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Abbreviation : TXA2
Long Form : thromboxane A2
No. Year Title Co-occurring Abbreviation
2021 ALOX12 mutation in a family with dominantly inherited bleeding diathesis. 12-HPETE, AA, COX, PLCB2
2021 Androgen Deprivation Therapy in Patients With Prostate Cancer Increases Serum Levels of Thromboxane A2: Cardiovascular Implications. ACh, ADTs, CORM-3, COX-2, HO-1, NA, PCa, SNP
2021 Chronic cyclooxygenase-2 inhibition prevents the worsening of hypertension and endothelial dysfunction induced by ouabain in resistance arteries of spontaneously hypertensive rats. c-Src, COX, MRA, NO, SHR
2021 Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure. AKR, KO, PGD2, PGF2 alpha, PM/PGFS, WT
2021 Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats. NO, PA, PAH, sGC
2021 Inhibition of human prostate stromal cell growth and smooth muscle contraction by thalidomide: A novel remedy in LUTS? EFS
2021 Intravital Imaging Identifies the VEGF-TXA2 Axis as a Critical Promoter of PGE2 Secretion from Tumor Cells and Immune Evasion. PGE2
2021 Monoclonal antibody therapy in COVID-19. COVID-19, IL, mAbs, SARS-CoV-2, TLR
2021 Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2. AA, PGD2
10  2021 Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries. EFS
11  2021 Prenatal endothelin or thromboxane receptor antagonism surpasses sympathoinhibition in improving cardiorenal malfunctions in preeclamptic rats. ET, GD20, PE
12  2021 Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2. AA, ALB, beta2-MG, CDKu, cPLA2, GSH-Px, LTB4, MAPK, NO, NOS, PGE2, SCr, SOD
13  2021 Signalling pathway of U46619-induced vascular smooth muscle contraction in mouse coronary artery. SR
14  2021 Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth. cPLA2
15  2021 The prostanoids, thromboxanes, mediate hemocytic immunity to bacterial infection in the lepidopteran Spodoptera exigua. RNAi, TXB2
16  2021 Thromboxane A2 is involved in the development of hypertension in chronic kidney disease rats. Ca, CKD, Cr
17  2021 Thromboxane A2 receptor antagonist (ONO-8809) attenuates renal disorders caused by salt overload in stroke-prone spontaneously hypertensive rats. CKD, HIF-1alpha, MCP-1, SHRSP
18  2021 Urinary Thromboxane B2 and Lethal Prostate Cancer in African American Men. AA, CI, EA, OR
19  2021 Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats. CV, ERalpha, TP, VDD
20  2021 [Role of prostacyclin and thromboxane A2 in pulmonary hyper-permeability induced by mechanical ventilation in rabbits]. MLCK, MV
21  2020 A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade. ADP, CLEC-2, p-Tyr
22  2020 Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia-induced experimental vascular cognitive impairment and dementia. HHcy, MWM, VCID
23  2020 Anti‑platelet activity of mineral‑balanced deep sea water ismediated via the regulation of Akt and ERK pathway crosstalk. ATP, cAMP, ERK, MBDSW, PDE, VASP
24  2020 Arctigenin attenuates platelet activation and clot retraction by regulation of thromboxane A2 synthesis and cAMP pathway. ---
25  2020 Association Between Inflammatory Mediators and Pulmonary Blood Flow in a Rabbit Model of Acute Pulmonary Embolism Combined With Shock. alpha-SMA, Arg-1, HE, IL-1beta, IL-6, iNOS, non-PE, PE, TNF-alpha
26  2020 Bleeding phenotype and diagnostic characterization of patients with congenital platelet defects. CNS, CPDs, HMB
27  2020 Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation. DZT, MCAO, PTGS1, UPLC-QTOF-MS
28  2020 Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage. beta-hCG, CRP, eNOS, qPCR, VEGF
29  2020 Effect of Prostanoids on Human Platelet Function: An Overview. PGD2, PGF2 alpha
30  2020 Gonadal function protects against organ culture-induced vascular damage. Involvement of prostanoids. ACh, PG, TP
31  2020 GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. GPCRs, GRK6, WT
