| 1 |
phosphodiesterase 4
(701 times)
|
Pharmacology
(173 times)
|
cAMP (95 times)
COPD (79 times)
AD (45 times)
|
1995 Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists.
|
| 2 |
phosphodiesterase type 4
(118 times)
|
Pharmacology
(33 times)
|
cAMP (14 times)
COPD (13 times)
TNF-alpha (6 times)
|
1995 Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats.
|
| 3 |
cAMP-phosphodiesterase 4
(8 times)
|
Biochemistry
(3 times)
|
PGs (1 time)
PNPX (1 time)
|
2001 Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny.
|
| 4 |
PDE type 4
(6 times)
|
Reproductive Medicine
(2 times)
|
PDE (4 times)
cAMP (2 times)
PDEs (2 times)
|
2003 Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation.
|
| 5 |
phosphodiesterase inhibitor 4
(3 times)
|
Neurology
(2 times)
|
ACO (1 time)
|
2007 A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia.
|
| 6 |
PDE4CAT
(2 times)
|
Chemistry
(2 times)
|
PDE (2 times)
|
2015 Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.
|
| 7 |
pan-phosphodiesterase-4
(1 time)
|
|
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|
2017 Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases.
|
| 8 |
PDE family 4
(1 time)
|
Biology
(1 time)
|
cAMP (1 time)
cGMP (1 time)
PDEs (1 time)
|
2010 An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.
|
| 9 |
PDE4B4, a new cAMP-specific phosphodiesterase
(1 time)
|
Biochemistry
(1 time)
|
UCR1 (1 time)
|
2002 Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
|
| 10 |
phosphodiesterase enzyme type-4
(1 time)
|
Pharmaceutical Preparations
(1 time)
|
CMS (1 time)
|
2012 Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on gamma-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress.
|
| 11 |
phosphodiesterases type 4B and 4D
(1 time)
|
Chemistry
(1 time)
|
db-cAMP (1 time)
PDE (1 time)
|
2002 Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons.
|
| 12 |
positron-emitting phosphodiesterase-4
(1 time)
|
Pharmacology
(1 time)
|
DIO (1 time)
DR (1 time)
NA (1 time)
|
2009 Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats.
|
| 13 |
preclinical data on phosphodiesterase 4
(1 time)
|
Neoplasms
(1 time)
|
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|
2016 Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies.
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