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Abbreviation: TPS
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
treatment planning system
(1146 times)
Biophysics
(626 times)
IMRT (177 times)
MC (168 times)
VMAT (131 times)
1991 Application of the LQ model to the interpretation of absorbed dose distribution in the daily practice of radiotherapy.
tumor proportion score
(219 times)
Neoplasms
(115 times)
PD-L1 (137 times)
NSCLC (112 times)
OS (38 times)
2016 Cost-effectiveness of pembrolizumab versus docetaxel for the treatment of previously treated PD-L1 positive advanced NSCLC patients in the United States.
tissue polypeptide specific antigen
(195 times)
Neoplasms
(98 times)
CEA (43 times)
TPA (26 times)
PSA (14 times)
1992 A prospective study of tissue polypeptide specific antigen (TPS) in breast cancer diagnosis.
thermoplastic starch
(121 times)
Polysaccharides
(50 times)
PLA (19 times)
SEM (16 times)
XRD (10 times)
2001 The role of plasticization in starch granule assembly.
terpene synthase
(114 times)
Botany
(48 times)
MeJA (8 times)
FPP (5 times)
GPP (4 times)
2000 Terpenoid secondary metabolism in Arabidopsis thaliana: cDNA cloning, characterization, and functional expression of a myrcene/(E)-beta-ocimene synthase.
trehalose-6-phosphate synthase
(113 times)
Biochemistry
(23 times)
TPP (39 times)
Tre (13 times)
T6P (11 times)
1991 Trehalose-6-phosphate synthase/phosphatase complex from bakers' yeast: purification of a proteolytically activated form.
titanium plasma-sprayed
(111 times)
Dentistry
(77 times)
HA (27 times)
SLA (20 times)
BIC (8 times)
1986 ITI endosteal hollow cylinder implant systems.
thin-plate spline
(110 times)
Diagnostic Imaging
(25 times)
CT (7 times)
MI (5 times)
PCA (5 times)
1997 Mutual information for automated unwarping of rat brain autoradiographs.
time-to-PS
(55 times)
Physiology
(12 times)
PS (55 times)
TR90 (20 times)
FFI (6 times)
2000 Diabetes enhances acetaldehyde-induced depression of cardiac myocyte contraction.
10  two-partner secretion
(44 times)
Microbiology
(18 times)
FHA (8 times)
AT (3 times)
CDI (3 times)
2001 Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins.
11  transition path sampling
(33 times)
Chemistry
(23 times)
CMD (3 times)
TIS (3 times)
YADH (3 times)
2005 Mechanism of ligand exchange studied using transition path sampling.
12  tea polysaccharides
(28 times)
Molecular Biology
(7 times)
TPP (4 times)
AOM/DSS (2 times)
EPS (2 times)
2001 [Chemical properties and scavenging effects on active oxygen radicals of tea polysaccharides].
13  transcatheter pacing system
(25 times)
Cardiology
(20 times)
AF (2 times)
AVN (1 time)
CRT (1 time)
2015 Early Performance and Safety of the Micra Transcatheter Pacemaker in Pigs.
14  Toyota Production System
(20 times)
Health Services
(8 times)
CKD (1 time)
CPI (1 time)
CQI (1 time)
2003 Driving improvement in patient care: lessons from Toyota.
15  Technical Performance Score
(19 times)
General Surgery
(14 times)
CI (6 times)
HR (6 times)
TOF (4 times)
2012 Surgical technical performance scores are predictors of late mortality and unplanned reinterventions in infants after cardiac surgery.
16  time-to-peak shortening
(18 times)
Cardiology
(8 times)
PS (10 times)
TR90 (6 times)
TPT (3 times)
1982 Contractile behavior of rat myocardium after reversal of hypertensive hypertrophy.
17  total performance score
(15 times)
Health Services
(7 times)
CMS (3 times)
HVBP (3 times)
POSH (2 times)
2013 Value-based purchasing and the doctor-patient relationship.
18  treatment planning software
(15 times)
Biophysics
(12 times)
IDD (2 times)
MC (2 times)
OAR (2 times)
2008 Poster - Thurs Eve-39: Full 3D dose calculation for total body irradiation: A comparison study between treatment planning systems in homogeneous and heterogeneous conditions.