32  2020 Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. ---
33  2020 IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra). IL-1ra, TXB2
34  2020 Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein. AC, ACh, CABG, GC, PDE, SV
35  2020 Modulation of arachidonic acid-evoked cardiorespiratory effects by the central lipoxygenase pathway. AA, COX, i.c.v, LOX, NDGA, PG
36  2020 Neuroprotective effects of thromboxane receptor antagonist SQ 29,548 after pilocarpine-induced status epilepticus in mice. SE
37  2020 Novel factor Xa inhibitor, maslinic acid, with antiplatelet aggregation activity. ADP, FXa, MA
38  2020 Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia. BCCAO, MWM, VaD
39  2020 Plantain (Plantago L.) species as modulators of prostaglandin E2 and thromboxane A2 production in inflammation. PGE2
40  2020 Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents. ADP, CVD, PAF
41  2020 Protective Effect of Saponins-Enriched Fraction of Gynostemma pentaphyllum against High Choline-Induced Vascular Endothelial Dysfunction and Hepatic Damage in Mice. AST, eNOS, ET-1, GSH-Px, LDL-C, MDA, NO, PGI2, SOD, TC, TG, TMAO, TSGP
42  2020 Reciprocal actions of constrictor prostanoids and superoxide in chronic hypoxia-induced pulmonary hypertension: roles of EETs. EETs, ET, HPH, PAAT, RVSP, sEH, sEHKO, VTI, WT
43  2020 Regulation of liver regeneration by prostaglandin E2 and thromboxane A2 following partial hepatectomy in rats. COX-2, PGE2
44  2020 Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2. ---
45  2019 A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. AIA, LPS, mPGES-1, OPG, PBCH, PGE-M, PGE2, RANKL, RF
46  2019 A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. MYPT, NO, ROCK
47  2019 A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions. COX-1, NSAIDs, PG, PGE2, SCHEC
48  2019 Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. COX-1
49  2019 Aspirin eugenol ester inhibits agonist-induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways. AEE, cAMP, cGMP, ERK2, JNK1, MAPK, TXB2, VASP
50  2019 Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets. ASK1, CIB1, JNK, MAPKKK, NCC, PLC, TNF
51  2019 Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs. ASA, LPS, LPS-RS, TLR4
52  2019 Chinese Medicine Shensong Yangxin Capsule () Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction. ELISA, eNOS, ET-1, MI, NO, PGI2, RT-MCE, VEGF, vWF
53  2019 Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer. 6-keto-PGF1alpha, L-NAME, NO, NOS, TXB2
54  2019 Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells. B2R, BK, Co-IP, GPCRs, PLA, TP, VSMC
55  2019 Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release. AA, COX-1, G-Ro
56  2019 Mechanisms of U46619-induced contraction in mouse intrarenal artery. NPPB, PI-PLC, PKC, VSMCs
57  2019 Mercury induces nuclear estrogen receptors to act as vasoconstrictors promoting endothelial denudation via the PI3K/Akt signaling pathway. COX-2, CVD, NO
58  2019 Morin hydrate inhibits platelet activation and clot retraction by regulating integrin alphaIIbbeta3, TXA2, and cAMP levels. cAMP, cPLA2, ERK, JNK, PI3K, PLCgamma2
59  2019 New strategies for inhibition of non-adrenergic prostate smooth muscle contraction by pharmacologic intervention. PAKs, SFKs
60  2019 Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin. aOR, CI, IQR, OR
61  2019 Polygalasaponin F treats mice with pneumonia induced by influenza virus. IAV, IFN, IkappaBalpha, IL, MEK1, NF, PGE2, TNF
62  2019 Positive influence of aqua exercise and burdock extract intake on fitness factors and vascular regulation substances in elderly. PGI2
63  2019 Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model. AA, AEA, FAAH, LTB4, OLV, PGI2, TLV
64  2019 Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. ---
65  2019 The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages. AA, NSAID, PGE2, trans-4
