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Abbreviation : PBTK
Long Form : physiologically based toxicokinetic
No. Year Title Co-occurring Abbreviation
1993 A descriptive and mechanistic study of the interaction between toluene and xylene in humans. TOL, XYL
1993 Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat. TOL, XYL
1994 Three-dimensional visualization of physiologically based kinetic model outputs. ---
1995 Biologically based dose response model for hepatic toxicity: a mechanistically based replacement for traditional estimates of noncancer risk. RfD, TD, TK
1995 Health risk assessment of chemical mixtures from a research perspective. ---
1996 Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model. ---
1999 A modeling approach to account for toxicokinetic interactions in the calculation of biological hazard index for chemical mixtures. BHI
1999 Physiologically based toxicokinetic modeling of inhaled ethyl tertiary-butyl ether in humans. ETBE, TBA
1999 The importance of measured end-points in demonstrating the occurrence of interactions: a case study with methylchloroform and m-xylene. MHA, TCA, TCE
10  2000 A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush). HCE, PCE, TCE
11  2000 Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. ---
12  2000 Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. ---
13  2000 Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics of components of complex chemical mixtures. BEN, DCM, EBZ, STY, TCE, TOL, VOCs
14  2000 Statistical issues in toxicokinetic modeling: a bayesian perspective. QRA
15  2000 Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures. ---
16  2001 Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. AUC, BD
17  2001 [Use of the ACSL simulation language for physiologic toxicokinetic models]. ACSL
18  2002 Impact of human variability on the biological monitoring of exposure to toluene: I. Physiologically based toxicokinetic modelling. EIs, GM, MCS, o-CR, TOL
19  2002 The role of physiologically based toxicokinetic models in biologically based risk assessment. ---
20  2002 [Specific nature of the software used to construct simulations: physiologically-based toxicokinetic models]. 2,3,-DMBA, ACSL, TMB
21  2003 A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. GI
22  2003 A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: II. simulation of chronic exposure scenarios. ---
23  2003 An in vivo microdialysis method for the qualitative analysis of hepatic phase I metabolites of phenol in rainbow trout (Oncorhynchus mykiss). CAT, HQ, MD
24  2003 Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats. ---
25  2003 Contribution of toxicokinetic modeling to the adjustment of exposure limits to unusual work schedules. ELs
26  2003 Physiologically-based kinetic modeling of vapours toxic to the respiratory tract. ---
27  2003 Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment. ICH
28  2004 Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. ---
29  2005 A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise. ---
30  2005 Behavioural effects and kinetics in brain in response to inhalation of constant or fluctuating toluene concentrations in the rat. ---
31  2005 Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry. EDR, nAChRs, PERC, TCE, VOCs, VSCCs
32  2005 Human exposure and internal dose assessments of acrylamide in food. ---
33  2006 A General Physiological and Toxicokinetic (GPAT) Model for Simulating Complex Toluene Exposure Scenarios in Humans. GPAT
34  2006 Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models. MCMC, MLE, TD
35  2006 Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes. AUC, TCE, THM
36  2006 In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models. ---
37  2006 Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. ---
38  2007 A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats. VOC
39  2007 Approaches to acrylamide physiologically based toxicokinetic modeling for exploring child-adult dosimetry differences. AUC, CYP
40  2007 Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. BD, DEB, EB, EBD, GSA
41  2007 Experimental exposure to 1,1,1-trifluoroethane (HFC-143a): uptake, disposition and acute effects in male volunteers. ---
42  2007 In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation. ---
43  2007 PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. JP-8
44  2007 Physiologically-based toxicokinetic modeling of durene (1,2,3,5-tetramethylbenzene) and isodurene (1,2,4,5-tetramethylbenzene) in humans. TETMB, VMAX
45  2007 Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats. DLM, GF, GI, SD, TK
46  2008 Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities. NHANES, NHEXAS
47  2009 Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb. AChE, AH-TK, ALU, ALX
48  2009 Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment. ---
49  2009 Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model. BPA
50  2010 A physiologically based toxicokinetic model for methylmercury in female American kestrels. ---
51  2010 Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity. GST
52  2010 Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models. BaP, PAHs
53  2011 A generic, cross-chemical predictive PBTK model with multiple entry routes running as application in MS Excel; design of the model and comparison of predictions with experimental results. PBPK
54  2011 Extrapolating the acute behavioral effects of toluene from 1- to 24-h exposures in rats: roles of dose metric and metabolic and behavioral tolerance. C t, Tol
55  2011 Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior. AQP9s, DMA, MMA, MRPs, TK, TR
56  2011 Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical predictive PBTK-model. PAH, QSPR
57  2012 Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. PCBs
58  2012 Evaluation of occupational exposure: comparison of biological and environmental variabilities using physiologically based toxicokinetic modeling. BM, EM
59  2012 Hexavalent chromium reduction kinetics in rodent stomach contents. ---
60  2012 Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies. BPA, TDI
61  2012 Predicting concentrations of organic chemicals in fish by using toxicokinetic models. TK
62  2012 Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches. ADME, TK
63  2013 A physiologically based toxicokinetic model for the zebrafish Danio rerio. ---
64  2013 PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. ---
65  2014 Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients. AUC, NOAEL, QSPRs, RtR
66  2014 In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine. ---
67  2014 Physiologically-based toxicokinetic model for cadmium using Markov-chain Monte Carlo analysis of concentrations in blood, urine, and kidney cortex from living kidney donors. ---
68  2014 Physiologically-based toxicokinetic modeling of zearalenone and its metabolites: application to the Jersey girl study. JGS, ZAL, ZEA
69  2014 Understanding receptor-mediated effects in rainbow trout: in vitro-in vivo extrapolation using physiologically based toxicokinetic models. ---
70  2015 A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla). ---
71  2015 Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals. ERPG-3
72  2016 Activities of xenobiotic metabolizing enzymes in rat placenta and liver in vitro. ADH, ALDH, FMO, GST, UGT
73  2016 Cross-Species Extrapolation of Uptake and Disposition of Neutral Organic Chemicals in Fish Using a Multispecies Physiologically-Based Toxicokinetic Model Framework. ---
74  2016 Fipronil and two of its transformation products in water and European eel from the river Elbe. ---
75  2016 Physicologically Based Toxicokinetic Models of Tebuconazole and Application in Human Risk Assessment. ADME
76  2016 Tissue-Specific Accumulation, Depuration, and Transformation of Triphenyl Phosphate (TPHP) in Adult Zebrafish (Danio rerio). d10-DPHP, TPHP
77  2016 Toxicokinetic models and related tools in environmental risk assessment of chemicals. ---
78  2017 A framework and case studies for evaluation of enzyme ontogeny in children's health risk evaluation. TK
79  2017 A review of quantitative structure-property relationships for the fate of ionizable organic chemicals in water matrices and identification of knowledge gaps. QSPRs
80  2017 Bioaccumulation mechanism of organophosphate esters in adult zebrafish (Danio rerio). OPEs
81  2017 Can poly-parameter linear-free energy relationships (pp-LFERs) improve modelling bioaccumulation in fish? BCF, PP-LFERs, sp
82  2017 Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches. IVIVE
83  2018 Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments. TK
84  2018 Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. AOP, IVIVE, POD, TD, TK
85  2018 Computational Analysis of Deposition and Translocation of Inhaled Nicotine and Acrolein in the Human Body with E-cigarette Puffing Topographies. CFPD, EC
86  2018 Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability. ---
87  2018 In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds. IVIVE, YAS, YES
88  2018 PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data. ADME, AOEL
89  2018 QSAR modeling of adipose/blood partition coefficients of Alcohols, PCBs, PBDEs, PCDDs and PAHs: A data gap filling approach. AD, ADMET, PAHs, PBDEs, PCBs, PCDDs, QSAR
90  2018 Read across for the derivation of Indoor Air Guidance Values supported by PBTK modelling. DNEL, IAGV, LCI, PUF, RW, VOC
91  2019 A Petri Net Approach to Physiologically Based Toxicokinetic Modeling. ODEs
92  2019 Can the inhalation exposure of a specific worker in a cross-ventilated factory be evaluated by time- and spatial-averaged contaminant concentration? CFD, CSP
93  2019 Elucidating the fate of perfluorooctanoate sulfonate using a rainbow trout (Oncorhynchus mykiss) physiologically-based toxicokinetic model. PFAS, PFOS
94  2019 Evaluation of toxicokinetics of nonylphenol in the adult female Sprague-Dawley rats using a physiologically based toxicokinetic model. NP, RMSE
95  2019 Physiologically based toxicokinetic models and in silico predicted partition coefficients to estimate tetrachlorodibenzo-p-dioxin transfer from feed into growing pigs. DDA, SIM, TCDD
96  2019 Physiologically based toxicokinetics (PBTK) models for pharmaceuticals and personal care products in wild common carp (Cyprinus carpio). PPCPs
97  2019 Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions. fup, IVIVE
98  2020 A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals. ---
99  2020 Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? MRL, PM
100  2020 Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S. BPA, BPS, p-PBTK
101  2020 Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model. ADME, PFAAs
102  2021 A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment. BCFs
103  2021 Bayesian toxicokinetic modeling of cadmium exposure in Chinese population. ABC-MCMC, Cd, MCMC, RMSE, TK
104  2021 Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks. IOCs
105  2021 High-throughput PBTK models for in vitro to in vivo extrapolation. HTS, HTTK, IVIVE, TK
106  2021 Liver-Based Probabilistic Risk Assessment of Exposure to Organophosphate Esters via Dust Ingestion Using a Physiologically Based Toxicokinetic (PBTK) Model. EDIs, IVIVE, MOE, OPEs, RfDs
107  2021 Mapping blood lead levels in French children due to environmental contamination using a modeling approach. BLLs
108  2021 Modeling acetylcholine esterase inhibition resulting from exposure to a mixture of atrazine and chlorpyrifos using a physiologically-based kinetic model in fish. AChE, ATR, CPF, CPF-oxon, TD
109  2021 Tissue-Specific Accumulation, Biotransformation, and Physiologically Based Toxicokinetic Modeling of Benzotriazole Ultraviolet Stabilizers in Zebrafish (Danio rerio). BCFs, BUVSs
110  2021 Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat. DM, ndl-PCBs
111  2022 Cytochrome P450 isoforms contribution, plasma protein binding, toxicokinetics of enniatin A in rats and in vivo clearance prediction in humans. ENNA
112  2022 Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation. BPA, BPZ
113  2022 Physiologically-based toxicokinetic modeling of human dermal exposure to diethyl phthalate: Application to health risk assessment. DEP, MEP, PCPs, SVOCs
114  2022 The construction and application of physiologically based toxicokinetic models for acrylamide, glycidamide and their biomarkers in rats and humans. AA, AAMA, AAVal, GA
115  2022 The toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model. BPA, BPA gluc, BPA sulf, TK