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Abbreviation: m6A
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
N6-methyladenosine
(3005 times)
Neoplasms
(486 times)
METTL3 (228 times)
FTO (158 times)
lncRNAs (126 times)
1976 5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.
N6-methylation of adenosine
(31 times)
Neoplasms
(8 times)
CRC (2 times)
GSEA (2 times)
lncRNA (2 times)
2015 N6-adenosine methylation in MiRNAs.
modification, N6-methyladenosine
(30 times)
Cell Biology
(5 times)
m5C (3 times)
KO (2 times)
LASSO (2 times)
2017 Detecting N6-methyladenosine sites from RNA transcriptomes using ensemble Support Vector Machines.
Methylation at the N6 position of adenosine
(17 times)
Virology
(3 times)
HA (2 times)
CLIP (1 time)
COVID-19 (1 time)
2017 Viral Epitranscriptomics.
methylation of adenosine at the N6-position
(6 times)
Genomics
(1 time)
SAM (2 times)
m1A (1 time)
METTL (1 time)
2019 m6A-mRNA methylation regulates cardiac gene expression and cellular growth.
METTL14, as one of N6-methyladenosine
(4 times)
Cell Biology
(2 times)
ALL (1 time)
ccRCC (1 time)
CIs (1 time)
2018 METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation.
modification in eukaryotic cells, N6-methyladenosine
(4 times)
Virology
(1 time)
circRNAs (1 time)
KSHV (1 time)
SV40 (1 time)
2018 The RNA Epitranscriptome of DNA Viruses.
N6-methylated adenine
(4 times)
Biochemistry
(2 times)
N6-mAMP (1 time)
2018 m6A RNA Degradation Products Are Catabolized by an Evolutionarily Conserved N6-Methyl-AMP Deaminase in Plant and Mammalian Cells.
methyl groups at the N6 position
(3 times)
Biological Science Disciplines
(1 time)
8-NO2-G (1 time)
CTD (1 time)
m5C (1 time)
2018 Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
10  methyltransferase which catalyze N6-methyladenosine
(3 times)
Cell Biology
(3 times)
ADPKD (1 time)
DUBs (1 time)
NRCMs (1 time)
2021 A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease.
11  mRNA and noncoding RNAs is N6-methyladenosine
(3 times)
Neoplasms
(1 time)
FTO (1 time)
GBM (1 time)
GC (1 time)
2019 Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer.
12  m62A and N6-methyladenine
(2 times)
Bacteriology
(1 time)
m1A (1 time)
m2G (1 time)
m6G (1 time)
1979 23S ribosomal ribonucleic acid of macrolide-producing streptomycetes contains methylated adenine.
13  markers and prognostic performance of N6-methyladenosine
(2 times)
Biomedical Research
(1 time)
CM (1 time)
CNV (1 time)
GTEx (1 time)
2021 Identification and Verification of Molecular Subtypes with Enhanced Immune Infiltration Based on m6A Regulators in Cutaneous Melanoma.
14  mechanisms, and N6-methyladenosine
(2 times)
Genetics
(1 time)
ABHD11-AS1 (1 time)
IDD (1 time)
lncRNA (1 time)
2020 Bioinformatics analysis integrating metabolomics of m6A RNA microarray in intervertebral disc degeneration.
15  methyl-6-adenosine
(2 times)
Molecular Biology
(1 time)
5mC (1 time)
LINE (1 time)
m5C (1 time)
2017 Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP).
16  methylate and demethylate N6-methyladenosine
(2 times)
Biochemistry
(1 time)
m6ACE-seq (1 time)
XIST (1 time)
2019 Atlas of quantitativesingle-base-resolution N6-methyl-adenine methylomes.
17  Methylation of the adenosine base at the nitrogen-6 position
(2 times)
Molecular Biology
(2 times)
ABEs (1 time)
SNP (1 time)
2017 Most m6A RNA Modifications in Protein-Coding Regions Are Evolutionarily Unconserved and Likely Nonfunctional.
18  microbiota and N6-methyladenosine
(2 times)
Immune System Diseases
(1 time)
TIICs (2 times)
TME (2 times)
BLCA (1 time)
2021 Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors.