19  theta pulse stimulation
(12 times)
Neurology
(10 times)
LTP (8 times)
PS (4 times)
fEPSP (3 times)
1996 Factors regulating the reversibility of long-term potentiation.
20  terahertz pulsed spectroscopy
(11 times)
Pharmacology
(8 times)
TPI (5 times)
NIR (2 times)
PCA (2 times)
2004 Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications.
21  total plaque score
(11 times)
Science
(3 times)
CAD (4 times)
CCTA (4 times)
SSS (4 times)
2013 Chronic kidney disease is associated with increased coronary artery atherosclerosis as revealed by multidetector computed tomographic angiography.
22  transpancreatic sphincterotomy
(11 times)
Gastroenterology
(7 times)
ERCP (7 times)
PEP (5 times)
DGT (3 times)
2012 Comparison of three types of precut technique to achieve common bile duct cannulation: a retrospective analysis of 274 cases.
23  thiopental sodium
(9 times)
Neurology
(5 times)
ADR (2 times)
SR (2 times)
A-ADR (1 time)
1968 [Study of some maternal and fetal serum enzyme activities during labor. II. In labor under general anesthesia with thiopental sodium (TPS)].
24  thoracic pedicle screw
(9 times)
Orthopedics
(9 times)
AIS (5 times)
CT (3 times)
APSF (1 time)
2005 Radiographic outcomes of anterior spinal fusion versus posterior spinal fusion with thoracic pedicle screws for treatment of Lenke Type I adolescent idiopathic scoliosis curves.
25  tubular perfusion system
(9 times)
Biotechnology
(6 times)
hMSCs (4 times)
hMSC (2 times)
AACs (1 time)
2010 Tubular perfusion system for the long-term dynamic culture of human mesenchymal stem cells.
26  tarsal platform show
(8 times)
Ophthalmology
(7 times)
BFS (3 times)
MMCR (2 times)
MRD1 (2 times)
2012 Cosmetic outcome of posterior approach ptosis surgery (an American Ophthalmological Society thesis).
27  Thin Plate Splines
(8 times)
Diagnostic Imaging
(3 times)
ANT (1 time)
ASD (1 time)
CAD (1 time)
2005 Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants.
28  time to peak strain
(8 times)
Cardiology
(3 times)
PAF (2 times)
SR (2 times)
2D-STE (1 time)
2006 Detection of significant stenotic lesions in the left anterior descending coronary artery using adenosine triphosphate stress strain imaging: comparison with coronary flow velocity reserve measurement using transthoracic Doppler echocardiography.
29  Transitional Pain Service
(8 times)
Medicine
(2 times)
CPSP (3 times)
ACT (2 times)
COU (1 time)
2015 The Toronto General Hospital Transitional Pain Service: development and implementation of a multidisciplinary program to prevent chronic postsurgical pain.
30  true potato seed
(8 times)
Genetics
(6 times)
FDR (2 times)
CIP (1 time)
ddh x cv (1 time)
1987 True potato seed quality.
31  tadpole shrimp
(7 times)
Environmental Health
(5 times)
B.t.i (1 time)
1990 Influence of tadpole shrimp, Triops longicaudatus (Notostraca:Triopsidae), stocking rate on Culex tarsalis development in experimental field microcosms.
32  tooth pulp stimulation
(7 times)
Neurology
(6 times)
CAs (1 time)
CS (1 time)
dEMG (1 time)
1984 Variations of the jaw opening reflex observed in awake, freely moving rats.
33  transperineal sonography
(7 times)
Gynecology
(4 times)
TAS (2 times)
aHR (1 time)
AoP (1 time)
2006 Comparison of the accuracy of trans-abdominal sonography (TAS) and transperineal sonography (TPS) in the diagnosis of Placenta Praevia.
34  Taiwan Photon Source
(6 times)
Radiology
(3 times)
BIB (1 time)
CL (1 time)
DCMs (1 time)
2010 Predicting induced radioactivity for the accelerator operations at the Taiwan Photon Source.
35  thermal protection systems
(6 times)
Ophthalmology
(2 times)
MGD (2 times)
BL (1 time)
DED (1 time)
2015 Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms.
36  tissue polypeptide antigen
(6 times)
Neoplasms
(2 times)
CEA (3 times)
SCC (3 times)
TPA (2 times)
1996 Independent prognostic value of preoperative serum markers CA 242, specific tissue polypeptide antigen and human chorionic gonadotrophin beta, but not of carcinoembryonic antigen or tissue polypeptide antigen in colorectal cancer.
37  Trust in Physician Scale
(6 times)
Nursing
(2 times)
BFI-10 (1 time)
CRS (1 time)
DLC (1 time)
2007 Further evaluating the acceptability of group visits in an uninsured or inadequately insured patient population with uncontrolled type 2 diabetes.
38  tumor predisposition syndrome
(6 times)
Neoplasms
(3 times)
TuPS (2 times)
AACR (1 time)
MRI (1 time)
2017 Validation of a clinical screening instrument for tumour predisposition syndromes in patients with childhood cancer (TuPS): protocol for a prospective, observational, multicentre study.
39  Team Performance Scale
(5 times)
Education
(3 times)
TBL (2 times)
CEM (1 time)
EL (1 time)
2010 Evaluating the quality of learning-team processes in medical education: development and validation of a new measure.
40  terpene synthase genes
(5 times)
Botany
(2 times)
GDP (1 time)
2001 Isolation and functional analysis of a cDNA encoding a myrcene synthase from holm oak (Quercus ilex L.).
41  thoracic propriospinal
(5 times)
Neurology
(5 times)
LDPT (4 times)
SCI (3 times)
PS (2 times)
2009 Lack of axonal sprouting of spared propriospinal fibers caudal to spinal contusion injury is attributed to chronic axonopathy.
42  tibial plateau slope
(5 times)
Veterinary Medicine
(4 times)
CWO (2 times)
ACL (1 time)
CCL (1 time)
2003 Comparison of radiographic assessments of the tibial plateau slope in dogs.
43  tibial posterior slope
(5 times)
Orthopedics
(3 times)
OWHTO (4 times)
CT (2 times)
FTA (2 times)
2011 Navigated opening wedge high tibial osteotomy improves intraoperative correction angle compared with conventional method.
44  tissue polypeptide-specific
(5 times)
Neoplasms
(3 times)
tPA (2 times)
CyA (1 time)
ER (1 time)
1994 Tissue polypeptide-specific antigen and CA 125 as serum tumor markers in ovarian carcinoma.
45  tissue-specific polypeptide antigen
(5 times)
Neoplasms
(3 times)
TPA (4 times)
CEA (2 times)
CA19-9 (1 time)
1994 A more objective staging of advanced prostate cancer--routine recognition of malignant endocrine structures: the assessment of serum TPS, PSA, and NSE values.
46  Total Problem Score
(5 times)
Psychopharmacology
(1 time)
BPFAS (2 times)
TFS (2 times)
ART (1 time)
2010 The Child Behavior Checklist for Ages 1.5-5 (CBCL/1(1/2)-5): assessment and analysis of parent- and caregiver-reported problems in a population-based sample of Danish preschool children.
47  total protein S
(5 times)
Hematology
(3 times)
FPS (3 times)
PAI-1 (3 times)
PC (2 times)
1990 [Maturation of proteins C and S in childhood].
48  traditional pedicle screws
(5 times)
Orthopedic Procedures
(2 times)
CBT (2 times)
TLIF (2 times)
AS (1 time)
2017 Biomechanical Investigation of a Novel Revision Device in an Osteoporotic Model: Pullout Strength of Pedicle Screw Anchor Versus Larger Screw Diameter.
49  transient plane source
(5 times)
Nanotechnology
(2 times)
SEM (2 times)
TGA (2 times)
13C NMR (1 time)
2009 Effect of vinyl-modified silica and raw silica particles on the properties of as-prepared polymer-silica nanocomposite foams.
