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Abbreviation : i.pl
Long Form : intraplantar
No. Year Title Co-occurring Abbreviation
2021 A new hypertonic saline assay for analgesic screening in mice: effects of animal strain, sex, and diurnal phase. CI, HS
2021 Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects. AST, cGMP, i.p, NO
2021 Chemokine CXCL1 in serum mediates the antinociceptive effect of manual acupuncture at ST36. CFA, ELISA, MA
2021 Common bacterial metabolite indole directly activates nociceptive neuron through TRPA1 channel. CFA, CGRP, DRG, GI, KO, TRPA1
2021 Electroacupuncture decreases inflammatory pain through a pro-resolving mechanism involving the peripheral annexin A1-formyl peptide receptor 2/ALX-opioid receptor pathway. CFA, EA
2021 Jararhagin, a snake venom metalloproteinase, induces mechanical hyperalgesia in mice with the neuroinflammatory contribution of spinal cord microglia and astrocytes. i.t, IL-1ra
2021 MCRT, a multifunctional ligand of opioid and neuropeptide FF receptors, attenuates neuropathic pain in spared nerve injury model. i.c.v, NPFF, SNI
2021 Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-alpha production. p.o
2021 Ononis spinosa alleviated capsaicin-induced mechanical allodynia in a rat model through transient receptor potential vanilloid 1 modulation. CAPS, PWT, TRPV1
10  2021 Patterns of brain c-Fos expression in response to feeding behavior in acute and chronic inflammatory pain condition. ACC, CeA, LH, LPBN, mPFC, NAcc, NAcS
11  2021 Peripheral mechanisms involved in Tityus bahiensis venom-induced pain. IL-1beta, MPO, NAG, NF-kappaB, TNF-alpha
12  2021 Role of peripheral 5-HT1D, 5-HT3 and 5-HT7 receptors in the mechanical allodynia induced by serotonin in mice. CNS
13  2021 The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior. CHA, HEMADO
14  2020 Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model. BK, CPIP, CRPS I, i.p, i.t
15  2020 ET-B receptors involvement in peripheral opioid analgesia induced by light-emitting diode photobiomodulation in male and female mice. CFA, ETBR, PBMT
16  2020 Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State. CFA, s.c
17  2020 The role of spinal inhibitory neuroreceptors in the antihyperalgesic effect of warm water immersion therapy. CB1, CFA, DPCPX, i.t, WWIT
18  2019 Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-alpha and CXCL-1 production and activating opioidergic mechanisms. CFA, i.p
19  2019 Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice. i.t, IL-1ra
20  2019 Investigation of the Involvement of the Endocannabinoid System in TENS-Induced Antinociception. i.dl.PAG, i.t, MAFP, TENS
21  2019 Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain. DPPH, HF, IBA
22  2019 Photobiomodulation therapy reduces acute pain and inflammation in mice. PBM, PMA
23  2019 Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation. i.p, MOR/DOR
24  2019 Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators. i.p, NO
25  2019 The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain. CCI, CFA, p.o
26  2018 Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. 6-PNG, SG, SR
27  2018 Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain. ET-1, NGF
28  2018 Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity. CFA, CNS, GABAAR, PNS
29  2018 Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury. BEO, beta-FNA, ERK, PSNL
30  2018 Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity. HS
31  2017 An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics. HS, i.p
32  2017 Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain. CCI, i.c.v, i.th, NOP, STZ
33  2017 Contribution of dopaminergic and noradrenergic systems in the antinociceptive effect of alpha-(phenylalanyl) acetophenone. i.g
34  2017 Effects of binge-like ethanol exposure during adolescence on the hyperalgesia observed during sickness syndrome in rats. i.c.v, IL-1beta, LPS, PND
35  2017 Involvement of peripheral P2Y1 receptors and potential interaction with IL-1 receptors in IL-1beta-induced thermal hypersensitivity in rats. IL-1beta, IL-1R, P2Y1R
36  2017 Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice. SP
37  2017 Leishmania (L). amazonensis induces hyperalgesia in balb/c mice: Contribution of endogenous spinal cord TNFalpha and NFkappaB activation. CL, i.t
38  2017 Pharmacological evidence for systemic and peripheral antinociceptive activities of pioglitazone in the rat formalin test: Role of PPARgamma and nitric oxide. i.p, NO, PIO
39  2017 Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice. at-HMGB1, ds-HMGB1, HMGB1, LPS, RAGE, TLR4, TM
40  2017 Systemic and local anti-nociceptive effects of simvastatin in the rat formalin assay: Role of peroxisome proliferator-activated receptor gamma and nitric oxide. i.p, NO, PPARgamma, SIM
41  2017 The role of the endocannabinoid system in the antihyperalgesic effect of Cedrus atlantica essential oil inhalation in a mouse model of postoperative pain. CaEO, FAAH, i.p, i.t, MAGL
42  2016 Acute mechanical sensitization of peripheral nociceptors by aldosterone through non-genomic activation of membrane bound mineralocorticoid receptors in naive rats. CGRP, i.t, IR, MR
43  2016 Analgesic effects evoked by a CCR2 antagonist or an anti-CCL2 antibody in inflamed mice. CFA, MCP-1
44  2016 Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats. CFA, ELISA, IL-1beta, IL-6, RA, TNF-alpha
45  2016 Ghrelin Exerts Analgesic Effects through Modulation of IL-10 and TGF-beta Levels in a Rat Model of Inflammatory Pain. ---