19  modified nucleotides are N6-methyladenosine
(2 times)
Cell Biology
(2 times)
m6Am (1 time)
TSSs (1 time)
2019 Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome.
20  molecules, and N6-methyladenosine
(2 times)
Neoplasms
(2 times)
DEFRlncRNAs (1 time)
FRGs (1 time)
FRlncRNAs (1 time)
2022 Construction of a Prognostic Model for KIRC and Identification of Drugs Sensitive to Therapies - A Comprehensive Biological Analysis Based on m6A-Related LncRNAs.
21  most abundant mRNA modification, N6-methyladenosine
(2 times)
Medical Informatics
(1 time)
m6A-reg-exp (1 time)
Tg (1 time)
2019 Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats.
22  mRNA and lncRNA, N6-methyladenosine
(2 times)
Biochemistry
(2 times)
m1A (1 time)
2022 m6A-TSHub: Unveiling the Context-specific m6A Methylation and m6A-affecting Mutations in 23 Human Tissues.
23  6-methylaminopurine
(1 time)
Biochemistry
(1 time)
m5C (1 time)
2005 The language of methylation in genomics of eukaryotes.
24  ARSTRACTN6-methyladenosine
(1 time)
Bioengineering
(1 time)
FTO (1 time)
KLF3 (1 time)
OS (1 time)
2022 Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Kruppel-like factor 3 (KLF3) promotes osteosarcoma progression.
25  foundN6-methyladenosine
(1 time)
Biotechnology
(1 time)
--- 2022 m6A-mediated modulation coupled with transcriptional regulation shapes long noncoding RNA repertoire of the cGAS-STING signaling.
26  hemi-methylated, and fully methylated N6-methyladenine
(1 time)
Biochemistry
(1 time)
m5C (1 time)
1990 Analysis of substrate specificity of the PaeR7 endonuclease: effect of base methylation on the kinetics of cleavage.
27  kit-8,N6-methyladenosine
(1 time)
Medicine
(1 time)
AML (1 time)
METTL3 (1 time)
2018 [Methyltransferase-like 3 Promotes the Proliferation of Acute Myeloid Leukemia Cells by Regulating N6-methyladenosine Levels of MYC].
28  M2 activation by targeting tuberous sclerosis 1 via an N6-methyladenosine
(1 time)
Biomedical Research
(1 time)
IL-4 (1 time)
mRNA (1 time)
STAT6 (1 time)
2021 The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARgamma.
29  m6A in immune response and explore N6-methyladenosine
(1 time)
Neoplasms
(1 time)
ccRCC (1 time)
2022 N6-methyladenosine methylation related immune biomarkers correlates with clinicopathological characteristics and prognosis in clear cell renal cell carcinoma.
30  m6A level via recruiting N6-methyladenosine
(1 time)
Cell Biology
(1 time)
HCC (1 time)
ILF3-AS1 (1 time)
lncRNA (1 time)
2021 Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m6A-dependent manner.
31  m6A sequencing, which confirmed that altered N6-methyladenosine
(1 time)
Environmental Health
(1 time)
COPD (1 time)
Cyth1 (1 time)
EMPs (1 time)
2022 PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification.
32  m6A, and methylated
(1 time)
Cardiology
(1 time)
FTO (1 time)
2018 FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair.
33  m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine
(1 time)
Biochemistry
(1 time)
--- 2020 m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome.
34  m6Am and 5'-UTR N6-methyladenosine
(1 time)
Biology
(1 time)
--- 2021 m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome.
