| 1 |
NOD-like receptor family, pyrin domain containing 3
(730 times)
|
Allergy and Immunology
(96 times)
|
IL (127 times)
IL-1beta (101 times)
ROS (73 times)
|
2009 Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
|
| 2 |
nucleotide-binding oligomerization domain-like receptor protein 3
(592 times)
|
Allergy and Immunology
(76 times)
|
IL (112 times)
IL-1beta (111 times)
LPS (69 times)
|
2009 Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.
|
| 3 |
NOD-like receptor protein 3
(484 times)
|
Pharmacology
(73 times)
|
IL-1beta (76 times)
IL (67 times)
ROS (59 times)
|
2009 Dysfunctional inflammasome in Schnitzler's syndrome.
|
| 4 |
NLR family pyrin domain containing 3
(369 times)
|
Molecular Biology
(48 times)
|
IL (57 times)
IL-1beta (57 times)
LPS (42 times)
|
2008 The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.
|
| 5 |
NOD-like receptor 3
(97 times)
|
Cell Biology
(15 times)
|
NF-KappaB (23 times)
ROS (19 times)
IL-1beta (17 times)
|
2012 Inflammaging: disturbed interplay between autophagy and inflammasomes.
|
| 6 |
domain leucine rich repeat and pyrin domain-containing protein 3
(19 times)
|
Neurology
(3 times)
|
ASC (4 times)
AD (3 times)
IL (2 times)
|
2015 Inflammasomes-dependent regulation of IL-1beta secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages.
|
| 7 |
NOD-like receptors containing pyrin domain 3
(19 times)
|
Toxicology
(2 times)
|
IL-1beta (4 times)
IL (3 times)
ASC (2 times)
|
2009 Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
|
| 8 |
domain, leucine-rich repeat-containing protein family, pyrin-containing domain 3
(5 times)
|
Allergy and Immunology
(2 times)
|
IL-1beta (2 times)
ALD (1 time)
AST (1 time)
|
2010 NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses.
|
| 9 |
NALP3, cryopyrin
(5 times)
|
Science
(2 times)
|
IL (2 times)
ASC (1 time)
HMGB1 (1 time)
|
2009 T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
|
| 10 |
NAcht Leucine-rich repeat Protein 3
(3 times)
|
Nucleic Acids
(1 time)
|
ASC (2 times)
HGFs (2 times)
P. gingivalis-LPS (2 times)
|
2019 Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1beta production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts.
|
| 11 |
NOD-like receptor thermoprotein domain 3
(3 times)
|
Complementary Therapies
(3 times)
|
ASC (2 times)
LDH (2 times)
DSS (1 time)
|
2021 [Effect of Huangqin Decoction on pyroptosis pathway of NLRP3/caspase-1 in mice with ulcerative colitis].
|
| 12 |
nucleotide leukin-rich polypeptide 3
(3 times)
|
Histocytochemistry
(1 time)
|
ABCA1 (1 time)
ALB (1 time)
AN (1 time)
|
2019 Expression and Contribution of NLRP3 Inflammasome During the Follicular Development Induced by PMSG.
|
| 13 |
oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3
(3 times)
|
Nutritional Sciences
(2 times)
|
TLR4 (1 time)
WAT (1 time)
|
2017 Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues.
|
| 14 |
NLR family pyrin domain containing 3 inflammasome
(2 times)
|
Allergy and Immunology
(2 times)
|
3-MA (1 time)
DR (1 time)
IL (1 time)
|
2020 Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response.
|
| 15 |
NLR protein 3
(2 times)
|
Microbiology
(1 time)
|
NLRC4 (2 times)
ALS (1 time)
ASC (1 time)
|
2018 Expression profile of pattern recognition receptors in skeletal muscle of SOD1(G93A) amyotrophic lateral sclerosis (ALS) mice and sporadic ALS patients.
|
| 16 |
NLR pyrin domain 3
(2 times)
|
Ophthalmology
(1 time)
|
FOXO1 (1 time)
IL-1beta (1 time)
NLRC4 (1 time)
|
2018 miR15a regulates NLRP3 inflammasome proteins in the retinal vasculature.
|
| 17 |
NLR-related protein 3
(2 times)
|
Biochemistry
(1 time)
|
NLR (2 times)
IL (1 time)
NOD (1 time)
|
2011 Inflammasome activation: from inflammatory disease to infection.
|
| 18 |
NOD-like receptor 3 inflammasome
(2 times)
|
Pharmacology
(1 time)
|
beta-GLU (1 time)
CLP (1 time)
DRV (1 time)
|
2018 Darunavir alleviates irinotecan-induced intestinal toxicity in Vivo.
|
| 19 |
Nod-like receptor 3 protein
(2 times)
|
Medicine
(1 time)
|
HE (1 time)
METH (1 time)
TEER (1 time)
|
2019 Methamphetamine Induces Intestinal Inflammatory Injury via Nod-Like Receptor 3 Protein (NLRP3) Inflammasome Overexpression In Vitro and In Vivo.
