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Abbreviation: HAD
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Long forms: 154

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
Hospital Anxiety and Depression
(647 times)
Medicine
(77 times)
VAS (42 times)
QoL (41 times)
SF-36 (38 times)
1988 Patterns of psychiatric morbidity in a genito-urinary clinic. A validation of the Hospital Anxiety Depression scale (HAD).
HIV-associated dementia
(343 times)
Neurology
(149 times)
HAND (56 times)
CNS (52 times)
HIV-1 (46 times)
1995 Bartonella (Rochalimaea) antibodies, dementia, and cat ownership among men infected with human immunodeficiency virus.
haloacid dehalogenase
(115 times)
Biochemistry
(53 times)
PSP (6 times)
beta-PGM (3 times)
FMN (3 times)
1994 Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes.
3-hydroxyacyl-CoA dehydrogenase
(110 times)
Physiology
(44 times)
CS (54 times)
LDH (30 times)
PFK (11 times)
1976 Ultrastructure and biochemical function of skeletal muscle in twins.
high-alcohol-drinking
(71 times)
Substance-Related Disorders
(39 times)
LAD (42 times)
NP (19 times)
ADE (5 times)
1989 Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats.
hot air drying
(37 times)
Food
(16 times)
FD (12 times)
FIRD (5 times)
MVD (5 times)
2009 Effects of different types of yam (Dioscorea alata) products on the blood pressure of spontaneously hypertensive rats.
hemadsorption
(29 times)
Virology
(11 times)
NDV (7 times)
HN (6 times)
ASFV (4 times)
1968 Hemadsorption of mumps virus examined by light and electron microscopy.
host-associated differentiation
(14 times)
Biology
(7 times)
AFLP (2 times)
CFH (1 time)
dbRDA (1 time)
2006 Host-associated genetic differentiation in phytophagous insects: general phenomenon or isolated exceptions? Evidence from a goldenrod-insect community.
hospitalization-associated disability
(9 times)
Geriatrics
(3 times)
CI (3 times)
ADL (2 times)
ADLs (2 times)
2015 Hospitalization-Associated Disability in Adults Admitted to a Safety-Net Hospital.
10  haloacid dehalogenase-like hydrolase
(8 times)
Microbiology
(3 times)
ABH (1 time)
AZC (1 time)
FSM (1 time)
2009 Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA.
11  heterotrophic and autotrophic denitrification
(8 times)
Environmental Health
(4 times)
AD (2 times)
HD (2 times)
CEHAD (1 time)
2012 Behavior of autotrophic denitrification and heterotrophic denitrification in an intensified biofilm-electrode reactor for nitrate-contaminated drinking water treatment.
12  H-bond-mediated aglycone delivery
(7 times)
Biochemistry
(5 times)
DMTST (1 time)
Pico (1 time)
2015 Hydrogen-bond-mediated aglycone delivery (HAD): a highly stereoselective synthesis of 1,2-cis alpha-D-glucosides from common glycosyl donors in the presence of bromine.
13  3-OH-acyl-CoA-dehydrogenase
(6 times)
Physiology
(3 times)
CS (6 times)
LDH (4 times)
BF (1 time)
1984 Fiber types and metabolic characteristics in muscles of wild boars, normal and halothane sensitive Swedish landrace pigs.
14  Hirschsprung's disease allied disorder
(6 times)
Pediatrics
(4 times)
MP (2 times)
HD (1 time)
IDs (1 time)
2000 Functional ileus in neonates: Hirschsprung's disease-allied disorders versus meconium-related ileus.
15  HIV dementia
(6 times)
Neurology
(2 times)
HIV (2 times)
ART (1 time)
BBB (1 time)
1999 Neurological characteristics of HIV-infected men and women seeking primary medical care.
16  hydrogen attachment/abstraction dissociation
(6 times)
Chemistry Techniques, Analytical
(5 times)
MS/MS (3 times)
MALDI (2 times)
DFT (1 time)
2016 Hydrogen Attachment/Abstraction Dissociation (HAD) of Gas-Phase Peptide Ions for Tandem Mass Spectrometry.
17  height-for-age difference
(5 times)
Nutritional Sciences
(2 times)
DHS (2 times)
HAZ (2 times)
COHORTS (1 time)
2015 Gender perceptions predict sex differences in growth patterns of indigenous Guatemalan infants and young children.
18  hospital anxiety and depression questionnaire
(5 times)
Obstetrics
(1 time)
ACT (1 time)
AQLQ (1 time)
BMI (1 time)
2004 [Effects of intervening measures on postpartum depression].
19  hospital-acquired diarrhea
(5 times)
Digestive System Diseases
(1 time)
CAD (3 times)
aRR (1 time)
CDI (1 time)
2012 [Investigation of adenovirus infection in hospitalized children with diarrhea during 2010 in Beijing, China].
20  hospital-associated deconditioning
(5 times)
Rehabilitation
(2 times)
FIM (2 times)
CI (1 time)
MMSE (1 time)
2013 [Length and outcome of acute inpatient rehabilitation for hospital-associated deconditioning in the elderly].
21  Hunan aqueous drainage
(5 times)
Ophthalmology
(2 times)
IOP (2 times)
MMC (1 time)
SLM (1 time)
1997 [A histopathological study on Hunan aqueous drainage implantation in rabbit's eye].
22  3-Hydroxyanthranilate-3,4-dioxygenase
(4 times)
Biochemistry
(2 times)
ACMS, 2 (1 time)
2005 The pyridine ring of NAD is formed by a nonenzymatic pericyclic reaction.
23  healthy leaf area duration
(4 times)
Botany
(3 times)
AUDPC (2 times)
HAA (2 times)
HLAI (2 times)
1997 Angular leaf spot of phaseolus beans: relationships between disease, healthy leaf area, and yield.
24  hepatic arterial dominant
(4 times)
Radiology
(3 times)
HCC (2 times)
TACE (2 times)
CDT (1 time)
2008 Angiographic evaluation of hepatic arterial damage after transarterial chemoembolization for hepatocellular carcinoma.
25  high AGEs diet
(4 times)
Endocrinology
(1 time)
AGEs (3 times)
AGE (1 time)
CML (1 time)
2002 Lowering of dietary advanced glycation endproducts (AGE) reduces neointimal formation after arterial injury in genetically hypercholesterolemic mice.
26  hydrogen-bond-assisted aglycon delivery
(4 times)
Chemistry
(4 times)
DMTST (1 time)
2014 Hydrogen bond mediated aglycone delivery: synthesis of linear and branched alpha-glucans.
27  healthy American diet
(3 times)
Nutritional Sciences
(2 times)
DASH (3 times)
BOLD (2 times)
SFA (2 times)
2011 Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins.
28  height-adjustable desks
(3 times)
Environmental Health
(2 times)
ABW (2 times)
PA (2 times)
SB (2 times)
2017 Who uses height-adjustable desks? - Sociodemographic, health-related, and psycho-social variables of regular users.
29  high-affinity desensitization
(3 times)
Pharmacology
(3 times)
ATP (3 times)
2006 Experimental and modeling studies of desensitization of P2X3 receptors.
30  high-altitude disease
(3 times)
Veterinary Medicine
(2 times)
PAP (2 times)
BWT (1 time)
CSU-BIC (1 time)
2006 Examination of potential methods to predict pulmonary arterial pressure score in yearling beef cattle.
31  highly active disease
(3 times)
Neurology
(3 times)
SC IFNB-1a (3 times)
MRI (2 times)
CARE-MS (1 time)
2019 Impact of alemtuzumab on health-related quality of life over 6 years in CARE-MS II trial extension patients with relapsing-remitting multiple sclerosis.
32  highly automated driving
(3 times)
Psychology
(2 times)
TOR (2 times)
NDR (1 time)
NDRTs (1 time)
2018 The effects of takeover request modalities on highly automated car control transitions.
33  horizontal adduction
(3 times)
Sports Medicine
(1 time)
IR (2 times)
ER (1 time)
EXT (1 time)
2014 A comparison of range of motion change across four posterior shoulder tightness measurements after external rotator fatigue.