35  m6Am rather than N6-methyladenosine
(1 time)
Science
(1 time)
FTO (1 time)
2016 Reversible methylation of m6Am in the 5' cap controls mRNA stability.
36  major RNA N6-adenosine methyltransferase
(1 time)
Biology
(1 time)
CNAB (1 time)
iCCA (1 time)
pCCA (1 time)
2022 The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.
37  mammalian messenger RNA, N6methyladenosine
(1 time)
Gynecology
(1 time)
EMT (1 time)
2018 METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
38  mark N 6-methyladenine
(1 time)
Plant Physiological Phenomena
(1 time)
ABA (1 time)
2021 ALKBH10B, an mRNA m6A Demethylase, Modulates ABA Response During Seed Germination in Arabidopsis.
39  Mechanism and Role of N6-Methyladenosine
(1 time)
Cardiovascular System
(1 time)
AD (1 time)
AS (1 time)
2022 The Mechanism and Role of N6-Methyladenosine (m6A) Modification in Atherosclerosis and Atherosclerotic Diseases.
40  mechanism by which N 6 -methyladenosine
(1 time)
Genetic Phenomena
(1 time)
FAK (1 time)
LASSO (1 time)
lncRNAs (1 time)
2022 N 6 -Methyladenosine-Related Long Non-Coding RNAs Are Identified as a Potential Prognostic Biomarker for Lung Squamous Cell Carcinoma and Validated by Real-Time PCR.
41  mechanism of the RNA N6,2'-O-dimethyladenosine
(1 time)
Hematology
(1 time)
METTL3 (1 time)
RIP (1 time)
UBXN1 (1 time)
2021 YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-kappaB and promote the malignant progression of glioma.
42  Mechanistically, FEZF1AS1 expression was influenced by N6methyladenosine
(1 time)
Neoplasms
(1 time)
lncRNAs (1 time)
miR (1 time)
NSCLC (1 time)
2020 Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.
43  messenger RNA, such as N6-methyladenosine
(1 time)
Genetics, Medical
(1 time)
--- 2020 N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
44  messenger RNAs identified, N6-methyladenosine
(1 time)
Genetics
(1 time)
--- 2017 Role of N6-methyladenosine modification in cancer.
45  metabolism were explored.N6-methyladenosine
(1 time)
Cell Biology
(1 time)
DMM (1 time)
ECM (1 time)
EVs (1 time)
2022 Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
46  methylated at internal adenosine residues to form N6-methyladenosine
(1 time)
Cell Biology
(1 time)
--- 1987 Unequal distribution of N6-methyladenosine in influenza virus mRNAs.
47  methylated at the N6 position of A to form N6-methyladenine
(1 time)
8-oxo-dGTP (1 time)
8-oxodG (1 time)
HG (1 time)
2018 The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.
48  methylation and post-transcriptionally by N-6-methyladenosine
(1 time)
Genetics
(1 time)
FA (1 time)
2020 Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells.
49  methylation at position N6 in adenosine
(1 time)
Neoplasms
(1 time)
lncRNAs (1 time)
mCRPC (1 time)
MTC (1 time)
2020 VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer.
50  methylation at position N6 of adenine is called N6-methyladenosine
(1 time)
Genetic Phenomena
(1 time)
DFI (1 time)
DSS (1 time)
GO (1 time)
2021 Contributions and Prognostic Values of N6-Methyladenosine RNA Methylation Regulators in Hepatocellular Carcinoma.
51  methylation of messenger RNA at the N6 position
(1 time)
Cell Biology
(1 time)
--- 2020 Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
52  methylations of adenosine to form either N 6-methyladenosine
(1 time)
Biology
(1 time)
m6Am (1 time)
mRNA (1 time)
2019 Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA.
53  METTL14 and N6-adenosine methylation
(1 time)
Chemistry
(1 time)
HDAC (1 time)
mESCs (1 time)
TSA (1 time)
2020 The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes.
54  METTL14 dimerize to form an N6-methyladenosine
(1 time)
Stem Cells
(1 time)
ESC (1 time)
METTL (1 time)
2022 METTLing in Stem Cell and Cancer Biology.
55  METTL14, a critical component of N6-methyladenosine
(1 time)
Neoplasms
(1 time)
--- 2021 METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children.
56  METTL3 and METTL14-mediated N6-methyladenosine
(1 time)
Reproductive Medicine
(1 time)
--- 2022 METTL3 and METTL14-mediated N6-methyladenosine modification promotes cell proliferation and invasion in a model of endometriosis.
