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Abbreviation : p-IRS-1
Long Form : phosphorylated insulin receptor substrate-1
No. Year Title Co-occurring Abbreviation
2022 Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. BPA, GLUT4, p-Akt
2022 Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice. p-Akt, p-GSK3beta, p-IRbeta, p-PDK1, p-PI3K, t-Akt, t-GSK3beta, t-IRbeta, t-IRS-1, t-PDK1, t-PI3K
2021 Astragalus polysaccharide regulates brown adipocytes differentiation by miR-6911 targeting Prdm16. APS, BAT, p-AKT, PRDM16
2021 Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer GSK-3, IL-6, IL-8, p-Akt, TNF-alpha, VEGF
2021 Peripheral inflammatory biomarkers define biotypes of bipolar depression. NEV, p-NF-kappaB, p-p38, TNF, TNFR1
2021 [Study on effect of gypenosides on insulin sensitivity of rats with diabetes mellitus via regulating NF-kappaB signaling pathway]. CRP, FBG, GLUT4, GPs, HOMA-IR, IL-1beta, IL-6, ISI, NF-kappaB, p-Akt, p-IkappaBalpha, p-p65, T2DM, TNF-alpha, Tyr
2020 Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells. AST IV, FFA, NAFLD, OA, pIR, PTP1B, SREBP-1c, TC, TG
2020 Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1alpha-NRF-1 and IRS1-AKT-GLUT2 signaling pathways. DHEA, GLUT2, HFD, PA, PGC-1alpha
2020 Dendrobium officinale Attenuates Myocardial Fibrosis via Inhibiting EMT Signaling Pathway in HFD/STZ-Induced Diabetic Mice. DCM, DOE, EMT, HDL-C, HFD, LDL-C, p-JNK, PPAR-alpha, STZ, TC, TG, TGF-beta1
10  2020 Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome. HFD, MS
11  2020 miR-155-5p alleviates ethanol-induced myocardial insulin resistance in H9C2 cells via regulating the mTOR signalling pathway. Rheb, S6K2
12  2020 Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation. CRP, IL-1beta, IL-6, IR, NF-kappaB, p-Akt, p-JNK, p-PI3K, SCAP, T2D, TNF-alpha
13  2019 miR-128-3p inhibits glioma cell proliferation and differentiation by targeting NPTX1 through IRS-1/PI3K/AKT signaling pathway. miR, NPTX1, PI3K
14  2019 Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. G6Pase, hMAO-A, p-Akt, PEPCK, PTP1B
15  2019 [Effects of AdipoRon orally on the functions of spleen and pancreas in type 2 diabetic mice]. DM, INSR, IRS-1, TNF-alpha
16  2019 [The intervention effects of AdipoRon on renal injury in type 2 diabetic mice]. AdipoRon, INSR, IRS-1, PDX-1, TNF-alpha
17  2018 Excessive treadmill training enhances the insulin signaling pathway and glycogen deposition in mice hearts. GLUT1, p-Akt, pIRbeta
18  2017 Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model. BCO2, CMHR, HFD, MZ, Nrf2, PPARgamma, TNF-alpha
19  2015 Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice. BPA, p-Akt, p-GSK3beta, pIR, RIA
20  2013 An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty acid metabolism and the development of glucose intolerance in prediabetic mice. CPT, Glut, HFD
21  2013 Resveratrol regulates the cell viability promoted by 17beta-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor alpha and insulin growth factor-1 receptor in BG-1 ovarian cancer cells. EDCs, ERalpha, IGF-1R
22  2012 Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin. BW, CrPic, HFD
23  2012 The anti-diabetic bis(maltolato)oxovanadium(IV) decreases lipid order while increasing insulin receptor localization in membrane microdomains. BMOV, CTAB, IR, pIR