| 1 |
sirtuin 1
(2753 times)
|
Biochemistry
(307 times)
|
AMPK (250 times)
ROS (171 times)
PGC-1alpha (132 times)
|
2004 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
|
| 2 |
silent information regulator 1
(660 times)
|
Pharmacology
(87 times)
|
AMPK (57 times)
ROS (52 times)
PGC-1alpha (38 times)
|
2006 SIRT1 stimulation by polyphenols is affected by their stability and metabolism.
|
| 3 |
silent mating type information regulation 2 homolog 1
(190 times)
|
Pharmacology
(18 times)
|
AMPK (22 times)
PGC-1alpha (16 times)
ROS (16 times)
|
2007 Enhancing cell longevity for cosmetic application: a complementary approach.
|
| 4 |
sirtuin type 1
(50 times)
|
Nutritional Sciences
(6 times)
|
MDA (10 times)
TNF-alpha (7 times)
SOD (6 times)
|
2008 Substituting N(epsilon)-thioacetyl-lysine for N(epsilon)-acetyl-lysine in peptide substrates as a general approach to inhibiting human NAD(+)-dependent protein deacetylases.
|
| 5 |
silent information regulator factor 2-related enzyme 1
(28 times)
|
Pharmacology
(6 times)
|
MDA (4 times)
IL-1beta (3 times)
NF-kappaB (3 times)
|
2015 Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice.
|
| 6 |
silent information regulator of transcription 1
(28 times)
|
Medicine
(3 times)
|
LPS (4 times)
ROS (3 times)
FOXO1 (2 times)
|
2011 SIRT1-mediated acute cardioprotection.
|
| 7 |
Sirtuin 1 deacetylase
(5 times)
|
Cell Biology
(1 time)
|
ER (2 times)
1-MT (1 time)
ac-Smad3 (1 time)
|
2011 Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons.
|
| 8 |
SIRT1H363Y
(3 times)
|
Biological Science Disciplines
(1 time)
|
FasL (1 time)
Sir2 (1 time)
SMC (1 time)
|
2013 Up-regulation of Fas ligand expression by sirtuin 1 in both flow-restricted vessels and serum-stimulated vascular smooth muscle cells.
|
| 9 |
sirtiun 1
(3 times)
|
Allergy and Immunology
(1 time)
|
ACC (1 time)
AMPK (1 time)
FAS (1 time)
|
2020 Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in HepG2 Cells through The SIRT1-AMPK Pathway.
|
| 10 |
studies revealed that sirtuin 1
(3 times)
|
Biochemistry
(1 time)
|
ARB (1 time)
CAP (1 time)
fPRDM16 (1 time)
|
2015 Influence of Olmesartan on Sirtuin 1 mRNA Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats.
|
| 11 |
signal regulating factor 1
(2 times)
|
Physiology
(1 time)
|
DRG (1 time)
Hcy (1 time)
NAD (1 time)
|
2016 Roles of NAD in Protection of Axon against Degeneration via SIRT1 Pathways.
|
| 12 |
significant increment of sirtuin 1
(2 times)
|
Food
(2 times)
|
alpha-SMA (1 time)
AMPK (1 time)
CKD (1 time)
|
2019 Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.
|
| 13 |
Sirtuin1 gene
(2 times)
|
Medicine
(1 time)
|
AMP (1 time)
AMPK (1 time)
ECT (1 time)
|
2018 Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
|
| 14 |
Sirutin 1
(2 times)
|
Ophthalmology
(1 time)
|
MDA (1 time)
miR-34a (1 time)
PGC-1alpha (1 time)
|
2018 Elevation of serum oxidative stress in patients with retina vein occlusions.
|
| 15 |
specific inhibitor of sirtuin 1
(2 times)
|
Medicine
(1 time)
|
AMPK (1 time)
DRG (1 time)
FOXO3 (1 time)
|
2015 Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.
|
| 16 |
AMPK-sirtuin 1
(1 time)
|
Physiology
(1 time)
|
ABCA1 (1 time)
AMPK (1 time)
LXRalpha (1 time)
|
2021 Danthron attenuates experimental atherosclerosis by targeting foam cell formation.
|
| 17 |
Autophagy-Sirtuin1
(1 time)
|
Geriatrics
(1 time)
|
CAS (1 time)
EPCs (1 time)
IFS (1 time)
|
2022 Autophagy-Sirtuin1(SIRT1) Alleviated the Coronary Atherosclerosis (AS)in Mice through Regulating the Proliferation and Migration of Endothelial Progenitor Cells (EPCs) via wnt/beta-catenin/GSK3beta Signaling Pathway.
|
| 18 |
deprivation-sirtuin-1
(1 time)
|
Nephrology
(1 time)
|
AMPK (1 time)
SGLT2 (1 time)
|
2020 Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
|
| 19 |
Iba-1+sirtuin 1
(1 time)
|
Neurology
(1 time)
|
EAE (1 time)
MS (1 time)
PT (1 time)
|
2022 Pterostilbene Protects the Optic Nerves and Retina in a Murine Model of Experimental Autoimmune Encephalomyelitis via Activation of SIRT1 Signaling.
|
| 20 |
IGF2-Sirtuin 1
(1 time)
|
Medicine
(1 time)
|
IGF2 (1 time)
PGC1alpha (1 time)
PMSCs (1 time)
|
2021 IGF2 deficiency causes mitochondrial defects in skeletal muscle.
|
| 21 |
NAD-sirtuin 1
(1 time)
|
Transplantation
(1 time)
|
BOS (1 time)
IFN (1 time)
NK (1 time)
|
2019 BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes.
|
| 22 |
SFN increased sirtuin-1
(1 time)
|
Pharmacology
(1 time)
|
HO-1 (1 time)
Nrf2 (1 time)
PGC-1alpha (1 time)
|
2021 Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1alpha/Nrf2 pathway and autophagy in retinal pigment epithelial cells.
|
| 23 |
showing reduced sirtuin 1
(1 time)
|
Neoplasms
(1 time)
|
AMPKalpha2 (1 time)
HIF1alpha (1 time)
PGC1alpha (1 time)
|
2017 Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells.
|
| 24 |
significant reduction of sirtuin 1
(1 time)
|
Neurology
(1 time)
|
CMT (1 time)
GST (1 time)
|
2019 Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K.
|
| 25 |
silencing-related enzyme 1
(1 time)
|
Food
(1 time)
|
AMPK (1 time)
HFD (1 time)
NAFLD (1 time)
|
2022 11beta-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway.
|
| 26 |
silent information regulator 2 associated protein 1
(1 time)
|
Cell Biology
(1 time)
|
AKI (1 time)
HO-1 (1 time)
I/R (1 time)
|
2018 Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway.
|
| 27 |
Silent information-regulated transcription factor 1
(1 time)
|
Geriatrics
(1 time)
|
---
|
2021 The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer's Disease.
|
| 28 |
silent mating type information regulator 2, S. cerevisiae, homolog 1
(1 time)
|
Biochemistry
(1 time)
|
MAR (1 time)
|
2012 SIRT1 deacetylates SATB1 to facilitate MAR HS2-MAR epsilon interaction and promote epsilon-globin expression.
|
| 29 |
silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1
(1 time)
|
Pathology
(1 time)
|
---
|
2013 Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
|
| 30 |
Simultaneously, (R)-TML104 upregulated sirtuin-1
(1 time)
|
Cardiovascular Diseases
(1 time)
|
PDGF-BB (1 time)
VSMC (1 time)
|
2021 A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation.
|
| 31 |
Sir2-like protein 1
(1 time)
|
Diabetes Mellitus
(1 time)
|
Sir2 (1 time)
|
2014 Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.
|
| 32 |
Sir2-Related Enzymes, Sirtuins1
(1 time)
|
Medicine
(1 time)
|
PGC-1alpha (1 time)
|
2019 Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor gamma Co-Activator 1alpha (PGC-1alpha) Axis.
|
| 33 |
siRNA-SIRT1
(1 time)
|
Drug Therapy
(1 time)
|
CFs (1 time)
MI (1 time)
|
2016 Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro.
|
| 34 |
SIRT1 iKO
(1 time)
|
Gastroenterology
(1 time)
|
IBD (1 time)
|
2017 Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
|
| 35 |
SIRT1-ASO
(1 time)
|
Biochemistry
(1 time)
|
MSCs (1 time)
|
2014 Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.
|
| 36 |
SIRT1-DeltaE2
(1 time)
|
Biological Science Disciplines
(1 time)
|
---
|
2017 Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.
|
| 37 |
SIRT1-H355A
(1 time)
|
Biochemistry
(1 time)
|
---
|
2011 Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization.
|
| 38 |
SIRT1-mut
(1 time)
|
Pharmacology
(1 time)
|
PPARdelta (1 time)
|
2018 Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor delta.
|
| 39 |
SIRT1-Tg
(1 time)
|
Pharmacology
(1 time)
|
PPARdelta (1 time)
|
2018 Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor delta.
|
| 40 |
Sirtuin 1 histon deacethylase
(1 time)
|
Endocrine System Diseases
(1 time)
|
DTC (1 time)
HC (1 time)
HT (1 time)
|
2018 Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer.
|
| 41 |
sirtuin 1 protein
(1 time)
|
Genetics, Medical
(1 time)
|
PBMCs (1 time)
|
2008 Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation.
|
| 42 |
sirtuin 2-related enzyme 1
(1 time)
|
Food
(1 time)
|
ACLT (1 time)
ADAMTS4 (1 time)
COX-2 (1 time)
|
2022 Melatonin Prevents Chondrocyte Matrix Degradation in Rats with Experimentally Induced Osteoarthritis by Inhibiting Nuclear Factor-kappaB via SIRT1.
|
| 43 |
sirtuin protein-1
(1 time)
|
|
---
|
2013 Involvement of SIRT1 in Zn2+, Streptozotocin, Non-Obese Diabetic, and Cytokine-Mediated Toxicities of beta-cells.
|
| 44 |
sirtuins, specifically situin 1
(1 time)
|
Chemistry, Pharmaceutical
(1 time)
|
---
|
2009 Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases.
|
| 45 |
siSIRT1
(1 time)
|
Medicine
(1 time)
|
3-MA (1 time)
HCQ (1 time)
OA (1 time)
|
2021 Dual Role of SIRT1 in Autophagy and Lipid Metabolism Regulation in Osteoarthritic Chondrocytes.
|
| 46 |
small interfering RNA against sirtuin1
(1 time)
|
Genetics, Medical
(1 time)
|
CDKN1A (1 time)
HCMs (1 time)
MIF (1 time)
|
2018 Macrophage migration inhibitory factor serves a pivotal role inthe regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway.
|
| 47 |
specifically reversed by sirtuin 1
(1 time)
|
Biochemistry
(1 time)
|
Tip60 (1 time)
|
2018 Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment.
|
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