAP1, NF-kappaB, TAK1
2021 TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma. ATs, BAP1, HEG1, L1CAM, MMs, MTAP
2020 Roles of TRAFs in Ischemia-Reperfusion Injury. IRI
2020 TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. FHA
2019 IL-17A neutralizing antibody attenuates eosinophilic meningitis caused by Angiostrongylus cantonensis by involving IL-17RA/Traf6/NF-kappaB signaling. A. cantonensis, Act, CNS, EM, IL, IL-17R A, NF
2019 Inhibitory Effect of beta-Carotene on Helicobacter pylori-Induced TRAF Expression and Hyper-Proliferation in Gastric Epithelial Cells. NF-B
2019 Recognition of TRAIP with TRAFs: Current understanding and associated diseases. GPIbbeta, GPVI, JNK, NF-KB, TNF, TNFR
10  2019 TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells. EMT
11  2019 USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. HHV-8, PEL, USP7
12  2018 Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis. MAVS
13  2018 Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA. HBP, LPS
14  2018 Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7. TC-NER, USP7, UVSS, UVSSA
15  2018 Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity. GPR54
16  2018 Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses. GC, TBK1, TNFRSF
17  2018 Roles of TRAF6 in Central Nervous System. TIR, TNF
18  2018 Structure of TRAF Family: Current Understanding of Receptor Recognition. ---
19  2018 Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. rHDL
20  2018 Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification. PKC, UBE3C, UCHL1
21  2017 Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease. AP, IBD, IFN, IL, LPS, LPS, MAPKs, NF-kappaB, SEMFs, siRNA, TAK, TLR
22  2017 Mechanism studies of Xinfeng capsule on improving cardiovascular function though toll-like receptor 4/nuclear factor kappa B pathway in a rat model of adjuvant arthritis. AA, AI, HR, IRAK, LVEDP, LVSP, MC, MTX, MyD, NC, NF-kappaB, TLR4, TNF-alpha, TPT, XFC
23  2017 TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection. cagT4SS, HBP, LPS
24  2017 TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis. ATG6
25  2017 Tumor necrosis factor receptor-associated factor (TRAF) 6 inhibition mitigates the pro-inflammatory roles and proliferation of rheumatoid arthritis fibroblast-like synoviocytes. FLSs, IF, MMP, RA, TRAF6
26  2016 Bioinformatics analysis of differentially expressed pathways related to the metastatic characteristics of osteosarcoma. DEGs, DEPs, FAIME, GEO, IRF7, MMP, OSA, PCA, SAM, SVM, TLR
27  2016 Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-kappaB Pathway. ChIP, CTB-INS, DCs, NIK
28  2016 Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-kappaB signaling by targeting MAVS complex. IFNs, IKK, MAVS, MCCC1
29  2016 Plant TRAF Proteins Regulate NLR Immune Receptor Turnover. MUSE13, NLR
30  2016 Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. dpi, IBV, IFN, IKK, ILs, IRF, LGP2, MAVS, MDA5, MIP-1beta, MyD88, NF-B, STING, TBK1, TLR
31  2016 Suppression of tumor cell proliferation by quinine via the inhibition of the tumor necrosis factor receptor‑associated factor6‑AKT interaction. Bcl, LPS
32  2015 Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6. ERK, HBsAg, HBV, MAPK, NLRP10
33  2015 Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling. MAVS, T6BM2, TRAF6
34  2015 Suppression of interferon beta gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. ATF2, BET, BRD4, IRF3, PLK, TLR3
35  2015 The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis. NFATc1, RANK, RANKL, TRAFs
36  2015 The Latent Membrane Protein 1 (LMP1). EBV, LMP1, MAPK, PI3K
37  2015 TRAF6-Mediated SM22alpha K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. G6PD, PDGF, SM, VSMC
38  2014 BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-kappaB-inducing kinase. BMP-7, cIAP1, HSA, NF, NIK, PTECs
39  2014 Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. TLR
40  2014 New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Co-IP, FIH-1, Hif1an, mib, Usp1, Usp9, Zranb1
41  2014 Transmembrane oligomeric form of Vibrio cholerae cytolysin triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages. IRAK, MAPK, MyD88, TLR, VCC
42  2014 [Correlation between synovial TRAF6 expression and serum bone metabolism markers in rheumatoid arthritis]. HAQ, RA, VAS
43  2013 A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. ---
44  2013 Functional characterization of domains of IPS-1 using an inducible oligomerization system. CARD, IFN, IRF3, NF-kappaB, RIG, TM
45  2013 Gene expression of tumor necrosis factor receptor associated-factor (TRAF)-1 and TRAF-2 in inflammatory bowel disease. AUROC, IBD, PCR, ROC
46  2013 HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages. HCV, HIV, MDMs, NF-kappaB
47  2013 Presenilins are novel substrates for TRAF6-mediated ubiquitination. APP
48  2013 Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. ---
49  2013 The tumor necrosis factor receptor-associated factor (TRAF)-like family protein SEVEN IN ABSENTIA 2 (SINA2) promotes drought tolerance in an ABA-dependent manner in Arabidopsis. ABA, ABF3, ABRE, SINA2
50  2012 Expression of the nuclear factor-kappaB inhibitor A20 is altered in the cystic fibrosis epithelium. CF, LPS, NF, RNF, TAX1BP1
51  2012 Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses. CREB, HFD, HGP
52  2012 SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses. AhR, IDO, SOCS
53  2012 Spatiotemporal patterns and essential role of TNF receptor-associated factor 5 expression after rat spinal cord Injury. SCI, TRAF5
54  2012 The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. ISKNV, ORF111L
55  2012 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. ---
56  2011 AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. FLIP, NF-kappaB, TNF, TNF-alpha, TRAF2, XIAP
57  2011 Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IkappaB-zeta. IL, IRAK
58  2011 Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1). LMP1, TRAF6
59  2011 The role of TBK1 and IKKepsilon in the expression and activation of Pellino 1. ---
60  2011 TLR signaling-mediated differential histone modification at IL-10 and IL-12 promoter region leads to functional impairments in tumor-associated macrophages. ERK, IL, IRAK, MAPK, MyD88, TAM, TLR
61  2011 TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. NEMO
62  2011 Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. ---
63  2010 A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. ---
64  2010 Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. APOE, CD40L
65  2010 Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. cIAP, IkappaB, LTbetaR, NF-kappaB, NIK
66  2010 Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin. CHOP, ERS, GRP, IRE, Thap
67  2010 TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population. htSNPs
68  2009 CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling. AD
69  2009 Suppression of tumor necrosis factor receptor associated factor (TRAF)-2 attenuates the proinflammatory and proliferative effect of aggregated IgG on rat renal mesangial cells. aIgG, GN, IC, IL, MCs, TNF
70  2009 TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. DCs, TIFAB
71  2009 TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. CSR, WT
72  2008 Regulation of the nuclear factor (NF)-kappaB pathway by ISGylation. ISG15, NF, TAK
73  2007 Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides. T6DP
74  2007 Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. IL-1, TLR4
75  2006 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. ---
76  2006 Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. TRIM37
77  2005 Dependence of self-tolerance on TRAF6-directed development of thymic stroma. mTECs, TECs
78  2004 Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4. TLR
79  2004 Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. JNK, LMP1
80  2004 TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. ---
81  2004 TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. TIR, TNF
82  2004 Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. NEMO
83  2003 Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. JNK, NF-kappaB
84  2003 Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. IRAK, KO, LMP1, MEFs
85  2003 Latent membrane protein 1, tumor necrosis factor receptor-associated factor (TRAF) 1, TRAF-2, TRAF-3, and nuclear factor kappa B expression in posttransplantation lymphoproliferative disorders. EBER, EBV, LMP1, NF-kappaB, PTLDs, TRAFs
86  2003 Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. LTbetaR, TANK, TRAFs
87  2003 Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation. BCR, BTK, PKD
88  2003 TDPOZ, a family of bipartite animal and plant proteins that contain the TRAF (TD) and POZ/BTB domains. BAC, EST
89  2003 Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. GFP, TNFR1
90  2003 Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. TNF
91  2002 CD40-mediated activation of NF-kappa B in airway epithelial cells. AEC
92  2002 CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line. ERK, MAPK, ODN
93  2002 Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Cmp, GC, hCD40
94  2002 Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. NTD
95  2002 Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. NF, TNF
96  2002 Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. B-CLL, IAP, IKK, NF-kappaB
97  2001 A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. TDs, TNFR
98  2001 A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. RANK
99  2001 Activation of TRAF5 and TRAF6 signal cascades negatively regulates the latent replication origin of Epstein-Barr virus through p38 mitogen-activated protein kinase. EBV, LMP1, LPS
100  2001 Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? ASM, NF-kappaB, TNF, TNFR