| 1 |
double knockout
(712 times)
|
Cell Biology
(62 times)
|
WT (129 times)
KO (56 times)
DMD (26 times)
|
1995 Targeted disruption of CD44 in MDAY-D2 lymphosarcoma cells has no effect on subcutaneous growth or metastatic capacity.
|
| 2 |
double KO
(102 times)
|
Biochemistry
(18 times)
|
KO (66 times)
WT (20 times)
APOE (9 times)
|
2000 Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression.
|
| 3 |
double knockout mice
(38 times)
|
Neurology
(7 times)
|
WT (5 times)
ACEI (2 times)
ACs (2 times)
|
2003 Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation.
|
| 4 |
double-gene-knockout
(3 times)
|
Cell Biology
(1 time)
|
2-APB (1 time)
COX-2 (1 time)
G proteins (1 time)
|
2002 Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts.
|
| 5 |
double knockout mouse model
(2 times)
|
Cardiology
(1 time)
|
AMD (1 time)
CaMKII (1 time)
CNV (1 time)
|
2016 Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
|
| 6 |
ApoE-double KO
(1 time)
|
Biochemistry
(1 time)
|
ATGL (1 time)
CGI-58 (1 time)
|
2014 Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
|
| 7 |
ATF3-double-KO
(1 time)
|
Heart Diseases
(1 time)
|
IRF7 (2 times)
ATF3 (1 time)
DTG (1 time)
|
2014 Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation.
|
| 8 |
cell-depleted RAG1-/- mice or RAG2-/-IL2rgamma-/-double knock-out
(1 time)
|
|
aGVHD (1 time)
HSCT (1 time)
|
2019 Induction of acute graft vs. host disease in lymphopenic mice.
|
| 9 |
defects were exacerbated in mir-486 KO:mdx 5cv
(1 time)
|
Biological Science Disciplines
(1 time)
|
DMD (1 time)
mir-486 KO (1 time)
|
2022 miR-486 is essential for muscle function and suppresses a dystrophic transcriptome.
|
| 10 |
deficient for Bax, Bak
(1 time)
|
Biochemistry
(1 time)
|
ER (1 time)
|
2003 Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
|
| 11 |
delta-subunit knockout
(1 time)
|
Drug Therapy
(1 time)
|
TSPO (1 time)
|
2015 Antiseizure Activity of Midazolam in Mice Lacking delta-Subunit Extrasynaptic GABA(A) Receptors.
|
| 12 |
desmin knockout
(1 time)
|
Genetics, Medical
(1 time)
|
AAV (1 time)
AAV-Des (1 time)
DKI (1 time)
|
2020 AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies.
|
| 13 |
Divya-Kayakalp-Oil
(1 time)
|
Complementary Therapies
(1 time)
|
DKV (1 time)
DKV-O (1 time)
IL (1 time)
|
2022 Modulation of psoriatic-like skin inflammation by traditional Indian medicine Divya-Kayakalp-Vati and Oil through attenuation of pro-inflammatory cytokines.
|
| 14 |
DKO-hu
(1 time)
|
Hematology
(1 time)
|
pDCs (1 time)
|
2011 Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻gamma C⁻/⁻ mice in vivo.
|
| 15 |
domain knockout mice on an apolipoprotein E knockout background
(1 time)
|
Biochemistry
(1 time)
|
NASH (1 time)
NMR (1 time)
|
2018 Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.
|
| 16 |
don't know option
(1 time)
|
Education
(1 time)
|
FS (1 time)
NR (1 time)
|
2015 The don't know option in progress testing.
|
| 17 |
double gene knockout zebrafish
(1 time)
|
Biochemistry
(1 time)
|
LCPUFAs (1 time)
PE-DHA (1 time)
WT (1 time)
|
2020 Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 invivo.
|
| 18 |
double knockout animals
(1 time)
|
Neoplasms
(1 time)
|
ABCA1 (1 time)
apoA-I (1 time)
HDL (1 time)
|
2017 Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
|
| 19 |
double knockout of FXR and SHP signaling
(1 time)
|
Gastroenterology
(1 time)
|
FXR (1 time)
SHP (1 time)
|
2017 Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.
|
| 20 |
double knockout with diabetes spontaneous mutation (Leprdb)
(1 time)
|
Biology
(1 time)
|
AhR (1 time)
AhR KO (1 time)
DR (1 time)
|
2022 Aryl hydrocarbon receptor deficiency augments dysregulated microangiogenesis and diabetic retinopathy.
|
| 21 |
double KO model
(1 time)
|
Cells
(1 time)
|
CPVT (1 time)
KO (1 time)
mPTP (1 time)
|
2023 Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.
|
| 22 |
double KO of Akita/MMP-9(-/-)
(1 time)
|
Biochemistry
(1 time)
|
Cxs (1 time)
ECM (1 time)
MMP-9 (1 time)
|
2015 MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator.
|
| 23 |
Double receptor knockout
(1 time)
|
Psychopharmacology
(1 time)
|
MCR (1 time)
WT (1 time)
|
2010 Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors.
|
| 24 |
double-knockout mutant
(1 time)
|
Environmental Health
(1 time)
|
---
|
2021 High-Affinity Sulfate Transporter Sultr1;2 Is a Major Transporter for Cr(VI) Uptake in Plants.
|
| 25 |
double-mutant knockout
(1 time)
|
Genetics, Medical
(1 time)
|
---
|
2006 Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
|
| 26 |
double-receptor knockout mice
(1 time)
|
Cardiology
(1 time)
|
I/R (1 time)
MIP (1 time)
MPG (1 time)
|
2001 Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals.
|
| 27 |
Ductal TAZ-knockout
(1 time)
|
Cell Biology
(1 time)
|
CCN2 (1 time)
CTGF (1 time)
DDC (1 time)
|
2022 CD133-Src-TAZ signaling stimulates ductal fibrosis following DDC diet-induced liver injury.
|
| 28 |
during capsid formation using ORF7-KO-, ORF7&17-double-KO
(1 time)
|
Virology
(1 time)
|
HSV-1 (1 time)
KO (1 time)
KSHV (1 time)
|
2022 The Contribution of Kaposi's Sarcoma-Associated Herpesvirus ORF7 and Its Zinc-Finger Motif to Viral Genome Cleavage and Capsid Formation.
|
| 29 |
GPR40-double knockout
(1 time)
|
Diabetes Mellitus
(1 time)
|
GIP (1 time)
GPR (1 time)
|
2019 Free fatty acid receptors, Gprotein-coupled receptor120 and Gprotein-coupled receptor40, are essential for oil-induced gastric inhibitory polypeptide secretion.
|
| 30 |
H2-D(b)-double knockout
(1 time)
|
Allergy and Immunology
(1 time)
|
Tg (1 time)
|
2002 Human MHC class I transgenic mice deficient for H2 class I expression facilitate identification and characterization of new HLA class I-restricted viral T cell epitopes.
|
| 31 |
Nrf2-Ucp2-double knockout
(1 time)
|
Biochemistry
(1 time)
|
NRF2 (1 time)
Nrf2-KO (1 time)
UCP2 (1 time)
|
2016 The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an invivo gene knockout study.
|
| 32 |
Pbx3-deficient genetic background
(1 time)
|
Anatomy
(1 time)
|
HSPCs (1 time)
|
2016 Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
|
| 33 |
PKCdelta-double knockout
(1 time)
|
Allergy and Immunology
(1 time)
|
BAFF-R (1 time)
BCR (1 time)
PKCdelta (1 time)
|
2006 Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation.
|
| 34 |
Ptpro-double-KO
(1 time)
|
Neurology
(1 time)
|
KO (1 time)
PTPRJ (1 time)
Ptprj-KO (1 time)
|
2018 Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.
|
| 35 |
TLR9-IRF3-double-KO
(1 time)
|
Molecular Biology
(1 time)
|
DCs (1 time)
IFN (1 time)
KO (1 time)
|
2010 TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.
|
| 36 |
utrophin-double-knockout
(1 time)
|
Cell Biology
(1 time)
|
DMD (1 time)
WT (1 time)
|
2014 Immunoproteasome in animal models of Duchenne muscular dystrophy.
|
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