| 1 |
2022 |
Herpes Simplex Virus 1 Expressing GFP-Tagged Virion Host Shutoff (vhs) Protein Uncouples the Activities of RNA Degradation and Differential Nuclear Retention of the Virus Transcriptome. |
GFP, HSV-1, IE |
| 2 |
2022 |
HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform. |
circRNAs, HSV-1, IAV, NEAT1 |
| 3 |
2021 |
DPV UL41 gene encoding protein induces host shutoff activity and affects viral replication. |
DEF, DPV, HSV, pol |
| 4 |
2021 |
Viperin has species-specific roles in response to herpes simplex virus infection. |
HSV-1 |
| 5 |
2020 |
Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level. |
HSV-1, p.i, WT |
| 6 |
2020 |
Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion. |
HSV-1, mRNA |
| 7 |
2020 |
VHS, US3 and UL13 viral tegument proteins are required for Herpes Simplex Virus-Induced modification of protein kinase R. |
PKR |
| 8 |
2019 |
The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA. |
dsRNA, PKR |
| 9 |
2018 |
A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus. |
HPG, HSV |
| 10 |
2018 |
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS. |
cGAS, dsRNA, eIF2alpha, HSV-1, PKR, SGs |
| 11 |
2018 |
Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA. |
EBV, VINORCs |
| 12 |
2018 |
Generation and characterization of UL41 null pseudorabies virus variant in vitro and in vivo. |
--- |
| 13 |
2018 |
Multiple Posttranscriptional Strategies To Regulate the Herpes Simplex Virus 1 vhs Endoribonuclease. |
HSV-1, PABP |
| 14 |
2018 |
Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins. |
--- |
| 15 |
2017 |
Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes. |
HSV |
| 16 |
2016 |
Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells. |
DC, EHV-1, MDDC, MHC-I |
| 17 |
2016 |
Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types. |
HFFs, HSV-1, NOKs |
| 18 |
2016 |
The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. |
HSV, PKR |
| 19 |
2016 |
The Splicing History of an mRNA Affects Its Level of Translation and Sensitivity to Cleavage by the Virion Host Shutoff Endonuclease during Herpes Simplex Virus Infections. |
EJCs, HSV, HSV-1, Rluc |
| 20 |
2015 |
Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage. |
HSV, UTRs |
| 21 |
2014 |
Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(A)-binding protein are distinct processes mediated by two Epstein Barr virus proteins. |
EBV |
| 22 |
2014 |
The herpes simplex virus 1 virion host shutoff protein enhances translation of viral late mRNAs by preventing mRNA overload. |
5'UTR, HSV-1 |
| 23 |
2013 |
Herpes simplex virus 1 ICP22 but not US 1.5 is required for efficient acute replication in mice and VICE domain formation. |
gC, HSV-1, ICP0, ICP22, M90A, MEFs, VICE |
| 24 |
2013 |
Proinflammatory cytokines and chemokines - but not interferon-beta - produced in response to HSV-2 in primary human genital epithelial cells are associated with viral replication and the presence of the virion host shutoff protein. |
GEC, IFN, NF-kappaB, WT |
| 25 |
2013 |
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein. |
AU, HSV-1, VP |
| 26 |
2013 |
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1. |
PKR |
| 27 |
2013 |
Virus-encoded endonucleases: expected and novel functions. |
KSHV |
| 28 |
2012 |
mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein. |
EMCV, HSV, IRES |
| 29 |
2011 |
B7 costimulation molecules encoded by replication-defective, vhs-deficient HSV-1 improve vaccine-induced protection against corneal disease. |
HSK, HSV-1 |
| 30 |
2011 |
Deletion of the virion host shut: off gene of pseudorabies virus results in selective upregulation of the expression of early viral genes in the late stage of infection. |
--- |
| 31 |
2011 |
Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection. |
BBB, CNS, HSV-1, IL-1beta, STAT, WT |
| 32 |
2011 |
Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells. |
HEK, HSV-2, IRF, MDA5, RIG-I, TLR, WT |
| 33 |
2011 |
The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-kappaB in dendritic cells in the absence of type I interferon signaling. |
DCs, HSV-1, IFN, KO, RLR |
| 34 |
2010 |
Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. |
--- |
| 35 |
2010 |
Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase. |
3'UTR, AREs |
| 36 |
2010 |
The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells. |
cDC, DCs, HSV-1, NDV, pDC, SeV |
| 37 |
2009 |
Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5. |
eIF2alpha, HSV-2, MEFs, PKR, PP1alpha |
| 38 |
2009 |
The effect of herpes simplex virus virion host shutoff gene- a new suicide gene- on tumor cells. |
ARE, HSV |
| 39 |
2009 |
Type I IFN response to Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) determines neuropathogenicity in mice. |
HVP2, HVP2, IFN, PMDF |
| 40 |
2008 |
Deletion of the Marek's disease virus UL41 gene (vhs) has no measurable effect on latency or pathogenesis. |
MDV |
| 41 |
2008 |
Host responses to wild-type and attenuated herpes simplex virus infection in the absence of Stat1. |
HSV-1, IL-6 |
| 42 |
2008 |
Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice. |
HSV, HSV-1, IFN |
| 43 |
2008 |
Sequence determination of a mildly virulent strain (CU-2) of Gallid herpesvirus type 2 using 454 pyrosequencing. |
ORF, SNPs |
| 44 |
2008 |
Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus. |
HSV, siRNAs |
| 45 |
2007 |
Infection of human dendritic cells with herpes simplex virus type 1 dramatically diminishes the mRNA levels of the prostaglandin E(2) receptors EP2 and EP4. |
APCs, DCs, EP2, EP4, HSV-1, moDCs, PCR |
| 46 |
2007 |
Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA. |
--- |
| 47 |
2007 |
Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase. |
BAC, HSV-1 |
| 48 |
2006 |
Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 gene. |
AREs, HSV, HSV-1, MAPK |
| 49 |
2006 |
Packaging of the virion host shutoff (Vhs) protein of herpes simplex virus: two forms of the Vhs polypeptide are associated with intranuclear B and C capsids, but only one is associated with enveloped virions. |
--- |
| 50 |
2006 |
The amino terminus of the herpes simplex virus 1 protein Vhs mediates membrane association and tegument incorporation. |
GFP, HSV |
| 51 |
2005 |
Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration. |
DCs, HSV-1 |
| 52 |
2005 |
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. |
GST, HSV |
| 53 |
2005 |
The varicella-zoster virus-mediated delayed host shutoff: open reading frame 17 has no major function, whereas immediate-early 63 protein represses heterologous gene expression. |
HSV, IE63, ORF17, VZV |
| 54 |
2004 |
Functional analysis of virion host shutoff protein of pseudorabies virus. |
PRV |
| 55 |
2004 |
Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. |
AREs, ICP4 |
| 56 |
2004 |
Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness. |
HSV-2, MEFs |
| 57 |
2004 |
Regulation of the vhs gene promoter of pseudorabies virus by IE180 and EP0, and the requirement of a Sp1 Site for the promoter function. |
EP0, PRV |
| 58 |
2004 |
Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis. |
--- |
| 59 |
2004 |
The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific. |
ARE |
| 60 |
2003 |
A subpopulation of tegument protein vhs localizes to detergent-insoluble lipid rafts in herpes simplex virus-infected cells. |
HSV |
| 61 |
2003 |
Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression. |
BHV-1, TAP, WT |
| 62 |
2003 |
Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo. |
HSV, HSV-2, IVAG |
| 63 |
2003 |
Inhibition of TAP by pseudorabies virus is independent of its vhs activity. |
EGFP, PRV, TAP, WT |
| 64 |
2003 |
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection. |
HSV |
| 65 |
2002 |
Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions. |
--- |
| 66 |
2002 |
Herpesvirus papio 2 encodes a virion host shutoff function. |
HSV, HVP-2 |
| 67 |
2002 |
mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease. |
GST |
| 68 |
2002 |
Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants. |
HSV-1 |
| 69 |
2002 |
Therapeutic immunization with a virion host shutoff-defective, replication-incompetent herpes simplex virus type 1 strain limits recurrent herpetic ocular infection. |
HSV-1 |
| 70 |
2002 |
Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice. |
HSV |
| 71 |
2001 |
Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. |
BAC, HSV |
| 72 |
2001 |
Generation of adenoviruses encoding the herpes simplex virus vhs gene: a novel strategy to generate adenoviruses expressing genes toxic to producer cells. |
--- |
| 73 |
2001 |
mRNA decay during herpesvirus infections: interaction between a putative viral nuclease and a cellular translation factor. |
--- |
| 74 |
2001 |
Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type 1. |
HSV-1, IFN, PK |
| 75 |
2001 |
The UL41-encoded virion host shutoff (vhs) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1. |
BHV-1, ER, TAP |
| 76 |
2001 |
The vhs1 mutant form of herpes simplex virus virion host shutoff protein retains significant internal ribosome entry site-directed RNA cleavage activity. |
HSV, RRL |
| 77 |
2000 |
A vhs-like activity of bovine herpesvirus-1. |
ActD, BHV-1, GAPDH, HSV, MHC |
| 78 |
2000 |
Assembly of infectious Herpes simplex virus type 1 virions in the absence of full-length VP22. |
HSV-1 |
| 79 |
2000 |
Disruption of virion host shutoff activity improves the immunogenicity and protective capacity of a replication-incompetent herpes simplex virus type 1 vaccine strain. |
HSV-1 |
| 80 |
2000 |
Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice. |
HSV, HSV-1 |
| 81 |
1999 |
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II. |
HSV-1, RNAPII |
| 82 |
1999 |
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. |
HSV, IRES |
| 83 |
1999 |
The herpes simplex virus vhs protein induces endoribonucleolytic cleavage of target RNAs in cell extracts. |
--- |
| 84 |
1999 |
The virion host shutoff function of herpes simplex virus degrades the 5' end of a target mRNA before the 3' end. |
HSV |
| 85 |
1998 |
Postexposure vaccination with a virion host shutoff defective mutant reduces UV-B radiation-induced ocular herpes simplex virus shedding in mice. |
HSV-1, UV |
| 86 |
1998 |
Protection from primary infection and establishment of latency by vaccination with a herpes simplex virus type 1 recombinant deficient in the virion host shutoff (vhs) function. |
HSV-1 |
| 87 |
1997 |
Herpes simplex virus type 1 (HSV-1) strain HSZP host shutoff gene: nucleotide sequence and comparison with HSV-1 strains differing in early shutoff of host protein synthesis. |
HSV-1 |
| 88 |
1997 |
Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras. |
HSV, HSV-1 |
| 89 |
1997 |
The virion host shutoff function of herpes simplex virus type 1 plays a role in corneal invasion and functions independently of the cell cycle. |
--- |
| 90 |
1996 |
Human herpes simplex virus (HSV)-specific CD8+ CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-gamma or when virion host shutoff functions are disabled. |
HSV |
| 91 |
1996 |
The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro. |
HSV, mRNase |
| 92 |
1995 |
Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins. |
HSV |
| 93 |
1995 |
Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis. |
HSV-1 |
| 94 |
1995 |
The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products. |
--- |
| 95 |
1994 |
Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: implications for viral latency and herpes vectors. |
HSV-1 |
| 96 |
1993 |
Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide. |
HSV-1 |
| 97 |
1991 |
Analysis of herpes simplex virus-induced mRNA destabilizing activity using an in vitro mRNA decay system. |
HSV-1 |
| 98 |
1991 |
In vitro mRNA degradation system to study the virion host shutoff function of herpes simplex virus. |
--- |
| 99 |
1989 |
The herpes simplex virus virion host shutoff function. |
HSV, WT |
| 100 |
1987 |
Effects of herpes simplex virus on mRNA stability. |
--- |
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