50  target plaque severity
(4 times)
Dermatology
(4 times)
COBRA (3 times)
GAI (3 times)
BSA (2 times)
2007 Topical monotherapy with clobetasol propionate spray 0.05% in the COBRA trial.
51  temporal-phase-shifting
(4 times)
Ophthalmology
(4 times)
BEMD-HT (1 time)
CWT (1 time)
WFT (1 time)
2003 Adaptive phase-shifting algorithm for temporal phase evaluation.
52  tender point score
(4 times)
Rheumatology
(4 times)
FIQ (3 times)
FM (2 times)
EFA (1 time)
2001 The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire.
53  tetraphenylsilole
(4 times)
Chemistry
(2 times)
AIE (2 times)
cRGD (1 time)
DEVD (1 time)
2014 Targeted theranostic platinum(IV) prodrug with a built-in aggregation-induced emission light-up apoptosis sensor for noninvasive early evaluation of its therapeutic responses in situ.
54  thermal power stations
(4 times)
Environmental Health
(4 times)
CWSP (1 time)
DE (1 time)
MARS (1 time)
1986 Natural radiation environment of the Nasik and Neyveli thermal power stations, India.
55  thin-plate spline analysis
(4 times)
Orthodontics
(3 times)
CCA (2 times)
EDMA (2 times)
CP (1 time)
2003 Morphometric analysis of the transverse dentoskeletal features of class II malocclusion in the mixed dentition.
56  titanium plasma-spray coating
(4 times)
Dentistry
(3 times)
HA (2 times)
TPSA (1 time)
1995 Maxillary and mandibular titanium implants 1 year after surgery: histologic examination in a cadaver.
57  tooth pulp specific
(4 times)
Physiology
(1 time)
WDR (4 times)
TP (3 times)
TTT (3 times)
1986 Tooth pulp input to the shell region of nucleus ventralis posteromedialis of the cat thalamus.
58  total points
(4 times)
Biological Science Disciplines
(2 times)
C-index (3 times)
OS (3 times)
HR (2 times)
2018 Prognostic nomogram for patients with Nasopharyngeal Carcinoma incorporating hematological biomarkers and clinical characteristics.
59  total polyp score
(4 times)
Otolaryngology
(3 times)
CRS (2 times)
CRSwNP (2 times)
ACT (1 time)
2018 Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size.
60  Total Position Spread
(4 times)
Chemistry
(4 times)
FCI (2 times)
SP (1 time)
SP-TPS (1 time)
2014 The Total Position Spread in mixed-valence compounds: A study on the H4+ model system.
61  trismus-pseudocamptodactyly syndrome
(4 times)
Dentistry
(2 times)
DA (1 time)
1982 Linkage analysis with the trismus-pseudocamptodactyly syndrome.
62  tryptase
(4 times)
Chemistry Techniques, Analytical
(2 times)
HIS (2 times)
AAPHNs (1 time)
DNA-NTs (1 time)
2011 [Allergic mediators in tear from children with seasonal and perennial allergic conjunctivitis].
63  tumor positive score
(4 times)
Neoplasms
(2 times)
CPS (3 times)
HNSCC (2 times)
ICS (2 times)
2020 Diabetes mellitus type 2 is associated with increased tumor expression of programmed death-ligand 1 (PD-L1) in surgically resected non-small cell lung cancer-A matched case-control study.
64  6-triisopropylbenzene-sulfonyl chloride
(3 times)
Biochemistry
(2 times)
DCC (1 time)
DCCI (1 time)
DMF (1 time)
1976 Investigation of the mechanism of the synthesis of oligonucleotides. IX. 31P NMR spectra of the active dinucleotide derivatives and their analogs.
65  talaporfin sodium
(3 times)
Surgical Procedures, Operative
(1 time)
PDT (3 times)
BDC (2 times)
HPLC (1 time)
2012 Photodynamic therapy using talaporfin sodium (Laserphyrin) for bile duct carcinoma: a preliminary clinical trial.
66  targeted panel sequencing
(3 times)
Cardiology
(1 time)
WES (2 times)
CNV (1 time)
CPVT (1 time)
2019 Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia.
