1 |
double knockout
(712 times)
|
Cell Biology (62 times)
|
WT (129 times) KO (56 times) DMD (26 times)
|
1995 Targeted disruption of CD44 in MDAY-D2 lymphosarcoma cells has no effect on subcutaneous growth or metastatic capacity.
|
2 |
double KO
(102 times)
|
Biochemistry (18 times)
|
KO (66 times) WT (20 times) APOE (9 times)
|
2000 Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression.
|
3 |
double knockout mice
(38 times)
|
Neurology (7 times)
|
WT (5 times) ACEI (2 times) ACs (2 times)
|
2003 Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation.
|
4 |
double-gene-knockout
(3 times)
|
Cell Biology (1 time)
|
2-APB (1 time) COX-2 (1 time) G proteins (1 time)
|
2002 Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts.
|
5 |
double knockout mouse model
(2 times)
|
Cardiology (1 time)
|
AMD (1 time) CaMKII (1 time) CNV (1 time)
|
2016 Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
|
6 |
ApoE-double KO
(1 time)
|
Biochemistry (1 time)
|
ATGL (1 time) CGI-58 (1 time)
|
2014 Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
|
7 |
ATF3-double-KO
(1 time)
|
Heart Diseases (1 time)
|
IRF7 (2 times) ATF3 (1 time) DTG (1 time)
|
2014 Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation.
|
8 |
cell-depleted RAG1-/- mice or RAG2-/-IL2rgamma-/-double knock-out
(1 time)
|
|
aGVHD (1 time) HSCT (1 time)
|
2019 Induction of acute graft vs. host disease in lymphopenic mice.
|
9 |
defects were exacerbated in mir-486 KO:mdx 5cv
(1 time)
|
Biological Science Disciplines (1 time)
|
DMD (1 time) mir-486 KO (1 time)
|
2022 miR-486 is essential for muscle function and suppresses a dystrophic transcriptome.
|
10 |
deficient for Bax, Bak
(1 time)
|
Biochemistry (1 time)
|
ER (1 time)
|
2003 Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
|
11 |
delta-subunit knockout
(1 time)
|
Drug Therapy (1 time)
|
TSPO (1 time)
|
2015 Antiseizure Activity of Midazolam in Mice Lacking delta-Subunit Extrasynaptic GABA(A) Receptors.
|
12 |
desmin knockout
(1 time)
|
Genetics, Medical (1 time)
|
AAV (1 time) AAV-Des (1 time) DKI (1 time)
|
2020 AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies.
|
13 |
Divya-Kayakalp-Oil
(1 time)
|
Complementary Therapies (1 time)
|
DKV (1 time) DKV-O (1 time) IL (1 time)
|
2022 Modulation of psoriatic-like skin inflammation by traditional Indian medicine Divya-Kayakalp-Vati and Oil through attenuation of pro-inflammatory cytokines.
|
14 |
DKO-hu
(1 time)
|
Hematology (1 time)
|
pDCs (1 time)
|
2011 Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻gamma C⁻/⁻ mice in vivo.
|
15 |
domain knockout mice on an apolipoprotein E knockout background
(1 time)
|
Biochemistry (1 time)
|
NASH (1 time) NMR (1 time)
|
2018 Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.
|
16 |
don't know option
(1 time)
|
Education (1 time)
|
FS (1 time) NR (1 time)
|
2015 The don't know option in progress testing.
|
17 |
double gene knockout zebrafish
(1 time)
|
Biochemistry (1 time)
|
LCPUFAs (1 time) PE-DHA (1 time) WT (1 time)
|
2020 Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 invivo.
|
18 |
double knockout animals
(1 time)
|
Neoplasms (1 time)
|
ABCA1 (1 time) apoA-I (1 time) HDL (1 time)
|
2017 Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
|
19 |
double knockout of FXR and SHP signaling
(1 time)
|
Gastroenterology (1 time)
|
FXR (1 time) SHP (1 time)
|
2017 Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.
|
20 |
double knockout with diabetes spontaneous mutation (Leprdb)
(1 time)
|
Biology (1 time)
|
AhR (1 time) AhR KO (1 time) DR (1 time)
|
2022 Aryl hydrocarbon receptor deficiency augments dysregulated microangiogenesis and diabetic retinopathy.
|
21 |
double KO model
(1 time)
|
Cells (1 time)
|
CPVT (1 time) KO (1 time) mPTP (1 time)
|
2023 Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.
|
22 |
double KO of Akita/MMP-9(-/-)
(1 time)
|
Biochemistry (1 time)
|
Cxs (1 time) ECM (1 time) MMP-9 (1 time)
|
2015 MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator.
|
23 |
Double receptor knockout
(1 time)
|
Psychopharmacology (1 time)
|
MCR (1 time) WT (1 time)
|
2010 Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors.
|
24 |
double-knockout mutant
(1 time)
|
Environmental Health (1 time)
|
---
|
2021 High-Affinity Sulfate Transporter Sultr1;2 Is a Major Transporter for Cr(VI) Uptake in Plants.
|
25 |
double-mutant knockout
(1 time)
|
Genetics, Medical (1 time)
|
---
|
2006 Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
|
26 |
double-receptor knockout mice
(1 time)
|
Cardiology (1 time)
|
I/R (1 time) MIP (1 time) MPG (1 time)
|
2001 Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals.
|
27 |
Ductal TAZ-knockout
(1 time)
|
Cell Biology (1 time)
|
CCN2 (1 time) CTGF (1 time) DDC (1 time)
|
2022 CD133-Src-TAZ signaling stimulates ductal fibrosis following DDC diet-induced liver injury.
|
28 |
during capsid formation using ORF7-KO-, ORF7&17-double-KO
(1 time)
|
Virology (1 time)
|
HSV-1 (1 time) KO (1 time) KSHV (1 time)
|
2022 The Contribution of Kaposi's Sarcoma-Associated Herpesvirus ORF7 and Its Zinc-Finger Motif to Viral Genome Cleavage and Capsid Formation.
|
29 |
GPR40-double knockout
(1 time)
|
Diabetes Mellitus (1 time)
|
GIP (1 time) GPR (1 time)
|
2019 Free fatty acid receptors, Gprotein-coupled receptor120 and Gprotein-coupled receptor40, are essential for oil-induced gastric inhibitory polypeptide secretion.
|
30 |
H2-D(b)-double knockout
(1 time)
|
Allergy and Immunology (1 time)
|
Tg (1 time)
|
2002 Human MHC class I transgenic mice deficient for H2 class I expression facilitate identification and characterization of new HLA class I-restricted viral T cell epitopes.
|
31 |
Nrf2-Ucp2-double knockout
(1 time)
|
Biochemistry (1 time)
|
NRF2 (1 time) Nrf2-KO (1 time) UCP2 (1 time)
|
2016 The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an invivo gene knockout study.
|
32 |
Pbx3-deficient genetic background
(1 time)
|
Anatomy (1 time)
|
HSPCs (1 time)
|
2016 Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
|
33 |
PKCdelta-double knockout
(1 time)
|
Allergy and Immunology (1 time)
|
BAFF-R (1 time) BCR (1 time) PKCdelta (1 time)
|
2006 Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation.
|
34 |
Ptpro-double-KO
(1 time)
|
Neurology (1 time)
|
KO (1 time) PTPRJ (1 time) Ptprj-KO (1 time)
|
2018 Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.
|
35 |
TLR9-IRF3-double-KO
(1 time)
|
Molecular Biology (1 time)
|
DCs (1 time) IFN (1 time) KO (1 time)
|
2010 TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.
|
36 |
utrophin-double-knockout
(1 time)
|
Cell Biology (1 time)
|
DMD (1 time) WT (1 time)
|
2014 Immunoproteasome in animal models of Duchenne muscular dystrophy.
|