57  METTL3, an enzyme catalyzes the formation of N6-methyladenosine
(1 time)
Biochemistry
(1 time)
ECM (1 time)
OA (1 time)
2019 METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.
58  miR-1299 and ZC3H13/N6-methyladenosine
(1 time)
Biochemistry
(1 time)
circRNAs (1 time)
HCC (1 time)
2022 circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N6-methyladenosine (m6A) to promote growth and invasion of hepatocellular carcinoma cells.
59  miR181d5p by the RNA N6methyladenosine
(1 time)
Neoplasms
(1 time)
CAFs (1 time)
CRC (1 time)
DGCR8 (1 time)
2022 N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer.
60  modification and regulation of N6-methyladenosine
(1 time)
Translational Medical Research
(1 time)
RCC (1 time)
RIP (1 time)
2020 ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
61  modification, N6-adenosine methylation
(1 time)
Immune System Diseases
(1 time)
METTL3 (1 time)
SOCS3 (1 time)
TP (1 time)
2022 YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
62  modifications after transcription, such as N6-methyladenosine
(1 time)
Gastroenterology
(1 time)
--- 2020 Epitranscriptomics in liver disease: Basic concepts and therapeutic potential.
63  modifications and, in particular, for N6-methyladenosine
(1 time)
Medical Informatics
(1 time)
MeRIP-seq (1 time)
MoAIMS (1 time)
2020 MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq.
64  modifications are common in pharmacogenes, especially N6-methyladenosine
(1 time)
Nucleic Acids
(1 time)
AML (1 time)
TNBC (1 time)
2022 Pharmacoepitranscriptomic landscape revealing m6A modification could be a drug-effect biomarker for cancer treatment.
65  modifications are known, such as 6-methyladenosine
(1 time)
AML (1 time)
HSPCs (1 time)
m5C (1 time)
2021 Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia.
66  modifications of DNA and RNA, with particular focus on N6-methyladenosine
(1 time)
Neoplasms
(1 time)
HDACs (1 time)
MAR (1 time)
2020 Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs.
67  modifications of RNA, such as N1methyladenosine, 2'Oribosemethylation, inosine, 5methylcytidine, N6methyladenosine
(1 time)
Neoplasms
(1 time)
AML (1 time)
circRNAs (1 time)
2021 Epigenetic modifications in acute myeloid leukemia: The emerging role of circular RNAs (Review).
68  Modifications Revealed Increased Levels of N 6-Methyladenosine
(1 time)
m1A (1 time)
ROC (1 time)
2021 Quantitative Analysis of Methylated Adenosine Modifications Revealed Increased Levels of N 6-Methyladenosine (m6A) and N 6,2'-O-Dimethyladenosine (m6Am) in Serum From Colorectal Cancer and Gastric Cancer Patients.
69  modulated by the writer, eraser, and reader proteins of N6-methyladenosine
(1 time)
Biology
(1 time)
--- 2019 HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.
70  monomethylating the N6-atom of adenine
(1 time)
Molecular Biology
(1 time)
MTases (1 time)
SAM (1 time)
2019 Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites.
71  morbidity and mortality. n6-methyladenosine
(1 time)
Immune System Diseases
(1 time)
CNV (1 time)
ESCA (1 time)
qRT-PCR (1 time)
2022 Identification of clinical prognostic features of esophageal cancer based on m6A regulators.
72  Moreover, ALKBH5-mediated N6-methyladenosine
(1 time)
Cell Death
(1 time)
CUL4A (1 time)
HCC (1 time)
lncRNAs (1 time)
2022 LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2.
73  Moreover,N6-methyladenosine
(1 time)
Neoplasms
(1 time)
lncRNAs (1 time)
METTL3 (1 time)
TNBC (1 time)
2022 WFDC21P promotes triple-negative breast cancer proliferation and migration through WFDC21P/miR-628/SMAD3 axis.
74  most abundant among them is N6-methyladenosine
(1 time)
Biological Science Disciplines
(1 time)
YTHDF3 (1 time)
2018 Dynamic m6A methylation facilitates mRNA triaging to stress granules.
75  most abundant, and encompasses N6-methyladenosine
(1 time)
Genetic Phenomena
(1 time)
m5C (1 time)
m7G (1 time)
2022 An m6A/m5C/m1A/m7G-Related Long Non-coding RNA Signature to Predict Prognosis and Immune Features of Glioma.
76  most common of which is the N6methyladenosine
(1 time)
Genes, Regulator
(1 time)
--- 2018 The m6A‑methylase complex and mRNA export.