67  thalamic pain syndrome
(3 times)
Neurosurgery
(2 times)
ACC (1 time)
DBS (1 time)
NRS (1 time)
1989 Thalamic pain syndrome.
68  Theoretical Profile Shape
(3 times)
Environmental Health
(2 times)
IHF (1 time)
PELMO (1 time)
RICEWQ (1 time)
2002 Volatilization of trifluralin, atrazine, metolachlor, chlorpyrifos, alpha-endosulfan, and beta-endosulfan from freshly tilled soil.
69  tomotherapy planning system
(3 times)
Radiotherapy
(1 time)
IMMPT (1 time)
2005 [The implementation of sharing treatment planning system based on DICOM].
70  total percentage score
(3 times)
Audiology
(1 time)
GIN (2 times)
ANC (1 time)
CI (1 time)
2017 Influence of temporal resolution skills in speech discrimination abilities of older subjects.
71  TPSLEQRTVYAK
(3 times)
Biomimetics
(1 time)
PCL (3 times)
EPCs (2 times)
HBOECs (1 time)
2012 Poly(epsilon-caprolactone) modified with fusion protein containing self-assembled hydrophobin and functional peptide for selective capture of human blood outgrowth endothelial cells.
72  transcranial perfusion sonography
(3 times)
Diagnostic Imaging
(2 times)
ROI (2 times)
AUC (1 time)
CBI (1 time)
2007 Ultrasonic contrast agents in transcranial perfusion sonography (TPS) for follow-up of patients with high grade gliomas.
73  transperineal ultrasound
(3 times)
Gynecology
(2 times)
BN (1 time)
FSFI (1 time)
GH (1 time)
2014 Pelvic floor muscle contractility: digital assessment vs transperineal ultrasound.
74  transsphenoidal pituitary surgery
(3 times)
Neurosurgery
(1 time)
CD (1 time)
NO (1 time)
TIVA (1 time)
2000 Treatment of pituitary-dependent Cushing's syndrome: long-term results of unilateral adrenalectomy followed by external pituitary irradiation compared to transsphenoidal pituitary surgery.
75  tree pollen season
(3 times)
Therapeutics
(1 time)
BPS (3 times)
SLIT (3 times)
ARC (1 time)
2018 Immunotherapy With the SQ Tree SLIT-tablet in Adults and Adolescents With Allergic Rhinoconjunctivitis.
76  truncated prolate spheroid
(3 times)
Biological Science Disciplines
(1 time)
LVEF (2 times)
US (2 times)
LV (1 time)
2017 New Mathematical Model for the Surface Area of the Left Ventricle by the Truncated Prolate Spheroid.
77  Tuckman Procrastination Scale
(3 times)
Medicine
(2 times)
PPC (2 times)
APS-SF (1 time)
BRCS (1 time)
2019 Relationship of academic procrastination with perceived competence, coping, self-esteem and self-efficacy in nursing students.
78  two-partner secretion system
(3 times)
Communicable Diseases
(1 time)
AT (1 time)
CCSs (1 time)
OM (1 time)
2007 Identification of a novel two-partner secretion locus in Moraxella catarrhalis.
79  two-phase system
(3 times)
Environmental Health
(2 times)
DOM (2 times)
AOM (1 time)
CCCD (1 time)
2011 Quality characteristics and fertilizing ability of ram sperm subpopulations separated by partition in an aqueous two-phase system.
80  3-(N,N-dimethyltetradecylammonio)propane sulfonate
(2 times)
Chemistry
(2 times)
CMC (2 times)
DPS (2 times)
HPS (2 times)
2008 Investigations on mixed micelles of binary mixtures of zwitterionic surfactants and triblock polymers: a cyclic voltammetric study.
81  temporary prostatic stent
(2 times)
Urology
(1 time)
IUC (1 time)
SUTI (1 time)
2017 Treating male retention patients with temporary prostatic stent in a large urology group practice.
82  therapy planning system
(2 times)
Medicine
(1 time)
4MV-3DCR T (1 time)
POI (1 time)
RT (1 time)
1997 [A practical study of the absorbed doses at the level of the organs at risk during the radiotherapy of bronchopulmonary cancer].
83  thermoelectric power station
(2 times)
Genetics
(2 times)
--- 1997 [Recombination in Drosophila melanogaster males exposed at a thermoelectric power plant].
