| 1 |
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
(901 times)
|
Biochemistry
(183 times)
|
AMPK (584 times)
AMP (36 times)
ACC (34 times)
|
1966 Aminoimidazolecarboxamide ribotide (AICAR)-transformylase of erythrocytes in formiminotransferase deficiency syndrome.
|
| 2 |
activator
(26 times)
|
Physiology
(5 times)
|
AMPK (14 times)
HFD (3 times)
BAT (2 times)
|
2009 Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
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| 3 |
5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide
(18 times)
|
Chemistry
(3 times)
|
AMPK (13 times)
AMP (3 times)
WT (3 times)
|
1999 Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
|
| 4 |
5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate
(12 times)
|
Biochemistry
(6 times)
|
AMPK (4 times)
AHX (2 times)
5'-ProFAR (1 time)
|
1993 Imidazole glycerol phosphate synthase: the glutamine amidotransferase in histidine biosynthesis.
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| 5 |
5-aminoimidazole-4-carboxamide
(8 times)
|
Endocrinology
(2 times)
|
AMPK (5 times)
5-FU (1 time)
Ad (1 time)
|
1994 Enhancement of antineoplastic activity of 5-fluorouracil in mice bearing colon 38 tumor by (6R)5,10-dideazatetrahydrofolic acid.
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| 6 |
AICA-riboside
(6 times)
|
Pharmacology
(2 times)
|
AMPK (4 times)
ACC (1 time)
ACh (1 time)
|
1989 Utility of AICAr for metabolic studies is diminished by systemic effects in situ.
|
| 7 |
aminoimidazolecarboxamide ribonucleoside monophosphate
(4 times)
|
Biochemistry
(3 times)
|
6-MP (2 times)
MTX (2 times)
PRPP (2 times)
|
1986 Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
|
| 8 |
N(1)-(beta-d-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
(4 times)
|
Chemistry
(1 time)
|
AMPK (4 times)
ER (2 times)
BiP (1 time)
|
2011 Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase.
|
| 9 |
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
(3 times)
|
Pediatrics
(1 time)
|
10-formyl-H2folate (1 time)
10-formyl-H4folate (1 time)
AICA (1 time)
|
1977 Lesch-Nyhan syndrome: the synthesis of inosine 5'-phosphate in the hypoxanthine-guanine phosphoribosyltransferase-deficient erythrocyte by alternate biochemical pathways.
|
| 10 |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
(2 times)
|
Pharmacogenetics
(1 time)
|
IMP (2 times)
ADRs (1 time)
ATIC (1 time)
|
2022 Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.
|
| 11 |
accumulation of phosphoribosylaminoimidazolecarboxamide
(2 times)
|
Science
(2 times)
|
MTX (1 time)
SHMT2 (1 time)
THF (1 time)
|
1985 Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
|
| 12 |
AICA ribonucleotide
(2 times)
|
Medicine
(1 time)
|
ES cells (2 times)
AMPK (1 time)
DAVID (1 time)
|
2013 AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by regulating transcription factor and epigenetic modulator expression.
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| 13 |
5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole
(1 time)
|
Genetics
(1 time)
|
---
|
2005 Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.
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| 14 |
5-amino-4-carboxamide imidazole riboside 5'-phosphate
(1 time)
|
Genetics
(1 time)
|
---
|
1993 The pleiotropic effects of his overexpression in Salmonella typhimurium do not involve AICAR-induced mutagenesis.
|
| 15 |
5-amino-imidazole-4-carboxamide
(1 time)
|
Biochemistry
(1 time)
|
bp (1 time)
GAR (1 time)
ORF (1 time)
|
1991 Nucleotide sequence analysis of purH and purD genes from Salmonella typhimurium.
|
| 16 |
5-Aminoimidazole-4-carboxamide riboside or acadesine
(1 time)
|
Hematology
(1 time)
|
AMPK (1 time)
ATM (1 time)
CLL (1 time)
|
2010 AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
|
| 17 |
acid insoluble carnitine
(1 time)
|
Biochemistry
(1 time)
|
ASCAR (1 time)
TCAR (1 time)
|
2000 Total acid soluble and insoluble carnitine levels in human brain tumors.
|
| 18 |
activator of AMPK
(1 time)
|
Complementary Therapies
(1 time)
|
HUVECs (1 time)
|
2019 Luteolin: A Natural Flavonoid Enhances the Survival of HUVECs against Oxidative Stress by Modulating AMPK/PKC Pathway.
|
| 19 |
activator ZMP
(1 time)
|
Chemistry Techniques, Analytical
(1 time)
|
AMPK (1 time)
CBS (1 time)
|
2007 Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.
|
| 20 |
activators that target the nucleotide-binding domain of the gamma subunit
(1 time)
|
Metabolism
(1 time)
|
ADaM (1 time)
AMPK (1 time)
BAT (1 time)
|
2021 Compound- and fiber type-selective requirement of AMPKgamma3 for insulin-independent glucose uptake in skeletal muscle.
|
| 21 |
active monophosphate form
(1 time)
|
Biochemistry
(1 time)
|
AICAr (1 time)
|
2014 Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr) transporters.
|
| 22 |
adenine nucleotide precursor supplementation
(1 time)
|
Vascular Diseases
(1 time)
|
---
|
1986 Biochemical studies: failure of tissue adenosine triphosphate levels to predict recovery of contractile function after controlled reperfusion.
|
| 23 |
adipocytes was supplemented with 100 muM ((2R,3S,4R,5R)-5-(4-Carbamoyl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl)methyl dihydrogen phosphate
(1 time)
|
Medicine
(1 time)
|
AMPK (2 times)
hADMSCs (1 time)
|
2016 AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype.
|
| 24 |
agonist, 5 -aminoimidazole -4 -carboxamide -1-beta-d-ribofuranoside
(1 time)
|
Biochemistry
(1 time)
|
AMPK (1 time)
ECs (1 time)
EIMD (1 time)
|
2015 Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage.
|
| 25 |
AICA riboside, acadesine
(1 time)
|
Pharmacology
(1 time)
|
NMDA (1 time)
|
1996 Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
|
| 26 |
AICA-ribose
(1 time)
|
Biochemistry
(1 time)
|
AMPK (1 time)
FLCN (1 time)
MNU (1 time)
|
2012 Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
|
| 27 |
AICAR injections
(1 time)
|
Physiology
(1 time)
|
AMPK (1 time)
beta-HAD (1 time)
FFAs (1 time)
|
2010 Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle.
|
| 28 |
AICAR monophosphate
(1 time)
|
Biochemistry
(1 time)
|
AMPK (1 time)
|
2010 Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity.
|
| 29 |
AMP-activated protein kinase
(1 time)
|
Biology
(1 time)
|
CPI-17 (1 time)
MLCK (1 time)
MLCP (1 time)
|
2014 Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain.
|
| 30 |
AMPK in controlling aminoimidazole-4-carboxymide-1-beta-d-ribofuranoside
(1 time)
|
Physiology
(1 time)
|
ACC2 (1 time)
AMPK (1 time)
KD (1 time)
|
2008 AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.
|
| 31 |
AMPK inhibitor, Compound C. AMPK activator
(1 time)
|
|
ACC (1 time)
ACS (1 time)
AMPK (1 time)
|
2010 Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase.
|
| 32 |
AMPK specific activator
(1 time)
|
Cell Biology
(1 time)
|
AMPK (1 time)
MAPK (1 time)
PKB (1 time)
|
2013 Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase.
|
| 33 |
biosynthesis-5-amino-4-imidazolecarboxamide ribotide
(1 time)
|
Biomedical Engineering
(1 time)
|
AICA (1 time)
AICAr (1 time)
IMP (1 time)
|
2006 Diagnosing AICA-ribosiduria by capillary electrophoresis.
|
| 34 |
N1-(beta-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide ribonucleotide
(1 time)
|
Pulmonary Medicine
(1 time)
|
AMPK (1 time)
HMGB1 (1 time)
HO-1 (1 time)
|
2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
|
| 35 |
p-ribosyl-s-amino-imidazole carboxamide
(1 time)
|
Biochemistry
(1 time)
|
FAS (1 time)
|
2006 Cerulenin-mediated apoptosis is involved in adenine metabolic pathway.
|
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