66  2019 The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. GPCR, GPVI, PTPN7
67  2019 Thromboxane A2 receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury. LSEC, MCT, MMPs, SOS, TP, WT
68  2019 Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. BUN, I/R, ROS, TP, TXB2
69  2019 UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats. 6-keto-PGF1alpha, AEE, ASA, Cr, LDH, PV, WBV
70  2018 Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro. AV
71  2018 Anticonvulsant-like effect of thromboxane receptor agonist U-46619 against pentylenetetrazol-induced seizures. PKC, PTZ
72  2018 Associations between thromboxane A synthase 1 gene polymorphisms and the risk of ischemic stroke in a Chinese Han population. CI, OR, TBXAS1
73  2018 Coordination of platelet agonist signaling during the hemostatic response in vivo. ADP
74  2018 Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine Pathometabolism; A Complex Therapeutic Design. HHcy, NO
75  2018 Diverse associations between oxidative stress and thromboxane A2 in hypertensive glomerular injury. SHRSP, TXAS, WKY
76  2018 Efficacy of inhalational sevoflurane anesthesia induction on inhibiting the stress response to endotracheal intubation in children with congenital heart disease. BIS, CHD, ET
77  2018 Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury. IL, NO, NOX4, TP, TXB2
78  2018 Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway. AA, NAFLD
79  2018 Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice. ---
80  2018 Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter Injury. IUGR
81  2018 Ligustrazine inhibits platelet activation via suppression of the Akt pathway. ADP, AKT, LH, RLW
82  2018 Lipid derivatives of arachidonic acid used as markers of atherosclerotic plaque instability: a pilot study. GSM, ICA, PGE2, USG
83  2018 Participation of Arachidonic Acid Metabolism in the Aortic Aneurysm Formation in Patients with Marfan Syndrome. 5-LOX, 6-keto-PG1alpha, AA, COXs, MFS, OA, PGE2, PLA2, TNF-alpha
84  2018 Prostaglandins in the pathogenesis of kidney diseases. COXs, PGs
85  2018 Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. DBP, ET-1, HR, IRI, LVDP, LVEDP, LVSP, MI, PAF, SBP
86  2018 Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats. Bax, Bcl-2, CK-MB, LDH, MDA, SOD
87  2018 RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. ADP, RGS
88  2018 Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching. HPV, NO, PA, PDE5, sGC
89  2018 The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism1. cTnI, ET-1, NOI, PGI2
90  2017 1, 6-di-O-caffeoyl-beta-D-glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation. AA, ADP, C. nudiflora, CGP, TP
91  2017 Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice. eNOS, HUVECs, ROCK
92  2017 Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid. COX-1, HA-PEI, LSECs, PH
93  2017 Comparison of ticagrelor and high-dose clopidogrel on the platelet functions in patients with inadequate response to clopidogrel. ACS, MACE, MPV, PAR, PDW, PLT
94  2017 Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery. NF-kappaB
95  2017 EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. COXs, EETs, PGH2, RVSP, sEH-KO, WT
96  2017 Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels in the anaesthetized rats in vivo. BT, IBU, PGE2
97  2017 Effects of Danhong Injection on platelet aggregation in hyperlipidemia rats. APTT, DHI, ELISA, HDL-C, LDL-C, MC, NC, PAF, PGE2, PGI2, PT, TC, TG, TT
98  2017 Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma. AST, PCNA, TXAS
99  2017 Effects of low-dose aspirin on maternal blood pressure and vascular function in an experimental model of gestational hypertension. COX, GD
100  2017 Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain. 2-AG, eCBs, eNOS, ET-1, ICAM-1, IL, iNOS, PGI2, TNF-a, VCAM-1