84  thermometer pain scale
(2 times)
General Surgery
(1 time)
VAS (2 times)
BPI (1 time)
FPS (1 time)
2010 Efficacy and tolerability of admixing 0.3% lidocaine with Dermicol-P35 27G for the treatment of nasolabial folds.
85  thiamin phosphate synthase
(2 times)
Molecular Biology
(2 times)
cat (1 time)
TPI (1 time)
2008 Sensitive genome-wide screen for low secondary enzymatic activities: the YjbQ family shows thiamin phosphate synthase activity.
86  thickened pituitary stalk
(2 times)
Endocrinology
(1 time)
DI (2 times)
LCH (1 time)
MR (1 time)
2005 Surgical implications of the thickened pituitary stalk accompanied by central diabetes insipidus.
87  thiopropyl-Sepharose
(2 times)
Molecular Biology
(1 time)
Acyl-RAC (1 time)
BST (1 time)
MS (1 time)
2012 Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry.
88  Thirty Point Score
(2 times)
Medicine
(2 times)
ICC (1 time)
IDRI (1 time)
VAS (1 time)
2016 First quality score for referral letters in gastroenterology-a validation study.
89  Thomson parabola spectrometer
(2 times)
Biophysics
(2 times)
TOFS (1 time)
2009 Ion spectrometer composed of time-of-flight and Thomson parabola spectrometers for simultaneous characterization of laser-driven ions.
90  Tibetan Plateau and the surrounding
(2 times)
Natural Science Disciplines
(2 times)
CAPE (1 time)
FD (1 time)
ID (1 time)
2017 Spatial patterns of wet season precipitation vertical gradients on the Tibetan Plateau and the surroundings.
91  tissue polypeptide antigen specific
(2 times)
Neoplasms
(2 times)
CEA (1 time)
tps (1 time)
1995 Tissue polypeptide antigen-specific (tps) and carcinoembryonic antigen (cea) levels in cancerous and precancerous lesions in human colon.
92  titanium plasma-sprayed screw implant
(2 times)
Dentistry
(2 times)
--- 1989 [Single support of atrophic edentulous mandible with endosseous implants. Modified method of implantation with Ledermann titanium plasma-coated screw implants (TPS)].
93  titanium-sprayed plasma
(2 times)
Dentistry
(2 times)
cpTi (2 times)
SEM (1 time)
2011 [Effect of surface roughness and titanium dioxide layers on commercially pure titanium on attachment of osteoblasts].
94  toggle-pin suture
(2 times)
Veterinary Medicine
(2 times)
LDA (2 times)
FCM (1 time)
2002 The effect of left displacement of abomasum corrected by toggle-pin suture on lactation, reproduction, and health of Holstein dairy cows.
95  total nasal endoscopic polyp score
(2 times)
Otolaryngology
(2 times)
CRSwNP (2 times)
AERD (1 time)
CT (1 time)
2018 Monoclonal antibodies for the treatment of chronic rhinosinusitis with nasal polyposis: a systematic review.
96  total pain score
(2 times)
Outcome Assessment (Health Care)
(1 time)
GHQ (1 time)
OHS (1 time)
SDS (1 time)
2005 An index of depression in patients with chronic nonspecific musculoskeletal pain.
97  total power spectrum
(2 times)
Environmental Health
(1 time)
7-NI (1 time)
HRV (1 time)
2001 [Effect of electroacupuncture and 7-NI on penicillin-induced epilepsy and their relation with intrahippocampal NO changes].
98  total prognostic scores
(2 times)
Biomedical Research
(1 time)
HBV (2 times)
OS (2 times)
C-index (1 time)
2018 Establishment and validation of a predictive nomogram model for non-small cell lung cancer patients with chronic hepatitis B viral infection.
99  total suspended particulates
(2 times)
Natural Science Disciplines
(1 time)
CF (1 time)
DI (1 time)
PAH (1 time)
2010 Determination of polycyclic aromatic hydrocarbons from ambient air particulate matter using a cold fiber solid phase microextraction gas chromatography-mass spectrometry method.
100  transcatheter Potts shunt
(2 times)
Cardiology
(2 times)
PAH (2 times)
DAo (1 time)
LPA (1 time)
2013 Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience.