| 1 |
cholesterol 7alpha-hydroxylase
(388 times)
|
Biochemistry
(112 times)
|
FXR (88 times)
SHP (50 times)
TC (44 times)
|
1999 Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter.
|
| 2 |
cytochrome P450 7A1
(39 times)
|
Biochemistry
(8 times)
|
FXR (7 times)
BA (4 times)
LDLR (4 times)
|
2000 A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
|
| 3 |
cytochrome P450 family 7 subfamily A member 1
(14 times)
|
Nutritional Sciences
(3 times)
|
FXR (6 times)
HFD (5 times)
ABCG5 (3 times)
|
2016 High-Molecular-Weight beta-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults.
|
| 4 |
cytochrome P450, family 7, subfamily A, polypeptide 1
(7 times)
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Nutritional Sciences
(3 times)
|
HMGCR (2 times)
ABC (1 time)
ACC (1 time)
|
2007 Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.
|
| 5 |
cholesterol removal is regulated by cholesterol 7alpha-hydroxylase
(4 times)
|
Biochemistry
(2 times)
|
ABCA1 (1 time)
CETP (1 time)
COS (1 time)
|
2003 FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.
|
| 6 |
classic pathway, initiated by microsomal cholesterol 7alpha-hydroxylase
(3 times)
|
Biochemistry
(2 times)
|
BA (1 time)
FGF19 (1 time)
StAR (1 time)
|
2001 Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
|
| 7 |
cholesterol 7alpha-hydroxylase activity
(2 times)
|
Science
(1 time)
|
ALB (1 time)
BMSCs (1 time)
CK-18 (1 time)
|
1998 Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia.
|
| 8 |
cholesterol levels through the activation of cholesterol 7alpha-hydroxylase
(2 times)
|
Complementary Therapies
(1 time)
|
CC (1 time)
GGPP (1 time)
HFD (1 time)
|
2012 Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice.
|
| 9 |
cholesterol-7alpha-monooxygenase
(2 times)
|
Nutritional Sciences
(1 time)
|
betaS (1 time)
gammaT (1 time)
HC (1 time)
|
2016 Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet.
|
| 10 |
contributing to the increased expression of cholesterol 7 alpha-hydroxylase
(2 times)
|
Chemistry
(1 time)
|
BA (1 time)
CGA (1 time)
FGF15 (1 time)
|
2009 Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism.
|
| 11 |
conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase
(2 times)
|
Genetics, Medical
(1 time)
|
CH (1 time)
FD (1 time)
FH (1 time)
|
2004 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals.
|
| 12 |
c-Jun protein and cholesterol 7a-hydroxylase
(1 time)
|
Pharmacology
(1 time)
|
HDL (1 time)
JNK (1 time)
LDL (1 time)
|
2014 Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway.
|
| 13 |
cAMP inhibit cholesterol 7alpha-hydroxylase
(1 time)
|
Gastroenterology
(1 time)
|
cAMP (1 time)
PEPCK (1 time)
PGC-1alpha (1 time)
|
2005 Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
|
| 14 |
can activate cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
ERK (1 time)
MAPK (1 time)
|
2006 A novel regulatory pathway for cholesterol degradation via lactostatin.
|
| 15 |
can activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
ASM (1 time)
DCA (1 time)
FASR (1 time)
|
2003 Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
|
| 16 |
carnitine palmitoyltransferase 1(CPT1), and cholesterol 7 alpha-hydroxylase
(1 time)
|
Nutritional Sciences
(1 time)
|
AKP (1 time)
AST (1 time)
CAT (1 time)
|
2020 Anti-obesity effect of Liupao tea extract by modulating lipid metabolism and oxidative stress in high-fat-diet-induced obese mice.
|
| 17 |
cassette sub-family G member 5/8 (ABCG5/G8) and 7alpha-hydroxylase1
(1 time)
|
Complementary Therapies
(1 time)
|
ACC (1 time)
ERS (1 time)
GIN (1 time)
|
2018 Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress.
|
| 18 |
cassette subfamily G member 5/8 (ABCG5/8), cholesterol 7-alpha hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
ABCB11 (1 time)
CSI (1 time)
FXR (1 time)
|
2020 The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models.
|
| 19 |
cassette subfamily G5/G8 (ABCG5/8), and cholesterol 7 alpha-hydroxylase
(1 time)
|
Food
(1 time)
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AMPK (1 time)
FXR (1 time)
LCAT (1 time)
|
2022 Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet.
|
| 20 |
cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase
(1 time)
|
Food
(1 time)
|
ACC (1 time)
FAS (1 time)
GPx (1 time)
|
2016 Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice.
|
| 21 |
catabolic process mediated by 7-alpha-hydroxylase
(1 time)
|
Molecular Biology
(1 time)
|
BASs (1 time)
HDL-C (1 time)
LRC-CPPT (1 time)
|
2022 Bile Acid Sequestrants for Hypercholesterolemia Treatment Using Sustainable Biopolymers: Recent Advances and Future Perspectives.
|
| 22 |
catalyzed by cholesterol 7alpha-hydroxylase
(1 time)
|
Gastroenterology
(1 time)
|
ACAT (1 time)
CEH (1 time)
HMGR (1 time)
|
2001 Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.
|
| 23 |
catalyzed by the liver-specific enzyme cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
RT-PCR (1 time)
|
1998 Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction.
|
| 24 |
catalyzing the 7alpha-hydroxylation, cholesterol 7alpha-hydroxylase
(1 time)
|
Drug Therapy
(1 time)
|
---
|
2007 The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.
|
| 25 |
cells express cholesterol-7 alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
---
|
2002 Expression of cholesterol-7alpha-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL.
|
| 26 |
cells, and significantly decrease the expression of cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
BSEP (1 time)
FXR (1 time)
NAFLD (1 time)
|
2022 Dihydroflavonoids as Bioactive Components of Penthorum chinense, a Miao Ethnomedicine, against NAFLD through Bile Acid Metabolism Pathway.
|
| 27 |
central to feedback repression of cholesterol 7alpha hydroxylase gene
(1 time)
|
Cell Biology
(1 time)
|
---
|
2004 Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.
|
| 28 |
chain reaction further confirmed the downregulated expression of cholesterol 7-alpha-hydroxylase
(1 time)
|
Pharmacognosy
(1 time)
|
DEGs (1 time)
GO (1 time)
HDL (1 time)
|
2021 Effects of Huatan Jiangzhuo decoction on diet-induced hyperlipidemia and gene expressions in rats.
|
| 29 |
chicken cholesterol 7alpha hydroxylase
(1 time)
|
Molecular Biology
(1 time)
|
HMGR (1 time)
LDLR (1 time)
LXRs (1 time)
|
2010 Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.
|
| 30 |
cholesterol 7a-hydroxylase expression
(1 time)
|
Nutritional Sciences
(1 time)
|
APOE (1 time)
LXRalpha (1 time)
|
2012 Cyanidin-3-O-beta-glucoside upregulates hepatic cholesterol 7alpha-hydroxylase expression and reduces hypercholesterolemia in mice.
|
| 31 |
cholesterol accumulation, because cholesterol 7alpha-hydroxylase
(1 time)
|
Physiology
(1 time)
|
GF (1 time)
HFA (1 time)
HFD (1 time)
|
2019 Whole barley prevents obesity and dyslipidemia without the involvement of the gut microbiota in germ free C57BL/6J obese mice.
|
| 32 |
cholesterol and cholesterol 7alpha-hydroxylase
(1 time)
|
|
mTOR (1 time)
|
2017 Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice.
|
| 33 |
cholesterol biosynthesis, and up-regulated the mRNA of cholesterol 7alpha-hydroxylase
(1 time)
|
Chemistry
(1 time)
|
AAPH (1 time)
AMVN (1 time)
ESR (1 time)
|
2008 Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes.
|
| 34 |
cholesterol concentrations were increased and cholesterol 7alpha-hydroxylase
(1 time)
|
Nutritional Sciences
(1 time)
|
IFP (1 time)
|
2009 The mechanism of the cholesterol-lowering effect of water-insoluble fish protein in ovariectomised rats.
|
| 35 |
cholesterol efflux, such as cholesterol 7 alpha-hydroxylase
(1 time)
|
Food
(1 time)
|
ABCA1 (1 time)
ABCG1 (1 time)
LXRalpha (1 time)
|
2019 Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats.
|
| 36 |
cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene
(1 time)
|
Biochemistry
(1 time)
|
LXRalpha (1 time)
RXR (1 time)
|
2002 Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
|
| 37 |
cholesterol levels and hepatic cholesterol 7alpha-hydroxylase activity
(1 time)
|
Nutritional Sciences
(1 time)
|
CH (1 time)
|
2003 The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid.
|
| 38 |
cholesterol metabolism by affecting activity of hepatic cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
HCMV (1 time)
HDL (1 time)
|
2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.
|
| 39 |
cholesterol metabolism-related enzymes including HMG-CoA reductase and cholesterol 7alpha-hydroxylase
(1 time)
|
Pharmacology
(1 time)
|
AI (1 time)
FTZ (1 time)
HDL-C (1 time)
|
2011 A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
|
| 40 |
cholesterol metabolism-related genes including cholesterol 7alpha-hydroxylase
(1 time)
|
Complementary Therapies
(1 time)
|
CAE (1 time)
FXR (1 time)
LDL-C (1 time)
|
2012 Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats.
|
| 41 |
cholesterol to bile acids by cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
FXR (1 time)
SHP (1 time)
TG (1 time)
|
2008 Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
|
| 42 |
cholesterol via the rate-limiting enzyme cholesterol 7 alpha-hydroxylase
(1 time)
|
Endocrinology
(1 time)
|
BA (1 time)
FGF19 (1 time)
OGTT (1 time)
|
2021 Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women.
|
| 43 |
cholesterol-7alpha-hydroxylase encoding gene
(1 time)
|
Medicine
(1 time)
|
CDCA (1 time)
|
2016 Diurnal variation in cholesterol 7alpha-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.
|
| 44 |
cholesterol-lowering effects of AqLA-L might be up-regulation of cholesterol 7-alpha-hydroxylase
(1 time)
|
Pharmacology
(1 time)
|
ABCA1 (1 time)
HCL (1 time)
HFD (1 time)
|
2020 Aqueous extracts of Lindera aggregate (Sims) Kosterm leaves regulate serum/hepatic lipid and liver function in normal and hypercholesterolemic mice.
|
| 45 |
cMRP group in the level of cholesterol 7 alpha-hydroxylase
(1 time)
|
Veterinary Medicine
(1 time)
|
HMGR (1 time)
MRP (1 time)
wMRP (1 time)
|
2015 Dietary Maillard reaction products and their fermented products reduce cardiovascular risk in an animal model.
|
| 46 |
CO supplementation upregulated the gene expression of hepatic cholesterol 7alpha-hydroxylase
(1 time)
|
Chemistry
(1 time)
|
NCD (1 time)
|
2020 Wild Melon Seed Oil Reduces Plasma Cholesterol and Modulates Gut Microbiota in Hypercholesterolemic Hamsters.
|
| 47 |
Compared with the Sow group, hepatic cholesterol 7alpha hydroxylase
(1 time)
|
Nutritional Sciences
(1 time)
|
SHP (1 time)
|
2018 Infant Formula Feeding Increases Hepatic Cholesterol 7alpha Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets.
|
| 48 |
compared with Xbp1fl/fl mice, indicating reduced cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
UPR (1 time)
|
2017 Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
|
| 49 |
compensatory, same-day, 4-fold induction of hepatic cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
IBAT (1 time)
|
2002 Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94.
|
| 50 |
composition and the expression of cholesterol 7alpha hydroxylase
(1 time)
|
General Surgery
(1 time)
|
BAAT (1 time)
BACS (1 time)
BAs (1 time)
|
2016 Effects of Bariatric Surgery on Serum Bile Acid Composition and Conjugation in a Diabetic Rat Model.
|
| 51 |
composition of bile acids via increasing cholesterol 7a-hydroxylase
(1 time)
|
Chemistry
(1 time)
|
FXR (1 time)
TGF-beta (1 time)
TLR4 (1 time)
|
2021 A Novel Sialoglycopeptide from Gadus morhua Eggs Prevents Liver Fibrosis Induced by CCl4 via Downregulating FXR/FGF15 and TLR4/TGF-beta/Smad Pathways.
|
| 52 |
concentrations of insulin rapidly stimulated cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
FOXO1 (1 time)
SREBP-1c (1 time)
|
2006 Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
|
| 53 |
contrary to the up-regulation of cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
SRE (1 time)
SREBPs (1 time)
|
2004 Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).
|
| 54 |
contributes to repression of the gene encoding cholesterol 7alpha-hydroxylase
(1 time)
|
Gastroenterology
(1 time)
|
ChIP (1 time)
GAPDH (1 time)
HDAC2 (1 time)
|
2014 A GAPDH-mediated trans-nitrosylation pathway is required for feedback inhibition of bile salt synthesis in rat liver.
|
| 55 |
controlled by the enzyme cholesterol 7alpha-hydroxylase
(1 time)
|
Internal Medicine
(1 time)
|
BAs (1 time)
FGF19 (1 time)
|
2006 Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.
|
| 56 |
correlated with increased hepatic expression of the cholesterol 7alpha-hydroxylase 1
(1 time)
|
Endocrinology
(1 time)
|
BA (1 time)
FGF (1 time)
RYGB (1 time)
|
2013 A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass.
|
| 57 |
COS on hepatic cholesterol 7 alpha-hydroxylase
(1 time)
|
Biology
(1 time)
|
COS (1 time)
LDL (1 time)
LDLR (1 time)
|
2012 Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.
|
| 58 |
could upregulate cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
HFD (1 time)
HMGCR (1 time)
LAB (1 time)
|
2021 Enhancing bile tolerance of Lactobacilli is involved in the hypolipidemic effects of liraglutide.
|
| 59 |
COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene
(1 time)
|
Biochemistry
(1 time)
|
BTEB (1 time)
COUP-TFII (1 time)
EMSA (1 time)
|
2000 HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
|
| 60 |
critical regulatory gene in bile acid synthesis, cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
FGF15 (1 time)
FGFR4 (1 time)
FXR (1 time)
|
2009 Bile acids: regulation of synthesis.
|
| 61 |
CYP7 which codes for cholesterol 7alpha-hydroxylase
(1 time)
|
Environmental Health
(1 time)
|
BAs (1 time)
CVDs (1 time)
HNF-4alpha (1 time)
|
2014 Hepatocyte nuclear factor-4alpha, a multifunctional nuclear receptor associated with cardiovascular disease and cholesterol catabolism.
|
| 62 |
cytochrome P450 cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
ABCA1 (1 time)
HNF-4 (1 time)
LXR (1 time)
|
2004 LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.
|
| 63 |
cytomegalovirus effects on human cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry
(1 time)
|
HCMV (1 time)
HDL (1 time)
|
2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.
|
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