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Abbreviation : rscu-PA
Long Form : recombinant single-chain urokinase-type plasminogen activator
No. Year Title Co-occurring Abbreviation
1  1997 Construction of Urokinase Mutant Glu154-mtcu-PA and Characterization of Its Properties. ---
2  1996 Construction and structure-activity relationships of chimeric prourokinase derivatives with intrinsic thrombin-inhibitory potential. ---
3  1995 Antithrombotic effects of thrombolytic agents in a platelet-rich femoral vein thrombosis model in the hamster. rt-PA, SK, UK
4  1993 Pharmacokinetics of saruplase, a recombinant unglycosylated human single-chain urokinase-type plasminogen activator and its effects on fibrinolytic and haemostatic parameters in healthy male subjects. PAI-1, tcu-PA, TDP
5  1993 Thrombin generation induced by the intrinsic or extrinsic coagulation pathway is accelerated by streptokinase, independently of plasminogen. rt-PA
6  1993 Thrombolytic profiles of clot-targeted plasminogen activators. Parameters determining potency and initial and maximal rates. rt-PA
7  1992 Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons. MA, uPA
8  1991 Effect of chemical conjugation of recombinant single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo. LIBS, SPDP
9  1991 Role of alpha 2-antiplasmin in fibrin-specific clot lysis with single-chain urokinase-type plasminogen activator in human plasma. alpha 2-AP
10  1990 Correlation between progressive adsorption of plasminogen to blood clots and their sensitivity to lysis. rt-PA
11  1990 Spin filter perfusion system for high density cell culture: production of recombinant urinary type plasminogen activator in CHO cells. CHO
12  1990 Thrombolytic and pharmacokinetic properties of a conjugate of recombinant single-chain urokinase-type plasminogen activator with a monoclonal antibody specific for cross-linked fibrin in a baboon venous thrombosis model. MA-1C8, SPDP, uPA
13  1989 Additional myocardial salvage by coadministration of the epoprostenol analog taprostene to recombinant single-chain urokinase-type plasminogen activator in a canine coronary thrombosis model. LCX
14  1989 Additive fibrinolysis by recombinant tissue-type plasminogen activator (r-t-PA) and recombinant single-chain urokinase type plasminogen activator (r-scu-PA) in rabbit pulmonary thrombosis. RTPA
15  1989 Biochemical properties of conjugates of urokinase-type plasminogen activator with a monoclonal antibody specific for cross-linked fibrin. ---
16  1989 Effect of retraction on the lysis of human clots with fibrin specific and non-fibrin specific plasminogen activators. rt-PA, rtcu-PA, SK
17  1988 Enhanced myocardial salvage by combined treatment with recombinant single-chain urokinase-type plasminogen activator and recombinant human superoxide dismutase in a canine coronary thrombosis model. LCX, r-HSOD
18  1988 Enzymatic properties of single-chain and two-chain forms of a Lys158----Glu158 mutant of urokinase-type plasminogen activator. ---
19  1988 Recombinant single-chain urokinase-type plasminogen activator (rscu-PA) induces thrombolysis and systemic fibrinolysis in a canine model of coronary artery thrombosis. ---
20  1987 Coronary arterial thrombolysis with low-dose synergistic combinations of recombinant tissue-type plasminogen activator (rt-PA) and recombinant single-chain urokinase-type plasminogen activator (rscu-PA) for acute myocardial infarction. rt-PA
21  1987 Thrombolysis with recombinant human single-chain urokinase-type plasminogen activator (rscu-PA): dose-response in dogs with coronary artery thrombosis. ---