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Abbreviation : qHTS
Long Form : quantitative high-throughput screening
No. Year Title Co-occurring Abbreviation
2022 A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling. ---
2022 Acetylcholinesterase Inhibition Assays for High-Throughput Screening. AChE
2022 High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition. CV, hERG, NCATS
2022 Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. HLM, p53-bla, RLM, Tox21
2022 Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data. AUC-ROC, DILI
2022 Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants. COECs, Tox21
2021 A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators Via High-Throughput Screening and CETSA. ERalpha, Nluc, NPC
2021 Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. ---
2021 Conditionally Reprogrammed Cells and Robotic High-Throughput Screening for Precision Cancer Therapy. CR
10  2021 Genome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for PMP22 Gene-Dosage Disorder Drug Discovery. CMT1A, PMP22
11  2021 High-throughput screening assays for SARS-CoV-2 drug development: Current status and future directions. COVID-19, SARS-CoV-2
12  2021 Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules. hPSCs, iPSCs
13  2021 Identification of Compounds for Butyrylcholinesterase Inhibition. ACh, AChE, BChE
14  2021 Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors. OPRs
15  2021 Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition. AChE, Tox21
16  2020 A mechanistic effect modeling approach to the prioritization of hidden drivers in chemical cocktails. EE, GSA
17  2020 Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening. 3CLpro, COVID-19, Mpro, SARS-CoV-2
18  2020 Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening. 3CLpro, COVID-19, Mpro, SARS-CoV-2
19  2020 Predictive Models for Human Organ Toxicity Based on In Vitro Bioactivity Data and Chemical Structure. AUC-ROC, BA, MCC
20  2019 Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays. ---
21  2019 Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ---
22  2019 Discovery of novel inhibitors of human galactokinase by virtual screening. Gal-1-P, GALT, VS
23  2019 Identification and Profiling of Environmental Chemicals That Inhibit the TGFbeta/SMAD Signaling Pathway. DTCs, RAR, SBE, SHH, SMAD, TGF-beta, WNT
24  2019 Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening. FH, FHD, HLRCC
25  2019 Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays. ---
26  2019 Nanoliter Quantitative High-Throughput Screening with Large-Scale Tunable Gradients Based on a Microfluidic Droplet Robot under Unilateral Dispersion Mode. MMP-9
27  2019 Quality Control of Quantitative High Throughput Screening Data. ANOVA, CASANOVA
28  2019 Quantitative high-throughput screening assays for the discovery and development of SIRPalpha-CD47 interaction inhibitors. TR-FRET, TSP-1
29  2019 Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis. TME
30  2019 Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements. NTP
31  2018 A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics. HTT
32  2018 Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles. ---
33  2018 High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. ESCRT, PCa, TRPS
34  2018 Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. ---
35  2018 Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells. PNFs, PNSTs
36  2018 Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response. CDK
37  2018 Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform. Tox21
38  2017 A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity. ALDHs, SAR
39  2017 Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms. AChE, LOPAC
40  2017 Omics-Based Platform for Studying Chemical Toxicity Using Stem Cells. hiPSCs, hMSCs
41  2017 The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity. ---
42  2017 Why are most phospholipidosis inducers also hERG blockers? hERG, PLD, PLS, ROC
43  2016 A cell-based quantitative high-throughput image screening identified novel autophagy modulators. CPZ, CQ, FPZ, IND, LOPAC, MEFs
44  2016 A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models. ER, ERSR, GRP78
45  2016 A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling. ---
46  2016 Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway. ARE, Nrf2
47  2016 Differential modulation of FXR activity by chlorophacinone and ivermectin analogs. CAR, FXR, LXRalpha, MOA, PXR, QSAR
48  2016 Hidden drivers of low-dose pharmaceutical pollutant mixtures revealed by the novel GSA-QHTS screening method. GSA
49  2016 Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling. HIF-1alpha, MAPK, PI3K, siRNAs, VEGF
50  2016 Identification of compounds that modulate retinol signaling using a cell-based qHTS assay. ATRA, LOPAC, RARE
51  2016 Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing. AUC-ROC, hERG, SVC
52  2016 Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer. EMT, ESR1, NK
53  2016 Using beta-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway. HIF-1, MOA
54  2016 Using In Vitro High-Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards. AOPs
55  2015 A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays. POD, wAUC
56  2015 A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation. miRNA, SUMO
57  2015 Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. NPEs
58  2015 Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kalpha Lipid Kinase. Fluc
59  2015 Carfilzomib is an effective anticancer agent in anaplastic thyroid cancer. ATC
60  2015 Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. PD
61  2015 Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1). ALDH1A1, ALDHs
62  2015 Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer. ATC, HDAC
63  2015 Identification of known drugs targeting the endoplasmic reticulum stress response. eIF2alpha, ER, ESRE, GRP78
64  2015 Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer. ATC
65  2015 Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase alpha in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format. PI5P4Kalpha, PtdIns
66  2015 Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor. hCAR
67  2015 Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis. ATC
68  2014 Biochemical assays for the discovery of TDP1 inhibitors. WCE
69  2014 Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease. PKC, PMP22
70  2014 Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. LOPAC, NTP, TR
71  2014 Minimizing Systematic Errors in Quantitative High Throughput Screening Data Using Standardization, Background Subtraction, and Non-Parametric Regression. LN, LOESS or LO
72  2014 Multiplexing high-content flow (HCF) and quantitative high-throughput screening (qHTS) to identify compounds capable of decreasing cell viability, activating caspase 3/7, expressing annexin V, and changing mitochondrial membrane integrity. DLBCL, HCF, NCATS
73  2014 Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. ERalpha, SARs
74  2014 Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. ATP, MMP
75  2013 Are hERG channel blockers also phospholipidosis inducers? hERG, PLD
76  2013 Bisphenol A affects androgen receptor function via multiple mechanisms. AR, BPA, BPAF, BPS, EDC, ERalpha, LBD
77  2013 Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. CLL
78  2013 Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds. HCV, LOPAC
79  2013 Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. AD, AUC-ROC, k-NN, SVM
80  2013 Robust Analysis of High Throughput Screening (HTS) Assay Data. FDR, HTS, NTP, PTE
81  2013 Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. MOA, NCGC, NTP
82  2013 Using weighted entropy to rank chemicals in quantitative high-throughput screening experiments. ---
83  2012 A three-stage algorithm to make toxicologically relevant activity calls from quantitative high throughput screening data. NTP
84  2012 Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. ACC, MCA
85  2012 Identification of drug modulators targeting gene-dosage disease CMT1A. betaLac, CMT1A, Fluc, PMP22, PNS
86  2012 Paradigm shift in toxicity testing and modeling. ---
87  2012 Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. ARE
88  2012 Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. ---
89  2012 Structure based model for the prediction of phospholipidosis induction potential of small molecules. AUC-ROC, LOPAC, MOE, NCGC, PLD, SVM
90  2011 A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. NHR, SRC2, TR
91  2011 Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. ---
92  2011 Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. ---
93  2011 Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. ---
94  2011 Exploiting domain knowledge for improved quantitative high-throughput screening curve fitting. DK-fitter
95  2011 Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. AC, NIH
96  2011 Modeling Choices for Virtual Screening Hit Identification. SVM, VISHID
97  2011 Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. CYP450, NCGC, ROC, SVC
98  2011 Quantitative high-throughput drug screening identifies novel classes of drugs with anticancer activity in thyroid cancer cells: opportunities for repurposing. ---
99  2011 Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. NSCLC, USPs
100  2010 High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. COX