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Abbreviation : siRNA
Long Form : small interfering ribonucleic acid
No. Year Title Co-occurring Abbreviation
2021 A Critical Review of the Efficacy and Safety of Inclisiran. CVD, LDL-C, PCSK9
2021 Astrocyte elevated gene-1 (AEG-1): A key driver of hepatocellular carcinoma (HCC). AEG-1, HCC
2021 Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB. ALP, BMP-2, DFCs, NF-kappaB, PKC, PTHrP
2021 Dihydrolipoic acid enhances autophagy and alleviates neurological deficits after subarachnoid hemorrhage in rats. DHLA, EBI, FJC, i.c.v, LAMP1, SAH
2021 Erythropoietin inhibits apoptosis of retinal ganglion cells induced by high glucose through JNK signaling pathway. caspase 3, CCK-8, EPO, JNK, PI, PTPN1, RGCs
2021 Familial Hypercholesterolemia: Update and Review. ---
2021 High expression of collagen 1A2 promotes the proliferation and metastasis of esophageal cancer cells. Col, DEGs, EMT, ESCA, GO, KEGG
2021 Inclisiran: A Novel Agent for Lowering Apolipoprotein B-containing Lipoproteins. ASCVD, LDL-C, LDLR, non-HDL-C, PCSK9, PCSK9i
2021 Inhibition of angiopoietin-like 3 for the management of severe hypercholesterolemia. ANGPTL3, HoFH, LDL-C, LLT
10  2021 Is the Mitochondrial Function of Keloid Fibroblasts Affected by Cytoglobin? CYGB, FMUI, mRNA, PGC-1alpha, SDH
11  2021 Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway. EBI, GPR54, KP54, SAH
12  2021 Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of GalNAc-conjugated siRNA disposition and gene silencing in preclinical species and humans. ASGPRs, AT, GalNAc-siRNA, mPBPK-PD, RISC, tris-GalNAc
13  2021 NUCKS Promotes the Proliferation, Migration and Invasion of Lung Cancer Cells Through Pi3k/Akt Signalling Pathway. NUCKS
14  2021 The Role of Smad2 in Transforming Growth Factor β1-Induced Hypertrophy of Ligamentum Flavum. LF, LFCs, p-Smad2,3,4, PCR, TGF-beta1
15  2021 [Long-lasting LDL-C lowering: silence at last]. LDL-C, PCSK9
16  2020 Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway. AVICs, NF-kappaB, RAGE, VIC
17  2020 Beta-Cell-Specific Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 Aggravates High-Fat Diet-Induced Impairment of Islet Insulin Secretion in Mice. cAMP, GIIS, mRNA, NOX-es
18  2020 Brn3a/Pou4f1 Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid Cancer. EMT, STAT3
19  2020 CUL4A promotes proliferation and inhibits apoptosis of colon cancer cells via regulating Hippo pathway. CC, CCK-8, CUL4A, NC, qRT-PCR, WB
20  2020 CUL4A promotes the invasion of cervical cancer cells by regulating NF-κB signaling pathway. CC, CUL4A, mRNA, MTT, NF-kappaB, qRT-PCR
21  2020 Culture medium used during small interfering RNA (siRNA) transfection determines the maturation status of dendritic cells. ---
22  2020 Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis. ---
23  2020 Degradable double hydrophilic block copolymers and tripartite polyionic complex micelles thereof for small interfering ribonucleic acids (siRNA) delivery. DHBCs, PCL, PEG, PIC, PLL
24  2020 Delayed recanalization after MCAO ameliorates ischemic stroke by inhibiting apoptosis via HGF/c-Met/STAT3/Bcl-2 pathway in rats. CC3, HGF, i.c.v, MCAO, p-STAT3, pMCAO
25  2020 Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. DHLA, FLU, LPS, Nrf2
26  2020 ET-1 regulates the human umbilical vein endothelial cell cycle by adjusting the ERβ/FOXN1 signaling pathway. AS, CCNA2, CCNB1, CCND1, CCNE1, mRNA, NC, qPCR, ROS, SOD
27  2020 Low-density Lipoprotein-Cholesterol Lowering Strategies for Prevention of Atherosclerotic Cardiovascular Disease: Focus on siRNA Treatment Targeting PCSK9 (Inclisiran). CV, LDL-C, PCSK9
28  2020 Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis. BMD, BN, GSNCA, MEGENA, PBMs
29  2020 PD-L1 Influences Cell Spreading, Migration and Invasion in Head and Neck Cancer Cells. EMT, HNSCC, PD-L1
30  2020 Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model. AQP4, BBB, beta-DG, BM, EB, GFAP, i.c.v, MMPs, Poldip2, rh-Poldip2, TEM, ZO-1
31  2020 Propofol Affects Non-Small-Cell Lung Cancer Cell Biology By Regulating the miR-21/PTEN/AKT Pathway In Vitro and In Vivo. CCK-8, CI, MD, miR-21, NSCLC, p-Akt, RNA, RT-PCR
32  2020 Purine signaling regulating HSCs inflammatory cytokines secretion, activation, and proliferation plays a critical role in alcoholic liver disease. ---
33  2020 Recent advances in the combination delivery of drug for leukemia and other cancers. ---
34  2020 Recombinant OX40 attenuates neuronal apoptosis through OX40-OX40L/PI3K/AKT signaling pathway following subarachnoid hemorrhage in rats. EBI, i.c.v, ReOX40, SAH, SD
35  2020 The role of interleukin-6/interleukin-6 receptor signaling in the mechanical stress-induced extracellular matrix remodeling of bladder smooth muscle. BOO, ECM, HBSMCs, IL-6, qRT-PCR
36  2020 Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review. CTLA-4, IBD, IL, MS, RA, SLE, TNF
37  2019 A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain. LPS, NF-kappaB
38  2019 A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance. Abs, ADA, ADA, ECL, FFP, HSP47, LNP, MRD, PEG, QCs
39  2019 Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages. CLR, MERS-CoV, PRR, RLR, Syk
40  2019 Activation of GPR30 with G1 attenuates neuronal apoptosis via src/EGFR/stat3 signaling pathway after subarachnoid hemorrhage in male rats. EBI, EGFR, FJC, GPR30, SAH, TUNEL
41  2019 Bishonokiol A inhibits breast cancer cell invasion and migration by suppressing hypoxia inducible factor-1alpha. HIF-1alpha, MMP-9
42  2019 C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells. ABCB1, HBV, HBx, HCC
43  2019 Carbonic Anhydrase 1-Mediated Calcification Is Associated With Atherosclerosis, and Methazolamide Alleviates Its Pathogenesis. AS, AZ, CA1, CCL2, GM-CSF, HDL-C, IFN, LDL-C, MCP-1, MTZ, NO, TC, TG, TNF-alpha, VSMCs
44  2019 Correlation of SOX9 and NM23 genes with the incidence and prognosis of prostate cancer. mRNAs, PC, RT-qPCR, SOX
45  2019 Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma. DKK1, ELISA, IL-6, MM, MTT, OB, OC
46  2019 Declined placental PLAC1 expression is involved in preeclampsia. IHC, PLAC1
47  2019 Deregulation of long noncoding RNA (TUG1) contributes to excessive podocytes apoptosis by activating endoplasmic reticulum stress in the development of diabetic nephropathy. CHOP, DN, ERS, HG, lncRNA, PGC-1alpha
48  2019 Downregulation of long non-coding RNA MEG3 promotes proliferation, migration, and invasion of human hepatocellular carcinoma cells by upregulating TGF-beta1. lncRNAs, MEG3
49  2019 Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-kappaB pathway. AKI, CRNDE, lncRNA, LPS, NF-kappaB, PAS, RT-PCR, TLR3, TUNEL
50  2019 Effect of lncRNA GAS5 on rats with acute myocardial infarction through regulating miR-21. AMI, ELISA, GAS5, ISO, lncRNA, MMP, RT-PCR, SD, TUNEL
51  2019 FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage. FGF, FGFR, i.c.v, IgG, p-Akt, rFGF-2, SAH
52  2019 Future role of proprotein convertase subtilisin/kexin type 9 inhibitors in preventive cardiology. LDL-C, PCSK9
53  2019 Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1alpha/AMPK/Sirt1/PGC-1alpha/UCP2 pathway in a rat model of neonatal HIE. GHSR-1alpha, HI, HIE, i.c.v, rh-Ghrelin, TUNEL
54  2019 Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IIalpha Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase. CaMKII, G6PD, MCAO, ROS, TTC
55  2019 Intratumoral delivery and therapeutic efficacy of nanoparticle-encapsulated anti-tumor siRNA following intrapulmonary administration for potential treatment of lung cancer. VEGF
56  2019 Involvement of C/EBPbeta-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. cyto c, DDIT4, METH, TSC2
57  2019 Knocking down PFL can improve myocardial ischemia/reperfusion injury in rats by up-regulating heat shock protein-20. Bax, HSP-20, I/R, LAD, lncRNA, MI, SD, TTC, TUNEL
58  2019 Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor. alpha-SMA, CBA, mRNA, NHLFs
59  2019 Lipid-based nanoparticle formulations for small molecules and RNA drugs. LNPs
60  2019 LncRNA NEAT1 alleviates sepsis-induced myocardial injury by regulating the TLR2/NF-kappaB signaling pathway. 4-HNE, CD45, ELISA, I/R, IL-1, lncRNA NEAT1, LPS, MCP-1, mRNA, NF-kappaB, RT-PCR, TLR2, TNF-alpha, TUNEL
61  2019 Membrane lipids destabilize short interfering ribonucleic acid (siRNA)/polyethylenimine nanoparticles. LA, NPs, POPC, POPS
62  2019 Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats. EBI, MitoQ, Nrf2, OPA1, PHB2, SAH
63  2019 Peptide-siRNA Supramolecular Particles for Neural Cell Transfection. dsRNA
64  2019 Poly(ethylene glycol)-Based Peptidomimetic "PEGtide" of Oligo-Arginine Allows for Efficient siRNA Transfection and Gene Inhibition. GDV, PEG
65  2019 Recent Advances in the Development of Bio-Reducible Polymers for Efficient Cancer Gene Delivery Systems. mRNA, pDNA
66  2019 Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia. CCK-8, EVTs, mRNA, RT-PCR, sFlt-1, VEGF
67  2019 RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats. FPR2, HI, NADPH, Rac1, RvD1
68  2019 Targeted siRNA Delivery Using Lipid Nanoparticles. SLNs
69  2019 Threatening cancer with nanoparticle aided combination oncotherapy. ---
70  2018 AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy. AMPK, ANP, beta-MHC, EF, mRNA, PE, RT-PCR, SIRT1, TAC
71  2018 AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. EBI, i.c.v, SAH
72  2018 Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer. BCPVs, DOX, GQDs
73  2018 Cell mimetic liposomal nanocarriers for tailored delivery of vascular therapeutics. CPP, DAG, LDSs, PEG, PS, VECs, VSMCs
74  2018 Effects of NOB1 on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin. CCK-8, NOB1
75  2018 Effects of PLK1 on proliferation, invasion and metastasis of gastric cancer cells through epithelial-mesenchymal transition. EMT, MTT
76  2018 Heart tissue repair and cardioprotection using drug delivery systems. ---
77  2018 Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain. ---
78  2018 Long noncoding RNA HOTAIR knockdown inhibits autophagy and epithelial-mesenchymal transition through the Wnt signaling pathway in radioresistant human cervical cancer HeLa cells. EMT, HOTAIR, RNA
79  2018 Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer. ---
80  2018 Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage. BWC, C-A1, i.p, ICH, OPN, rOPN
81  2018 Possible Insulinotropic Action of Apolipoprotein A-I Through the ABCA1/Cdc42/cAMP/PKA Pathway in MIN6 Cells. ABCA1, apo, Cdc42, GSIS, PKA
82  2018 Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice. AdipoR1, AMPK, CTRP9, ICH, NF-kappaB, rCTRP9
83  2018 Role of CXCR1 and Interleukin-8 in Methamphetamine-Induced Neuronal Apoptosis. CXCR1, IL, METH, NF-kappaB
84  2018 Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion. ---
85  2018 Study on Regulation of Low Density Lipoprotein Cholesterol Metabolism using PCSK9 Gene Silencing: A computational Approach. LDLR, PCSK9
86  2017 A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4. GPCR, HEK293, PAR2, TRPV4
87  2017 A QCM-D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA. LNPs, PHY, QCM
88  2017 Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling. MAPK, PTPIP51
89  2017 Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. ALP, Angptl2, ERK, JNK, NF-kappaB
90  2017 Bacterial magnetosomes as an efficient gene delivery platform for cancer theranostics. BMs
91  2017 Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery. cESG, TPPS
92  2017 CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor beta1 and tumor necrosis factor alpha in lung cancer: Preliminary findings. CSC, EMT, NSCLC, OCT4, TGF-beta1, TNF-alpha
93  2017 Central Signaling Elements of Intercellular Reactive Oxygen/Nitrogen Species-dependent Induction of Apoptosis in Malignant Cells. DUOX1, Nox1
94  2017 Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells. FCM, MMP, OC, p-Akt, RT-PCR, SALL2
95  2017 Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. EBI, Ex-4, FJC, GLP-1R, SAH
96  2017 Microenvironmental stromal cells abrogate NF-kappaB inhibitor-induced apoptosis in chronic lymphocytic leukemia. BTK, CLL, DHMEQ, NF-kappaB
97  2017 RNAi-mediated knockdown of CAIX enhances the radiosensitivity of nasopharyngeal carcinoma cell line, CNE-2. CAIX, NPC, SF2
98  2017 Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury. ---
99  2017 Yangjing Capsule extract promotes proliferation of GC-1 spg cells via up-regulated POU3F1 pathway. GDNF, GFRalpha1, PI3K, SPG, SSCs, YC
100  2016 ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response. DDR, NSCLC