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Abbreviation : TRIM21
Long Form : tripartite motif-containing 21
No. Year Title Co-occurring Abbreviation
2022 CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy. DCs
2022 Clinical characteristics of idiopathic interstitial pneumonias with anti-Ro52/tripartite motif-containing 21 antibodies. IIPs, IPAF
2022 Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors. GABAA
2022 The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment. ---
2022 TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer. OC
2022 TRIM21 inhibits the osteogenic differentiation of mesenchymal stem cells by facilitating K48 ubiquitination-mediated degradation of Akt. MSCs
2021 Acute acidification stress weakens the head kidney immune function of juvenile Lates calcarifer. IRF7, STAT1, STAT3
2021 Anti-Ro60 and anti-Ro52/TRIM21: Two distinct autoantibodies in systemic autoimmune diseases. SLE
2021 E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation. ADIN, HBV, HDI, Smc6
10  2021 NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21. IAV, IRF, NMI
11  2021 TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability. APA, EZH1, GC
12  2021 TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex. IAPs, MLKL, TRAIL
13  2021 TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy. ANXA2, OS, PM
14  2021 Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-kappaB-mediated NLRP3 inflammasome activation. LPS
15  2021 WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma. NPC, WIPI-1
16  2020 Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma. CREB, CUEDC2, GDNF
17  2020 TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis. GMPS, NPC, SERPINB5
18  2019 A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days. iBAQ, TEAD4
19  2019 Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. C19orf53, EWSR1, IBM, PLATO, RIOK3
20  2019 Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21. DC
21  2019 Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage. ---
22  2019 TRIM21-From Intracellular Immunity to Therapy. ---
23  2018 Cytosolic Internalization of Anti-DNA Antibodies by Human Monocytes Induces Production of Pro-inflammatory Cytokines Independently of the Tripartite Motif-Containing 21 (TRIM21)-Mediated Pathway. scFv-Fc, SLE
24  2018 Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability. NPC, SGSM1
25  2018 Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection. IFNgamma, MEFs, PV, WT
26  2018 Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif-containing 21. SALL4
27  2018 TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production. CVB3
28  2017 A review of the role andclinical utility of anti-Ro52/TRIM21 in systemic autoimmunity. ---
29  2017 Antiviral Functions of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific IgG Antibodies: Effects of Antiretroviral Therapy and Implications for Therapeutic HIV-1 Vaccine Design. ART, Fc, GC, HIV-1, NHP
30  2016 TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity. AdV5
31  2015 TRIM21, a negative modulator of LFG in breast carcinoma MDA-MB-231 cells in vitro. LFG
32  2015 TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity. ---
33  2013 Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21. ADIN, IL-6, MAV-1, qPCR, TNF-alpha, VCP
34  2012 AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. VCP
35  2012 The suppression of TRIM21 and the accumulation of IFN-alpha play crucial roles in the pathogenesis of osteonecrosis of the femoral head. IFN, IRFs, LPS, mPSL, NAC, NF-kappaB, ONFH
36  2010 Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). ---
37  2009 TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. IRF3