|
| 20 |
NOD-like receptor family, pyrin domain containing 3 inflammasome
(2 times)
|
Cell Biology
(1 time)
|
DAG (1 time)
FC (1 time)
HFHCD (1 time)
|
2016 Role of Linear Ubiquitination in Health and Disease.
|
| 21 |
NOD-like receptor pyrin-containing receptor 3
(2 times)
|
Cell Biology
(2 times)
|
AMPK (1 time)
CMKLR1 (1 time)
DAMPs (1 time)
|
2021 HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia.
|
| 22 |
nucleotide-binding domain, leucine-rich family, pyrin-containing 3
(2 times)
|
Neoplasms
(2 times)
|
AKT (1 time)
CCK-8 (1 time)
CIK (1 time)
|
2018 NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway.
|
| 23 |
nucleotide-binding domain, leucine-rich repeat, and Pyrin domain 3
(2 times)
|
Antioxidants
(1 time)
|
AMD (2 times)
IL (2 times)
LDH (2 times)
|
2021 Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells.
|
| 24 |
nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain
(2 times)
|
Nervous System Diseases
(1 time)
|
HDAC6 (1 time)
IL-1beta (1 time)
PD (1 time)
|
2020 Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease.
|
| 25 |
canonicalnod-like receptor pyrin domain-containing 3
(1 time)
|
Neurosciences
(1 time)
|
PND (1 time)
|
2020 Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice.
|
| 26 |
domain-containing protein-like receptor family, pyrin domain containing protein 3
(1 time)
|
Biochemistry
(1 time)
|
DSS (1 time)
IL (1 time)
SPC (1 time)
|
2016 Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo.
|
| 27 |
NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3
(1 time)
|
Biochemistry
(1 time)
|
MP (1 time)
MPP (1 time)
NF-kappaB (1 time)
|
2018 Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-kappaB pathway after Mycoplasma pneumoniae infection.
|
| 28 |
NACHT leucin-rich repeat PYD protein 3
(1 time)
|
Medicine
(1 time)
|
TIR-containing (1 time)
|
2016 Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.
|
| 29 |
NACHT leucin-rich repeat PYD protein 3 inflammasome
(1 time)
|
|
TcpC (1 time)
TLR (1 time)
|
2021 Regulation of Expression of the TIR-Containing Protein C Gene of the Uropathogenic Escherichia coli Strain CFT073.
|
| 30 |
NACHT leucine rich repeat and pyd domains-containing 3
(1 time)
|
Clinical Laboratory Techniques
(1 time)
|
ASC (1 time)
HG (1 time)
IL (1 time)
|
2019 Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes.
|
| 31 |
NACHT leucine-rich repeat- and PYD-containing 3
(1 time)
|
Diabetes Mellitus
(1 time)
|
HMGB1 (1 time)
ISO (1 time)
NF-kappaB (1 time)
|
2020 Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation.
|
| 32 |
NLR family containing protein 3
(1 time)
|
Allergy and Immunology
(1 time)
|
AIM2 (1 time)
CEES (1 time)
Drp1 (1 time)
|
2021 Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study.
|
| 33 |
NLR family, domain of pyrin containing 3
(1 time)
|
Environmental Health
(1 time)
|
CNS (1 time)
KO (1 time)
|
2021 The role of NLRP3 in lead-induced neuroinflammation and possible underlying mechanism.
|
| 34 |
NLR pyrin family domain 3
(1 time)
|
Hematology
(1 time)
|
ATP (1 time)
GVHD (1 time)
IL-1beta (1 time)
|
2019 Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.
|
| 35 |
NLR-containing protein 3
(1 time)
|
Dentistry
(1 time)
|
IL-1beta (1 time)
NLR (1 time)
|
2015 Activation of inflammasomes in dendritic cells and macrophages by Mycoplasma salivarium.
|
| 36 |
NLR-family inflammasome pyrin domain-containing 3
(1 time)
|
Biochemistry
(1 time)
|
CA2 (1 time)
|
2021 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target.
|
| 37 |
NLR-family, leucine-rich repeat protein 3
(1 time)
|
Allergy and Immunology
(1 time)
|
CARDS (1 time)
IL-1beta (1 time)
|
2017 NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.
|
| 38 |
NLR3-containing a pyrin domain
(1 time)
|
|
AOSD (1 time)
SNPs (1 time)
|
2021 CARD8 SNP rs11672725 Identified as a Potential Genetic Variant for Adult-Onset Still's Disease.
|
| 39 |
NLRP3 inflammasome
(1 time)
|
Geriatrics
(1 time)
|
AD (1 time)
|
2021 NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease.
|
| 40 |
NLRP3-knockout mice
(1 time)
|
Neurology
(1 time)
|
HMGB1 (1 time)
TBI (1 time)
|
2021 HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury.
|
| 41 |
NLRP3-siRNA
(1 time)
|
Ophthalmology
(1 time)
|
BC (1 time)
FBC (1 time)
HCECs (1 time)
|
2021 Black Carbon Induces Complement Activation via NLRP3 Inflammasome in Human Corneal Epithelial Cells.
|
| 42 |
NOD protein-like receptor 3
(1 time)
|
Chemistry
(1 time)
|
DSS (1 time)
LPP (1 time)
SCFAs (1 time)
|
2021 Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Acid-Free Fatty Acid Receptor Anti-inflammatory Pathway by Regulating Microbiota and Mitigate Intestinal Barrier Damage in Dextran Sulfate Sodium-Induced Colitis in Mice.
|
| 43 |
NOD-like receptor domain of pyrin containing 3
(1 time)
|
Bioengineering
(1 time)
|
TXNIP (1 time)
|
2021 Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury.
|
| 44 |
NOD-like receptor family, pyrin domain containing family member 3
(1 time)
|
Inflammation
(1 time)
|
Epac1 (1 time)
PKR (1 time)
REC (1 time)
|
2019 Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells.
|
| 45 |
NOD-like receptor hot protein domain-associated protein 3
(1 time)
|
Occupational Medicine
(1 time)
|
BALF (1 time)
IL-1beta (1 time)
RT-PCR (1 time)
|
2018 [The effects of methylprednisolone on NLRP3 inflammasome in rats with acute lung injury Induced by Phosgene].
|
| 46 |
Nod-like receptor pyrin containing 3 inflammasome
(1 time)
|
Allergy and Immunology
(1 time)
|
IL-18 (1 time)
IL-1beta (1 time)
MDD (1 time)
|
2017 NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings.
|
| 47 |
Nod-like receptor pyrin-domain protein 3
(1 time)
|
Cell Biology
(1 time)
|
AMD (1 time)
IKBalpha (1 time)
NF-kappaB (1 time)
|
2021 P2X7 Receptor Antagonist Attenuates Retinal Inflammation and Neovascularization Induced by Oxidized Low-Density Lipoprotein.
|
| 48 |
Nod-like receptor thermoprotein domain-related protein 3
(1 time)
|
|
CCK-8 (1 time)
ELISA (1 time)
IFN-gamma (1 time)
|
2021 Antifungal Activity of a Neodymium-Doped Yttrium Aluminum Garnet 1,064-Nanometer Laser against Sporothrix globosa by Inducing Apoptosis and Pyroptosis via the NLRP3/Caspase-1 Signaling Pathway: In Vitro and In Vivo Study.
|
| 49 |
nonobese diabetic-like receptor family pyrin domain containing 3
(1 time)
|
Pathology
(1 time)
|
TXNIP (1 time)
|
2020 Knockdown of Long Noncoding RNAs of Maternally Expressed 3 Alleviates Hyperoxia-Induced Lung Injury via Inhibiting Thioredoxin-Interacting Protein-Mediated Pyroptosis by Binding to miR-18a.
|
| 50 |
nucleotide binding to the oligonucleotide receptor protein 3
(1 time)
|
Nervous System Physiological Phenomena
(1 time)
|
STAT3 (1 time)
|
2018 Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome.
|
| 51 |
nucleotide receptor protein 3
(1 time)
|
Biology
(1 time)
|
FXII (1 time)
IL-1beta (1 time)
|
2020 Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
|
| 52 |
nucleotide-binding leucine-rich repeat-containing pyrin receptor 3
(1 time)
|
Biochemistry
(1 time)
|
FMF (1 time)
MEFV (1 time)
|
2012 Reduced expression of NLRP3 and MEFV in human ischemic heart tissue.
|
| 53 |
proteins leucine-rich repeat protein 3
(1 time)
|
Neurology
(1 time)
|
ASC (1 time)
OPCs (1 time)
SCI (1 time)
|
2019 The relationship between inflammasomes and the endoplasmic reticulum stress response in the injured spinal cord.
|
| 54 |
sensor leucine-rich-containing family, pyrin domain containing 3
(1 time)
|
Endocrinology
(1 time)
|
IL (1 time)
SAT (1 time)
VAT (1 time)
|
2016 A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.
|
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