1 |
cholesterol 7alpha-hydroxylase
(388 times)
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Biochemistry (112 times)
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FXR (88 times) SHP (50 times) TC (44 times)
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1999 Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter.
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2 |
cytochrome P450 7A1
(39 times)
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Biochemistry (8 times)
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FXR (7 times) BA (4 times) LDLR (4 times)
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2000 A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
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3 |
cytochrome P450 family 7 subfamily A member 1
(14 times)
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Nutritional Sciences (3 times)
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FXR (6 times) HFD (5 times) ABCG5 (3 times)
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2016 High-Molecular-Weight beta-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults.
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4 |
cytochrome P450, family 7, subfamily A, polypeptide 1
(7 times)
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Nutritional Sciences (3 times)
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HMGCR (2 times) ABC (1 time) ACC (1 time)
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2007 Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.
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5 |
cholesterol removal is regulated by cholesterol 7alpha-hydroxylase
(4 times)
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Biochemistry (2 times)
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ABCA1 (1 time) CETP (1 time) COS (1 time)
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2003 FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.
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6 |
classic pathway, initiated by microsomal cholesterol 7alpha-hydroxylase
(3 times)
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Biochemistry (2 times)
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BA (1 time) FGF19 (1 time) StAR (1 time)
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2001 Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
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7 |
cholesterol 7alpha-hydroxylase activity
(2 times)
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Science (1 time)
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ALB (1 time) BMSCs (1 time) CK-18 (1 time)
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1998 Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia.
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8 |
cholesterol levels through the activation of cholesterol 7alpha-hydroxylase
(2 times)
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Complementary Therapies (1 time)
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CC (1 time) GGPP (1 time) HFD (1 time)
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2012 Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice.
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9 |
cholesterol-7alpha-monooxygenase
(2 times)
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Nutritional Sciences (1 time)
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betaS (1 time) gammaT (1 time) HC (1 time)
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2016 Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet.
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10 |
contributing to the increased expression of cholesterol 7 alpha-hydroxylase
(2 times)
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Chemistry (1 time)
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BA (1 time) CGA (1 time) FGF15 (1 time)
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2009 Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism.
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11 |
conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase
(2 times)
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Genetics, Medical (1 time)
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CH (1 time) FD (1 time) FH (1 time)
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2004 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals.
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12 |
c-Jun protein and cholesterol 7a-hydroxylase
(1 time)
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Pharmacology (1 time)
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HDL (1 time) JNK (1 time) LDL (1 time)
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2014 Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway.
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13 |
cAMP inhibit cholesterol 7alpha-hydroxylase
(1 time)
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Gastroenterology (1 time)
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cAMP (1 time) PEPCK (1 time) PGC-1alpha (1 time)
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2005 Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
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14 |
can activate cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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ERK (1 time) MAPK (1 time)
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2006 A novel regulatory pathway for cholesterol degradation via lactostatin.
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15 |
can activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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ASM (1 time) DCA (1 time) FASR (1 time)
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2003 Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
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16 |
carnitine palmitoyltransferase 1(CPT1), and cholesterol 7 alpha-hydroxylase
(1 time)
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Nutritional Sciences (1 time)
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AKP (1 time) AST (1 time) CAT (1 time)
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2020 Anti-obesity effect of Liupao tea extract by modulating lipid metabolism and oxidative stress in high-fat-diet-induced obese mice.
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17 |
cassette sub-family G member 5/8 (ABCG5/G8) and 7alpha-hydroxylase1
(1 time)
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Complementary Therapies (1 time)
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ACC (1 time) ERS (1 time) GIN (1 time)
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2018 Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress.
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18 |
cassette subfamily G member 5/8 (ABCG5/8), cholesterol 7-alpha hydroxylase
(1 time)
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Biochemistry (1 time)
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ABCB11 (1 time) CSI (1 time) FXR (1 time)
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2020 The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models.
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19 |
cassette subfamily G5/G8 (ABCG5/8), and cholesterol 7 alpha-hydroxylase
(1 time)
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Food (1 time)
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AMPK (1 time) FXR (1 time) LCAT (1 time)
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2022 Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet.
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20 |
cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase
(1 time)
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Food (1 time)
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ACC (1 time) FAS (1 time) GPx (1 time)
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2016 Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice.
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21 |
catabolic process mediated by 7-alpha-hydroxylase
(1 time)
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Molecular Biology (1 time)
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BASs (1 time) HDL-C (1 time) LRC-CPPT (1 time)
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2022 Bile Acid Sequestrants for Hypercholesterolemia Treatment Using Sustainable Biopolymers: Recent Advances and Future Perspectives.
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22 |
catalyzed by cholesterol 7alpha-hydroxylase
(1 time)
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Gastroenterology (1 time)
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ACAT (1 time) CEH (1 time) HMGR (1 time)
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2001 Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.