46  2016 High-Intensity Swimming Exercise Decreases Glutamate-Induced Nociception by Activation of G-Protein-Coupled Receptors Inhibiting Phosphorylated Protein Kinase A. DPCPX, G-PCR, p-PKA, PKA
47  2016 Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons. ERK, JNK, KOR, nor-BNI
48  2016 Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4. at-HMGB1, bt-HMGB1, ds-HMGB1
49  2016 Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat. ES, mGluR, NMDARs
50  2016 Selective sensitization of C-fiber nociceptors by hydrogen sulfide. SW
51  2016 The peptide Phalpha1beta, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice. AITC, DRG, i.t
52  2016 [Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats]. beta-END, MOR, PWL
53  2015 (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. CFA, GABAAR, i.t, SNL
54  2015 Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. IL-6, JAK2, STAT3
55  2015 Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ACC
56  2015 Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. i.t
57  2015 Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain. i.p, p.o
58  2015 Role of peripheral sigma-1 receptors in ischaemic pain: Potential interactions with ASIC and P2X receptors. ASICs, MA, Sig-1Rs, TIIP
59  2015 SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation. BV, CXCR4, DRG, ERK, i.t, p-ERK, SGCs
60  2015 Spinal 5-HT3AR contributes to BmK I-induced inflammatory pain in rats. i.t
61  2015 Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. CNS, FCA, TPM
62  2015 [Activation of spinal MrgC receptors inhibits hyperalgesia in rats]. CFA, CGRP, i.t, MOR, MrgC, MSH, MSH, NOS
63  2014 Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema. p.o, PTD-OH, TNF
64  2014 Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. CCI, s.c
65  2014 Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. ---
66  2014 Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test. NPS
67  2014 Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ---
68  2014 Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice. GA, TRPA1
69  2014 Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. 5-aza-dC, DRG, i.c.v, i.t, MOR, PP, s.c
70  2014 Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury. CFA, NK1R, RVM, Sub P, TACR1
71  2014 Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. DRG, GABA, T-channels
72  2014 Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of ellagic acid in the rat formalin test. EA, i.p
73  2014 Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors. dmPGE2, DRG, IL-6, PGE2
74  2014 Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors. s.c, sigma1-KO
75  2014 TRPA1, NMDA receptors and nitric oxide mediate mechanical hyperalgesia induced by local injection of magnesium sulfate into the rat hind paw. MS, NO, PWT
76  2013 Anti-inflammatory and anti-hyperalgesic effect of all-trans retinoic acid in carrageenan-induced paw edema in Wistar rats: involvement of peroxisome proliferator-activated receptor-beta/delta receptors. ATRA, MH, PPAR, TH
77  2013 Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. i.t
78  2013 Antinociceptive effects of analgesic-antitumor peptide (AGAP), a neurotoxin from the scorpion Buthus martensii Karsch, on formalin-induced inflammatory pain through a mitogen-activated protein kinases-dependent mechanism in mice. AGAP, phospho-MAPKs
79  2013 Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. PWL, s.c
80  2013 Light-emitting diode therapy induces analgesia in a mouse model of postoperative pain through activation of peripheral opioid receptors and the L-arginine/nitric oxide pathway. i.t, LEDT, NO, PI
81  2013 Microglial activation of p38 contributes to scorpion envenomation-induced hyperalgesia. BmK, VGSCs
82  2013 Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway. cGMP, NO, ODQ
83  2013 Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats. DIC, DRG, HMGB1, rhsTM
84  2013 Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice. APP, CFA, DRG
85  2013 Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain. CCI
86  2013 Synergistic effects of celecoxib and bupropion in a model of chronic inflammation-related depression in mice. CFA
87  2012 AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia. AKAP150, db-cAMP, DRG, T currents
88  2012 Involvement of peripheral cannabinoid and opioid receptors in beta-caryophyllene-induced antinociception. BCP, CB
89  2012 Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs. NSAIDs
90  2012 Peripherally injected linalool and bergamot essential oil attenuate mechanical allodynia via inhibiting spinal ERK phosphorylation. BEO, ERK, PSNL
91  2012 Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. i.c.v, i.t, i.v, MORs, NLXM
92  2012 The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. CFA, OLAMs, TRPV1
93  2012 Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats. L5SNC
94  2011 Antinociceptive and anti-hypernociceptive effects of Se-phenyl thiazolidine-4-carboselenoate in mice. AMPA, AST, i.t, NMDA, trans-ACPD
95  2011 Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways. BV, CPCCOEt, EC-HIP, MPEP
96  2011 Effects of intraplantar nocistatin and ()-J 113397 injections on nociceptive behavior in a rat model of inflammation. i.t, N/OFQ, NST
97  2011 Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. 2-AG
98  2011 Involvement of mast cells in a mouse model of postoperative pain. ---
99  2011 Plant derived alkaloid (-)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models. ---
100  2011 The mechanisms of antihyperalgesic effect of topiramate in a rat model of inflammatory hyperalgesia. GABA