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■ Search Result - Abbreviation : SHP2

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Abbreviation: SHP2
Appearance Frequency: 223 time(s)
Long forms: 20

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
Src homology-2 domain containing protein tyrosine phosphatase-2
(130 times)
Biochemistry
(17 times)
MAPK (9 times)
PI3K (8 times)
ERK (7 times)
1998 Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase.
Src homology phosphotyrosyl phosphatase 2
(28 times)
Neoplasms
(10 times)
EGFR (3 times)
IL (3 times)
RTK (3 times)
2002 Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
Src homology phosphatase 2
(17 times)
Biochemistry
(6 times)
PTP1B (4 times)
SHP-1 (4 times)
TCPTP (4 times)
1997 Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.
SH2 domain-containing phosphatase-2
(11 times)
Cell Biology
(4 times)
ERK (3 times)
BMMCs (2 times)
EGF (2 times)
2009 SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.
SHATTERPROOF2
(8 times)
Botany
(3 times)
SHP1 (4 times)
FUL (3 times)
IND (2 times)
2000 SHATTERPROOF MADS-box genes control seed dispersal in Arabidopsis.
SH2 domain-containing PTP-2
(5 times)
Medicine
(3 times)
HCM (2 times)
PTP (2 times)
BTK (1 time)
2000 Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.
SH2-containing phosphatase 2
(5 times)
Endocrinology
(1 time)
SH2 (2 times)
GH (1 time)
IL-6 (1 time)
1998 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.
shatterproof 2
(4 times)
Gastroenterology
(2 times)
CCA (2 times)
cDNA (1 time)
ERK (1 time)
2009 Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
Src-homology-2 domain containing PTPase
(4 times)
Physiology
(1 time)
EPEC (2 times)
PTP (2 times)
NSML (1 time)
2017 Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC).
10  PD-1-Src homology region 2
(1 time)
PD-L1 (1 time)
TIGIT (1 time)
2018 Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype.
11  SH protein tyrosine phosphatase-2
(1 time)
Endocrinology
(1 time)
CNS (1 time)
Grb2 (1 time)
SHC (1 time)
2002 Effects of age on elements of insulin-signaling pathway in central nervous system of rats.
12  SHP2-CS
(1 time)
Biology
(1 time)
CNS (1 time)
2000 Increased susceptibility to ischemia-induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2.
13  SHP2-KO
(1 time)
Biochemistry
(1 time)
EC (1 time)
IFN-gamma (1 time)
2009 JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.
14  SHP2-PTP
(1 time)
Pharmacology
(1 time)
--- 2021 A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors.
15  SHP2-WT
(1 time)
Biochemistry
(1 time)
JMML (1 time)
2018 Exploring the effect of E76K mutation on SHP2 cause gain-of-function activity by a molecular dynamics study.
16  SHP2DeltaN
(1 time)
Biochemistry
(1 time)
BTAM (1 time)
EGF (1 time)
ERK (1 time)
2001 Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
17  SHP2DN
(1 time)
Biochemistry
(1 time)
EGF (1 time)
2003 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
18  Src homologous protein phosphotyrosyl phosphatase 2
(1 time)
Neoplasms
(1 time)
--- 2015 A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
19  Src homology region 2, phosphatase 2
(1 time)
Medicine
(1 time)
CHD (1 time)
NS (1 time)
2007 Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
20  Src homology-2 domain PTP 2
(1 time)
Cardiology
(1 time)
NO (1 time)
PI3K (1 time)
PTP (1 time)
2010 Mechanisms related to NO-induced motility in differentiated rat aortic smooth muscle cells.