34  human adjuvant disease
(3 times)
Pulmonary Medicine
(1 time)
CFS (1 time)
1994 Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.
35  human immunodeficiency virus-associated dementia
(3 times)
Neurology
(2 times)
CNS (2 times)
AD (1 time)
BBB (1 time)
1998 Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia.
36  hyperspectral anomaly detection
(3 times)
Cybernetics
(2 times)
OPD (2 times)
AD (1 time)
ALDR (1 time)
2021 Weakly Supervised Low-Rank Representation for Hyperspectral Anomaly Detection.
37  hyperstriatum accessorium/dorsale
(3 times)
Behavioral Sciences
(2 times)
ANC (3 times)
LNH (3 times)
MNH (3 times)
1988 Isolation-dependent enhancement of 2-[14C]deoxyglucose uptake in the forebrain of zebra finch males.
38  3beta-hydroxyandrosta-5,16-diene
(2 times)
Biochemistry
(1 time)
ADEK (2 times)
AR (2 times)
DHEA (1 time)
2005 Identification of steroid derivatives that function as potent antiandrogens.
39  HangAm-Dan
(2 times)
Pulmonary Medicine
(1 time)
EWCC (1 time)
HER2 (1 time)
NSCLC (1 time)
2010 Prospective analysis on survival outcomes of nonsmall cell lung cancer stages over IIIb treated with HangAm-Dan.
40  hazardous alcohol drinking
(2 times)
Molecular Biology
(1 time)
AUC (1 time)
DNAm (1 time)
EWAS (1 time)
2017 Predicting the onset of hazardous alcohol drinking in primary care: development and validation of a simple risk algorithm.
41  health administrative databases
(2 times)
Medicine
(2 times)
EGB (1 time)
LTC (1 time)
MICE (1 time)
2015 Potentially inappropriate prescribing (PIP) in long-term care (LTC) patients: validation of the 2014 STOPP-START and 2012 Beers criteria in a LTC population--a protocol for a cross-sectional comparison of clinical and health administrative data.
42  high-arginine diet
(2 times)
Food
(1 time)
HFD (1 time)
ND (1 time)
2016 The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia.
43  hippocampal afterdischarges
(2 times)
Physiology
(1 time)
CN (1 time)
GP (1 time)
GPi (1 time)
1984 Hippocampal afterdischarge interferes with storage of spatial information in a working memory test.
44  Hospital Depression and Anxiety
(2 times)
Nursing
(1 time)
CHF (1 time)
SDS (1 time)
THI (1 time)
2008 Fatigue in patients with chronic heart failure - a burden associated with emotional and symptom distress.
45  hospital-associated decline
(2 times)
Nursing
(2 times)
CI (1 time)
OR (1 time)
2021 Mealtime and patient factors associated with meal completion in hospitalised older patients: An exploratory observation study.
46  human alpha-defensin
(2 times)
Chemistry
(1 time)
hBD (2 times)
BALF (1 time)
IL (1 time)
2001 Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection.
47  hyaluronan amide derivative
(2 times)
Biomedical Engineering
(1 time)
HA (1 time)
hGH (1 time)
hMSCs (1 time)
2015 Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes.
48  hyaluronic acid dialdehyde
(2 times)
Histology
(1 time)
CH (1 time)
siRNA (1 time)
2018 Hyaluronic Acid Dictates Chondrocyte Morphology and Migration in Composite Gels.
49  3-hydroxy-acyl-CoA-dehydrogenase activity
(1 time)
Biophysics
(1 time)
CS (1 time)
T2D (1 time)
2005 Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect.
50  3-OH-acyl-coenzyme A-dehydrogenase
(1 time)
Veterinary Medicine
(1 time)
ASAT (1 time)
CK (1 time)
CS (1 time)
1995 Supplementation of broiler diets with all-rac-alpha- or a mixture of natural source RRR-alpha-,gamma-,delta-tocopheryl acetate. 1. effect on vitamin E status of broilers in vivo and at slaughter.
51  4-Hydroxyandrost-4-ene-3,17-dione
(1 time)
Biochemistry
(1 time)
--- 1986 Metabolism of the aromatase inhibitor 4-hydroxyandrostenedione in vivo. Identification of the glucuronide as a major urinary metabolite in patients and biliary metabolite in the rat.
52  beta-hydroxyacyl-ACP dehydratase
(1 time)
Plant Physiological Phenomena
(1 time)
TEM (1 time)
zl16 (1 time)
2018 Identification and Phenotypic Characterization of ZEBRA LEAF16 Encoding a beta-Hydroxyacyl-ACP Dehydratase in Rice.
53  HA combined with demineralized bone
(1 time)
General Surgery
(1 time)
HA (1 time)
HAB (1 time)
HAO (1 time)
1987 Mandibular augmentation in dogs with hydroxylapatite combined with demineralized bone.
54  HA decay
(1 time)
Sports Medicine
(1 time)
HA (1 time)
HR (1 time)
HRA (1 time)
2017 Heat Acclimation Decay and Re-Induction: A Systematic Review and Meta-Analysis.
55  had dementia
(1 time)
Diagnostic Imaging
(1 time)
BG (1 time)
Cr (1 time)
FWM (1 time)
2010 Brain metabolism and cognitive impairment in HIV infection: a 3-T magnetic resonance spectroscopy study.
56  Hadley Centre
(1 time)
Environmental Health
(1 time)
AOGCMs (1 time)
MPI (1 time)
2006 Linked models to assess the impacts of climate change on nitrogen in a Norwegian river basin and FJORD system.
57  haemadsorbent ASFVs
(1 time)
Animal Diseases
(1 time)
ASFV (1 time)
2021 Dynamics of African swine fever virus (ASFV) infection in domestic pigs infected with virulent, moderate virulent and attenuated genotype II ASFV European isolates.
58  haemagglutination-defective
(1 time)
Virology
(1 time)
TGEV (1 time)
2000 Characterization of the sialic acid binding activity of transmissible gastroenteritis coronavirus by analysis of haemagglutination-deficient mutants.
59  hair deformation
(1 time)
Botany
(1 time)
--- 2004 Perception of Bradyrhizobium japonicum Nod factor by soybean [Glycine max (L.) Merr.] root hairs under abiotic stress conditions.
60  haloacid dehalogenase superfamily
(1 time)
Biophysics
(1 time)
PCho (1 time)
PchP (1 time)
2011 Site-directed mutations and kinetic studies show key residues involved in alkylammonium interactions and reveal two sites for phosphorylcholine in Pseudomonas aeruginosa phosphorylcholine phosphatase.
61  Hamilton Anxiety-Depression Scale
(1 time)
Sexually Transmitted Diseases
(1 time)
DLQI (1 time)
PASI (1 time)
2009 The relationship between symptoms and patient characteristics among psoriasis patients.
62  Hamilton Depression Rating Scale
(1 time)
Neurology
(1 time)
AIMS (1 time)
HD (1 time)
2007 Short-term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross-over trial.
63  HAND diagnosis
(1 time)
Neurology
(1 time)
cART (1 time)
HAND (1 time)
NP (1 time)
2010 HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
64  Hansen's disease
(1 time)
Nephrology
(1 time)
ESRD (1 time)
GN (1 time)
HD (1 time)
2004 End-stage renal disease in leprosy.
65  Hausdorff Average Distance
(1 time)
Neurology
(1 time)
DT-CWT (1 time)
MR (1 time)
nDSC (1 time)
2020 Detector of 3-D salient points based on the dual-tree complex wavelet transform for the positioning of hippocampi meshes in magnetic resonance images.
66  HD-allied disorders
(1 time)
Gastroenterology
(1 time)
HD (1 time)
LDH (1 time)
2012 A rapid lactate dehydrogenase histochemical method for the intraoperative assessment of Hirschsprung's disease.
67  Health Anxiety Disorder
(1 time)
Therapeutics
(1 time)
--- 2012 Health anxiety disorders: a cognitive construal.
68  Health Assessment Document
(1 time)
Toxicology
(1 time)
CNG (1 time)
DE (1 time)
EPA (1 time)
2005 A reevaluation of the literature regarding the health assessment of diesel engine exhaust.
69  healthcare avoidance and delay
(1 time)
Social Sciences
(1 time)
--- 2021 Does Discrimination Affect Whether Transgender People Avoid or Delay Healthcare?: A Nationwide Cross-sectional Survey in South Korea.
70  healthy adult donors
(1 time)
Biomedical Research
(1 time)
IP-10 (1 time)
QFT-IT (1 time)
TB (1 time)
2015 Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children.
71  hearing aid device
(1 time)
CNN (1 time)
CRNN (1 time)
SE (1 time)
2020 Design and Integration of Alert Signal Detector and Separator for Hearing Aid Applications.
72  hearing level-ACET discrepancy
(1 time)
Pediatrics
(1 time)
ACET (1 time)
BC (1 time)
HL (1 time)
2008 Air-conduction estimated from tympanometry (ACET): 2. The use of hearing level-ACET discrepancy (HAD) to determine appropriate use of bone-conduction tests in identifying permanent and mixed impairments.
73  heart assist devices
(1 time)
Health Services Research
(1 time)
LVAD (1 time)
1994 Mock circulatory system for in vitro reproduction of the left ventricle, the arterial tree and their interaction with a left ventricular assist device.
74  heavy alcohol drinking
(1 time)
Health Services
(1 time)
AD (1 time)
CCHS (1 time)
FVC (1 time)
2016 Impact of the 2008 global financial crisis on the health of Canadians: repeated cross-sectional analysis of the Canadian Community Health Survey, 2007-2013.
75  heavy-atom data bank
(1 time)
Chemistry Techniques, Analytical
(1 time)
--- 1999 HAD, a data bank of heavy-atom binding sites in protein crystals: a resource for use in multiple isomorphous replacement and anomalous scattering.
76  hemadsorption activity
(1 time)
Virology
(1 time)
4-GU-DANA (1 time)
HN (1 time)
HPF3 (1 time)
2001 Human parainfluenza virus type 3 HN-receptor interaction: effect of 4-guanidino-Neu5Ac2en on a neuraminidase-deficient variant.
77  hemostatic adhesive
(1 time)
Biological Science Disciplines
(1 time)
HC (1 time)
2021 Snake extract-laden hemostatic bioadhesive gel cross-linked by visible light.
78  hepatic artery diameter
(1 time)
Gastrointestinal Diseases
(1 time)
mDF (1 time)
PI (1 time)
RI (1 time)
2015 Hepatic artery duplex Doppler ultrasound in severe alcoholic hepatitis and correlation with Maddrey's discriminant function.
79  hepatic artery dissection
(1 time)
Diagnostic Imaging
(1 time)
CT (1 time)
LDLT (1 time)
2015 The computed tomographic angiography finding of hepatic artery dissection after living donor liver transplantation; what is the clinical significance?
80  hepatic artery intimal dissection
(1 time)
Transplantation
(1 time)
HA (1 time)
HAT (1 time)
2020 Managing Recipient Hepatic Artery Intimal Dissection During Living Donor Liver Transplantation.
81  heroin-abusing-duration
(1 time)
Complementary Therapies
(1 time)
DHAQ (1 time)
E-LPO (1 time)
E-SOD (1 time)
2002 Primary studies on heroin abuse and injury induced by oxidation and lipoperoxidation.
82  Heterotrophic anodic denitrification
(1 time)
Chemistry
(1 time)
HADMFCs (1 time)
MFC (1 time)
TOC (1 time)
2020 Effect of heterotrophic anodic denitrification on anolyte pH control and bioelectricity generation enhancement of bufferless microbial fuel cells.
83  Heweianshen decoction
(1 time)
Complementary Therapies
(1 time)
CCK-8 (1 time)
PCPA (1 time)
2016 Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia.
84  hexamethylenediamine
(1 time)
Nutritional Sciences
(1 time)
EDA (1 time)
IPDA (1 time)
PUMCs (1 time)
2021 Achieving Win-Win Ecotoxicological Safety and Fungicidal Activity of Pyraclostrobin-Loaded Polyurea Microcapsules by Selecting Proper Polyamines.
85  hierarchical atom-type definition
(1 time)
Chemistry
(1 time)
--- 2015 Hierarchical atom type definitions and extensible all-atom force fields.
86  hierarchical attentive decoding
(1 time)
Nervous System
(1 time)
SOI (1 time)
2020 Species Classification for Neuroscience Literature Based on Span of Interest Using Sequence-to-Sequence Learning Model.
87  High AD
(1 time)
Neurology
(1 time)
AD (1 time)
AMB (1 time)
APOE4 (1 time)
2019 APOE ɛ4/ɛ4 Is Associated with Aberrant Motor Behavior Through Both Lewy Body and Cerebral Amyloid Angiopathy Pathology in High Alzheimer's Disease Pathological Load.
88  high allergen dose
(1 time)
Allergy and Immunology
(1 time)
AE (1 time)
LAD (1 time)
SCIT (1 time)
2005 The safety of sublingual-swallow immunotherapy: an analysis of published studies.
89  high altitude dwellers
(1 time)
Metabolism
(1 time)
--- 1975 Adrenal response to tolbutamide-induced hypoglycemia in high altitude dwellers.
90  high and low alcohol preference, namely the high
(1 time)
Substance-Related Disorders
(1 time)
DA (1 time)
NP (1 time)
VTA (1 time)
2006 Comparison of VTA dopamine neuron activity in lines of rats selectively bred to prefer or avoid alcohol.
91  high antigen density
(1 time)
Neoplasms
(1 time)
HN (1 time)
LAD (1 time)
mAb (1 time)
1998 Introduction of adhesive and costimulatory immune functions into tumor cells by infection with Newcastle Disease Virus.
92  high antioxidant diet
(1 time)
Reproductive Medicine
(1 time)
RDI (1 time)
2009 Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet.
93  high anxiety, depression
(1 time)
Neoplasms
(1 time)
MAC (1 time)
1999 Predicting delayed anxiety and depression in patients with gastrointestinal cancer.
94  High Aswan Dam
(1 time)
Science
(1 time)
GERD (1 time)
2020 Understanding and managing new risks on the Nile with the Grand Ethiopian Renaissance Dam.
95  high-altitude-born
(1 time)
Pulmonary Medicine
(1 time)
mPAP (1 time)
1975 Regional distribution of pulmonary blood flow in normal high-altitude dwellers at 3,650 m (12,200 ft).
96  high-functioning autistic disorder
(1 time)
Psychology
(1 time)
DLD (1 time)
WCST (1 time)
2001 Executive functioning in high-functioning children with autism.
97  high-molecular weight adiponectin
(1 time)
Obesity
(1 time)
T-Ad (1 time)
2016 Changes in the Composition of Adiponectin Fractions over a 3-Year Period in Children: A Population-Based Cohort Study.
98  High-solid anaerobic digestion
(1 time)
Toxicology
(1 time)
EPS (1 time)
HS (1 time)
2020 Humification in extracellular polymeric substances (EPS) dominates methane release and EPS reconstruction during the sludge stabilization of high-solid anaerobic digestion.
99  highly acetylated derivatives
(1 time)
Chemistry
(1 time)
MTT (1 time)
PD (1 time)
2005 Antioxidant activity and cytoprotective effect of kappa-carrageenan oligosaccharides and their different derivatives.
100  highly angiogenic and disseminated in the peripheral blood
(1 time)
Neoplasms
(1 time)
CK19 (1 time)
ER (1 time)
MVD (1 time)
2003 Assessment of highly angiogenic and disseminated in the peripheral blood disease in breast cancer patients predicts for resistance to adjuvant chemotherapy and early relapse.