1 |
phosphodiesterase 4
(752 times)
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Pharmacology (186 times)
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cAMP (106 times) COPD (83 times) AD (46 times)
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1995 Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists.
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2 |
phosphodiesterase type 4
(119 times)
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Pharmacology (33 times)
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cAMP (14 times) COPD (13 times) TNF-alpha (6 times)
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1995 Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats.
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3 |
cAMP-phosphodiesterase 4
(8 times)
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Biochemistry (3 times)
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PGs (1 time) PNPX (1 time)
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2001 Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny.
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4 |
PDE type 4
(6 times)
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Reproductive Medicine (2 times)
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PDE (4 times) cAMP (2 times) PDEs (2 times)
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2003 Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation.
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5 |
phosphodiesterase inhibitor 4
(3 times)
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Neurology (2 times)
|
ACO (1 time)
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2007 A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia.
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6 |
PDE4CAT
(2 times)
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Chemistry (2 times)
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PDE (2 times)
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2015 Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.
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7 |
pan-phosphodiesterase-4
(1 time)
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|
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2017 Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases.
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8 |
PDE family 4
(1 time)
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Biology (1 time)
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cAMP (1 time) cGMP (1 time) PDEs (1 time)
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2010 An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.
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9 |
PDE4B4, a new cAMP-specific phosphodiesterase
(1 time)
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Biochemistry (1 time)
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UCR1 (1 time)
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2002 Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
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10 |
phosphodiesterase enzyme type-4
(1 time)
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Pharmaceutical Preparations (1 time)
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CMS (1 time)
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2012 Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on gamma-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress.
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11 |
phosphodiesterase protein 4
(1 time)
|
Nervous System Diseases (1 time)
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CREB (1 time) HAND (1 time)
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2022 HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.
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12 |
phosphodiesterases type 4B and 4D
(1 time)
|
Chemistry (1 time)
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db-cAMP (1 time) PDE (1 time)
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2002 Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons.
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13 |
positron-emitting phosphodiesterase-4
(1 time)
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Pharmacology (1 time)
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DIO (1 time) DR (1 time) NA (1 time)
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2009 Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats.
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14 |
preclinical data on phosphodiesterase 4
(1 time)
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Neoplasms (1 time)
|
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2016 Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies.
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