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23 |
catalyzed by the liver-specific enzyme cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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RT-PCR (1 time)
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1998 Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction.
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24 |
catalyzing the 7alpha-hydroxylation, cholesterol 7alpha-hydroxylase
(1 time)
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Drug Therapy (1 time)
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---
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2007 The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.
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25 |
cells express cholesterol-7 alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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---
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2002 Expression of cholesterol-7alpha-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL.
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26 |
cells, and significantly decrease the expression of cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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BSEP (1 time) FXR (1 time) NAFLD (1 time)
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2022 Dihydroflavonoids as Bioactive Components of Penthorum chinense, a Miao Ethnomedicine, against NAFLD through Bile Acid Metabolism Pathway.
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27 |
central to feedback repression of cholesterol 7alpha hydroxylase gene
(1 time)
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Cell Biology (1 time)
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---
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2004 Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.
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28 |
chain reaction further confirmed the downregulated expression of cholesterol 7-alpha-hydroxylase
(1 time)
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Pharmacognosy (1 time)
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DEGs (1 time) GO (1 time) HDL (1 time)
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2021 Effects of Huatan Jiangzhuo decoction on diet-induced hyperlipidemia and gene expressions in rats.
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29 |
chicken cholesterol 7alpha hydroxylase
(1 time)
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Molecular Biology (1 time)
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HMGR (1 time) LDLR (1 time) LXRs (1 time)
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2010 Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.
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30 |
cholesterol 7a-hydroxylase expression
(1 time)
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Nutritional Sciences (1 time)
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APOE (1 time) LXRalpha (1 time)
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2012 Cyanidin-3-O-beta-glucoside upregulates hepatic cholesterol 7alpha-hydroxylase expression and reduces hypercholesterolemia in mice.
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31 |
cholesterol accumulation, because cholesterol 7alpha-hydroxylase
(1 time)
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Physiology (1 time)
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GF (1 time) HFA (1 time) HFD (1 time)
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2019 Whole barley prevents obesity and dyslipidemia without the involvement of the gut microbiota in germ free C57BL/6J obese mice.
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32 |
cholesterol and cholesterol 7alpha-hydroxylase
(1 time)
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mTOR (1 time)
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2017 Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice.
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33 |
cholesterol biosynthesis, and up-regulated the mRNA of cholesterol 7alpha-hydroxylase
(1 time)
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Chemistry (1 time)
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AAPH (1 time) AMVN (1 time) ESR (1 time)
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2008 Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes.
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34 |
cholesterol concentrations were increased and cholesterol 7alpha-hydroxylase
(1 time)
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Nutritional Sciences (1 time)
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IFP (1 time)
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2009 The mechanism of the cholesterol-lowering effect of water-insoluble fish protein in ovariectomised rats.
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35 |
cholesterol efflux, such as cholesterol 7 alpha-hydroxylase
(1 time)
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Food (1 time)
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ABCA1 (1 time) ABCG1 (1 time) LXRalpha (1 time)
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2019 Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats.
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36 |
cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene
(1 time)
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Biochemistry (1 time)
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LXRalpha (1 time) RXR (1 time)
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2002 Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
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37 |
cholesterol levels and hepatic cholesterol 7alpha-hydroxylase activity
(1 time)
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Nutritional Sciences (1 time)
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CH (1 time)
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2003 The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid.
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38 |
cholesterol metabolism by affecting activity of hepatic cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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HCMV (1 time) HDL (1 time)
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2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.
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39 |
cholesterol metabolism-related enzymes including HMG-CoA reductase and cholesterol 7alpha-hydroxylase
(1 time)
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Pharmacology (1 time)
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AI (1 time) FTZ (1 time) HDL-C (1 time)
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2011 A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
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40 |
cholesterol metabolism-related genes including cholesterol 7alpha-hydroxylase
(1 time)
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Complementary Therapies (1 time)
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CAE (1 time) FXR (1 time) LDL-C (1 time)
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2012 Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats.
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41 |
cholesterol to bile acids by cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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FXR (1 time) SHP (1 time) TG (1 time)
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2008 Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
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42 |
cholesterol via the rate-limiting enzyme cholesterol 7 alpha-hydroxylase
(1 time)
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Endocrinology (1 time)
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BA (1 time) FGF19 (1 time) OGTT (1 time)
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2021 Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women.
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43 |
cholesterol-7alpha-hydroxylase encoding gene
(1 time)
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Medicine (1 time)
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CDCA (1 time)
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2016 Diurnal variation in cholesterol 7alpha-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.
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44 |
cholesterol-lowering effects of AqLA-L might be up-regulation of cholesterol 7-alpha-hydroxylase
(1 time)
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Pharmacology (1 time)
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ABCA1 (1 time) HCL (1 time) HFD (1 time)
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2020 Aqueous extracts of Lindera aggregate (Sims) Kosterm leaves regulate serum/hepatic lipid and liver function in normal and hypercholesterolemic mice.
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45 |
cMRP group in the level of cholesterol 7 alpha-hydroxylase
(1 time)
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Veterinary Medicine (1 time)
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HMGR (1 time) MRP (1 time) wMRP (1 time)
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2015 Dietary Maillard reaction products and their fermented products reduce cardiovascular risk in an animal model.
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46 |
CO supplementation upregulated the gene expression of hepatic cholesterol 7alpha-hydroxylase
(1 time)
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Chemistry (1 time)
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NCD (1 time)
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2020 Wild Melon Seed Oil Reduces Plasma Cholesterol and Modulates Gut Microbiota in Hypercholesterolemic Hamsters.
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47 |
Compared with the Sow group, hepatic cholesterol 7alpha hydroxylase
(1 time)
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Nutritional Sciences (1 time)
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SHP (1 time)
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2018 Infant Formula Feeding Increases Hepatic Cholesterol 7alpha Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets.
|
48 |
compared with Xbp1fl/fl mice, indicating reduced cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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UPR (1 time)
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2017 Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
|
49 |
compensatory, same-day, 4-fold induction of hepatic cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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IBAT (1 time)
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2002 Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94.
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50 |
composition and the expression of cholesterol 7alpha hydroxylase
(1 time)
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General Surgery (1 time)
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BAAT (1 time) BACS (1 time) BAs (1 time)
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2016 Effects of Bariatric Surgery on Serum Bile Acid Composition and Conjugation in a Diabetic Rat Model.
|
51 |
composition of bile acids via increasing cholesterol 7a-hydroxylase
(1 time)
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Chemistry (1 time)
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FXR (1 time) TGF-beta (1 time) TLR4 (1 time)
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2021 A Novel Sialoglycopeptide from Gadus morhua Eggs Prevents Liver Fibrosis Induced by CCl4 via Downregulating FXR/FGF15 and TLR4/TGF-beta/Smad Pathways.
|
52 |
concentrations of insulin rapidly stimulated cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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FOXO1 (1 time) SREBP-1c (1 time)
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2006 Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
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53 |
contrary to the up-regulation of cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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SRE (1 time) SREBPs (1 time)
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2004 Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).
|
54 |
contributes to repression of the gene encoding cholesterol 7alpha-hydroxylase
(1 time)
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Gastroenterology (1 time)
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ChIP (1 time) GAPDH (1 time) HDAC2 (1 time)
|
2014 A GAPDH-mediated trans-nitrosylation pathway is required for feedback inhibition of bile salt synthesis in rat liver.
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55 |
controlled by the enzyme cholesterol 7alpha-hydroxylase
(1 time)
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Internal Medicine (1 time)
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BAs (1 time) FGF19 (1 time)
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2006 Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.
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56 |
correlated with increased hepatic expression of the cholesterol 7alpha-hydroxylase 1
(1 time)
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Endocrinology (1 time)
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BA (1 time) FGF (1 time) RYGB (1 time)
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2013 A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass.
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57 |
COS on hepatic cholesterol 7 alpha-hydroxylase
(1 time)
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Biology (1 time)
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COS (1 time) LDL (1 time) LDLR (1 time)
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2012 Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.
|
58 |
could upregulate cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
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HFD (1 time) HMGCR (1 time) LAB (1 time)
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2021 Enhancing bile tolerance of Lactobacilli is involved in the hypolipidemic effects of liraglutide.
|
59 |
COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene
(1 time)
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Biochemistry (1 time)
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BTEB (1 time) COUP-TFII (1 time) EMSA (1 time)
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2000 HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
|
60 |
critical regulatory gene in bile acid synthesis, cholesterol 7alpha-hydroxylase
(1 time)
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Biochemistry (1 time)
|
FGF15 (1 time) FGFR4 (1 time) FXR (1 time)
|
2009 Bile acids: regulation of synthesis.
|
61 |
CYP7 which codes for cholesterol 7alpha-hydroxylase
(1 time)
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Environmental Health (1 time)
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BAs (1 time) CVDs (1 time) HNF-4alpha (1 time)
|
2014 Hepatocyte nuclear factor-4alpha, a multifunctional nuclear receptor associated with cardiovascular disease and cholesterol catabolism.
|
62 |
cytochrome P450 cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry (1 time)
|
ABCA1 (1 time) HNF-4 (1 time) LXR (1 time)
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2004 LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.
|
63 |
cytomegalovirus effects on human cholesterol 7alpha-hydroxylase
(1 time)
|
Biochemistry (1 time)
|
HCMV (1 time) HDL (1 time)
|
2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.
|