77  mRNA and protein expression in an N6-methyladenosine
(1 time)
Hematologic Diseases
(1 time)
ALKBH5 (1 time)
PAQR4 (1 time)
2023 ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner.
78  mRNA and suppressed its stability through interaction with the N6-methyladenosine
(1 time)
Biochemistry
(1 time)
GC (1 time)
lncRNA (1 time)
2019 LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells.
79  mRNA in eukaryotes is N6-methyladenosine
(1 time)
Biology
(1 time)
IGF2BPs (1 time)
RBPs (1 time)
2022 The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer.
80  mRNA in higher eukaryotes, N6-methyladenosine
(1 time)
Hematology
(1 time)
CTCL (1 time)
2022 The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.
81  mRNA- and RNA-binding protein composition by regulating N6-methyladenosine
(1 time)
Antioxidants
(1 time)
LLPS (1 time)
MLOs (1 time)
PTMs (1 time)
2021 Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.
82  mRNAs, N6-adenosine methylation
(1 time)
Genes, Regulator
(1 time)
--- 2018 The role of RNA adenosine demethylases in the control of gene expression.
83  multi-omics data, including immune characteristics, N 6-methyladenosine
(1 time)
Genetic Phenomena
(1 time)
GInLncRNAs (1 time)
GInLncSig (1 time)
GSEA (1 time)
2022 Multi-Omics Analysis Based on Genomic Instability for Prognostic Prediction in Lower-Grade Glioma.
84  multiple N6methyladenosine
(1 time)
Neoplasms
(1 time)
EC (1 time)
2022 RNA m6A methylation regulators in endometrial cancer (Review).
85  N4-methylcytosine and N6-methyladenine
(1 time)
Biochemistry
(1 time)
--- 2006 Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.
86  N6-methyl-A
(1 time)
Biochemistry
(1 time)
m7G (2 times)
m1G (1 time)
m5C (1 time)
1984 Antibody-nucleic acid complexes. Antigenic domains within nucleosides as defined by solid-phase immunoassay.
87  N6-methylandrostenedione
(1 time)
GEO (1 time)
STAD (1 time)
2022 Prognostic Role of M6A-Associated Immune Genes and Cluster-Related Tumor Microenvironment Analysis: A Multi-Omics Practice in Stomach Adenocarcinoma.
88  N6-methylation found on adenosine
(1 time)
Biochemistry
(1 time)
MTases (1 time)
2021 A comprehensive review of m6A/m6Am RNA methyltransferase structures.
89  N6-methylation of internal adenosines
(1 time)
Science
(1 time)
Ck1delta (1 time)
2018 Two Ck1delta transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.
90  N6-methyldeoxyadenine
(1 time)
Molecular Biology
(1 time)
m5C (1 time)
MTases (1 time)
1997 Chlorella virus SC-1A encodes at least five functional and one nonfunctional DNA methyltransferases.
91  N6-monomethyl adenine
(1 time)
Bacteriology
(1 time)
rRNA (1 time)
1975 Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria.
92  Potential-N6-methyladenosine
(1 time)
Translational Medical Research
(1 time)
AUC (1 time)
GEO (1 time)
GSEA (1 time)
2022 Genome-wide screening and immune landscape suggest a potential-m6A-related lncRNA risk signature for predicting prognosis of melanoma.
93  S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA
(1 time)
Biological Science Disciplines
(1 time)
METTL3 (1 time)
ssDNA (1 time)
2022 RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro.