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Abbreviation: INa
Appearance Frequency: 220 time(s)
Long forms: 134

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
inward current
(39 times)
Physiology
(11 times)
ICa (4 times)
TTX (3 times)
4-HNE (1 time)
1981 Voltage-clamp studies of a slow inward current in bullfrog sympathetic ganglion cells.
inward sodium current
(26 times)
Cardiology
(7 times)
TTX (3 times)
AF (2 times)
AP (2 times)
1980 [Changes in the sodium current under the action of etmozin and lidocaine inside and outside the membrane of single rat myocardial cells].
increased sodium current
(10 times)
Cardiology
(4 times)
DRG (2 times)
Ad-Nav1.5 (1 time)
AF (1 time)
1999 Acute effects of thyroid hormone analogs on sodium currents in neonatal rat myocytes.
fast-inactivating sodium current
(3 times)
Neurology
(2 times)
CN (1 time)
I-V (1 time)
PPB (1 time)
1991 Effect of metabolic inhibition on the excitability of isolated hippocampal CA1 neurons: developmental aspects.
increased Na current
(3 times)
Molecular Biology
(1 time)
AP (1 time)
CaMKIIdelta (1 time)
ELF-EMF (1 time)
1996 Cerebrospinal fluid from multiple sclerosis patients inactivates neuronal Na+ current.
inhibited both voltage-gated sodium current
(3 times)
Anesthesiology
(1 time)
HVA (1 time)
LVA (1 time)
TRCs (1 time)
1994 Local anesthetics depress the calcium current of rat sensory neurons in culture.
inhibits Na+ current
(3 times)
Vascular Diseases
(1 time)
AF (1 time)
AFCL (1 time)
HEK293 (1 time)
1989 Modulation of the voltage-dependent sodium channel by agents affecting G-proteins: a study in Xenopus oocytes injected with brain RNA.
including the Na+ current
(2 times)
Stem Cells
(1 time)
AP (1 time)
APs (1 time)
CiPA (1 time)
2017 Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative.
inhibited late sodium current
(2 times)
Cardiology
(1 time)
AP (1 time)
CyPPA (1 time)
DAD (1 time)
2013 Wenxin Keli suppresses ventricular triggered arrhythmias via selective inhibition of late sodium current.
10  inhibited the peak and late components of voltage-gated Na+ current
(2 times)
Chemistry
(1 time)
Ang II (1 time)
ETA (1 time)
Gom A (1 time)
2020 Inhibitory Effectiveness of Gomisin A, a Dibenzocyclooctadiene Lignan Isolated from Schizandra chinensis, on the Amplitude and Gating of Voltage-Gated Na+ Current.
11  inward channel
(2 times)
Cardiology
(2 times)
--- 2000 [Electrical remodeling in atrial fibrillation--cellular and molecular mechanisms].
12  inward sodium
(2 times)
Biology
(1 time)
AP (1 time)
PAHs (1 time)
TTX (1 time)
2004 Effects of pressure overload-induced hypertrophy on TTX-sensitive inward currents in guinea pig left ventricle.
13  ionic currents, e.g., voltage-gated Na+ currents
(2 times)
Biology
(1 time)
DR (1 time)
SesA (1 time)
SSM (1 time)
2020 Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na+ and K+ Currents.
14  A-induced voltage-gated Na(+) current
(1 time)
Neurology
(1 time)
ARIP1 and ARIP2 (1 time)
2013 Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells.
15  agent-induced tonic and phasic block of the Na+ current
(1 time)
Biochemistry
(1 time)
--- 1999 Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle.
16  bupivacaine-induced block of the fast Na+ current
(1 time)
Anesthesiology
(1 time)
--- 2013 Lipid rescue reverses the bupivacaine-induced block of the fast Na+ current (INa) in cardiomyocytes of the rat left ventricle.
17  Cardiac Nav1.5 and Kir2.1-2.3 channels generate Na
(1 time)
Biomedical Research
(1 time)
BrS (1 time)
ER (1 time)
GRASPs (1 time)
2018 Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels.
18  hypokalemia-induced ventricular tachycardia/fibrillation, as did the selective late Na current
(1 time)
Cardiology
(1 time)
CaMKII (1 time)
EADs (1 time)
2015 Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation.
19  I antiarrhythmic agent, on Na+ current
(1 time)
Pharmacology
(1 time)
--- 1994 Block of Na+ channel by moricizine hydrochloride in isolated feline ventricular myocytes.
20  I drugs to depress cardiac sodium currents
(1 time)
Cardiology
(1 time)
--- 1984 Block of sodium currents by antiarrhythmic agents: analysis of the electrophysiologic effects of propafenone in heart muscle.
21  ICa-L but slower than sodium current
(1 time)
Biochemistry
(1 time)
F-LVAD (1 time)
HLVMs (1 time)
NF (1 time)
2020 A low voltage activated Ca2+ current found in a subset of human ventricular myocytes.
22  identification of the in vivo roles of sodium current
(1 time)
Neurology
(1 time)
MO (1 time)
RB (1 time)
2005 Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons.
23  IDMPP, Na+ currents
(1 time)
Pharmacology
(1 time)
AChR (1 time)
DMPP (1 time)
1996 Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells.
24  If ATP produced similar effects on the Na+ current
(1 time)
Cardiology
(1 time)
--- 1994 Effect of extracellular ATP on the Na+ current in rat ventricular myocytes.
25  II reduced Na+ current
(1 time)
Cardiology
(1 time)
AF (1 time)
Ang II (1 time)
AP (1 time)
2018 Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation.
26  III cells with a thin dendrite had voltage-gated sodium
(1 time)
Neurology
(1 time)
--- 2001 Physiology of morphologically identified cells of the bullfrog fungiform papilla.
27  importance of the Na+ current
(1 time)
Biology
(1 time)
AP (1 time)
2006 Significance of Na+ current in the excitability of atrial and ventricular myocardium of the fish heart.
28  improve the selectivity for cardiac late Na+ current
(1 time)
Cardiology
(1 time)
LQT3 (1 time)
2017 Eleclazine exhibits enhanced selectivity for long QT syndrome type 3-associated late Na+ current.
29  in vivo was sufficient to alter the cardiac sodium current
(1 time)
Cardiology
(1 time)
IH (1 time)
2013 Lasting alterations of the sodium current by short-term hyperlipidemia as a mechanism for initiation of cardiac remodeling.
30  inactivate the Na+ current
(1 time)
Physiology
(1 time)
SR (1 time)
tpk (1 time)
1996 The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes.
31  inactivating TTX-sensitive sodium current
(1 time)
Cell Biology
(1 time)
--- 2003 Stem cells from the adult human brain develop into functional neurons in culture.
32  inactivation and prominent late Na+ currents
(1 time)
Medicine
(1 time)
LQT3 (1 time)
WT (1 time)
2018 Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease.
33  inactivation and reactivation of the sodium ion current
(1 time)
Cardiology
(1 time)
TTX (1 time)
1997 Electrophysiological analyses of threshold conditions and rate-dependent failure of excitation in single myocytes from rabbit ventricle.
34  inactivation ensure adequate sodium current
(1 time)
Cardiology
(1 time)
AP (1 time)
Fhf2KO (1 time)
Fhf2WT (1 time)
2020 Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.
35  inactivation for the block of sodium current
(1 time)
Drug Therapy
(1 time)
--- 1992 Disopyramide block of cardiac sodium current after removal of the fast inactivation process in guinea pig ventricular myocytes.
36  inactivation gate j of the sodium current
(1 time)
Physiological Phenomena
(1 time)
AP (1 time)
APD (1 time)
CL (1 time)
2016 Supernormal Conduction and Suppression of Spatially Discordant Alternans of Cardiac Action Potentials.
37  inactivation kinetics of sodium current
(1 time)
Cardiology
(1 time)
I-V (1 time)
WT (1 time)
2013 Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
38  inactivation kinetics of VGSCs
(1 time)
Medicine
(1 time)
2-AG (1 time)
CN (1 time)
KA (1 time)
2021 [Modulatory effect of 2-arachidonoylglycerol on voltage-gated sodium currents in rat caudate nucleus neurons with kainic acid-induced injury].
39  inactivation of both sodium
(1 time)
Science
(1 time)
DHA (1 time)
EPA (1 time)
PUFAs (1 time)
1996 Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.
40  inactivation of Na+ currents
(1 time)
Physiology
(1 time)
--- 1996 Single-channel basis of slow inactivation of Na+ channels in rat skeletal muscle.
41  inactivation of the fast sodium current
(1 time)
Cardiology
(1 time)
AF (1 time)
AP (1 time)
SR (1 time)
2000 Ionic mechanisms of electrical remodeling in human atrial fibrillation.
42  inactivation of the transient Na+ current
(1 time)
Neurology
(1 time)
--- 1998 Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing.
43  inactivation phase of the macroscopic sodium current
(1 time)
Biophysics
(1 time)
--- 1991 The quantal gating charge of sodium channel inactivation.
44  inactivation resembled that of the Na+ currents
(1 time)
Biochemistry
(1 time)
TTX (1 time)
1995 Tetrodotoxin-sensitive Ca2+ and Ba2+ currents in human atrial cells.
45  increase in voltage-gated sodium current
(1 time)
Biological Science Disciplines
(1 time)
CGN (1 time)
SUMO (1 time)
2016 SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.
46  increased late sodium channel current
(1 time)
Cardiology
(1 time)
LV (1 time)
2006 Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.
47  increased persistent or resurgent sodium current
(1 time)
Nervous System Diseases
(1 time)
DEEs (1 time)
Nav1.1 (1 time)
VGSC (1 time)
2020 Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52.
48  increased the amiloride-sensitive short-circuit current
(1 time)
Physiology
(1 time)
8-BrcAMP (1 time)
8-BrcGMP (1 time)
1991 Stimulation by cGMP of apical Na channels and cation channels in toad urinary bladder.
49  increased the amplitude of voltage-gated Na+ current
(1 time)
Toxicology
(1 time)
--- 2009 Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons.
50  increases in persistent sodium current
(1 time)
Science
(1 time)
AP (1 time)
EAD (1 time)
EIEE (1 time)
2017 Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.
51  incubation with and without mexiletine, macroscopic voltage-gated sodium current
(1 time)
Biochemistry
(1 time)
WT (1 time)
2018 Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients.
52  indapamide on Na+
(1 time)
Cardiology
(1 time)
--- 1998 Effects of the diuretic agent indapamide on Na+, transient outward, and delayed rectifier currents in canine atrial myocytes.
53  indicated greater sodium current density
(1 time)
Biological Science Disciplines
(1 time)
GJs (1 time)
SCN5A (1 time)
SPC (1 time)
2018 The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.
54  individual Xenopus oocytes the macroscopic amiloride-sensitive sodium current
(1 time)
Science
(1 time)
ENaC (1 time)
1996 Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach.
55  induced two phenomenologically-different types of sodium current
(1 time)
Neurology
(1 time)
--- 1982 The effect of yohimbine on sodium and gating currents in frog Ranvier node membrane.
56  inexcitable and do not have measurable sodium current
(1 time)
Science
(1 time)
GFL (1 time)
1987 Synthesis of sodium channels in the cell bodies of squid giant axons.
57  influx through voltage-sensitive Na+ channels
(1 time)
Physiology
(1 time)
Na (1 time)
TTX (1 time)
1991 Na(+)-activated K+ channels and voltage-evoked ionic currents in brain stem and parasympathetic neurones of the chick.
58  inhibit both calcium and sodium currents
(1 time)
Neurology
(1 time)
LES (1 time)
SCLC (1 time)
1992 Lambert-Eaton syndrome: antigen-antibody interaction and calcium current inhibition in chromaffin cells.
59  inhibit cardiac Na+ current
(1 time)
Anesthesiology
(1 time)
BIS (1 time)
PKC (1 time)
PTX (1 time)
1998 Sensitization of the cardiac Na channel to alpha1-adrenergic stimulation by inhalation anesthetics: evidence for distinct modulatory pathways.
60  inhibited the peak sodium current
(1 time)
Biochemistry
(1 time)
APA (1 time)
APD (1 time)
APs (1 time)
2020 Antiarrhythmic effect of crotonoside by regulating sodium and calcium channels in rabbit ventricular myocytes.
61  inhibited voltage-dependent Na+ current
(1 time)
Biochemistry
(1 time)
--- 2003 Purification, characterization of two peptides from Buthus martensi Karch.
62  inhibition Nav currents
(1 time)
Pain
(1 time)
LAs (1 time)
LB (1 time)
2022 QX-OH/Levobupivacaine: A Structurally Novel, Potent Local Anesthetic Produces Fast-Onset and Long-Lasting Regional Anesthesia in Rats.
63  inhibition of cardiac sodium channel current
(1 time)
Cardiology
(1 time)
--- 2016 Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis.
64  Inhibition of fast Na+ current
(1 time)
Biology
(1 time)
APD (1 time)
IKrec (1 time)
1998 Cardiac actions of taurine as a modulator of the ion channels.
65  inhibition of sodium channels
(1 time)
Biology
(1 time)
NPA (1 time)
1985 [Differences in the action of Ca2+ ions on a cumulative Na-channel blockade due to tertiary and quaternary amines].
66  inhibition of the cardiac late sodium current
(1 time)
Cardiology
(1 time)
AF (1 time)
PTa (1 time)
TWA (1 time)
2016 Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation.
67  inhibition of the Na channel current
(1 time)
Molecular Biology
(1 time)
--- 1984 Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder.
68  Inhibition of the persistent or late Na current
(1 time)
Cardiology
(1 time)
--- 2009 A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine.
69  inhibition of voltage-dependent sodium currents
(1 time)
Molecular Biology
(1 time)
LES (1 time)
SCLC (1 time)
TTX (1 time)
1995 Voltage-dependent sodium channels in human small-cell lung cancer cells: role in action potentials and inhibition by Lambert-Eaton syndrome IgG.
70  inhibition of voltage-gated Na+
(1 time)
Cardiology
(1 time)
AP (1 time)
ECC (1 time)
SR (1 time)
2020 Effect of carvedilol on atrial excitation-contraction coupling, Ca2+ release, and arrhythmogenicity.
71  inhibition of whole-cell Na+ current
(1 time)
Physiology
(1 time)
OAG (1 time)
PKA (1 time)
PKC (1 time)
1997 Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C.
72  inhibition on voltage-gated Na+ current
(1 time)
APs (1 time)
BRV (1 time)
LEV (1 time)
2021 The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability.
73  inhibitor of the persistent cardiac Na(+) current
(1 time)
Natural Science Disciplines
(1 time)
SMC (1 time)
2015 Antagonism of Nav channels and alpha1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine.
74  inhibitory effect on voltage-gated Na+ current
(1 time)
Chemistry
(1 time)
--- 2022 Evidence for Inhibitory Perturbations on the Amplitude, Gating, and Hysteresis of A-Type Potassium Current, Produced by Lacosamide, a Functionalized Amino Acid with Anticonvulsant Properties.
75  inhibitory effects on the cardiac sodium current
(1 time)
Cardiology
(1 time)
--- 1995 Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes.
76  inhibitory modulation of the voltage-gated sodium current
(1 time)
Physiology
(1 time)
CDCs (1 time)
1991 Inhibitory modulation by FMRFamide of the voltage-gated sodium current in identified neurones in Lymnaea stagnalis.
77  inhibits the cardiac late Na+ current
(1 time)
Cardiology
(1 time)
UDB (1 time)
WT (1 time)
2009 Use-dependent block of cardiac late Na(+) current by ranolazine.
78  inner side of the membrane reduced peak Na current
(1 time)
Cardiology
(1 time)
LB (1 time)
LPC (1 time)
1991 Modulation of cardiac sodium channel gating by lysophosphatidylcholine.
79  input resistances, membrane potentials and voltage-gated membrane currents for sodium
(1 time)
Molecular Biology
(1 time)
--- 2002 Membrane ion conductances of mammalian skeletal muscle in the post-decompression state after high-pressure treatment.
80  insensitivity and leads to reduced sodium current
(1 time)
Neurology
(1 time)
--- 2015 pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.
81  interacted to produce complex pVT: Na(+) current
(1 time)
Cardiology
(1 time)
EADs (1 time)
LQT1 (1 time)
PVT (1 time)
2014 Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.
82  interestingly, also during Na+ current
(1 time)
Physiology
(1 time)
--- 2000 L-type Ca2+ current as the predominant pathway of Ca2+ entry during I(Na) activation in beta-stimulated cardiac myocytes.
83  Interestingly, the developmental change of voltage-gated Na(+) current
(1 time)
Stem Cells
(1 time)
APs (1 time)
ES (1 time)
FoxG1 (1 time)
2012 Coordinated development of voltage-gated Na+ and K+ currents regulates functional maturation of forebrain neurons derived from human induced pluripotent stem cells.
84  into tsA-201 cells, and whole-cell sodium currents
(1 time)
Cardiology
(1 time)
WT (2 times)
EIT (1 time)
PKA (1 time)
2020 Biophysical defects of an SCN5A V1667I mutation associated with epinephrine-induced marked QT prolongation.
85  intracellular sodium concentration ((Na)i) and sodium currents
(1 time)
Anesthesiology
(1 time)
Na (1 time)
2004 Lidocaine increases intracellular sodium concentration through voltage-dependent sodium channels in an identified lymnaea neuron.
86  Intramembrane charge movement (Q) and sodium current
(1 time)
Physiology
(1 time)
--- 1982 Kinetics of intramembrane charge movement and sodium current in frog node of Ranvier.
87  intravascular pressure regulates the surface density of SUMO-PKD2-mediated Na+ currents
(1 time)
Science
(1 time)
PKD2 (1 time)
SUMO-1 (1 time)
2019 SUMO1 modification of PKD2 channels regulates arterial contractility.
88  intrinsic differences between atrial and ventricular cardiac voltage-gated sodium currents
(1 time)
Cardiology
(1 time)
AF (1 time)
2022 Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels.
89  INTRODUCTION: Our previous experiments showed that the transient sodium current
(1 time)
Cardiology
(1 time)
--- 2019 Effects of atorvastatin on time-dependent change of fast sodium current in simulated acute ischaemic ventricular myocytes.
90  investigate the characteristics of two types of sodium current
(1 time)
Physiology
(1 time)
DRG (1 time)
TEA (1 time)
TTX (1 time)
1993 Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia.
91  investigate the role of Na+ currents
(1 time)
Neurology
(1 time)
4,9-ah-TTX (1 time)
INaP (1 time)
TTX (1 time)
2020 Persistent and resurgent Na+ currents in vestibular calyx afferents.
92  investigated how IL-1beta modulates the total voltage-dependent sodium currents
(1 time)
Neurology
(1 time)
IL-1beta (1 time)
TTX-R (1 time)
2005 Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons.
93  investigated the compound's effect on sodium current
(1 time)
Biochemistry
(1 time)
--- 2021 Eugenol interacts with cardiac sodium channel and reduces heart excitability and arrhythmias.
94  investigated the effects of dexmedetomidine on voltage-gated sodium channel currents
(1 time)
Biochemistry
(1 time)
GPCRs (1 time)
TG (1 time)
2018 Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via alpha2-Adrenoceptors in Trigeminal Ganglion Neurons.
95  investigated the role of the fast sodium current
(1 time)
Physiology
(1 time)
SR (1 time)
TTX (1 time)
1995 Calcium transients which accompany the activation of sodium current in rat ventricular myocytes at 37 degrees C: a trigger role for reverse Na-Ca exchange activated by membrane potential?
96  investigated when sodium current
(1 time)
Physiology
(1 time)
WT (1 time)
2020 The sodium channel NaV 1.5 impacts on early murine embryonic cardiac development, structure and function in a non-electrogenic manner.
97  investigated, during the first postnatal week, a voltage-gated sodium current
(1 time)
Neurology
(1 time)
--- 2006 Hypergravity affects the developmental expression of voltage-gated sodium current in utricular hair cells.
98  investigates the effects of PRAX-562 on sodium current
(1 time)
Brain
(1 time)
CBZ (1 time)
LTG (1 time)
MES (1 time)
2022 The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.
99  involved, we measured Na+ currents
(1 time)
Cardiology
(1 time)
--- 1992 Mechanism of the increase in intracellular sodium during metabolic inhibition: direct evidence against mediation by voltage-dependent sodium channels.
100  inward current, which consisted of Na+
(1 time)
Physiology
(1 time)
--- 1996 T-type Ca2+ channel lowers the threshold of spike generation in the newt olfactory receptor cell.